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ETS1 Gene

protein-coding   GIFtS: 73
GCID: GC11M128328

V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog...


(Previous symbol: EWSR2)
  See ETS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 11 2     p542 3
EWSR21 2 3     ETS-12
Avian Erythroblastosis Virus E26 (V-Ets) Oncogene Homolog-11 2     Protein C-Ets-12
Ets Protein1 2     V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 12

External Ids:    HGNC: 34881   Entrez Gene: 21132   Ensembl: ENSG000001349547   OMIM: 1647205   UniProtKB: P149213   

Export aliases for ETS1 gene to outside databases

Previous GC identifers: GC11M130331 GC11M129841 GC11M128362 GC11M127869 GC11M127866 GC11M127833 GC11M124277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ETS1 Gene:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a
conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These
proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem
cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for ETS1 Gene:
ETS1 (v-ets avian erythroblastosis virus E26 oncogene homolog 1) is a protein-coding gene. Diseases associated with ETS1 include jacobsen syndrome, and meningioma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
Function: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety
of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.
May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration
and invasion

Gene Wiki entry for ETS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ETS1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ETS1 promoter sequence
   Search Chromatin IP Primers for ETS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q23.3

ETS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128328:  view genomic region     (about GC identifiers)

Start:
128,328,656 bp from pter      End:
128,457,453 bp from pter
Size:
128,798 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921 (See protein sequence)
Recommended Name: Protein C-ets-1  
Size: 441 amino acids; 50408 Da
Subunit: Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF
and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with
DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional
activity
6 PDB 3D structures from and Proteopedia for ETS1:
1GVJ (3D)        2NNY (3D)        2STT (3D)        2STW (3D)        3MFK (3D)        3RI4 (3D)    
Secondary accessions: A9UL17 F5GYX9 Q14278 Q16080 Q6N087
Alternative splicing: 4 isoforms:  P14921-1   P14921-2   P14921-3   P14921-4   (Acts as a dominant-negative for isoform c-ETS-1A)

Explore the universe of human proteins at neXtProt for ETS1: NX_P14921

Explore proteomics data for ETS1 at MOPED

Post-translational modifications: 

  • Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity (By
    similarity)1
  • Ubiquitinated; which induces proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys8, Lys50, Lys58, Lys245, Lys399
  • Modification sites at PhosphoSitePlus

  • See ETS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137292.1  NP_001155894.1  NP_005229.1  

    ENSEMBL proteins: 
     ENSP00000376436   ENSP00000433500   ENSP00000435666   ENSP00000324578   ENSP00000476649  
     ENSP00000340485   ENSP00000441430  
    Reactome Protein details: P14921

    ETS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for ETS1
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    OriGene Protein Over-expression Lysate for ETS1
    OriGene MassSpec for ETS1
    OriGene Custom Protein Services for ETS1
    GenScript Custom Purified and Recombinant Proteins Services for ETS1
    Novus Biologicals ETS1 Proteins
    Novus Biologicals ETS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ETS1
    Cloud-Clone Corp. Proteins for ETS1

     
    Search eBioscience for Proteins for ETS1 

    ETS1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ETS1
    R&D Systems Antibodies for ETS1 (Ets-1)
    Cell Signaling Technology (CST) Antibodies for ETS1  (Ets-1)
    OriGene Antibodies for ETS1
    OriGene Custom Antibody Services for ETS1
    Novus Biologicals ETS1 Antibodies
    Abcam antibodies for ETS1
    Cloud-Clone Corp. Antibodies for ETS1
    ThermoFisher Antibody for ETS1
    LSBio Antibodies in human, mouse, rat for ETS1

    ETS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ETS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ETS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ETS1
    Cloud-Clone Corp. CLIAs for ETS1
    Search eBioscience for ELISAs for ETS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR016311 Transform_prot_C-ets
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry P14921

    ProtoNet protein and cluster: P14921

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Find genes that share domains with ETS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETS1_HUMAN, P14921
    Function: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety
    of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.
    May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration
    and invasion
    Induction: Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at
    protein level)

         Genatlas biochemistry entry for ETS1:
    avian erythroblastosis virus E26 (v-ets) oncogene homolog 1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10698492
    GO:0005515protein binding IPI10698492
    GO:0008134transcription factor binding NAS10698492
         
    Find genes that share ontologies with ETS1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ets1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with ETS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ETS1: Ets1tm1Jml Ets1tm2Jml Ets1tm1Fwa Ets1tm1.1Dds

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ETS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ETS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETS1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ACAGGAAGTG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ETS1:
    hsa-mir-193b-3p (MIRT005516), hsa-mir-10a-5p (MIRT047624), hsa-mir-222-3p (MIRT006064), hsa-mir-31-5p (MIRT004975), hsa-mir-155-5p (MIRT005104), hsa-mir-208a-3p (MIRT005541), hsa-mir-9-5p (MIRT000641), hsa-mir-200b-3p (MIRT003783), hsa-mir-125b-5p (MIRT006387), hsa-mir-30c-5p (MIRT047908)

    Block miRNA regulation of human, mouse, rat ETS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETS1 (see all 122):
    hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-759 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidETS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ETS1
    Predesigned siRNA for gene silencing in human, mouse, rat ETS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ETS1

    Clone
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    OriGene clones in human, mouse for ETS1 (see all 15)
    OriGene ORF clones in mouse, rat for ETS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ETS1 (NM_005238)
    Sino Biological Human cDNA Clone for ETS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ETS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ETS1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ETS1_HUMAN, P14921: Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform
    Ets-1 p27
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP10698492
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ETS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ETS1 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    2ERK Signaling
    ERK Signaling0.61
    3CNTF Signaling
    Nur77-Induced AICD in Macrophage0.45
    4B cell receptor signaling pathway (KEGG)
    BCR signaling pathway0.42
    5Sorafenib Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics0.37


    Find genes that share SuperPaths with ETS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ETS1
        Nur77-Induced AICD in Macrophage
    ERK Signaling
    HGF Pathway
    MIF Action Through Endocytic Pathway
    Macrophage Differentiation and Growth Inhibition by METS

    1 Cell Signaling Technology (CST) Pathway for ETS1
        Angiogenesis

    1 GeneGo (Thomson Reuters) Pathway for ETS1
        Immune response MIF-mediated glucocorticoid regulation

    Selected BioSystems Pathways for ETS1 (see all 11)
        Neural Crest Differentiation
    TGF-beta Receptor Signaling Pathway
    IL-4 signaling Pathway
    IL4-mediated signaling events
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)


    1 Reactome Pathway for ETS1
        Oncogene Induced Senescence

    1 PharmGKB Pathway for ETS1
        Vemurafenib Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for ETS1):
        Ras signaling pathway
    Dorso-ventral axis formation
    HTLV-I infection
    Pathways in cancer
    Renal cell carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ETS1 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ETS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ETS1 (P149211, 2, 3 ENSP000003764364) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAL1P175421, 2, 3, ENSP000002943394EBI-913209,EBI-1753878 MINT-8142126 MINT-8142147 I2D: score=1 STRING: ENSP00000294339
    ENSG00000231617Q9UER72, 3, ENSP000004046234MINT-16586 I2D: score=5 STRING: ENSP00000404623
    ENSG00000206206Q9UER72, 3MINT-16586 I2D: score=5 
    ENSG00000206279Q9UER72, 3MINT-16586 I2D: score=5 
    ENSG00000227046Q9UER72, 3MINT-16586 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IDA7753825

    Find genes that share ontologies with ETS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ETS1

    Selected Novoseek inferred chemical compound relationships for ETS1 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 55 92 15788677 (8), 17283532 (7), 12475439 (6), 12851814 (5) (see all 33)
    ionomycin 33.2 8 7500040 (2), 9190901 (2), 9190210 (2), 12632071 (1) (see all 5)
    oligonucleotide 33 28 16455618 (6), 16888027 (2), 9595399 (1), 1766672 (1) (see all 9)
    pd 98,059 27.2 6 15492268 (2), 18948081 (2), 9648911 (1), 15972796 (1)
    matrigel 23.3 2 16317516 (1), 18234959 (1)
    okadaic acid 21.1 5 8437861 (1), 7604037 (1), 9178763 (1), 12210726 (1)
    threonine 15.4 4 8552081 (2), 17105191 (1), 11948414 (1)
    curcumin 9.19 9 17590421 (5)
    sb 203580 7.73 1 9648911 (1)
    tgf beta1 6.73 4 16469114 (3), 15225617 (1)



    Find genes that share compounds with ETS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ETS1 gene (3 alternative transcripts): 
    NM_001143820.1  NM_001162422.1  NM_005238.3  

    Unigene Cluster for ETS1:

    V-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
    Hs.369438  [show with all ESTs]
    Unigene Representative Sequence: NM_005238
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392668(uc001qej.2) ENST00000526145 ENST00000531611 ENST00000319397
    ENST00000530924 ENST00000608978 ENST00000525404 ENST00000527676 ENST00000345075(uc010sbs.1 uc009zcg.2)
    ENST00000535549(uc009zch.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ETS1 (see all 122):
    hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3653 hsa-miR-759 hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidETS1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ETS1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ETS1 (NM_005238)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS1
    Primer
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    OriGene qPCR primer pairs and template standards for ETS1
    OriGene qSTAR qPCR primer pairs in human, mouse for ETS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETS1
      QuantiTect SYBR Green Assays in human, mouse, rat ETS1
      QuantiFast Probe-based Assays in human, mouse, rat ETS1

    Additional mRNA sequence: 

    AK001630.1 AK291840.1 AK301405.1 AL832693.1 AY943926.1 BC017314.2 BT019452.1 BT019453.1 
    BX640634.1 CR542254.1 J04101.1 S87905.1 X14798.1 

    10 DOTS entries:

    DT.91912037  DT.40303481  DT.97805404  DT.446760  DT.40127706  DT.75124395  DT.91704327  DT.120734178 
    DT.95091465  DT.97765772 

    Selected AceView cDNA sequences (see all 209):

    CA407336 BQ100810 AI524394 AI792010 CK824827 BF448849 N74080 N38729 
    AA347480 AW291745 BX494199 BQ949717 T29011 CR542254 BQ941805 AI911677 
    AI288405 BF431450 BE220842 NM_005238 BF204016 CA943663 AU132590 BP365215 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ETS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -                                                         
    SP2:        -                                   -     -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for ETS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ETS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTTACTC
    ETS1 Expression
    About this image


    ETS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Mesenchymal Cells Epicardium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Proepicardial Progenitor cells Proepicardium
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Cranial Neural Crest
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
    ETS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ETS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369438

    UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921
    Tissue specificity: Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in
    all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ETS1 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ETS1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ets11 , 5 E26 avian leukemia oncogene 1, 5' domain1, 5 92.35(n)1
    97.27(a)1
      9 (17.97 cM)5
    238711  NM_011808.21  NP_035938.21 
     326362215 
    chicken
    (Gallus gallus)
    Aves ETS11 v-ets erythroblastosis virus E26 oncogene 84.66(n)
    95.92(a)
      396235  NM_205298.2  NP_990629.2 
    lizard
    (Anolis carolinensis)
    Reptilia ETS16
    v-ets avian erythroblastosis virus E26 oncogene ho...
    90(a)
    1 ↔ 1
    GL343197.1(4553735-4679135)
    African clawed frog
    (Xenopus laevis)
    Amphibia ets1a-A-prov2 c-ets-1a proto-oncogene 78.44(n)    X52692.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11162 idibd1116 78.17(n)   58005  BU808703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pnt3 anti-apoptosis type II transforming
    growth factor-beta more
    57(a)     --


    ENSEMBL Gene Tree for ETS1 (if available)
    TreeFam Gene Tree for ETS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ETS1 gene
    ETV12  ETV32  ERF2  ETV52  ETV3L2  GABPA2  ETS22  ERG2  
    FEV2  ETV42  ETV22  FLI12  
    4 SIMAP similar genes for ETS1 using alignment to 4 protein entries:     ETS1_HUMAN (see all proteins):
    TLS-ERG    ELK3    ETS2    FEV

    Find genes that share paralogs with ETS1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ETS1
    PGOHUM00000260928


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ETS1 (see all 2504)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601063751,2
    C--124296570(+) GGAGGG/AAGGGA 3 -- int17Minor allele frequency- A:0.02NA WA CSA EA 248
    rs1918277831,2
    --124296612(+) GGGAAA/GGAAAG 3 -- int10--------
    rs1427144561,2
    C--124296623(+) AAGGA-/AGGA  
     AGGAAGG
    AGGAA
    3 -- int10--------
    rs1404879301,2
    C--124296730(+) GGAGA-/GAGG  
            
    GAGGG
    3 -- int10--------
    rs128070251,2
    C--124296738(+) GGAGGA/GAGGAA 3 -- int1 trp31Minor allele frequency- G:0.00CSA 1
    rs344222891,2
    C--124299439(+) TATTCT/-TTATC 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs2013146701,2
    C--124299439(+) TATTCC/TTTATC 3 -- int10--------
    rs679127381,2
    C--124371058(+) GGACG-/TAGGTC 1 -- int10--------
    rs1387877771,2
    C--128197549(+) TCCACC/TAAAGA 3 -- ds50010--------
    rs754076181,2
    C--128197584(+) AGGAAC/TGGTAC 3 -- ds50013Minor allele frequency- T:0.04CSA WA EA 240

    HapMap Linkage Disequilibrium report for ETS1 (128328656 - 128457453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ETS1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1237588CNV Deletion17803354
    esv2745239CNV Deletion23290073
    esv2745238CNV Deletion23290073
    esv2745237CNV Deletion23290073
    esv269752CNV Insertion20981092
    esv1757388CNV Insertion17803354
    esv25513CNV Loss19812545
    nsv898448CNV Loss21882294
    nsv517012CNV Loss19592680
    esv275584CNV Loss21479260

    Human Gene Mutation Database (HGMD): ETS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ETS1
    DNA2.0 Custom Variant and Variant Library Synthesis for ETS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164720    OMIM disorders: --

    2 diseases for ETS1:    
    About MalaCards
    jacobsen syndrome    meningioma

    1 disease from the University of Copenhagen DISEASES database for ETS1:
    Cancer

    Find genes that share disorders with ETS1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ETS1 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 72.2 12 16894529 (2), 15848191 (1), 15994290 (1), 19083476 (1) (see all 6)
    friend leukemia 52.5 1 15994290 (1)
    tumors 45.5 120 16240325 (4), 11353051 (4), 10392639 (3), 15940256 (3) (see all 65)
    anaplastic meningioma 40.3 2 11147600 (1), 16722933 (1)
    metastasis 39.1 42 17283532 (6), 14562368 (4), 12475439 (3), 11068545 (2) (see all 21)
    leukemia t-cell 34.4 1 2209540 (1)
    neovascularization 33.2 2 12932931 (1), 15816498 (1)
    carcinoma 33.1 47 19253033 (4), 8952528 (4), 10765128 (4), 11353051 (4) (see all 22)
    leukemia 31.9 8 2189104 (1), 8099060 (1), 18958307 (1), 2250910 (1) (see all 7)
    benign meningioma 31.5 3 16894529 (1), 11147600 (1)

    Genetic Association Database (GAD): ETS1
    Human Genome Epidemiology (HuGE) Navigator: ETS1 (5 documents)
    Tumor Gene Database (TGDB): ETS1

    Export disorders for ETS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ETS1 gene, integrated from 10 sources (see all 602):
    (articles sorted by number of sources associating them with ETS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. (PubMed id 8231246)1, 2, 9 Collyn d'Hooghe M.... Kerckaert J.P. (Leukemia 1993)
    2. Sp100 interacts with ETS-1 and stimulates its transcriptional activity. (PubMed id 11909962)1, 2, 9 Wasylyk C.... Wasylyk B. (Mol. Cell. Biol. 2002)
    3. Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin- conjugating enzyme. (PubMed id 9333025)1, 2, 9 Hahn S.L.... Wasylyk B. (Oncogene 1997)
    4. SP100 inhibits ETS1 activity in primary endothelial cells. (PubMed id 15592518)1, 2, 9 Yordy J.S.... Watson D.K. (Oncogene 2005)
    5. Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter. (PubMed id 1614856)1, 2, 9 Majerus M.-A....Bailleul B. (Nucleic Acids Res. 1992)
    6. Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51. (PubMed id 19377509)1, 2, 9 Laitem C.... Aumercier M. (Oncogene 2009)
    7. Regulation of the transcription factor Ets-1 by DNA-mediated homo- dimerization. (PubMed id 18566588)1, 2, 9 Lamber E.P....Wilmanns M. (EMBO J. 2008)
    8. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    9. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. (PubMed id 20169177)1, 4 Yang W....Lau Y.L. (PLoS Genet. 2010)
    10. Transcription factor Ets-1 in cytokine and chemokine gene regulation. (PubMed id 20378371)1, 2 Russell L. and Garrett-Sinha L.A. (Cytokine 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2113 HGNC: 3488 AceView: ETS1 Ensembl:ENSG00000134954 euGenes: HUgn2113
    ECgene: ETS1 Kegg: 2113 H-InvDB: ETS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ETS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ETS1 gene:
    Search GeneIP for patents involving ETS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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