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ETS1 Gene

protein-coding GIFtS: 69

GC11M127833

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
(Previous name: v-ets avian erythroblastosis virus E26 oncogene homolog 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EWSR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ETS-1 ^¹, ²
EWSR2 ^², ³
FLJ10768 ^¹, ²
p54 ^³

Descriptions
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1 ^²
ets protein ^²
v-ets avian erythroblastosis virus E2 oncogene homolog 1 ^²
v-ets avian erythroblastosis virus E26 oncogene homolog 1 ^¹, ²
v-ets erythroblastosis virus E26 oncogene homolog 1 ^²
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) ^²

External Ids
HGNC: 3488¹
Entrez Gene: 2113²
UniProtKB: P14921³
Ensembl: ENSG00000134954⁷

Search outside databases for aliases for ETS1 gene

Previous GC identifers: GC11M130331 GC11M129841 GC11M128362 GC11M127869 GC11M127866

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ETS1:

ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell

development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these

proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA

sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921

Function: Transcription factor

Gene Wiki entry for ETS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ETS1 gene

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q23.3

ETS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M127833: (about GC identifiers)

Start:	127,833,870 bp from pter
End:	127,948,235 bp from pter
Size:	114,366 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921 (See protein sequence)

Recommended Name: Protein C-ets-1

Size: 441 amino acids; 50408 Da

Subunit: Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1GVJ (3D)

2NNY (3D)

2STT (3D)

2STW (3D)

Secondary accessions: Q14278 Q16080

Alternative splicing: 2 isoforms: P14921-1 P14921-2

Post-translational modifications:

Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity

(By similarity)¹

Ubiquitinated; which induces proteasomal degradation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001137292.1 NP_005229.1

ENSEMBL proteins:

ENSP00000376436 ENSP00000324578 ENSP00000340485

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ETS1)
	Human Recombinant Proteins from Abnova (ETS1)

OriGene Purified Recombinant Human Protein: ETS1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for ETS1:

	Invitrogen Antibodies for ETS1
	Millipore Mono- and Polyclonal Antibodies for the study of ETS1
	Sigma-Aldrich Antibodies for ETS1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ETS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ETS1)
	Novus Biologicals Antibody for ETS1

Assays for ETS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14921

ProtoNet protein and cluster: P14921

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001143820

Applied Biosystems Silencer® siRNAs for ETS1

Sigma-Aldrich siRNA for ETS1

Sigma-Aldrich shRNA Panels and shRNA for ETS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ETS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001143820
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001143820
untagged cDNA clones in CMV expression vector (see all 2): NM_001143820

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001143820

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921

Function: Transcription factor

Genatlas biochemistry entry for ETS1:

avian erythroblastosis virus E26 (v-ets) oncogene homolog 1

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ets1):

cellular	growth/size	hematopoietic system	immune system	lethality-postnatal
lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0008134	transcription factor binding	NAS	10698492
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for ETS1 (Your Favorite Gene powered by Ingenuity)

GM-CSF Signaling
HGF Signaling
B Cell Receptor Signaling
ERK/MAPK Signaling
Renal Cell Carcinoma Signaling

GeneDecks ETS1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ETS1

5/116 Interacting proteins for ETS1 (P14921^{1, 2} ENSP00000324578³) via UniProtKB, MINT, and/or STRING (see all 116 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275², ENSP00000363822³	MINT-5207344 MINT-5207365 STRING (score=.702)
POU1F1	P28069², ENSP00000342931³	MINT-14055 STRING (score=.977)
DAXX	Q9UER7-1¹	MINT-16586 EBI-913209, EBI-287635
ENSG00000206206	Q9UER7²	MINT-16586
ENSG00000206279	Q9UER7²	MINT-16586

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006955	immune response	TAS	2187191
GO:0008285	negative regulation of cell proliferation	TAS	2187191
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	IDA	15247905
GO:0030578	PML body organization	IDA	11909962 15247905

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ETS1
10/22 Novoseek chemical compound relationships for ETS1 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	34.21	28	16455618 (6), 16888027 (2), 9595399 (1), 1766672 (1) (see all 9)
ionomycin	34.10	8	7500040 (2), 9190901 (2), 9190210 (2), 12632071 (1) (see all 5)
okadaic acid	22.18	5	8437861 (1), 7604037 (1), 9178763 (1), 12210726 (1)
matrigel	19.65	2	16317516 (1), 18234959 (1)
pd 98,059	18.21	6	15492268 (2), 18948081 (2), 9648911 (1), 15972796 (1)
tgf beta1	8.67	4	16469114 (3), 15225617 (1)
threonine	8.19	4	8552081 (2), 17105191 (1), 11948414 (1)
nitric oxide	2.21	1	16510587 (1)
oxygen	1.91	2	16234432 (1)
glucose	1.52	3	11696476 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001143820

Sigma-Aldrich siRNA for ETS1

Sigma-Aldrich shRNA Panels and shRNA for ETS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001143820 NM_005238

REFSEQ mRNAs for ETS1 gene (2 alternative transcripts):

NM_001143820.1 NM_005238.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001143820 NM_005238

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001143820
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001143820
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001143820

Additional cDNA sequence:

AK001630.1 AK291840.1 AK301405.1 AL832693.1 BC017314.2 BT019452.1 BT019453.1 BX640634.1

CR542254.1 J04101.1 S87905.1 X14798.1

10 DOTS entries:

DT.91912037 DT.40303481 DT.97805404 DT.446760 DT.40127706 DT.75124395 DT.91704327 DT.120734178

DT.97765772 DT.95091465

24/209 AceView cDNA sequences (see all 209 ):

BF448849 CA395797 BP365215 AA458924 CB265553 N38729 AI524394 N74080

AW291745 CA407336 BQ941805 AI288405 BF431450 CA943663 BF224148 BE220842

AI792010 AA807444 BX118916 AI457252 BX494199 AA347480 BC017314 AI494491

highest scoring ESTs for ETS1:

J04101 BC017314 BE146366 BE799215 BI911387 BM142037 BX640634 CK819846 W53018 X14798

Unigene Cluster for ETS1:

V-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

Hs.369438 [show with all ESTs]

Unigene Representative Sequence: NM_005238

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ETS1

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b
SP1:			-
SP2:			-												-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for ETS1

3 Ensembl transcripts including schematic representations:

ENST00000392668 ENST00000319397 ENST00000345075

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ETS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ETS1

¹ / ² / ³

9 probe-sets matching ETS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1518_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.76	J04101	1.00	1.00	1.00	1
1977_s_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.43	X14798	0.80	1.00	0.91	1
57073_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.73	W53018	0.80	1.00	0.91	1
90641_at²^{, 3}	U95-D	1	0.38	1.00	0.55	1.12	AI820614	0.60	1.00	0.82	1
224833_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE218980	0.40	1.00	0.76	1
214447_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_005238	0.60	1.00	0.82	1
224833_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555355_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214447_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks ETS1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCGCTTACTC

SOURCE GeneReport for Unigene cluster: Hs.369438
Expression variation in blood from EXPOLDB for ETS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ETS1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ETS1¹	--	v-ets erythroblastosis virus E26 oncogene homolog 1 more	95.09(n) 99.09(a)	489287 XM_546405.2 XP_546405.2
cow (Bos taurus)	ETS1¹	--	v-ets erythroblastosis virus E26 oncogene homolog 1 more	92.06(n) 98.41(a)	540313 XM_877179.2 XP_882272.1
rat (Rattus norvegicus)	Ets1¹	--	v-ets erythroblastosis virus E26 oncogene homolog 1 more	92.59(n) 98.87(a)	24356 NM_012555.1 NP_036687.1
mouse (Mus musculus)	Ets1^{1, 5}	9 (15.00 cM)⁵	E26 avian leukemia oncogene 1, 5' domain^{1, 5}	92.35(n)¹ 97.27(a)¹	23871¹ NM_011808.2¹ NP_035938.2¹ AI196000⁵ AI448617⁵ (see all 28)
chicken (Gallus gallus)	ETS1¹	--	v-ets erythroblastosis virus E26 oncogene homolog 1 more	84.73(n) 96.15(a)	768354 XM_001231220.1 XP_001231221.1

About this table Species with no ortholog for ETS1

ENSEMBL Gene Tree for ETS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ETS1 gene

ETS2² ELK1² GABPA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/305 NCBI SNPs in ETS1 are shown (see all 305 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 149)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8705^1,2	A,C,F,H	127834123(+)	`ATCTTA/GCTTCT`	1	--	ut3¹		14		MN EA NA EU WA	1424
	rs4937333^1,2	A,C,F,H	127835730(+)	`ACTTTT/CCCTCA`	1	--	ut3¹ ese³		7		NA EU EA WA	562
	rs1128334^1,2	C,F,H	127834169(-)	`AACttG/Atattt`	1	--	ut3¹		4		EU EA WA	412
	rs2269458^1,2	A,C	127897705(-)	`GCCCCA/TGCCTG`	1	--	ng3¹		0	--	--	--	--
	rs12288765^1,2	F,H	127835897(+)	`GAACCT/GCCTTC`	1	--	ut3¹ ese³ trp³		4		EU EA WA	414
	rs12276431^1,2	H	127898073(+)	`GGGGAG/CTCCAG`	1	--	ng3¹		4		EU EA WA	418
--	rs4937332^1,2	A	127835196(+)	`ACACAA/CACACA`	1	--	ut3¹ ese³		0	--	--	--	--
	rs7111236^1,2	A,C,F,H	127838713(+)	`TGCCAC/TAGCTG`	1	L/L	syn¹ ese³		17		EA NA EU WA	1438
	rs34846069^1,2	F	127837472(+)	`CACTCG/ATCGGC`	1	D/D	syn¹		1		NA	76
	rs11819995^1,2	A,C,F,H	127894601(+)	`AGCTAC/TGCTGT`	1	--	int¹		12		EU EA WA	1252

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HapMap Linkage Disequilibrium images for ETS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164720

UniProtKB/Swiss-Prot: ETS1_HUMAN, P14921

ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of

the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic

leukemia

10/62 Novoseek disease relationships for ETS1 gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroblastosis	72.80	12	16894529 (2), 15848191 (1), 15994290 (1), 19083476 (1) (see all 6)
friend leukemia	53.53	1	15994290 (1)
tumors	42.97	111	16240325 (4), 11353051 (4), 10392639 (3), 15940256 (3) (see all 61)
anaplastic meningioma	41.34	2	11147600 (1), 16722933 (1)
metastasis	37.38	39	17283532 (6), 14562368 (4), 12475439 (3), 11068545 (2) (see all 20)
leukemia t-cell	35.55	1	2209540 (1)
neovascularization	35.24	2	12932931 (1), 15816498 (1)
leukemia	33.39	8	2189104 (1), 8099060 (1), 18958307 (1), 2250910 (1) (see all 7)
benign meningioma	33.28	3	16894529 (1), 11147600 (1)
ewings sarcoma	30.81	3	16537893 (2), 11973649 (1)

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1 PharmGKB disease relationship for ETS1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Ovarian Neoplasms	FA	15331930

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Genetic Association Database: ETS1
Tumor Gene Database: ETS1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/477 PubMed articles for ETS1 gene (see all 477 ):

Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. (PubMed id 8231246)^{1, 3, 4} Collyn d'Hooghe M.... Kerckaert J.P. (1993)
Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin- conjugating enzyme. (PubMed id 9333025)^{1, 3, 4} Hahn S.L.... Wasylyk B. (1997)
Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter. (PubMed id 1614856)^{1, 3, 4} Majerus M.A....Bailleul B. (1992)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Clinical implications of expression of ETS-1 related to angiogenesis in metastatic lesions of ovarian cancers. (PubMed id 15331930)^{1, 7} Fujimoto J....Tamaya T. (2004)
EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. (PubMed id 10698492)^{3, 4} Li R.... Papas T.S. (2000)
The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation. (PubMed id 8521493)^{3, 4} Werner M.H.... Gronenborn A.M. (1995)
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. (PubMed id 1522903)^{2, 3} Delattre O.... Thomas G. (1992)
Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene. (PubMed id 3060801)^{3, 4} Reddy E.S.P. and Rao V.N. (1988)
Mammalian ets-1 and ets-2 genes encode highly conserved proteins. (PubMed id 2847145)^{3, 4} Watson D.K.... Papas T.S. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2113	HGNC: 3488	AceView: ETS1	Ensembl:ENSG00000134954	euGenes: HUgn2113
ECgene: ETS1	H-InvDB: ETS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ETS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ETS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ETS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ETS1-related products

	Millipore Custom Antibody & Bulk Services
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Antibodies for ETS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ETS1 Gene at Home site.
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ETS1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ETS1

Summaries
for ETS1

Genomic Location
for ETS1

Proteins
for ETS1

Protein Domains/
Families
for ETS1

Gene Function
for ETS1

Pathways & Interactions
for ETS1

Drugs & Compounds
for ETS1

Transcripts
for ETS1

Expression
for ETS1

Orthologs
for ETS1

Paralogs
for ETS1

SNPs/Variants
for ETS1

Disorders & Mutations
for ETS1

Medical News
for ETS1

Publications
for ETS1

Search for ETS1

Genome Databases showing ETS1

Other Databases showing ETS1

Specialized Databases showing ETS1

Licensable Technologies
for ETS1

Services
for ETS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ETS1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ETS1

Summariesfor ETS1

Genomic Locationfor ETS1

Proteinsfor ETS1

Protein Domains/Familiesfor ETS1

Gene Functionfor ETS1

Pathways & Interactionsfor ETS1

Drugs & Compoundsfor ETS1

Transcriptsfor ETS1

Expression for ETS1

Orthologsfor ETS1

Paralogsfor ETS1

SNPs/Variantsfor ETS1

Disorders & Mutationsfor ETS1

Medical Newsfor ETS1

Publicationsfor ETS1

Search for ETS1

Genome Databases showing ETS1

Other Databases showing ETS1

Specialized Databases showing ETS1

Licensable Technologiesfor ETS1

Servicesfor ETS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ETS1

Summaries
for ETS1

Genomic Location
for ETS1

Proteins
for ETS1

Protein Domains/
Families
for ETS1

Gene Function
for ETS1

Pathways & Interactions
for ETS1

Drugs & Compounds
for ETS1

Transcripts
for ETS1

Expression
for ETS1

Orthologs
for ETS1

Paralogs
for ETS1

SNPs/Variants
for ETS1

Disorders & Mutations
for ETS1

Medical News
for ETS1

Publications
for ETS1

Licensable Technologies
for ETS1

Services
for ETS1