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ETNK2 Gene

protein-coding   GIFtS: 58
GCID: GC01M204100

Ethanolamine Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ethanolamine Kinase 21 2
EKI22 3 5
Ethanolamine Kinase-Like Protein2 3
EKI 22 3
HMFT17162
EC 2.7.1.823

External Ids:    HGNC: 255751   Entrez Gene: 552242   Ensembl: ENSG000001438457   OMIM: 6098595   UniProtKB: Q9NVF93   

Export aliases for ETNK2 gene to outside databases

Previous GC identifers: GC01M200832 GC01M202366 GC01M175267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ETNK2 Gene:
The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step
of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ETNK2 Gene:
ETNK2 (ethanolamine kinase 2) is a protein-coding gene. Diseases associated with ETNK2 include hepatoblastoma, and essential hypertension. GO annotations related to this gene include ethanolamine kinase activity. An important paralog of this gene is CHKA.

UniProtKB/Swiss-Prot: EKI2_HUMAN, Q9NVF9
Function: Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ETNK2 gene promoter:
         c-Fos   CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ETNK2 promoter sequence
   Search Chromatin IP Primers for ETNK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETNK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ETNK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETNK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M204100:  view genomic region     (about GC identifiers)

Start:
204,100,190 bp from pter      End:
204,121,307 bp from pter
Size:
21,118 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EKI2_HUMAN, Q9NVF9 (See protein sequence)
Recommended Name: Ethanolamine kinase 2  
Size: 386 amino acids; 44781 Da
Sequence caution: Sequence=BAH13637.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7Z7K1 Q5SXX5 Q68CK3 Q96G05
Alternative splicing: 3 isoforms:  Q9NVF9-1   Q9NVF9-2   Q9NVF9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ETNK2: NX_Q9NVF9

Explore proteomics data for ETNK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ETNK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060678.2  
    ENSEMBL proteins: 
     ENSP00000356169   ENSP00000356170   ENSP00000356165   ENSP00000410580   ENSP00000405497  
     ENSP00000398091   ENSP00000406241   ENSP00000394618   ENSP00000356167   ENSP00000356166  
    Reactome Protein details: Q9NVF9

    ETNK2 Human Recombinant Protein Products:

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    Novus Biologicals ETNK2 Protein
    Novus Biologicals ETNK2 Lysates
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    Cloud-Clone Corp. Proteins for ETNK2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NVF9

    ProtoNet protein and cluster: Q9NVF9

    1 Blocks protein domain: IPB002573 Choline/ethanolamine kinase

    UniProtKB/Swiss-Prot: EKI2_HUMAN, Q9NVF9
    Similarity: Belongs to the choline/ethanolamine kinase family


    ETNK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EKI2_HUMAN, Q9NVF9
    Function: Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity)
    Catalytic activity: ATP + ethanolamine = ADP + O-phosphoethanolamine

         Enzyme Number (IUBMB): EC 2.7.1.821

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004305ethanolamine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    ETNK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ETNK2:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Etnk2):
     homeostasis/metabolism  nervous system  normal  other  reproductive system 

    ETNK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Etnk2tm1Mkar for ETNK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ETNK2
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    miRNA
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    miRTarBase miRNAs that target ETNK2:
    hsa-mir-142-3p (MIRT021559), hsa-mir-132-3p (MIRT021789)

    Block miRNA regulation of human, mouse, rat ETNK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETNK2 (see all 26):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-let-7c hsa-miR-650 hsa-let-7g hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidETNK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ETNK2

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    GenScript: all cDNA clones in your preferred vector: ETNK2 (NM_018208)
    Sino Biological Human cDNA Clone for ETNK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETNK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETNK2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETNK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    ETNK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ETNK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PE0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3phosphatidylethanolamine biosynthesis II
    phosphatidylethanolamine biosynthesis II

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ETNK2
        phosphatidylethanolamine biosynthesis II


    1 Reactome Pathway for ETNK2
        Synthesis of PE


    2 Kegg Pathways  (Kegg details for ETNK2):
        Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: EKI2_HUMAN, Q9NVF9
    Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from
    ethanolamine: step 1/3


    ETNK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ETNK2
    Interactions:

        Search GeneGlobe Interaction Network for ETNK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ETNK2 (Q9NVF93 ENSP000003561704) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOL3O609363, ENSP000002686054I2D: score=4 STRING: ENSP00000268605
    MDFIQ997503, ENSP000002303214I2D: score=1 STRING: ENSP00000230321
    UBE2AP494593, ENSP000003606134I2D: score=1 STRING: ENSP00000360613
    BEGAINQ9BUH83I2D: score=1 
    KRTAP4-12Q9BQ663I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001890placenta development IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006646phosphatidylethanolamine biosynthetic process TAS--
    GO:0008150biological_process ND--

    ETNK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ETNK2 (EKI2)

    4 HMDB Compounds for ETNK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Ethanolamine1-Amino-2-hydroxyethane (see all 28)141-43-5--
    O-PhosphoethanolaminePhosphoryethanolamine (see all 28)1071-23-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ETNK2 gene: 
    NM_018208.2  

    Unigene Cluster for ETNK2:

    Ethanolamine kinase 2
    Hs.497469  [show with all ESTs]
    Unigene Representative Sequence: NM_018208
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367201(uc010pqr.2) ENST00000367202 ENST00000367197 ENST00000422072
    ENST00000472340 ENST00000492392 ENST00000422699 ENST00000452983 ENST00000444817
    ENST00000477125 ENST00000429525 ENST00000367199(uc001hao.4 uc001han.4 uc010pqs.2 uc010pqt.2)
    ENST00000367198
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ETNK2 (see all 26):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-let-7c hsa-miR-650 hsa-let-7g hsa-miR-124 hsa-miR-298
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      QuantiTect SYBR Green Assays in human, mouse, rat ETNK2
      QuantiFast Probe-based Assays in human, mouse, rat ETNK2

    Additional mRNA sequence: 

    AB073608.1 AK001623.1 AK293426.1 AK302145.1 AK316493.1 BC010082.2 

    9 DOTS entries:

    DT.450735  DT.95271569  DT.95271567  DT.95256052  DT.95271566  DT.121338325  DT.95271568  DT.95271570 
    DT.95271571 

    Selected AceView cDNA sequences (see all 98):

    BF732629 BM705498 BU742232 AI924138 BM700015 AI209013 BC010082 AA854978 
    U69201 BM762896 BM669973 BI764913 BM560490 AI798887 AA339690 AK001623 
    AI424024 BM810526 BQ773063 AI955219 NM_018208 AB073608 BE257267 BG718122 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ETNK2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
    SP1:              -     -                 -           -           -     -           -           -                           
    SP2:              -     -                 -           -           -     -           -                                       
    SP3:                                                                    -           -           -                           
    SP4:                                                  -           -     -           -           -                           
    SP5:                                                                                -           -                           


    ECgene alternative splicing isoforms for ETNK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ETNK2 expression in normal human tissues (normalized intensities)      ETNK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTCTTTC
    ETNK2 Expression
    About this image


    ETNK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    ETNK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ETNK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497469

    UniProtKB/Swiss-Prot: EKI2_HUMAN, Q9NVF9
    Tissue specificity: Expressed in kidney, liver, ovary, testis and prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETNK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ETNK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Etnk21 , 5 ethanolamine kinase 21, 5 86.67(n)1
    87.53(a)1
      1 (57.91 cM)5
    2142531  NM_175443.51  NP_780652.21 
     1333635725 
    chicken
    (Gallus gallus)
    Aves ETNK21 ethanolamine kinase 2 71.71(n)
    67.11(a)
      426690  XM_424313.4  XP_424313.4 
    lizard
    (Anolis carolinensis)
    Reptilia ETNK26
    ethanolamine kinase 2
    59(a)
    1 ↔ 1
    4(117870798-117902598)
    zebrafish
    (Danio rerio)
    Actinopterygii etnk21 ethanolamine kinase 2 69.49(n)
    66.08(a)
      555330  NM_001034175.1  NP_001029347.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eas6
    easily shocked
    32(a)
    1 → many
    X(16172360-16179651)
    worm
    (Caenorhabditis elegans)
    Secernentea ckc-16
    Protein CKC-1, isoform a
    33(a)
    1 → many
    X(3576608-3578957) WBGene00000515
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EKI16
    CKI16
    Ethanolamine kinase, primarily responsible for pho...
    Choline kinase, catalyzing the first step in phosp...
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    IV(751631-753235) YDR147W
    XII(408445-410193) YLR133W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb11871 emb1187 47.59(n)
    37.74(a)
      817224  NM_128240.3  NP_180251.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04384001 Os09g0438400 41.21(n)
    30.38(a)
      4347160  NM_001069804.1  NP_001063269.1 


    ENSEMBL Gene Tree for ETNK2 (if available)
    TreeFam Gene Tree for ETNK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ETNK2 gene
    CHKA2  CHKB2  ETNK12  CHKB-CPT1B2  
    5 SIMAP similar genes for ETNK2 using alignment to 10 protein entries:     EKI2_HUMAN (see all proteins):
    CHKB-CPT1B    ETNK1    DKFZp434E1212    CHKA    CHKB

    ETNK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ETNK2
    PGOHUM00000259574


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ETNK2 (see all 472)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429951851,2
    --204099734(+) CTGCTC/TTTCCT 1 -- ds50010--------
    rs1155472641,2
    F--204099926(+) ATCCAC/TAGCCT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1901461901,2
    --204100039(+) GCCTTC/TGGAGC 1 -- ds50010--------
    rs1165907451,2
    C,F--204100273(+) AGGCCC/TCAGGA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1141873991,2
    C,F--204100449(+) ACCTCG/AGGTCA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1459681211,2
    C--204100580(+) CCCTCC/TGGCTA 1 -- ut310--------
    rs767182401,2
    C,F--204100708(+) TCCTCG/AGGCTG 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs1813360421,2
    C--204100792(+) CAATTC/GTTGGC 1 -- ut310--------
    rs794036991,2
    C--204100946(+) CCTCCA/TTCCCC 1 -- ut310--------
    rs758767131,2
    C--204100947(+) CTCCTG/TCCCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ETNK2 (204100190 - 204121307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ETNK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826398CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ETNK2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609859    OMIM disorders: --

    4 diseases for ETNK2:    About MalaCards
    hepatoblastoma    essential hypertension    hypertension    prostatitis


    ETNK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ETNK2
    Human Genome Epidemiology (HuGE) Navigator: ETNK2 (3 documents)

    Export disorders for ETNK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ETNK2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ETNK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. (PubMed id 18953568)1, 4, 9 Schoenhard J.A....Williams S.M. (Hum. Genet. 2008)
    2. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PubMed id 21177773)1, 4 Moyer A.M....Weinshilboum R.M. (Toxicol. Sci. 2011)
    3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. (PubMed id 11044454)1, 2 Lykidis A.... Jackowski S. (J. Biol. Chem. 2001)
    7. Eki2 is upregulated specifically in the testis during mouse sex determination. (PubMed id 15161093)1, 9 Hurley T.M....Sinclair A.H. (Gene Expr. Patterns 2004)
    8. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    9. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    10. Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. (PubMed id 16861741)1 Tian Y....Jackowski S. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55224 HGNC: 25575 AceView: ETNK2 Ensembl:ENSG00000143845 euGenes: HUgn55224
    ECgene: ETNK2 Kegg: 55224 H-InvDB: ETNK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ETNK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ETNK2 gene:
    Search GeneIP for patents involving ETNK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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