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Aliases for ETNK2 Gene

Aliases for ETNK2 Gene

  • Ethanolamine Kinase 2 2 3 5
  • Ethanolamine Kinase-Like Protein 3 4
  • EKI2 3 4
  • EC 4
  • HMFT1716 3
  • EKI 2 4

External Ids for ETNK2 Gene

Previous GeneCards Identifiers for ETNK2 Gene

  • GC01M200832
  • GC01M202366
  • GC01M175267

Summaries for ETNK2 Gene

Entrez Gene Summary for ETNK2 Gene

  • The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ETNK2 Gene

ETNK2 (Ethanolamine Kinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and ethanolamine kinase activity. An important paralog of this gene is ETNK1.

UniProtKB/Swiss-Prot for ETNK2 Gene

  • Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETNK2 Gene

Genomics for ETNK2 Gene

Regulatory Elements for ETNK2 Gene

Enhancers for ETNK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204347 1.5 FANTOM5 Ensembl ENCODE 12.6 -197.7 -197668 4.3 PKNOX1 ARNT SIN3A ZNF766 FOS DEK ZHX2 REST MBD2 MAFF PLEKHA6 ETNK2 ENSG00000231691 GOLT1A PPP1R15B PIK3C2B RPL21P19 LINC00628
GH01F204100 1.7 FANTOM5 Ensembl ENCODE 10.9 +48.5 48529 5.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS SOX13 LAX1 LOC101929441 ETNK2 KRT8P29 CNTN2 SNRPE PPP1R15B ENSG00000261065
GH01F204361 1.6 FANTOM5 Ensembl ENCODE 11.4 -210.9 -210902 3.9 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 GLIS2 PPP1R15B ENSG00000231691 GOLT1A ETNK2 LOC101929441 PLEKHA6 SOX13 LINC00628 RPL21P19
GH01F204285 1.6 FANTOM5 Ensembl ENCODE 10.5 -135.5 -135469 4.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF48 YY1 GOLT1A PLEKHA6 ETNK2 LOC101929441 PIK3C2B ENSG00000231691 RPL21P19
GH01F204318 1.6 FANTOM5 Ensembl ENCODE 10.3 -168.5 -168464 5.2 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 FOS DEK ZNF263 PLEKHA6 MDM4 GYG2P2 PPP1R15B ENSG00000231691 ETNK2 ZBED6 SOX13 RPL21P19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ETNK2 on UCSC Golden Path with GeneCards custom track

Promoters for ETNK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000551271 482 1801 ZNF76 ARID4B RAD21 GLIS2 EGR2 THAP11 SP3 SP5 CEBPB REST

Genomic Location for ETNK2 Gene

204,131,061 bp from pter
204,152,182 bp from pter
21,122 bases
Minus strand

Genomic View for ETNK2 Gene

Genes around ETNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETNK2 Gene

Proteins for ETNK2 Gene

  • Protein details for ETNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ethanolamine kinase 2
    Protein Accession:
    Secondary Accessions:
    • B7Z7K1
    • Q5SXX5
    • Q68CK3
    • Q96G05

    Protein attributes for ETNK2 Gene

    386 amino acids
    Molecular mass:
    44781 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAH13637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ETNK2 Gene


neXtProt entry for ETNK2 Gene

Post-translational modifications for ETNK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETNK2 Gene

Domains & Families for ETNK2 Gene

Protein Domains for ETNK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the choline/ethanolamine kinase family.
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with ETNK2: view

No data available for Gene Families for ETNK2 Gene

Function for ETNK2 Gene

Molecular function for ETNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

Enzyme Numbers (IUBMB) for ETNK2 Gene

Gene Ontology (GO) - Molecular Function for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004305 ethanolamine kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ETNK2: view
genes like me logo Genes that share phenotypes with ETNK2: view

Animal Models for ETNK2 Gene

MGI Knock Outs for ETNK2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETNK2 Gene

Localization for ETNK2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETNK2 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ETNK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ETNK2 Gene

Pathways & Interactions for ETNK2 Gene

genes like me logo Genes that share pathways with ETNK2: view

Pathways by source for ETNK2 Gene

UniProtKB/Swiss-Prot Q9NVF9-EKI2_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for ETNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001890 placenta development IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ETNK2: view

No data available for SIGNOR curated interactions for ETNK2 Gene

Drugs & Compounds for ETNK2 Gene

(3) Drugs for ETNK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(1) Additional Compounds for ETNK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ETNK2: view

Transcripts for ETNK2 Gene

Unigene Clusters for ETNK2 Gene

Ethanolamine kinase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETNK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP9: - -

Relevant External Links for ETNK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ETNK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ETNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETNK2 Gene

This gene is overexpressed in Kidney - Cortex (x7.6), Liver (x7.6), and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for ETNK2 Gene

This gene is overexpressed in Fetal ovary (33.2), Ovary (23.2), and Testis (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ETNK2 Gene

Protein tissue co-expression partners for ETNK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETNK2 Gene:


SOURCE GeneReport for Unigene cluster for ETNK2 Gene:


mRNA Expression by UniProt/SwissProt for ETNK2 Gene:

Tissue specificity: Expressed in kidney, liver, ovary, testis and prostate.
genes like me logo Genes that share expression patterns with ETNK2: view

Primer Products

Orthologs for ETNK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ETNK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ETNK2 34 35
  • 100 (n)
(Canis familiaris)
Mammalia ETNK2 34 35
  • 90.68 (n)
(Bos Taurus)
Mammalia ETNK2 34 35
  • 89.7 (n)
(Mus musculus)
Mammalia Etnk2 34 16 35
  • 86.67 (n)
(Monodelphis domestica)
Mammalia ETNK2 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ETNK2 35
  • 66 (a)
(Gallus gallus)
Aves ETNK2 34 35
  • 71.71 (n)
(Anolis carolinensis)
Reptilia ETNK2 35
  • 59 (a)
(Danio rerio)
Actinopterygii etnk2 34 35
  • 69.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta eas 35
  • 32 (a)
(Caenorhabditis elegans)
Secernentea ckc-1 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EKI1 35
  • 16 (a)
CKI1 35
  • 14 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1187 34
  • 47.59 (n)
(Oryza sativa)
Liliopsida Os09g0438400 34
  • 41.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1866 35
  • 43 (a)
Species where no ortholog for ETNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETNK2 Gene

Gene Tree for ETNK2 (if available)
Gene Tree for ETNK2 (if available)

Paralogs for ETNK2 Gene

Paralogs for ETNK2 Gene Pseudogenes for ETNK2 Gene

genes like me logo Genes that share paralogs with ETNK2: view

Variants for ETNK2 Gene

Sequence variations from dbSNP and Humsavar for ETNK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10793755 -- 204,141,206(+) AAATC(A/G)AGGTC intron-variant, upstream-variant-2KB
rs10900552 -- 204,135,008(+) AATGG(C/T)CAGTG intron-variant
rs10900553 -- 204,139,035(+) TCTCA(C/T)ATCAA intron-variant
rs10900554 -- 204,140,704(+) ATTTT(C/T)AGTAG intron-variant, upstream-variant-2KB
rs1106778 -- 204,146,420(+) GAGCA(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETNK2 Gene

Variant ID Type Subtype PubMed ID
nsv826398 CNV gain 20364138
esv2762138 CNV gain 21179565

Variation tolerance for ETNK2 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETNK2 Gene

Disorders for ETNK2 Gene

Relevant External Links for ETNK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ETNK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETNK2 Gene

Publications for ETNK2 Gene

  1. Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. (PMID: 18953568) Schoenhard J.A. … Williams S.M. (Hum. Genet. 2008) 3 22 46 64
  2. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PMID: 21177773) Moyer A.M. … Weinshilboum R.M. (Toxicol. Sci. 2011) 3 46 64
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Eki2 is upregulated specifically in the testis during mouse sex determination. (PMID: 15161093) Hurley T.M. … Sinclair A.H. (Gene Expr. Patterns 2004) 3 22 64

Products for ETNK2 Gene

Sources for ETNK2 Gene

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