Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETNK1 Gene

protein-coding   GIFtS: 54
GCID: GC12P022778

ethanolamine kinase 1
 Explore 4 diseases affiliated with
ETNK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ETNK1    

Aliases
for ETNK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ethanolamine Kinase 11 2     Nbla103962
EKI11 2 3 5     Putative Protein Product Of Nbla103962
EKI1 2     EC 2.7.1.823
EKI 12 3     

External Ids:    HGNC: 246491   Entrez Gene: 555002   Ensembl: ENSG000001391637   OMIM: 6098585   UniProtKB: Q9HBU63   

Export aliases for ETNK1 gene to outside databases

Previous GC identifers: GC12P022670 GC12P022544


Summaries
for ETNK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ETNK1:
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine
synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on
choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6
Function: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine
biosynthesis




Genomic Views
for ETNK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETNK1 gene promoter:
         Spz1   LHX3b/Lhx3b   AP-1   Sp1   HTF   E47   GATA-6   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ETNK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ETNK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETNK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.2

ETNK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETNK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P022778:  view genomic region     (about GC identifiers)

Start:
 22,778,009 bp from pter      End:
 22,843,608 bp from pter
Size:
 65,600 bases      Orientation:
 plus strand

Proteins
for ETNK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6 (See protein sequence)
Recommended Name: Ethanolamine kinase 1  
Size: 452 amino acids; 50968 Da
Subcellular location: Cytoplasm

Explore the universe of human proteins at neXtProt for ETNK1: NX_Q9HBU6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBU6

    • ETNK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034570.1  NP_061108.2  

    ENSEMBL proteins: 
     ENSP00000266517   ENSP00000334041   ENSP00000446292   ENSP00000444155   ENSP00000439614  
    Reactome Protein details: Q9HBU6
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ETNK1
    OriGene Protein Over-expression Lysate: ETNK1
    OriGene Custom Protein Services for ETNK1 
    GenScript Custom Purified and Recombinant Proteins Services for ETNK1
    Novus Biologicals ETNK1 Proteins
    Novus Biologicals ETNK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ETNK1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--


    ETNK1 for ontologies           About GeneDecksing



    ETNK1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ETNK1 
    GenScript Custom Superior Antibodies Services for ETNK1
    Novus Biologicals ETNK1 Antibodies
    Search for Antibodies for ETNK1 at Abcam  
    Uscn Antibodies for ETNK1
    ThermoFisher Antibodies for ETNK1

    Assay Products for ETNK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ETNK1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ETNK1

    Protein Domains /
    Families
    for ETNK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ETNK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR026712 Cho/Etha_kinase

    Graphical View of Domain Structure for InterPro Entry Q9HBU6

    ProtoNet protein and cluster: Q9HBU6

    1 Blocks protein family: IPB002573 Choline/ethanolamine kinase

    UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6
    Similarity: Belongs to the choline/ethanolamine kinase family


    Function
    for ETNK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6
    Function: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine
    biosynthesis
    Catalytic activity: ATP + ethanolamine = ADP + O-phosphoethanolamine

    Enzyme Number (IUBMB): EC 2.7.1.821

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ETNK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETNK1
    8/138 QIAGEN miScript miRNA Assays for microRNAs that regulate ETNK1 (see all 138):
    hsa-miR-579 hsa-miR-100* hsa-miR-199a-3p hsa-miR-519a hsa-miR-130b hsa-miR-877 hsa-miR-130a* hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETNK1 (see all 4)
    OriGene shRNA RFP: ETNK1
    OriGene siRNA: ETNK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETNK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ETNK1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ETNK1 (NM_018638)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETNK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETNK1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ETNK1
    Search LifeMap BioReagents cell lines for ETNK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETNK1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004305ethanolamine kinase activity IDA11044454
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----


    ETNK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ETNK1:
     Decreased mitotic index  Increased G1 DNA content 


    Pathways & Interactions
    for ETNK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Glycerophospholipid metabolism0.54
    		Phospholipid metabolism0.64
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Synthesis of PE
    		Synthesis of PE1.00
    		phosphatidylethanolamine biosynthesis II0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ETNK1 
        phosphatidylethanolamine biosynthesis II

    5        Reactome Pathways for ETNK1
        Glycerophospholipid biosynthesis
    Metabolism
    Phospholipid metabolism
    Synthesis of PE
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for ETNK1):
        Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6
    Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine:
    step 1/3


    ETNK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ETNK1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ETNK1 (Q9HBU63 ENSP000002665174) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS3P233963I2D: score=3 
    PCYT2ENSP000003317194STRING: ENSP00000331719
    PHOSPHO1ENSP000004069094STRING: ENSP00000406909
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006646phosphatidylethanolamine biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046474glycerophospholipid biosynthetic process TAS--


    ETNK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ETNK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETNK1

    4 HMDB Compounds for ETNK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Ethanolamine1-Amino-2-hydroxyethane (see all 28)141-43-5--
    O-PhosphoethanolaminePhosphoryethanolamine (see all 28)1071-23-4--
    Search CenterWatch for drugs/clinical trials and news about ETNK1 / EKI1 

    Transcripts
    for ETNK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ETNK1 gene (2 alternative transcripts): 
    NM_001039481.1  NM_018638.4  

    Unigene Cluster for ETNK1:

    Ethanolamine kinase 1
    Hs.29464  [show with all ESTs]
    Unigene Representative Sequence: NM_018638
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266517(uc001rft.3 uc009ziz.3) ENST00000335148(uc001rfs.3)
    ENST00000538218 ENST00000541247 ENST00000545979 ENST00000539974 ENST00000544191


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ETNK1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETNK1
    8/138 QIAGEN miScript miRNA Assays for microRNAs that regulate ETNK1 (see all 138):
    hsa-miR-579 hsa-miR-100* hsa-miR-199a-3p hsa-miR-519a hsa-miR-130b hsa-miR-877 hsa-miR-130a* hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETNK1 (see all 4)
    OriGene shRNA RFP: ETNK1
    OriGene siRNA: ETNK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETNK1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ETNK1 (NM_018638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETNK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETNK1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ETNK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ETNK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETNK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETNK1

    Additional cDNA sequence: 

    AB074182.1 AF207600.2 AK027113.1 AK074425.1 AL110180.1 AL117563.1 AL137750.1 BC006111.1 
    BC037324.2 BC045794.1 BC066907.1 BT007084.1 CR749601.1 

    15 DOTS entries:

    DT.315767  DT.445990  DT.97774891  DT.408000  DT.95234982  DT.121123479  DT.121123507  DT.91747234 
    DT.95254695  DT.86856193  DT.100788998  DT.121123472  DT.121204400  DT.91720290  DT.91730982 

    24/96 AceView cDNA sequences (see all 96):

    AL137750 NM_018638 CK822915 BP336773 CK822914 AI003792 AI357819 AA770489 
    AI361619 AI140596 CA412716 BM129168 BQ045414 AW183403 BQ102310 BI770061 
    BM129637 AA724933 AK074425 BQ086206 BT007084 BC066907 CA406305 AA558957 

    GeneLoc Exon Structure


    Expression
    for ETNK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETNK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACTGGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ETNK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ETNK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETNK1

    SOURCE GeneReport for Unigene cluster: Hs.29464

    UniProtKB/Swiss-Prot: EKI1_HUMAN, Q9HBU6
    Tissue specificity: Expressed in kidney, liver, placenta, heart, leukocyte, ovary and testis

        SABiosciences Custom PCR Arrays for ETNK1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ETNK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ETNK1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETNK1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETNK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETNK1

    Orthologs
    for ETNK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ETNK1 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Etnk11 , 5 ethanolamine kinase 11, 5 88.06(n)1
    93.94(a)1    		   6 (75.41 cM)5
    753201  NM_029250.21  NP_083526.21 
     1431672305 
    chicken
    (Gallus gallus)    		 Aves ETNK11 ethanolamine kinase 1 80.26(n)
    86.23(a)    		   418196  XM_416426.3  XP_416426.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ETNK16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 5(6865269-6894414)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb38f122 Transcribed sequence with moderate similarity to protein more 76.79(n)    57097249 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eas1 easily shocked 54.18(n)
    47.73(a)    		   32585  NM_078640.3  NP_523364.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea ckc-11 Protein CKC-1 48.49(n)
    36.77(a)    		   188971  NM_001029758.1  NP_001024929.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons emb11876
    		 protein kinase-like protein
    		 32(a)
    		 1 → many
    		 2(11443561-11447171)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 choline/ethanolamine kinase, putative, expressed
    		 30(a)
    		 1 → many
    		 9(16223957-16228507)


    ENSEMBL Gene Tree for ETNK1 (if available)
    TreeFam Gene Tree for ETNK1 (if available) 

    Paralogs
    for ETNK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETNK1 gene
    CHKA2  CHKB2  CHKB-CPT1B2  ETNK22  
    2 SIMAP similar genes for ETNK1 using alignment to 5 protein entries:     EKI1_HUMAN (see all proteins):
    DKFZp434E1212    ETNK2

    ETNK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ETNK1
    PGOHUM00000245717


    Genomic Variants
    for ETNK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1033 NCBI SNPs in ETNK1 are shown (see all 1033)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730804621,2
    		C,F,--22776078(+) GTTCTG/CGGACT 2 -- us2k12Minor allele frequency- C:0.03NA EA 240
    rs1833696181,2
    		--22776192(+) TCCTCC/GTCTCC 2 -- us2k10--------
    rs1880183801,2
    		--22776209(+) ACAGCA/GCTTTT 2 -- us2k10--------
    rs1465669511,2
    		--22776244(+) ATTTCA/CATGTC 2 -- us2k10--------
    rs38091961,2
    		C,F,--22776300(-) ATAATG/ACAATT 2 -- us2k12Minor allele frequency- A:0.03NA EA 240
    rs1392101401,2
    		--22776365(+) TATGAA/CTATGG 2 -- us2k10--------
    rs1897500201,2
    		--22776440(+) CCTAAC/TAGTTT 2 -- us2k10--------
    rs1420106041,2
    		--22776442(+) AATAG-/TTTTTT 2 -- us2k10--------
    rs1823636841,2
    		--22776478(+) GACTCG/TTATTT 2 -- us2k10--------
    rs38091951,2
    		C,F,H,--22776605(-) TCTCTT/AGTATT 2 -- us2k1 tfbs39Minor allele frequency- A:0.16NS EA WA CSA NA 774

    HapMap Linkage Disequilibrium report for ETNK1 (22778009 - 22843608 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ETNK1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ETNK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ETNK1

    Disorders / Diseases
    for ETNK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ETNK1 for disorders           About GeneDecksing

    OMIM gene information: 609858    OMIM disorders: --

    4 diseases for ETNK1:    About MalaCards
    scabies    seminoma    malaria    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: ETNK1 (4 documents)

    Export disorders for ETNK1 gene to outside databases

    Publications
    for ETNK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETNK1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ETNK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. (PubMed id 11044454)1, 2, 3, 9 Lykidis A.... Jackowski S. (2001)
    2. Coamplification of DAD-R, SOX5, and EKI1 in human tes ticular seminomas, with specific overexpression of DAD-R, correlates with reduc ed levels of apoptosis and earlier clinical manifestation. (PubMed id 11912161)1, 3, 9 Zafarana G....Looijenga L.H. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for ETNK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ETNK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55500 HGNC: 24649 AceView: ETNK1 Ensembl:ENSG00000139163 euGenes: HUgn55500
    ECgene: ETNK1 Kegg: 55500 H-InvDB: ETNK1

    Other Databases showing ETNK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ETNK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETNK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ETNK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ETNK1 gene:
    Search GeneIP for patents involving ETNK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ETNK1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ETNK1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETNK1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ETNK1  
     OriGene Protein Over-expression Lysate for ETNK1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ETNK1   OriGene 3'-UTR Clone for ETNK1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETNK1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ETNK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ETNK1   OriGene Custom Protein Services for ETNK1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ETNK1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ETNK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETNK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETNK1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETNK1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETNK1
     GenScript Custom Purified and Recombinant Proteins Services for ETNK1 GenScript cDNA clones with any tag delivered in your preferred vector for ETNK1
     GenScript Custom Assay Services for ETNK1 GenScript Custom Superior Antibodies Services for ETNK1
     GenScript Custom overexpressing Cell Line Services for ETNK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ETNK1 promoter
     Search Chromatin IP Primers for ETNK1
     RT2 qPCR Primer Assay in human, mouse, rat ETNK1
     Search GNC Networks for ETNK1
     SABiosciences Custom PCR Arrays for ETNK1
     Search Tocris compounds for ETNK1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ETNK1 antibodies
     ETNK1 proteins
     ETNK1 lysates
     Search for Antibodies for ETNK1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ETNK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ETNK1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ETNK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETNK1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ETNK1
     SwitchGear Promoter luciferase reporter plasmids for ETNK1
     ThermoFisher Antibodies for ETNK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETNK1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ETNK1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4