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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETS1 Gene

protein-coding   GIFtS: 71
GCID: GC11M128328

V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog...


(Previous symbol: EWSR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 11 2     p542 3
EWSR21 2 3     ETS-12
Avian Erythroblastosis Virus E26 (V-Ets) Oncogene Homolog-11 2     Protein C-Ets-12
Ets Protein1 2     V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 12

External Ids:    HGNC: 34881   Entrez Gene: 21132   Ensembl: ENSG000001349547   OMIM: 1647205   UniProtKB: P149213   

Export aliases for ETS1 gene to outside databases

Previous GC identifers: GC11M130331 GC11M129841 GC11M128362 GC11M127869 GC11M127866 GC11M127833 GC11M124277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ETS1 Gene:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These
proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem
cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for ETS1 Gene: 
ETS1 (v-ets avian erythroblastosis virus E26 oncogene homolog 1) is a protein-coding gene. Diseases associated with ETS1 include jacobsen syndrome, and colonic neoplasm, and among its related super-pathways are Development HGF signaling pathway and Rho Family GTPases. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
Function: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety
of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.
May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration
and invasion

Gene Wiki entry for ETS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETS1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ETS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ETS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q23.3

ETS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128328:  view genomic region     (about GC identifiers)

Start:
128,328,656 bp from pter      End:
128,457,453 bp from pter
Size:
128,798 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921 (See protein sequence)
Recommended Name: Protein C-ets-1  
Size: 441 amino acids; 50408 Da
Subunit: Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF
and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with
DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional
activity
Subcellular location: Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform
Ets-1 p27
6 PDB 3D structures from and Proteopedia for ETS1:
1GVJ (3D)        2NNY (3D)        2STT (3D)        2STW (3D)        3MFK (3D)        3RI4 (3D)    
Secondary accessions: A9UL17 F5GYX9 Q14278 Q16080 Q6N087
Alternative splicing: 4 isoforms:  P14921-1   P14921-2   P14921-3   P14921-4   (Acts as a dominant-negative for isoform c-ETS-1A)

Explore the universe of human proteins at neXtProt for ETS1: NX_P14921

Explore proteomics data for ETS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity (By
    similarity)
  • UniProtKB: Ubiquitinated; which induces proteasomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14921

  • ETS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ETS1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137292.1  NP_001155894.1  NP_005229.1  

    ENSEMBL proteins: 
     ENSP00000376436   ENSP00000435666   ENSP00000324578   ENSP00000433500   ENSP00000340485  
     ENSP00000441430  

    Human Recombinant Protein Products for ETS1: 
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    OriGene Purified Protein for ETS1
    OriGene Protein Over-expression Lysate for ETS1
    OriGene MassSpec for ETS1 
    OriGene Custom Protein Services for ETS1
    GenScript Custom Purified and Recombinant Proteins Services for ETS1
    Novus Biologicals ETS1 Proteins
    Novus Biologicals ETS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ETS1
    Cloud-Clone Corp. Proteins for ETS1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP10698492
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--

    ETS1 for ontologies           About GeneDecksing



    ETS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ETS1
    R&D Systems Antibodies for ETS1 (Ets-1)
    Cell Signaling Technology (CST) Antibodies for ETS1  (Ets-1)
    OriGene Antibodies for ETS1
    OriGene Custom Antibody Services for ETS1
    GenScript Custom Superior Antibodies Services for ETS1
    Novus Biologicals ETS1 Antibodies
    Abcam antibodies for ETS1
    Cloud-Clone Corp. Antibodies for ETS1 
    ThermoFisher Antibody for ETS1
    LSBio Antibodies in human, mouse, rat for ETS1 

    Assay Products for ETS1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ETS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ETS1 
    Cloud-Clone Corp. CLIAs for ETS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR016311 Transform_prot_C-ets
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry P14921

    ProtoNet protein and cluster: P14921

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ETS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETS1_HUMAN, P14921
    Function: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety
    of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.
    May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration
    and invasion
    Induction: Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at
    protein level)

         Genatlas biochemistry entry for ETS1:
    avian erythroblastosis virus E26 (v-ets) oncogene homolog 1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10698492
    GO:0005515protein binding IPI10698492
    GO:0008134transcription factor binding NAS10698492
    GO:0043565sequence-specific DNA binding IEA--
         
    ETS1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ets1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging 

    ETS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ETS1: Ets1tm1Jml Ets1tm2Jml Ets1tm1Fwa Ets1tm1.1Dds

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ETS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ETS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETS1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ETS1:
    hsa-mir-9 (MIRT000641), hsa-mir-193b (MIRT005516), hsa-mir-31 (MIRT004975), hsa-mir-200b (MIRT003783), hsa-mir-155 (MIRT005104), hsa-mir-208a (MIRT005541)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETS1
    8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate ETS1 (see all 122):
    hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-759 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidETS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ETS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ETS1
    Sirion Biotech Customized adenovirus for overexpression of ETS1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ETS1 (see all 18)
    OriGene ORF clones in mouse, rat for ETS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ETS1 (NM_005238)
    Sino Biological Human cDNA Clone for ETS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS1
    Sirion Biotech Customized lentivirus for stable overexpression of ETS1 
                         Customized lentivirus expression plasmids for stable overexpression of ETS1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ETS1
    Search LifeMap BioReagents cell lines for ETS1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ETS1 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Renal cell carcinoma0.30
    2Rho Family GTPases
    ERK Signaling0.61
    3Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF-mediated glucocorticoid regulation1.00
    4CNTF Signaling
    Nur77-Induced AICD in Macrophage0.45
    5B cell receptor signaling pathway
    BCR signaling pathway0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ETS1
        Immune response MIF-mediated glucocorticoid regulation

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ETS1
        Nur77-Induced AICD in Macrophage
    ERK Signaling
    HGF Pathway
    MIF Action Through Endocytic Pathway
    Macrophage Differentiation and Growth Inhibition by METS

    1 Cell Signaling Technology (CST) Pathway for ETS1
        Angiogenesis

    1 GeneGo (Thomson Reuters) Pathway for ETS1
        Immune response MIF-mediated glucocorticoid regulation

    5/11 BioSystems Pathways for ETS1 (see all 11)
        Neural Crest Differentiation
    IL-4 signaling Pathway
    TGF-beta Receptor Signaling Pathway
    BCR signaling pathway
    HIF-1-alpha transcription factor network


    1 PharmGKB Pathway for ETS1
        Vemurafenib Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for ETS1):
        Dorso-ventral axis formation
    HTLV-I infection
    Pathways in cancer
    Renal cell carcinoma


    ETS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ETS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for ETS1 (P149211, 2, 3 ENSP000003764364) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000231617Q9UER72, 3, ENSP000004046234MINT-16586 I2D: score=5 STRING: ENSP00000404623
    ENSG00000206206Q9UER72, 3MINT-16586 I2D: score=5 
    ENSG00000206279Q9UER72, 3MINT-16586 I2D: score=5 
    ENSG00000227046Q9UER72, 3MINT-16586 I2D: score=5 
    ARP102752, 3, ENSP000003638224MINT-5207344 MINT-5207365 I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IDA7753825

    ETS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ETS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETS1

    10/39 Novoseek inferred chemical compound relationships for ETS1 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 55 92 15788677 (8), 17283532 (7), 12475439 (6), 12851814 (5) (see all 33)
    ionomycin 33.2 8 7500040 (2), 9190901 (2), 9190210 (2), 12632071 (1) (see all 5)
    oligonucleotide 33 28 16455618 (6), 16888027 (2), 9595399 (1), 1766672 (1) (see all 9)
    pd 98,059 27.2 6 15492268 (2), 18948081 (2), 9648911 (1), 15972796 (1)
    matrigel 23.3 2 16317516 (1), 18234959 (1)
    okadaic acid 21.1 5 8437861 (1), 7604037 (1), 9178763 (1), 12210726 (1)
    threonine 15.4 4 8552081 (2), 17105191 (1), 11948414 (1)
    curcumin 9.19 9 17590421 (5)
    sb 203580 7.73 1 9648911 (1)
    tgf beta1 6.73 4 16469114 (3), 15225617 (1)

    Search CenterWatch for drugs/clinical trials and news about ETS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ETS1 gene (3 alternative transcripts): 
    NM_001143820.1  NM_001162422.1  NM_005238.3  

    Unigene Cluster for ETS1:

    V-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
    Hs.369438  [show with all ESTs]
    Unigene Representative Sequence: NM_005238
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392668(uc001qej.2) ENST00000531611 ENST00000319397 ENST00000526145
    ENST00000530924 ENST00000525404 ENST00000527676 ENST00000345075(uc010sbs.1 uc009zcg.2)
    ENST00000535549(uc009zch.2)
    miRNA
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    8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate ETS1 (see all 122):
    hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-759 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidETS1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ETS1 (NM_005238)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS1
    Sirion Biotech Customized lentivirus for stable overexpression of ETS1 
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    OriGene qPCR primer pairs and template standards for ETS1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETS1

    Additional mRNA sequence: 

    AK001630.1 AK291840.1 AK301405.1 AL832693.1 AY943926.1 BC017314.2 BT019452.1 BT019453.1 
    BX640634.1 CR542254.1 J04101.1 S87905.1 X14798.1 

    10 DOTS entries:

    DT.91912037  DT.40303481  DT.97805404  DT.446760  DT.40127706  DT.75124395  DT.91704327  DT.120734178 
    DT.95091465  DT.97765772 

    24/209 AceView cDNA sequences (see all 209):

    AI288405 AA347480 BE220842 AA807444 CA407336 AI524394 AU132590 BF204016 
    BF224148 CB265553 J04101 AW291745 AA504110 BQ100810 CK824827 AI457252 
    CA943663 N74080 N38729 BF448849 BU172084 T29011 AI434908 BM458695 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ETS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -                                                         
    SP2:        -                                   -     -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for ETS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETS1 expression in normal human tissues (normalized intensities)      ETS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTTACTC
    ETS1 Expression
    About this image


    ETS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Mesenchymal Cells Epicardium
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             Cranial Neural Crest Cells Cranial Neural Crest
             skeleton/cranium   
     
     Spleen (Hematopoietic System)    fully expand to see all 3 entries
             Conventional Dendritic Cells II Spleen
             spleen ; cells in white pulp   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             skeleton/cranium   

    See ETS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETS1

    SOURCE GeneReport for Unigene cluster: Hs.369438

    UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
    Tissue specificity: Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in
    all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ETS1 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ETS1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ets11 , 5 E26 avian leukemia oncogene 1, 5' domain1, 5 92.35(n)1
    97.27(a)1
      9 (17.97 cM)5
    238711  NM_011808.21  NP_035938.21 
     326960425 
    chicken
    (Gallus gallus)
    Aves TNIP11 TNFAIP3 interacting protein 1 84.66(n)
    95.92(a)
      396235  NM_205298.2  NP_990629.2 
    lizard
    (Anolis carolinensis)
    Reptilia ETS16
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    90(a)
    83(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    GL343197.1(4553735-4679135)
    GL343514.1(389882-391152)
    African clawed frog
    (Xenopus laevis)
    Amphibia ets1a-A-prov2 c-ets-1a proto-oncogene 78.44(n)    X52692.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11162 idibd1116 78.17(n)   58005  BU808703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pnt3 anti-apoptosis type II transforming
    growth factor-beta more
    57(a)     --


    ENSEMBL Gene Tree for ETS1 (if available)
    TreeFam Gene Tree for ETS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETS1 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  GABPA2  ETS22  
    ELK12  ERG2  FEV2  ETV42  ETV22  FLI12  ELK32  
    4 SIMAP similar genes for ETS1 using alignment to 3 protein entries:     ETS1_HUMAN (see all proteins):
    TLS-ERG    ELK3    ETS2    FEV

    ETS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ETS1
    PGOHUM00000260928


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2504 SNPs in ETS1 are shown (see all 2504)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601063751,2
    C--124296570(+) GGAGGG/AAGGGA 3 -- int17Minor allele frequency- A:0.02NA WA CSA EA 248
    rs1918277831,2
    --124296612(+) GGGAAA/GGAAAG 3 -- int10--------
    rs1427144561,2
    C--124296623(+) AAGGA-/AGGA  
     AGGAAGG
    AGGAA
    3 -- int10--------
    rs1404879301,2
    C--124296730(+) GGAGA-/GAGG  
            
    GAGGG
    3 -- int10--------
    rs128070251,2
    C--124296738(+) GGAGGA/GAGGAA 3 -- int1 trp31Minor allele frequency- G:0.00CSA 1
    rs344222891,2
    C--124299439(+) TATTCT/-TTATC 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs2013146701,2
    C--124299439(+) TATTCC/TTTATC 3 -- int10--------
    rs679127381,2
    C--124371058(+) GGACG-/TAGGTC 1 -- int10--------
    rs1387877771,2
    C--128197549(+) TCCACC/TAAAGA 3 -- ds50010--------
    rs754076181,2
    C--128197584(+) AGGAAC/TGGTAC 3 -- ds50013Minor allele frequency- T:0.04CSA WA EA 240

    HapMap Linkage Disequilibrium report for ETS1 (128328656 - 128457453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ETS1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1237588CNV Deletion17803354
    esv2745239CNV Deletion23290073
    esv2745238CNV Deletion23290073
    esv2745237CNV Deletion23290073
    esv269752CNV Insertion20981092
    esv1757388CNV Insertion17803354
    esv25513CNV Loss19812545
    nsv898448CNV Loss21882294
    nsv517012CNV Loss19592680
    esv275584CNV Loss21479260


    Human Gene Mutation Database (HGMD): ETS1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164720    OMIM disorders: --

    20/81 diseases for ETS1 (see all 81):    About MalaCards
    jacobsen syndrome    colonic neoplasm    benign meningioma    bile duct carcinoma
    meningioma    ventricular septal defect    dermatofibrosarcoma    dermatofibrosarcoma protuberans
    ovarian endometriosis    angiosarcoma    ataxia telangiectasia    nasopharyngitis
    hemangioma    clear cell renal cell carcinoma    gastrointestinal stromal tumor    thymoma
    abdominal aortic aneurysm    endometriosis    fibrous histiocytoma    germ cell tumors

    1 disease from the University of Copenhagen DISEASES database for ETS1:
    Cancer

    ETS1 for disorders           About GeneDecksing

    10/62 Novoseek inferred disease relationships for ETS1 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 72.2 12 16894529 (2), 15848191 (1), 15994290 (1), 19083476 (1) (see all 6)
    friend leukemia 52.5 1 15994290 (1)
    tumors 45.5 120 16240325 (4), 11353051 (4), 10392639 (3), 15940256 (3) (see all 65)
    anaplastic meningioma 40.3 2 11147600 (1), 16722933 (1)
    metastasis 39.1 42 17283532 (6), 14562368 (4), 12475439 (3), 11068545 (2) (see all 21)
    leukemia t-cell 34.4 1 2209540 (1)
    neovascularization 33.2 2 12932931 (1), 15816498 (1)
    carcinoma 33.1 47 19253033 (4), 8952528 (4), 10765128 (4), 11353051 (4) (see all 22)
    leukemia 31.9 8 2189104 (1), 8099060 (1), 18958307 (1), 2250910 (1) (see all 7)
    benign meningioma 31.5 3 16894529 (1), 11147600 (1)

    Genetic Association Database (GAD): ETS1
    Human Genome Epidemiology (HuGE) Navigator: ETS1 (5 documents)
    Tumor Gene Database (TGDB): ETS1

    Export disorders for ETS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETS1 gene, integrated from 9 sources (see all 589):
    (articles sorted by number of sources associating them with ETS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. (PubMed id 8231246)1, 2, 9 Collyn d'Hooghe M.... Kerckaert J.P. (1993)
    2. Sp100 interacts with ETS-1 and stimulates its transcriptional activity. (PubMed id 11909962)1, 2, 9 Wasylyk C....Wasylyk B. (2002)
    3. Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin- conjugating enzyme. (PubMed id 9333025)1, 2, 9 Hahn S.L.... Wasylyk B. (1997)
    4. SP100 inhibits ETS1 activity in primary endothelial cells. (PubMed id 15592518)1, 2, 9 Yordy J.S....Watson D.K. (2005)
    5. Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter. (PubMed id 1614856)1, 2, 9 Majerus M.-A....Bailleul B. (1992)
    6. Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51. (PubMed id 19377509)1, 2, 9 Laitem C.... Aumercier M. (2009)
    7. Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. (PubMed id 18566588)1, 2, 9 Lamber E.P....Wilmanns M. (2008)
    8. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (2012)
    9. Genome-wide association study in Asian populations id entifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosu s. (PubMed id 20169177)1, 4 Yang W....Lau Y.L. (2010)
    10. Transcription factor Ets-1 in cytokine and chemokine gene regulation. (PubMed id 20378371)1, 2 Russell L. and Garrett-Sinha L.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2113 HGNC: 3488 AceView: ETS1 Ensembl:ENSG00000134954 euGenes: HUgn2113
    ECgene: ETS1 Kegg: 2113 H-InvDB: ETS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ETS1 gene:
    Search GeneIP for patents involving ETS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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