Aliases for ETFA Gene
External Ids for ETFA Gene
Previous GeneCards Identifiers for ETFA Gene
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ETFA Gene
ETFA (Electron Transfer Flavoprotein Alpha Subunit) is a Protein Coding gene. Diseases associated with ETFA include Glutaric Acidemia Iic and Multiple Acyl-Coa Dehydrogenation Deficiency, Severe Neonatal Type. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding.
UniProtKB/Swiss-Prot for ETFA Gene
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).