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Aliases for ETF1 Gene

Aliases for ETF1 Gene

  • Eukaryotic Translation Termination Factor 1 2 3 5
  • Sup45 (Yeast Omnipotent Suppressor 45) Homolog-Like 1 2 3
  • Polypeptide Chain Release Factor 1 2 3
  • Protein Cl1 3 4
  • SUP45L1 3 4
  • TB3-1 3 4
  • ERF1 3 4
  • RF1 3 4
  • Eukaryotic Release Factor 1 4
  • D5S1995 3
  • ERF 3

External Ids for ETF1 Gene

Previous HGNC Symbols for ETF1 Gene

  • SUP45L1
  • ERF1
  • ERF

Previous GeneCards Identifiers for ETF1 Gene

  • GC05M137716
  • GC05M137872
  • GC05M137918
  • GC05M137869
  • GC05M133032
  • GC05M137843

Summaries for ETF1 Gene

Entrez Gene Summary for ETF1 Gene

  • This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

GeneCards Summary for ETF1 Gene

ETF1 (Eukaryotic Translation Termination Factor 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and ribosome binding.

UniProtKB/Swiss-Prot for ETF1 Gene

  • Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for ETF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETF1 Gene

Genomics for ETF1 Gene

Regulatory Elements for ETF1 Gene

Enhancers for ETF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ETF1 on UCSC Golden Path with GeneCards custom track

Promoters for ETF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ETF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ETF1 Gene

Chromosome:
5
Start:
138,506,093 bp from pter
End:
138,543,300 bp from pter
Size:
37,208 bases
Orientation:
Minus strand

Genomic View for ETF1 Gene

Genes around ETF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETF1 Gene

Proteins for ETF1 Gene

  • Protein details for ETF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62495-ERF1_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor subunit 1
    Protein Accession:
    P62495
    Secondary Accessions:
    • B2R6B4
    • D3DQC1
    • P46055
    • Q5M7Z7
    • Q96CG1

    Protein attributes for ETF1 Gene

    Size:
    437 amino acids
    Molecular mass:
    49031 Da
    Quaternary structure:
    • Heterodimer of two subunits, one of which binds GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

    Three dimensional structures from OCA and Proteopedia for ETF1 Gene

    Alternative splice isoforms for ETF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETF1 Gene

Proteomics data for ETF1 Gene at MOPED

Post-translational modifications for ETF1 Gene

  • Ubiquitination at Lys 171, Lys 384, and Lys 404
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ETF1 Gene

Domains & Families for ETF1 Gene

Suggested Antigen Peptide Sequences for ETF1 Gene

Graphical View of Domain Structure for InterPro Entry

P62495

UniProtKB/Swiss-Prot:

ERF1_HUMAN :
  • Belongs to the eukaryotic release factor 1 family.
Family:
  • Belongs to the eukaryotic release factor 1 family.
genes like me logo Genes that share domains with ETF1: view

No data available for Gene Families for ETF1 Gene

Function for ETF1 Gene

Molecular function for ETF1 Gene

GENATLAS Biochemistry:
eukaryotic translation termination factor 1,associating with the catalytic subunit of protein phosphatase 2A
UniProtKB/Swiss-Prot Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003747 translation release factor activity TAS 15326224
genes like me logo Genes that share ontologies with ETF1: view
genes like me logo Genes that share phenotypes with ETF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETF1 Gene

Localization for ETF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETF1 Gene COMPARTMENTS Subcellular localization image for ETF1 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for ETF1 Gene

Pathways & Interactions for ETF1 Gene

genes like me logo Genes that share pathways with ETF1: view

Pathways by source for ETF1 Gene

Gene Ontology (GO) - Biological Process for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006449 regulation of translational termination TAS 7990965
genes like me logo Genes that share ontologies with ETF1: view

No data available for SIGNOR curated interactions for ETF1 Gene

Drugs & Compounds for ETF1 Gene

(5) Drugs for ETF1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for ETF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ETF1: view

Transcripts for ETF1 Gene

Unigene Clusters for ETF1 Gene

Eukaryotic translation termination factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6: - - - -
SP7:

Relevant External Links for ETF1 Gene

GeneLoc Exon Structure for
ETF1
ECgene alternative splicing isoforms for
ETF1

Expression for ETF1 Gene

mRNA expression in normal human tissues for ETF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETF1 Gene



SOURCE GeneReport for Unigene cluster for ETF1 Gene Hs.483494

genes like me logo Genes that share expression patterns with ETF1: view

Protein tissue co-expression partners for ETF1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ETF1 Gene

Orthologs for ETF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ETF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETF1 35
  • 96.57 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETF1 35
  • 96.64 (n)
  • 99.77 (a)
ETF1 36
  • 100 (a)
OneToMany
ETF1 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Etf1 35
  • 94.97 (n)
  • 100 (a)
Etf1 16
Etf1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETF1 35
  • 100 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etf1 35
  • 95.04 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ETF1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETF1 35
  • 88.86 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETF1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia etf1 35
  • 84.36 (n)
  • 98.86 (a)
MGC75958 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3333 35
zebrafish
(Danio rerio)
Actinopterygii etf1 35
etf1 35
  • 79.1 (n)
  • 97.25 (a)
etf1 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eRF1 37
  • 84 (a)
eRF1 35
  • 71.02 (n)
  • 85.78 (a)
eRF1 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010310 35
  • 71.25 (n)
  • 85.78 (a)
worm
(Caenorhabditis elegans)
Secernentea T05H4.6a 37
  • 80 (a)
T05H4.6b 37
  • 80 (a)
etf-1 35
  • 71.93 (n)
  • 81.07 (a)
etf-1 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER028C 35
  • 63.57 (n)
  • 68.84 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11231g 35
  • 67.06 (n)
  • 72.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP45 35
  • 66.04 (n)
  • 68.71 (a)
SUP45 36
  • 67 (a)
OneToOne
SUP45 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ERF1-1 35
  • 65.65 (n)
  • 72.47 (a)
soybean
(Glycine max)
eudicotyledons Gma.18085 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8098 35
barley
(Hordeum vulgare)
Liliopsida Hv.3060 35
rice
(Oryza sativa)
Liliopsida Os.7009 35
Os01g0939500 35
  • 66.74 (n)
  • 73.95 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5741 35
corn
(Zea mays)
Liliopsida Zm.13318 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4884 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00410 35
  • 66.12 (n)
  • 74.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sup45 35
  • 61.97 (n)
  • 66.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7901 36
  • 84 (a)
OneToOne
Species with no ortholog for ETF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ETF1 Gene

ENSEMBL:
Gene Tree for ETF1 (if available)
TreeFam:
Gene Tree for ETF1 (if available)

Paralogs for ETF1 Gene

Pseudogenes.org Pseudogenes for ETF1 Gene

genes like me logo Genes that share paralogs with ETF1: view

No data available for Paralogs for ETF1 Gene

Variants for ETF1 Gene

Sequence variations from dbSNP and Humsavar for ETF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10633 -- 138,506,984(-) GTAGC(A/G)ATGGA utr-variant-3-prime
rs11857 -- 138,507,577(-) GCGTT(A/T)GGGAG utr-variant-3-prime
rs860394 -- 138,535,617(+) ttggg(A/G)ggctg intron-variant
rs861150 -- 138,535,588(+) tggtg(A/G)cgggt intron-variant
rs865442 -- 138,535,645(+) gaacc(C/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETF1 Gene

Variant ID Type Subtype PubMed ID
nsv329728 CNV Loss 16902084
esv2669716 CNV Deletion 23128226
esv2677157 CNV Deletion 23128226

Variation tolerance for ETF1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ETF1 Gene

Disorders for ETF1 Gene

Relevant External Links for ETF1

Genetic Association Database (GAD)
ETF1
Human Genome Epidemiology (HuGE) Navigator
ETF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETF1

No disorders were found for ETF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETF1 Gene

Publications for ETF1 Gene

  1. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. (PMID: 7990965) Frolova L. … Kisselev L. (Nature 1994) 2 3 4 23 67
  2. Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. (PMID: 18256688) Ivanov P.V. … Kulozik A.E. (EMBO J. 2008) 3 23
  3. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. (PMID: 18447585) Singh G. … Lykke-Andersen J. (PLoS Biol. 2008) 3 23
  4. Invariant amino acids essential for decoding function of polypeptide release factor eRF1. (PMID: 16282590) Kolosov P. … Kisselev L. (Nucleic Acids Res. 2005) 3 23
  5. The effect of eukaryotic release factor depletion on translation termination in human cell lines. (PMID: 15326224) Janzen D.M. … Geballe A.P. (Nucleic Acids Res. 2004) 3 23

Products for ETF1 Gene

  • Addgene plasmids for ETF1

Sources for ETF1 Gene

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