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Aliases for ETNK2 Gene

Aliases for ETNK2 Gene

  • Ethanolamine Kinase 2 2 3 5
  • Ethanolamine Kinase-Like Protein 3 4
  • EKI2 3 4
  • EC 2.7.1.82 4
  • HMFT1716 3
  • EKI 2 4

External Ids for ETNK2 Gene

Previous GeneCards Identifiers for ETNK2 Gene

  • GC01M200832
  • GC01M202366
  • GC01M175267

Summaries for ETNK2 Gene

Entrez Gene Summary for ETNK2 Gene

  • The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ETNK2 Gene

ETNK2 (Ethanolamine Kinase 2) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and phosphatidylethanolamine biosynthesis II. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and ethanolamine kinase activity. An important paralog of this gene is ETNK1.

UniProtKB/Swiss-Prot for ETNK2 Gene

  • Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETNK2 Gene

Genomics for ETNK2 Gene

Regulatory Elements for ETNK2 Gene

Enhancers for ETNK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ETNK2 on UCSC Golden Path with GeneCards custom track

Promoters for ETNK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ETNK2 Gene

Chromosome:
1
Start:
204,131,061 bp from pter
End:
204,152,182 bp from pter
Size:
21,122 bases
Orientation:
Minus strand

Genomic View for ETNK2 Gene

Genes around ETNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETNK2 Gene

Proteins for ETNK2 Gene

  • Protein details for ETNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVF9-EKI2_HUMAN
    Recommended name:
    Ethanolamine kinase 2
    Protein Accession:
    Q9NVF9
    Secondary Accessions:
    • B7Z7K1
    • Q5SXX5
    • Q68CK3
    • Q96G05

    Protein attributes for ETNK2 Gene

    Size:
    386 amino acids
    Molecular mass:
    44781 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAH13637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ETNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETNK2 Gene

Post-translational modifications for ETNK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETNK2 Gene

Domains & Families for ETNK2 Gene

Protein Domains for ETNK2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NVF9

UniProtKB/Swiss-Prot:

EKI2_HUMAN :
  • Belongs to the choline/ethanolamine kinase family.
Family:
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with ETNK2: view

No data available for Gene Families for ETNK2 Gene

Function for ETNK2 Gene

Molecular function for ETNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

Enzyme Numbers (IUBMB) for ETNK2 Gene

Gene Ontology (GO) - Molecular Function for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004305 ethanolamine kinase activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ETNK2: view
genes like me logo Genes that share phenotypes with ETNK2: view

Animal Models for ETNK2 Gene

MGI Knock Outs for ETNK2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ETNK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETNK2 Gene

Localization for ETNK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETNK2 Gene COMPARTMENTS Subcellular localization image for ETNK2 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ETNK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ETNK2 Gene

Pathways & Interactions for ETNK2 Gene

genes like me logo Genes that share pathways with ETNK2: view

Pathways by source for ETNK2 Gene

UniProtKB/Swiss-Prot Q9NVF9-EKI2_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001890 placenta development IEA --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with ETNK2: view

No data available for SIGNOR curated interactions for ETNK2 Gene

Drugs & Compounds for ETNK2 Gene

(3) Drugs for ETNK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(1) Additional Compounds for ETNK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ETNK2: view

Transcripts for ETNK2 Gene

Unigene Clusters for ETNK2 Gene

Ethanolamine kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ETNK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETNK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - -

Relevant External Links for ETNK2 Gene

GeneLoc Exon Structure for
ETNK2
ECgene alternative splicing isoforms for
ETNK2

Expression for ETNK2 Gene

mRNA expression in normal human tissues for ETNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETNK2 Gene

This gene is overexpressed in Kidney - Cortex (x7.6), Liver (x7.6), and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for ETNK2 Gene

This gene is overexpressed in Fetal ovary (33.2), Ovary (23.2), and Testis (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ETNK2 Gene



Protein tissue co-expression partners for ETNK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETNK2 Gene:

ETNK2

SOURCE GeneReport for Unigene cluster for ETNK2 Gene:

Hs.497469

mRNA Expression by UniProt/SwissProt for ETNK2 Gene:

Q9NVF9-EKI2_HUMAN
Tissue specificity: Expressed in kidney, liver, ovary, testis and prostate.
genes like me logo Genes that share expression patterns with ETNK2: view

Primer Products

Orthologs for ETNK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ETNK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETNK2 34
  • 89.7 (n)
  • 91.03 (a)
ETNK2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETNK2 34
  • 90.68 (n)
  • 91.64 (a)
ETNK2 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etnk2 34
  • 86.67 (n)
  • 87.53 (a)
Etnk2 16
Etnk2 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETNK2 34
  • 100 (n)
  • 100 (a)
ETNK2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ETNK2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETNK2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETNK2 34
  • 71.71 (n)
  • 67.11 (a)
ETNK2 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETNK2 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii etnk2 34
  • 69.49 (n)
  • 66.08 (a)
etnk2 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eas 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ckc-1 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 35
  • 14 (a)
ManyToMany
EKI1 35
  • 16 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1187 34
  • 47.59 (n)
  • 37.74 (a)
rice
(Oryza sativa)
Liliopsida Os09g0438400 34
  • 41.21 (n)
  • 30.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1866 35
  • 43 (a)
OneToMany
Species where no ortholog for ETNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETNK2 Gene

ENSEMBL:
Gene Tree for ETNK2 (if available)
TreeFam:
Gene Tree for ETNK2 (if available)

Paralogs for ETNK2 Gene

Paralogs for ETNK2 Gene

Pseudogenes.org Pseudogenes for ETNK2 Gene

genes like me logo Genes that share paralogs with ETNK2: view

Variants for ETNK2 Gene

Sequence variations from dbSNP and Humsavar for ETNK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_022145 -
rs940651 -- 204,146,458(-) GCCCT(C/G)CTGAC intron-variant
rs940652 -- 204,146,349(-) CTTAG(A/G)GGATG intron-variant
rs878656 -- 204,136,099(+) GTATA(C/T)ACACA intron-variant
rs1106778 -- 204,146,420(+) GAGCA(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETNK2 Gene

Variant ID Type Subtype PubMed ID
esv2762138 CNV gain 21179565
nsv826398 CNV gain 20364138

Variation tolerance for ETNK2 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETNK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETNK2 Gene

Disorders for ETNK2 Gene

Relevant External Links for ETNK2

Genetic Association Database (GAD)
ETNK2
Human Genome Epidemiology (HuGE) Navigator
ETNK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETNK2

No disorders were found for ETNK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETNK2 Gene

Publications for ETNK2 Gene

  1. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. (PMID: 18953568) Schoenhard J.A. … Williams S.M. (Hum. Genet. 2008) 3 22 46 65
  2. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PMID: 21177773) Moyer A.M. … Weinshilboum R.M. (Toxicol. Sci. 2011) 3 46 65
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Eki2 is upregulated specifically in the testis during mouse sex determination. (PMID: 15161093) Hurley T.M. … Sinclair A.H. (Gene Expr. Patterns 2004) 3 22 65

Products for ETNK2 Gene

Sources for ETNK2 Gene

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