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Aliases for ETNK1 Gene

Aliases for ETNK1 Gene

  • Ethanolamine Kinase 1 2 3 5
  • EKI 1 3 4
  • EKI1 3 4
  • Putative Protein Product Of Nbla10396 3
  • EC 4
  • Nbla10396 3
  • EKI 3

External Ids for ETNK1 Gene

Previous GeneCards Identifiers for ETNK1 Gene

  • GC12P022670
  • GC12P022778
  • GC12P022544

Summaries for ETNK1 Gene

Entrez Gene Summary for ETNK1 Gene

  • This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ETNK1 Gene

ETNK1 (Ethanolamine Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and ethanolamine kinase activity. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for ETNK1 Gene

  • Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETNK1 Gene

Genomics for ETNK1 Gene

Regulatory Elements for ETNK1 Gene

Enhancers for ETNK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ETNK1 on UCSC Golden Path with GeneCards custom track

Promoters for ETNK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ETNK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ETNK1 Gene

22,625,075 bp from pter
22,690,674 bp from pter
65,600 bases
Plus strand

Genomic View for ETNK1 Gene

Genes around ETNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETNK1 Gene

Proteins for ETNK1 Gene

  • Protein details for ETNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ethanolamine kinase 1
    Protein Accession:
    Secondary Accessions:
    • G5E969

    Protein attributes for ETNK1 Gene

    452 amino acids
    Molecular mass:
    50968 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ETNK1 Gene


neXtProt entry for ETNK1 Gene

Proteomics data for ETNK1 Gene at MOPED

Post-translational modifications for ETNK1 Gene

  • Ubiquitination at Lys 172 and Lys 184
  • Modification sites at PhosphoSitePlus

Other Protein References for ETNK1 Gene

No data available for DME Specific Peptides for ETNK1 Gene

Domains & Families for ETNK1 Gene

Protein Domains for ETNK1 Gene


Suggested Antigen Peptide Sequences for ETNK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the choline/ethanolamine kinase family.
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with ETNK1: view

No data available for Gene Families for ETNK1 Gene

Function for ETNK1 Gene

Molecular function for ETNK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

Enzyme Numbers (IUBMB) for ETNK1 Gene

genes like me logo Genes that share phenotypes with ETNK1: view

miRNA for ETNK1 Gene

miRTarBase miRNAs that target ETNK1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETNK1 Gene

Localization for ETNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETNK1 Gene


Subcellular locations from

Jensen Localization Image for ETNK1 Gene COMPARTMENTS Subcellular localization image for ETNK1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ETNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ETNK1: view

Pathways & Interactions for ETNK1 Gene

genes like me logo Genes that share pathways with ETNK1: view

Pathways by source for ETNK1 Gene

UniProtKB/Swiss-Prot Q9HBU6-EKI1_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for ETNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
genes like me logo Genes that share ontologies with ETNK1: view

No data available for SIGNOR curated interactions for ETNK1 Gene

Drugs & Compounds for ETNK1 Gene

(3) Drugs for ETNK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(1) Additional Compounds for ETNK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ETNK1: view

Transcripts for ETNK1 Gene

Unigene Clusters for ETNK1 Gene

Ethanolamine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETNK1 Gene

No ASD Table

Relevant External Links for ETNK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ETNK1 Gene

mRNA expression in normal human tissues for ETNK1 Gene

Protein differential expression in normal tissues from HIPED for ETNK1 Gene

This gene is overexpressed in Liver, secretome (49.4) and Plasma (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETNK1 Gene

SOURCE GeneReport for Unigene cluster for ETNK1 Gene Hs.29464

mRNA Expression by UniProt/SwissProt for ETNK1 Gene

Tissue specificity: Expressed in kidney, liver, placenta, heart, leukocyte, ovary and testis.
genes like me logo Genes that share expression patterns with ETNK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ETNK1 Gene

Orthologs for ETNK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ETNK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ETNK1 35
  • 93.36 (n)
  • 93.81 (a)
ETNK1 36
  • 97 (a)
(Canis familiaris)
Mammalia ETNK1 35
  • 92.55 (n)
  • 92.7 (a)
ETNK1 36
  • 92 (a)
(Mus musculus)
Mammalia Etnk1 35
  • 88 (n)
  • 93.91 (a)
Etnk1 16
Etnk1 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Etnk1 35
  • 88.92 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia ETNK1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ETNK1 36
  • 68 (a)
(Pan troglodytes)
Mammalia ETNK1 36
  • 100 (a)
(Gallus gallus)
Aves ETNK1 35
  • 80.24 (n)
  • 86.43 (a)
ETNK1 36
  • 86 (a)
(Anolis carolinensis)
Reptilia ETNK1 36
  • 72 (a)
(Danio rerio)
Actinopterygii etnk1 35
  • 68.99 (n)
  • 72.35 (a)
wufb38f12 35
etnk1 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000010 35
  • 51.36 (n)
  • 47.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta eas 35
  • 54.48 (n)
  • 48.34 (a)
eas 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea ckc-1 35
  • 48.17 (n)
  • 36.77 (a)
ckc-1 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 36
  • 15 (a)
EKI1 36
  • 17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02726 35
  • 47.47 (n)
  • 38.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1866 36
  • 44 (a)
Species with no ortholog for ETNK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETNK1 Gene

Gene Tree for ETNK1 (if available)
Gene Tree for ETNK1 (if available)

Paralogs for ETNK1 Gene

Paralogs for ETNK1 Gene

(2) SIMAP similar genes for ETNK1 Gene using alignment to 3 proteins: Pseudogenes for ETNK1 Gene

genes like me logo Genes that share paralogs with ETNK1: view

Variants for ETNK1 Gene

Sequence variations from dbSNP and Humsavar for ETNK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2046602 -- 22,638,513(-) GCACT(G/T)TGGGA intron-variant
rs9435 -- 22,690,273(+) AGAAA(A/C)TATCT utr-variant-3-prime
rs7135431 -- 22,681,890(+) atttt(C/G)ccttt intron-variant
rs171888 -- 22,639,695(+) GATCT(A/G)GAACC intron-variant
rs174437 -- 22,638,155(-) CACTT(C/T)TAGAG intron-variant

Variation tolerance for ETNK1 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ETNK1 Gene

Disorders for ETNK1 Gene

Relevant External Links for ETNK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ETNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETNK1 Gene

Publications for ETNK1 Gene

  1. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. (PMID: 11044454) Lykidis A. … Jackowski S. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. (PMID: 11912161) Zafarana G. … Looijenga L.H. (Cancer Res. 2002) 2 3 23
  3. Recurrent ETNK1 mutations in atypical chronic myeloid leukemia. (PMID: 25343957) Gambacorti-Passerini C.B. … Piazza R. (Blood 2015) 3
  4. Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia. (PMID: 25615281) Lasho T.L. … Pardanani A. (Blood Cancer J 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ETNK1 Gene

Sources for ETNK1 Gene