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ESX1 Gene

protein-coding   GIFtS: 50
GCID: GC0XM103494

ESX Homeobox 1

(Previous names: extraembryonic, spermatogenesis, homeobox 1 homolog (mouse))
(Previous symbol: ESX1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ESX Homeobox 11 2     Extraembryonic, Spermatogenesis, Homeobox 1 Homolog2
ESX1L1 2 3 5     Homeobox Protein ESX12
ESXR12 5     ESX1R3
Extraembryonic, Spermatogenesis, Homeobox 1 Homolog (Mouse)1     Extraembryonic, Spermatogenesis, Homeobox 13
ESX1-Related Protein2     

External Ids:    HGNC: 148651   Entrez Gene: 807122   Ensembl: ENSG000001235767   OMIM: 3001545   UniProtKB: Q8N6933   

Export aliases for ESX1 gene to outside databases

Previous GC identifers: GC0XM103381 GC0XM093122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ESX1 Gene:
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa
N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain.
The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the
nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally
imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
(provided by RefSeq, Jan 2010)

GeneCards Summary for ESX1 Gene:
ESX1 (ESX homeobox 1) is a protein-coding gene. Diseases associated with ESX1 include allan-herndon-dudley syndrome, and testicular germ cell tumor. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RHOXF1.

UniProtKB/Swiss-Prot: ESX1_HUMAN, Q8N693
Function: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits
degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase.
ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the
first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover

Gene Wiki entry for ESX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ESX1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidESX1 promoter sequence
   Search Chromatin IP Primers for ESX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

ESX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM103494:  view genomic region     (about GC identifiers)

Start:
103,494,719 bp from pter      End:
103,499,614 bp from pter
Size:
4,896 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ESX1_HUMAN, Q8N693 (See protein sequence)
Recommended Name: Homeobox protein ESX1  
Size: 406 amino acids; 44297 Da
Secondary accessions: B0QYU3 Q7Z6K7

Explore the universe of human proteins at neXtProt for ESX1: NX_Q8N693

Explore proteomics data for ESX1 at MOPED

Post-translational modifications: 

  • Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20
    kDa C-terminal fragment (ESXR1-C)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ESX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_703149.1  
    ENSEMBL proteins: 
     ENSP00000361669  

    ESX1 Human Recombinant Protein Products:

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    Novus Biologicals ESX1 Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ESX1

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ESX1
    Cloud-Clone Corp. CLIAs for ESX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    4 InterPro protein domains:
     IPR013847 POU
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8N693

    ProtoNet protein and cluster: Q8N693

    1 Blocks protein domain: IPB000327 POU domain

    UniProtKB/Swiss-Prot: ESX1_HUMAN, Q8N693
    Similarity: Contains 1 homeobox DNA-binding domain


    ESX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ESX1_HUMAN, Q8N693
    Function: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits
    degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase.
    ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the
    first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IDA15897875
         
    ESX1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Esx1):
     cardiovascular system  embryogenesis  growth/size/body 

    ESX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Esx1tm1Bhr for ESX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ESX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ESX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ESX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ESX1:
    hsa-mir-335-5p (MIRT018679)

    Block miRNA regulation of human, mouse, rat ESX1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ESX1:
    hsa-miR-548a-3p hsa-miR-548am hsa-miR-548g hsa-miR-548x hsa-miR-3126-3p hsa-miR-548e hsa-miR-3148 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidESX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ESX1
    Predesigned siRNA for gene silencing in human, mouse, rat ESX1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ESX1 (NM_003865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESX1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ESX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ESX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ESX1_HUMAN, Q8N693: Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C
    localizes specifically to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    lysosome2
    vacuole2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15235584
    GO:0005737cytoplasm IDA15235584

    ESX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ESX1
        Transcriptional Regulatory Network in Embryonic Stem Cell


        Pathway & Disease-focused RT2 Profiler PCR Array including ESX1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ESX1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ESX1 (Q8N6932 ENSP000003616694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC2ENSP000002304494STRING: ENSP00000230449
    TRAP1ENSP000002469574STRING: ENSP00000246957
    CHEK2ENSP000003720234STRING: ENSP00000372023
    --P310162MINT-8107688
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA15897875

    ESX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ESX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ESX1 gene: 
    NM_153448.3  

    Unigene Cluster for ESX1:

    ESX homeobox 1
    Hs.223782  [show with all ESTs]
    Unigene Representative Sequence: NM_153448
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372588(uc004ely.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ESX1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ESX1:
    hsa-miR-548a-3p hsa-miR-548am hsa-miR-548g hsa-miR-548x hsa-miR-3126-3p hsa-miR-548e hsa-miR-3148 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidESX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ESX1
    Predesigned siRNA for gene silencing in human, mouse, rat ESX1
    Clone
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    OriGene clones in human, mouse for ESX1 (see all 4)
    OriGene ORF clones in mouse, rat for ESX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ESX1 (NM_003865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ESX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ESX1
      QuantiTect SYBR Green Assays in human, mouse, rat ESX1
      QuantiFast Probe-based Assays in human, mouse, rat ESX1

    Additional mRNA sequence: 

    AK097704.1 AY114148.1 BC042633.1 BC053599.1 

    2 DOTS entries:

    DT.75164582  DT.100741424 

    8 AceView cDNA sequences:

    AY114148 NM_153448 BM553237 AK097704 BC053599 AI964078 BC042633 BI831835 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ESX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTTTTTC
    ESX1 Expression
    About this image

    ESX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ESX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.223782

    UniProtKB/Swiss-Prot: ESX1_HUMAN, Q8N693
    Tissue specificity: Expressed in placenta and testis. Expressed in testicular germ cell tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including ESX1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ESX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ESX1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ESX1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Esx15 extraembryonic, spermatogenesis, homeobox 1   --   X (59.10 cM) 137115397 


    ENSEMBL Gene Tree for ESX1 (if available)
    TreeFam Gene Tree for ESX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ESX1 gene
    RHOXF12  RHOXF22  RHOXF2B2  
    3 SIMAP similar genes for ESX1 using alignment to 33 protein entries:     ESX1_HUMAN (see all proteins):
    POU6F1    RHOXF1    RAX2

    ESX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ESX1 (see all 161)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506743721,2
    --103463721(+) ATTTGA/GAGAGT 1 -- int10--------
    rs1834986801,2
    --103463939(+) GGGGGA/GAGGTG 1 -- int10--------
    rs1878280731,2
    --103463943(+) GGAGGC/TGTGGA 1 -- int10--------
    rs1923142651,2
    --103464003(+) GTGATA/GTGCAG 1 -- int10--------
    rs1834211591,2
    --103464139(+) AACGTA/TCTATT 1 -- ut310--------
    rs1884754421,2
    --103464198(+) AACAGG/TGCATT 1 -- ut310--------
    rs2014136461,2
    --103464282(+) TTTCTA/GTCTGG 1 -- ut310--------
    rs1927297791,2
    C--103464313(+) ACTGTC/TATGAA 1 -- ut310--------
    rs98033381,2
    C,H--103464330(+) ACTTTA/GGAAAA 2 Q * stop-lostese3 trp34Minor allele frequency- G:0.00NS EA NA 290
    rs1456487371,2
    F--103464332(+) TTTAGA/GAAAAG 2 S F mis11Minor allele frequency- G:0.00NA 4530

    HapMap Linkage Disequilibrium report for ESX1 (103494719 - 103499614 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ESX1: --
    Locus Specific Mutation Databases (LSDB): ESX1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ESX1
    DNA2.0 Custom Variant and Variant Library Synthesis for ESX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300154    OMIM disorders: --

    7 diseases for ESX1:    
    About MalaCards
    allan-herndon-dudley syndrome    testicular germ cell tumor    pituitary hypoplasia    holoprosencephaly
    hypopituitarism    germ cell tumors    tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for ESX1:
    Tuberculosis     Allan-Herndon-Dudley syndrome

    ESX1 for disorders           About GeneDecksing


    Export disorders for ESX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ESX1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ESX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis. (PubMed id 11374906)1, 2, 3 Fohn L.E. and Behringer R.R. (Genomics 2001)
    2. Mapping and identification of candidate loci responsible for Peromyscus hybrid overgrowth. (PubMed id 17242862)1, 3 Loschiavo M....Vrana P.B. (Mamm. Genome 2007)
    3. Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene. (PubMed id 15897875)1, 2 Yanagihara M....Hatakeyama M. (Oncogene 2005)
    4. Paired-like homeodomain protein ESXR1 possesses a cleavable C- terminal region that inhibits cyclin degradation. (PubMed id 15235584)1, 2 Ozawa H.... Hatakeyama M. (Oncogene 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development. (PubMed id 15601583)1, 9 Figueiredo A.L....Porto L.C. (J. Cell. Mol. Med. 2004)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men. (PubMed id 20356899)1 Bonaparte E....Miozzo M. (Hum. Reprod. 2010)
    10. Rapid evolution of primate ESX1, an X-linked placenta- and testis- expressed homeobox gene. (PubMed id 17588961)1 Wang X. and Zhang J. (Hum. Mol. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80712 HGNC: 14865 AceView: ESX1L Ensembl:ENSG00000123576 euGenes: HUgn80712
    ECgene: ESX1 H-InvDB: ESX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ESX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ESX1 gene:
    Search GeneIP for patents involving ESX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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