Aliases for ETFA Gene
External Ids for ETFA Gene
Previous GeneCards Identifiers for ETFA Gene
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ETFA Gene
ETFA (Electron-Transfer-Flavoprotein, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ETFA include glutaric acidemia iic and multiple acyl-coa dehydrogenation deficiency, mild type. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding.
UniProtKB/Swiss-Prot for ETFA Gene
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)