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Aliases for ETF1 Gene

Aliases for ETF1 Gene

  • Eukaryotic Translation Termination Factor 1 2 3
  • ERF1 3 4 6
  • RF1 3 4 6
  • Sup45 (Yeast Omnipotent Suppressor 45) Homolog-Like 1 2 3
  • Polypeptide Chain Release Factor 1 2 3
  • Protein Cl1 3 4
  • SUP45L1 3 4
  • TB3-1 3 4
  • Eukaryotic Peptide Chain Release Factor Subunit 1 3
  • Eukaryotic Release Factor 1 4
  • D5S1995 3
  • ERF 3

External Ids for ETF1 Gene

Previous Symbols for ETF1 Gene

  • SUP45L1
  • ERF1
  • ERF

Summaries for ETF1 Gene

Entrez Gene Summary for ETF1 Gene

  • This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

GeneCards Summary for ETF1 Gene

ETF1 (Eukaryotic Translation Termination Factor 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Cellular Senescence. GO annotations related to this gene include RNA binding and translation release factor activity.

UniProtKB/Swiss-Prot for ETF1 Gene

  • Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for ETF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETF1 Gene

Genomics for ETF1 Gene

Genomic Location for ETF1 Gene

Start:
138,506,093 bp from pter
End:
138,543,300 bp from pter
Size:
37,208 bases
Orientation:
Minus strand

Genomic View for ETF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETF1 Gene

Regulatory Elements for ETF1 Gene

Proteins for ETF1 Gene

  • Protein details for ETF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62495-ERF1_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor subunit 1
    Protein Accession:
    P62495
    Secondary Accessions:
    • B2R6B4
    • D3DQC1
    • P46055
    • Q5M7Z7
    • Q96CG1

    Protein attributes for ETF1 Gene

    Size:
    437 amino acids
    Molecular mass:
    49031 Da
    Quaternary structure:
    • Heterodimer of two subunits, one of which binds GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

    Three dimensional structures from OCA and Proteopedia for ETF1 Gene

    Alternative splice isoforms for ETF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETF1 Gene

Proteomics data for ETF1 Gene at MOPED

Post-translational modifications for ETF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys171, Lys384, and Lys404

Other Protein References for ETF1 Gene

No data available for DME Specific Peptides for ETF1 Gene

Domains for ETF1 Gene

UniProtKB/Swiss-Prot:

ERF1_HUMAN
Family:
  • Belongs to the eukaryotic release factor 1 family.:
    • P62495
genes like me logo Genes that share domains with ETF1: view

No data available for Gene Families for ETF1 Gene

Function for ETF1 Gene

Molecular function for ETF1 Gene

GENATLAS Biochemistry: eukaryotic translation termination factor 1,associating with the catalytic subunit of protein phosphatase 2A
UniProtKB/Swiss-Prot Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7990965
GO:0003747 translation release factor activity TAS 15326224
GO:0005515 protein binding IPI 16189514
GO:0008079 translation termination factor activity TAS 10413110
GO:0016149 translation release factor activity, codon specific IBA --
genes like me logo Genes that share ontologies with ETF1: view
genes like me logo Genes that share phenotypes with ETF1: view

miRNA for ETF1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ETF1 Gene

Localization for ETF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETF1 Gene COMPARTMENTS Subcellular localization image for ETF1 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0018444 translation release factor complex IBA --
genes like me logo Genes that share ontologies with ETF1: view

Pathways for ETF1 Gene

genes like me logo Genes that share pathways with ETF1: view

Pathways by source for ETF1 Gene

1 BioSystems pathway for ETF1 Gene
1 KEGG pathway for ETF1 Gene

Gene Ontology (GO) - Biological Process for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006415 translational termination TAS --
GO:0006449 regulation of translational termination TAS 7990965
GO:0006479 protein methylation IDA 18539146
genes like me logo Genes that share ontologies with ETF1: view

Compounds for ETF1 Gene

(1) HMDB Compounds for ETF1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(13) Novoseek inferred chemical compound relationships for ETF1 Gene

Compound -log(P) Hits PubMed IDs
4-thiouridine 77.1 2
gtp 67.4 27
aminoacyl-trna 66.8 3
trna 64.8 6
gdp 62.3 13
genes like me logo Genes that share compounds with ETF1: view

Transcripts for ETF1 Gene

Unigene Clusters for ETF1 Gene

Eukaryotic translation termination factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6: - - - -
SP7:

Relevant External Links for ETF1 Gene

GeneLoc Exon Structure for
ETF1
ECgene alternative splicing isoforms for
ETF1

Expression for ETF1 Gene

mRNA expression in normal human tissues for ETF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETF1 Gene

SOURCE GeneReport for Unigene cluster for ETF1 Gene Hs.483494

genes like me logo Genes that share expressions with ETF1: view

Orthologs for ETF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ETF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETF1 36
  • 100 (n)
  • 100 (a)
ETF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETF1 36
  • 96.57 (n)
  • 100 (a)
ETF1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETF1 36
  • 96.64 (n)
  • 99.77 (a)
ETF1 37
  • 100 (a)
OneToMany
ETF1 37
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Etf1 36
  • 94.97 (n)
  • 100 (a)
Etf1 16
Etf1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ETF1 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etf1 36
  • 95.04 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ETF1 36
  • 88.86 (n)
  • 100 (a)
ETF1 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETF1 37
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3333 36
tropical clawed frog
(Silurana tropicalis)
Amphibia etf1 36
  • 84.36 (n)
  • 98.86 (a)
MGC75958 36
zebrafish
(Danio rerio)
Actinopterygii etf1 36
etf1 36
  • 79.1 (n)
  • 97.25 (a)
etf1 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010310 36
  • 71.25 (n)
  • 85.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta eRF1 36
  • 71.02 (n)
  • 85.78 (a)
eRF1 37
  • 80 (a)
OneToOne
eRF1 38
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea etf-1 36
  • 71.93 (n)
  • 81.07 (a)
etf-1 37
  • 61 (a)
OneToOne
T05H4.6a 38
  • 80 (a)
T05H4.6b 38
  • 80 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER028C 36
  • 63.57 (n)
  • 68.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP45 36
  • 66.04 (n)
  • 68.71 (a)
SUP45 37
  • 67 (a)
OneToOne
SUP45 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11231g 36
  • 67.06 (n)
  • 72.37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8098 36
soybean
(Glycine max)
eudicotyledons Gma.18085 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ERF1-1 36
  • 65.65 (n)
  • 72.47 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3060 36
corn
(Zea mays)
Liliopsida Zm.13318 36
rice
(Oryza sativa)
Liliopsida Os.7009 36
Os01g0939500 36
  • 66.74 (n)
  • 73.95 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5741 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00410 36
  • 66.12 (n)
  • 74.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sup45 36
  • 61.97 (n)
  • 66.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4884 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7901 37
  • 84 (a)
OneToOne
Species with no ortholog for ETF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ETF1 Gene

ENSEMBL:
Gene Tree for ETF1 (if available)
TreeFam:
Gene Tree for ETF1 (if available)

Paralogs for ETF1 Gene

Pseudogenes.org Pseudogenes for ETF1 Gene

genes like me logo Genes that share paralogs with ETF1: view

No data available for Paralogs for ETF1 Gene

Variants for ETF1 Gene

Sequence variations from dbSNP and Humsavar for ETF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10633 -- 138,506,984(-) GTAGC(A/G)ATGGA utr-variant-3-prime
rs11857 -- 138,507,577(-) GCGTT(A/T)GGGAG utr-variant-3-prime
rs154067 -- 138,514,370(-) cgcta(C/T)gttgc intron-variant
rs154068 -- 138,513,970(-) TCTTT(C/G)TGGTT intron-variant
rs154069 -- 138,541,231(-) GGTAA(C/T)ATAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETF1 Gene

Variant ID Type Subtype PubMed ID
nsv329728 CNV Loss 16902084
esv2669716 CNV Deletion 23128226
esv2677157 CNV Deletion 23128226

Relevant External Links for ETF1 Gene

HapMap Linkage Disequilibrium report
ETF1

Disorders for ETF1 Gene

(1) Novoseek inferred disease relationships for ETF1 Gene

Disease -log(P) Hits PubMed IDs
mimicry 33.2 2

Relevant External Links for ETF1

Genetic Association Database (GAD)
ETF1
Human Genome Epidemiology (HuGE) Navigator
ETF1
genes like me logo Genes that share disorders with ETF1: view

No data available for UniProtKB/Swiss-Prot for ETF1 Gene

Publications for ETF1 Gene

  1. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. (PMID: 7990965) Frolova L. … Kisselev L. (Nature 1994) 2 3 4 23
  2. The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1. (PMID: 9003791) Andjelkovic N. … Hemmings B.A. (EMBO J. 1996) 3 4 23
  3. Human release factor eRF1: structural organisation of the unique functional gene on chromosome 5 and of the three processed pseudogenes. (PMID: 10413110) Guenet L. … Le Treut A. (FEBS Lett. 1999) 3 4 23
  4. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. (PMID: 9620853) Czaplinski K. … Peltz S.W. (Genes Dev. 1998) 3 23
  5. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. (PMID: 9712840) Hoshino S. … Katada T. (J. Biol. Chem. 1998) 3 23

Products for ETF1 Gene

Sources for ETF1 Gene

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