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ESRRA Gene

protein-coding   GIFtS: 67

GC11P064073
estrogen-related receptor alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ESRL1)
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Aliases &
Descriptions
for ESRRA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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  User Feedback
Aliases & Descriptions
estrogen-related receptor alpha1 2 3     ERRa1 2
NR3B11 2 3     Nuclear receptor subfamily 3 group B member 12 3
ERR11 2 3     Estrogen receptor-like 12 3
ESRL12 3 5     ERR-alpha2 3
ERRalpha1 2     steroid hormone receptor ERR12

External Ids:    HGNC: 34711   Entrez Gene: 21012   Ensembl: ENSG000001731537   UniProtKB: P114743   

Search outside databases for aliases for ESRRA gene

Previous GC identifers: GC11P066588 GC11P065754 GC11P064323 GC11P063848 GC11P063829

Summaries
for ESRRA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for ESRRA:
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein
acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton
factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been
demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A
dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome
13q12.1. (provided by RefSeq)

UniProtKB/Swiss-Prot: ERR1_HUMAN, P11474
Function: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can
bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important
regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the
coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism

Gene Wiki entry for ESRRA (Estrogen-related receptor alpha)

Genomic Views
for ESRRA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the ESRRA gene upstream (promoter) region "":
CREB   deltaCREB   STAT1   STAT1alpha   STAT1beta   C/EBPbeta   HNF-4alpha2   AhR   FOXO1a   Sox9   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for ESRRA:  ""
MePH15304-2A   MePH15301-3A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12

ESRRA Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064073:  view genomic region     (about GC identifiers)

Start:
 64,073,044 bp from pter
End:
 64,084,215 bp from pter
Size:
 11,172 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

Proteins
for ESRRA gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: ERR1_HUMAN, P11474 (See protein sequence)
Recommended Name: Steroid hormone receptor ERR1  
Size: 423 amino acids; 45510 Da
Subunit: Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3
motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts
with PIAS4; the interaction enhances sumoylation
Subcellular location: Nucleus
Sequence caution: Sequence=AAB17015.1; Type=Erroneous initiation; Sequence=CAA35778.1; Type=Frameshift; Positions=345,
354;
PDB structures from "" and Proteopedia "" :
1XB7 (3D) ""    2PJL (3D) ""    3D24 (3D) ""    
Secondary accessions: Q14514
Alternative splicing: 2 isoforms:  P11474-1   P11474-2   

Post-translational modifications:

  • Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity1
  • Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by
    • interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular
    location nor on DNA binding1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_004442.3  

    ENSEMBL proteins: 
    ENSP00000366916 ENSP00000384851 ENSP00000000442 ENSP00000385971 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""HuPro® and/or Recombinant Proteins from Abnova for ESRRA ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Proteins for ESRRA  ""
    Novus Biologicals Lysate for ESRRA
    ""Browse Sino Biological Recombinant Proteins  ""

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    "" ESRRA for ontologies           About GeneDecksing



    Antibodies for ESRRA: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for ESRRA
    ""R&D Systems Antibodies for ESRRA (ERR alpha/NR3B1)
    ""Monoclonal and Polyclonal Antibodies from Abnova (ESRRA)
    "" Origene Antibodies: ESRRA ""
    ""Novus Biologicals Antibodies for ESRRA
    ""Epitomics antibodies for ESRRA

    Assays for ESRRA: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for ESRRA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" ESRRA for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P11474

    ProtoNet protein and cluster: P11474

    2 Blocks protein families:
    IPB000003 Retinoic acid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: ERR1_HUMAN, P11474
    Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain

    Gene Function
    for ESRRA gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ESRRA)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ESRRA
    Origene shRNA RFP: ESRRA
    Origene basic RS shRNA: ESRRA

    ""Applied Biosystems Silencer® siRNAs for ESRRA
    ""Sigma-Aldrich siRNA Panels and siRNA for ESRRA
    Sigma-Aldrich shRNA Panels and shRNA for ESRRA
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: ESRRA
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: ESRRA
    Origene untagged cDNA clones in CMV expression vector: ESRRA
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: ERR1_HUMAN, P11474
    Function: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can
    bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important
    regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the
    coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism
    Induction: Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle

    Genatlas biochemistry entry for ESRRA:
    estrogen-related receptor A,orphan receptors family,steroid/thyroid hormone receptor superfamily,involved in the
    expression of SV40 major late promoter modulator of ESR response of lactoferrin promoter,regulator of medium chain
    acyl CoA dehydrogenase

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS9286700
    GO:0003700 transcription factor activity IEA--
    GO:0003707 steroid hormone receptor activity IEA--
    GO:0004879 ligand-dependent nuclear receptor activity TAS9286700
    GO:0005496 steroid binding IEA--
    About this table

    "" ESRRA for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 3 alleles"") (MGI details for Esrra):

    adipose tissuegrowth/sizehomeostasis/metabolismnormal

    "" ESRRA for phenotypes           About GeneDecksing

    Pathways & Interactions
    for ESRRA gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" ESRRA for pathways           About GeneDecksing

    1 "" GeneAssist Pathway for ESRRA
      ""  PGC1Alpha Pathway

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ESRRA

    5/9 Interacting proteins for ESRRA (ENSP000000004423 P114741, 2) via UniProtKB, MINT, and/or STRING (see all 9 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRRAPQ9Y4A51EBI-372412,EBI-399128
    LOC100131261Q9NPJ42MINT-15069
    PNRC2Q9NPJ42MINT-15069
    IGF1RENSP000002680353STRING: ENSP00000268035
    MEF2AENSP000002843683STRING: ENSP00000284368
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0042127 regulation of cell proliferation IEA--
    GO:0045667 regulation of osteoblast differentiation IEA--
    GO:0045670 regulation of osteoclast differentiation IEA--
    GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA--
    About this table

    "" ESRRA for ontologies           About GeneDecksing


    Drugs & Compounds
    for ESRRA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" ESRRA for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for ESRRA
    ""Sigma-Aldrich Small Molecules for ESRRA:
    Small Molecule - Antagonist

    "" Compounds for ESRRA available from Tocris Bioscience
    CompoundAction CAS number
    GSK 4716Selective ERRgamma and ERRbeta agonist[101574-65-6]
    About this table


    10/57 ""Novoseek chemical compound relationships for ESRRA gene (see all 57 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    xct790 28.91 8 20222459 (2), 17631492 (2), 19546226 (1), 18550029 (1) (see all 6)
    fulvestrant 7.34 5 16687070 (3), 17631492 (1), 15968320 (1)
    kaempferol 3.57 3 19171140 (3)
    benzophenone-2 2.38 1 15458797 (1)
    4-oht 2.19 1 14751226 (1)
    diethylstilbestrol 1.54 3 19186820 (1), 18822397 (1), 11559547 (1)
    benzophenone-3 1.39 1 15458797 (1)
    biochanin a 1.38 1 16515477 (1)
    ethynylestradiol 1.30 1 19186820 (1)
    acyl-coa 1.24 2 15930184 (1), 12181319 (1)
    About this table

    1 PharmGKB drug compound relationship for ESRRA gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    gemfibrozilPD  GN  12172398
    About this table


    Transcripts
    for ESRRA gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ESRRA)
    ""Applied Biosystems Silencer® siRNAs:  NM_004451  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ESRRA
    Origene shRNA RFP: ESRRA
    Origene basic RS shRNA: ESRRA

    ""Sigma-Aldrich siRNA Panels and siRNA for ESRRA
    Sigma-Aldrich shRNA Panels and shRNA for ESRRA
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""10/22 SABiosciences microRNAs that regulate ESRRA (see all 22 ): ""
    hsa-miR-34b* hsa-miR-125a-5p hsa-miR-328 hsa-miR-137 hsa-miR-15a hsa-miR-449a hsa-miR-103 hsa-miR-424 hsa-miR-125b hsa-miR-326
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_004451  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: ESRRA
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: ESRRA
    Origene untagged cDNA clones in CMV expression vector: ESRRA
    Primers:"" Origene genome-wide validated SYBR primer pairs: ESRRA
    ""SABiosciences RT2 qPCR Primer Assay for ESRRA: PPH05884A ""

    REFSEQ mRNAs for ESRRA gene: 

    NM_004451.3  

    Additional cDNA sequence: 

    AB362579.1 BC007915.2 BC011528.1 BC033701.1 BC063795.1 BC073956.1 BC092470.1 BC093720.1 
    BC093722.1 CR624219.1 L38487.1 

    21 DOTS entries:

    DT.75155335  DT.100788956  DT.92032780  DT.100796196  DT.95275489  DT.120754174  DT.100788950  DT.100788958 
    DT.100796190  DT.100038831  DT.120754141  DT.120754248  DT.92023307  DT.40267222  DT.95130749  DT.102838738 
    DT.92412672  DT.97860417  DT.100788945  DT.100788946  DT.120754246 

    24/828 AceView cDNA sequences (see all 828 ):

    BM019150 BM662662 CB054865 CD559086 AA373344 BE728065 BM789618 BM760930 
    BQ674944 BM702822 BM760651 BM739017 BM853924 BM739014 BM791802 BE278200 
    BM040936 BG397458 BF664452 CF131663 BQ941699 BE790729 BU734349 L38487 

    "" highest scoring ESTs for ESRRA:

    L38487 AA031933 AA063567 AA098896 AA126057 AA393960 AA435782 AA514917 AA535904 AA541277 

    Unigene Cluster for ESRRA:

    Estrogen-related receptor alpha
    Hs.110849  [show with all ESTs]
    Unigene Representative Sequence: BC092470


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ESRRA

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -           -                                 
    SP2:                                                            
    SP3:              -           -                                 
    SP4:                                                            
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for ESRRA

    6 Ensembl transcripts including schematic representations:
    ENST00000377688  ENST00000467987  ENST00000468670  ENST00000405666  ENST00000000442  ENST00000406310  

    Expression
    for ESRRA gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    ESRRA expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for ESRRA

    1""  / 2""  / 3""

    5 probe-sets matching ESRRA gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1487_at2, 3 U133-A 1 1.00 1.00 1.00 1.00 L38487 1.00 1.00 1.00 1
    1487_at2, 3 U133-A 1 1.00 1.00 -- -- L38487 1.00 1.00 1.00 1
    203193_at2, 3 U133-A 1 0.91 1.00 -- -- NM_004451 0.60 1.00 0.82 1
    1487_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    203193_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    "" ESRRA for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGCAAGCCA

    SOURCE GeneReport for Unigene cluster: Hs.110849

    Expression variation in blood from EXPOLDB for ESRRA

    Primers:"" Origene genome-wide validated SYBR primer pairs: ESRRA ""
    ""SABiosciences RT2 qPCR Primer Assay for ESRRA: PPH05884A ""

    Orthologs
    for ESRRA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for ESRRA gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ESRRA1   -- estrogen-related receptor alpha 92.65(n)
    99.53(a)    		 403169  NM_001002936.1  NP_001002936.1 
    chimpanzee
    (Pan troglodytes)    		 ESRRA1   -- estrogen-related receptor alpha 99.53(n)
    100(a)    		 466651  XM_522050.2  XP_522050.1 
    rat
    (Rattus norvegicus)    		 Esrra1   -- estrogen related receptor, alpha 90.82(n)
    97.39(a)    		 293701  NM_001008511.1  NP_001008511.1 
    mouse
    (Mus musculus)    		 Esrra1, 5 19 (3.00 cM)5
    		 estrogen related receptor, alpha1, 5 91.39(n)1
    98.34(a)1    		 263791  NM_007953.21  NP_031979.21 
     AK0085365  AK0192225  (see all 17)
    zebrafish
    (Danio rerio)    		 esrra1   -- estrogen-related receptor alpha 65.34(n)
    68.49(a)    		 405891  NM_212955.1  NP_998120.1 
    About this table        Species with no ortholog for ESRRA

    ENSEMBL Gene Tree for ESRRA

    Paralogs
    for ESRRA gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for ESRRA gene
    NR4A32  RXRG2  PGR2  ESR22  ESRRB2  NR4A22  HNF4G2  ESRRG2  
    NR2F62  NR2E12  NR5A22  NR3C22  RXRA2  NR4A12  NR2F12  NR5A12  
    NR3C12  NR2E32  NR2F22  AR2  ESR12  NR2C12  HNF4A2  RXRB2  
    NR6A12  NR2C22  

    "" ESRRA for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene


    Genomic Variants
    for ESRRA gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/12 NCBI SNPs in ESRRA are shown (see all 12 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 46)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs22760141,2
    		C,F64081445(-) GAGGCC/TGGACA 2 P syn1 ref1 ese3""20Minor allele frequency- T:0.08EA NA NS 2810""
    ""
    rs6500081,2
    		C,F,A,H60410178(+) GTGCGT/CTTGCT 1 -- int1""24Minor allele frequency- C:0.14EA NA NS 2730""
    ""
    rs4930521,2
    		C,F,A,H60406110(+) TTCCCG/ACTCTG 1 -- int1""16Minor allele frequency- A:0.14NS EA NA 992""
    ""
    rs7317031,2
    		C,F,A60406436(+) TCCTGG/ACCAGT 1 -- int1""18Minor allele frequency- A:0.16NA EA NS 1314""
    --
    rs11522261,2
    		C,F60407350(+) ccatgC/Tccggc 1 -- int1""8Minor allele frequency- T:0.01NS NA 160""
    ""
    rs6206451,2
    		C,F60408165(+) aggacG/Ataggt 1 -- int1""17Minor allele frequency- A:0.05MN NS EA NA WA 992""
    --
    rs5465381,2
    		C60403061(+) TGTTAA/TTTTCC 1 -- int1""0--------
    ""
    rs22760121,2
    		C60409590(-) CCACAA/GTGCTC 1 -- int1""0--------
    --
    rs22760131,2
    		H60409344(-) GGCCTC/TACCCC 1 -- int1""5Minor allele frequency- T:0.00EA NS 1912""
    --
    rs16385541,2
    		--64083500(+) CCCAAG/TGGCTG 1 -- ut31 ese3""0--------
    About this table

    HapMap Linkage Disequilibrium images for ESRRA (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for ESRRA: --

    Disorders & Mutations
    for ESRRA gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" ESRRA for disorders           About GeneDecksing

    OMIM: 601998

    10/42 ""Novoseek disease relationships for ESRRA gene (see all 42 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial cancer 31.39 32 17697604 (8), 16464951 (7), 17068614 (4), 17010074 (3) (see all 10)
    breast cancer 9.92 47 19138740 (6), 19622763 (5), 19491275 (5), 19429439 (5) (see all 16)
    disorder; metabolic 5.05 7 19462000 (1), 18778951 (1), 18052088 (1), 17556356 (1) (see all 7)
    adenocarcinoma endometrial 2.99 3 16681769 (3)
    breast tumor 2.90 7 19622763 (2), 12438245 (2), 19276159 (1), 17631492 (1) (see all 5)
    ovarian cancer 2.80 11 16202294 (6), 17509876 (3), 18974123 (1), 17259555 (1)
    response, acute phase 2.34 3 16061943 (3)
    ubiquinone dehydrogenase 2.32 1 20107110 (1)
    lead line 1.96 1 19429439 (1)
    osteoblastic osteosarcoma 1.82 1 9178750 (1)
    About this table

    1 PharmGKB disease relationship for ESRRA gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    ObesityPD  GN  12172398
    About this table

    Genetic Association Database: ESRRA
    Human Genome Epidemiology Navigator: ESRRA (6 documents)

    Medical News
    for ESRRA gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for ESRRA gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/143 PubMed articles for ESRRA gene (see all 143 ):

    Search for ESRRA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Disorders
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    Genome Databases showing ESRRA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2101 HGNC: 3471 AceView: ESRRAandPRDX5 Ensembl:ENSG00000173153 euGenes: HUgn2101
    ECgene: ESRRA H-InvDB: ESRRA

    Other Databases showing ESRRA gene

    (According to HUGE)
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    Specialized Databases showing ESRRA gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for ESRRA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for ESRRA gene: ""
    Search GeneIP for patents involving ESRRA

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for ESRRA gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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