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ESYT2 Gene

protein-coding   GIFtS: 50
GCID: GC07M158523

Extended Synaptotagmin-Like Protein 2

(Previous names: family with sequence similarity 62 (C2 domain containing),...)
(Previous symbol: FAM62B)
  Search for ESYT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Extended Synaptotagmin-Like Protein 21 2     Chr2 Synaptotagmin2
FAM62B1 2 3     Extended Synaptotagmin-22
Family With Sequence Similarity 62 (C2 Domain Containing), Member B1 2     Chr2Syt3
E-Syt22 3     KIAA12283
CHR2SYT2     

External Ids:    HGNC: 222111   Entrez Gene: 574882   Ensembl: ENSG000001178687   UniProtKB: A0FGR83   

Export aliases for ESYT2 gene to outside databases

Previous GC identifers: GC07M158217 GC07M152262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ESYT2 Gene:
ESYT2 (extended synaptotagmin-like protein 2) is a protein-coding gene. An important paralog of this gene is ESYT1.

UniProtKB/Swiss-Prot: ESYT2_HUMAN, A0FGR8
Function: May play a role as calcium-regulated intrinsic membrane protein

Gene Wiki entry for ESYT2 (FAM62B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ESYT2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ESYT2 promoter sequence
   Search Chromatin IP Primers for ESYT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESYT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.3   Ensembl cytogenetic band:  7q36.3   HGNC cytogenetic band: 7q36.3

ESYT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESYT2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M158523:  view genomic region     (about GC identifiers)

Start:
158,523,686 bp from pter      End:
158,622,944 bp from pter
Size:
99,259 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 157,728,008-157,826,023     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ESYT2_HUMAN, A0FGR8 (See protein sequence)
Recommended Name: Extended synaptotagmin-2  
Size: 921 amino acids; 102357 Da
Sequence caution: Sequence=BAA91539.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC85769.1; Type=Frameshift; Positions=800;
3 PDB 3D structures from and Proteopedia for ESYT2:
2DMG (3D)        4NPJ (3D)        4NPK (3D)    
Secondary accessions: A4D229 Q69YJ2 Q6UKI4 Q6ZTU0 Q6ZVU1 Q9BQS0 Q9NW47 Q9ULJ2
Alternative splicing: 5 isoforms:  A0FGR8-1   A0FGR8-2   A0FGR8-4   A0FGR8-5   A0FGR8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ESYT2: NX_A0FGR8

Explore proteomics data for ESYT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys239, Lys405, Lys411
  • Modification sites at PhosphoSitePlus

  • See ESYT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065779.1  
    ENSEMBL proteins: 
     ENSP00000251527   ENSP00000275418   ENSP00000411488  

    ESYT2 Human Recombinant Protein Products:

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    Novus Biologicals ESYT2 Protein
    Novus Biologicals ESYT2 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ESYT2

     
    Search eBioscience for Proteins for ESYT2 

    ESYT2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ESYT2

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    Search eBioscience for ELISAs for ESYT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry A0FGR8

    ProtoNet protein and cluster: A0FGR8

    UniProtKB/Swiss-Prot: ESYT2_HUMAN, A0FGR8
    Similarity: Belongs to the extended synaptotagmin family
    Similarity: Contains 3 C2 domains


    Find genes that share domains with ESYT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ESYT2_HUMAN, A0FGR8
    Function: May play a role as calcium-regulated intrinsic membrane protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005544calcium-dependent phospholipid binding IDA17360437
         
    Find genes that share ontologies with ESYT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ESYT2:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESYT2
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    miRNA
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    miRTarBase miRNAs that target ESYT2:
    hsa-mir-124-3p (MIRT022374), hsa-mir-21-5p (MIRT030756), hsa-mir-34a-5p (MIRT025347), hsa-mir-193b-3p (MIRT016414)

    Block miRNA regulation of human, mouse, rat ESYT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ESYT2 (see all 40):
    hsa-miR-21* hsa-miR-579 hsa-miR-146a hsa-miR-138-2* hsa-miR-374c hsa-miR-124 hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidESYT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ESYT2

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    GenScript: all cDNA clones in your preferred vector: ESYT2 (NM_020728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESYT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESYT2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ESYT2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESYT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ESYT2_HUMAN, A0FGR8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA17360437

    Find genes that share ontologies with ESYT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ESYT2
    Interactions:

        Search GeneGlobe Interaction Network for ESYT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ESYT2 (A0FGR81, 3 ENSP000002515274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAMKK2Q96RR43, ENSP000003127414I2D: score=3 STRING: ENSP00000312741
    CLN3Q132863, ENSP000003530734I2D: score=3 STRING: ENSP00000353073
    BECN1Q144573I2D: score=1 
    SLC2A4P146723I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ESYT2

    1 HMDB Compound for ESYT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ESYT2 gene: 
    NM_020728.2  

    Unigene Cluster for ESYT2:

    Extended synaptotagmin-like protein 2
    Hs.490795  [show with all ESTs]
    Unigene Representative Sequence: NM_020728
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251527(uc003wny.1 uc003wnz.1 uc003woa.1 uc003wob.1 uc003wod.1)
    ENST00000275418(uc003woc.1) ENST00000435514 ENST00000483958 ENST00000497111

    miRNA
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    Block miRNA regulation of human, mouse, rat ESYT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ESYT2 (see all 40):
    hsa-miR-21* hsa-miR-579 hsa-miR-146a hsa-miR-138-2* hsa-miR-374c hsa-miR-124 hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidESYT2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ESYT2
    Clone
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    OriGene clones in human, mouse for ESYT2 (see all 6)
    OriGene ORF clones in mouse, rat for ESYT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ESYT2 (NM_020728)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESYT2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ESYT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ESYT2
      QuantiTect SYBR Green Assays in human, mouse, rat ESYT2
      QuantiFast Probe-based Assays in human, mouse, rat ESYT2

    Additional mRNA sequence: 

    AJ303365.1 AK001181.1 AK026710.1 AK056953.1 AK308824.1 AL833233.1 AY368150.1 BC013957.2 

    19 DOTS entries:

    DT.215666  DT.40218943  DT.91782492  DT.95119048  DT.91929370  DT.91782577  DT.100056600  DT.40274105 
    DT.97782122  DT.97870664  DT.100646095  DT.102834082  DT.110470  DT.121057437  DT.121057461  DT.121057465 
    DT.437916  DT.91866527  DT.91940999 

    Selected AceView cDNA sequences (see all 358):

    BQ686655 BM810399 AA931736 AW192617 BU859047 BM757878 BM722550 BQ277720 
    BU174902 BQ961649 AJ303365 AW009175 BU931219 NM_020728 R22341 CA429127 
    BF059258 AI830247 BM479737 BQ670311 AI275397 CB215710 BM908613 AI920974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ESYT2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a ·
    SP1:                                                                                                              -                       -                 -   
    SP2:                                                                                                                                      -                     
    SP3:                                                                                                              -                       -                     
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c · 27d
    SP1:        -     -     -           -                 -                                       
    SP2:        -     -     -           -                 -                                       
    SP3:        -     -     -           -                 -                                       
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ESYT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ESYT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATTCA
    ESYT2 Expression
    About this image

    ESYT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ESYT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490795

    UniProtKB/Swiss-Prot: ESYT2_HUMAN, A0FGR8
    Tissue specificity: Widely expressed with high level in cerebellum

        Custom PCR Arrays for ESYT2
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    QuantiFast Probe-based Assays in human, mouse, rat ESYT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESYT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ESYT2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Esyt21 , 5 extended synaptotagmin-like protein 21, 5 87.78(n)1
    93.18(a)1
      12 (62.65 cM)5
    526351  NM_028731.51  NP_083007.21 
     1162812225 
    chicken
    (Gallus gallus)
    Aves NCAPG21 non-SMC condensin II complex, subunit G2 79.27(n)
    88.84(a)
      420451  XM_003640633.2  XP_003640681.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    77(a)
    75(a)
    1 ↔ many
    1 ↔ many
    GL344095.1(15620-28012)
    GL344095.1(46797-78347)
    African clawed frog
    (Xenopus laevis)
    Amphibia kiaa1228-prov2 membrane bound C2 domain containing protein 77.68(n)    BC046701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI884904.12   -- 71.26(n)    BI884904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Esyt21 Esyt2 48.05(n)
    37.37(a)
      42929  NM_170653.3  NP_733011.2 
    worm
    (Caenorhabditis elegans)
    Secernentea esyt-21 esyt-2 47.9(n)
    37.77(a)
      175882  NM_171156.3  NP_741181.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYTB1 SYTB 45.41(n)
    28.44(a)
      838597  NM_101862.4  NP_173436.4 


    ENSEMBL Gene Tree for ESYT2 (if available)
    TreeFam Gene Tree for ESYT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ESYT2 gene
    ESYT12  ESYT32  MCTP22  MCTP12  
    5 SIMAP similar genes for ESYT2 using alignment to 3 protein entries:     ESYT2_HUMAN (see all proteins):
    ESYT1    ESYT3    CHR11SYT    SYT1    SYT11

    Find genes that share paralogs with ESYT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ESYT2 (see all 2762)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361481701,2
    C--157779480(+) AGAGG-/TGTGTGT 1 -- int10--------
    rs49941571,2
    C--158523225(+) CGGTGC/G/TCAAAG 1 -- ds50011NA 2
    rs49941561,2
    C,F,A,H--158523226(+) GGTGTG/CAAAGG 1 -- ds50014Minor allele frequency- C:0.29NA CSA 7
    rs624788951,2
    C--158523230(+) TCAAAT/GGCCCA 1 -- ds50012Minor allele frequency- G:0.25NA CSA 4
    rs624788961,2
    C--158523234(+) AGGCCG/CACAGT 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs756666641,2
    C--158523236(+) GCCCAG/CAGTCA 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs624788971,2
    C--158523238(+) CCACAG/ATCAAG 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs599762161,2
    C--158523259(+) GTGCCC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs2016204921,2
    C--158523277(-) GTAGCC/TGCTCG 1 -- ds50010--------
    rs1820038791,2
    --158523282(+) GGCTAC/TGAGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ESYT2 (158523686 - 158622944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ESYT2 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671217CNV Deletion23128226
    esv2736038CNV Deletion23290073
    esv2660913CNV Deletion23128226
    esv1040592CNV Deletion17803354
    esv4476CNV Deletion18987735
    esv2588508CNV Deletion19546169
    esv2736037CNV Deletion23290073
    esv1110311CNV Deletion17803354
    esv2736032CNV Deletion23290073
    esv2736033CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ESYT2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ESYT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. (PubMed id 17360437)1, 2 Min S.-W.... Suedhof T.C. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    2. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. (PubMed id 17672888)1, 3 Craxton M. (BMC Genomics 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 2 Craxton M.A. (Genomics 2001)
    8. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57488 HGNC: 22211 AceView: KIAA1228 Ensembl:ENSG00000117868 euGenes: HUgn57488
    ECgene: ESYT2 H-InvDB: ESYT2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1228

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ESYT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ESYT2 gene:
    Search GeneIP for patents involving ESYT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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