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Aliases for ESRRA Gene

Aliases for ESRRA Gene

  • Estrogen-Related Receptor Alpha 2 3 4
  • ESRL1 3 4 6
  • Nuclear Receptor Subfamily 3 Group B Member 1 3 4
  • Estrogen Receptor-Like 1 3 4
  • ERR-Alpha 3 4
  • NR3B1 3 4
  • ERR1 3 4
  • Estrogen-Related Nuclear Receptor Alpha 3
  • Steroid Hormone Receptor ERR1 3
  • ERRalpha 3
  • ERRa 3

External Ids for ESRRA Gene

Previous Symbols for ESRRA Gene

  • ESRL1

Summaries for ESRRA Gene

Entrez Gene Summary for ESRRA Gene

  • The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for ESRRA Gene

ESRRA (Estrogen-Related Receptor Alpha) is a Protein Coding gene. Diseases associated with ESRRA include endometrial cancer and breast cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include sequence-specific DNA binding and steroid hormone receptor activity. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for ESRRA Gene

  • Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5-TNAAGGTCA-3. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

Tocris Summary for ESRRA Gene

  • Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. In females, estrogens main targets are the ovaries, uterus, vagina and mammary glands. In the male, target organs are the testes, prostate and epididymis. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen exerts most of its actions via estrogen receptors (ER). Estrogen receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Today, two estrogen receptors are known, ERalpha and ERbeta. ERalpha protein is highly homologous to ERbeta protein, especially in the DNA and ligand binding domains, although divergence exists in the N-terminal transactivation domain. Both receptors interact with the same DNA response element and show a similar ligand binding profile. Upon ligand binding estrogen receptors undergo a conformational change allowing spontaneous dimerization to form either homo- or heterodimers. As a dimer, the estrogen receptor binds to the estrogen response element (ERE) in the promoter region of target genes. ERalpha and ERbeta which are present in a broad spectrum of tissues.

Gene Wiki entry for ESRRA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRRA Gene

Genomics for ESRRA Gene

Genomic Location for ESRRA Gene

Start:
64,305,528 bp from pter
End:
64,316,743 bp from pter
Size:
11,216 bases
Orientation:
Plus strand

Genomic View for ESRRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESRRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRRA Gene

Regulatory Elements for ESRRA Gene

Proteins for ESRRA Gene

  • Protein details for ESRRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11474-ERR1_HUMAN
    Recommended name:
    Steroid hormone receptor ERR1
    Protein Accession:
    P11474
    Secondary Accessions:
    • Q14514

    Protein attributes for ESRRA Gene

    Size:
    423 amino acids
    Molecular mass:
    45510 Da
    Quaternary structure:
    • Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation.
    SequenceCaution:
    • Sequence=AAB17015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA35778.1; Type=Frameshift; Positions=345, 354; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESRRA Gene

    Alternative splice isoforms for ESRRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRRA Gene

Proteomics data for ESRRA Gene at MOPED

Post-translational modifications for ESRRA Gene

  • Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
  • Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
  • Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ESRRA Gene

No data available for DME Specific Peptides for ESRRA Gene

Domains for ESRRA Gene

Gene Families for ESRRA Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P11474

UniProtKB/Swiss-Prot:

ERR1_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • P11474
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.:
    • P11474
genes like me logo Genes that share domains with ESRRA: view

Function for ESRRA Gene

Molecular function for ESRRA Gene

GENATLAS Biochemistry: estrogen-related receptor A,orphan receptors family,steroid/thyroid hormone receptor superfamily,involved in the expression of SV40 major late promoter modulator of ESR response of lactoferrin promoter,regulator of medium chain acyl CoA dehydrogenase
UniProtKB/Swiss-Prot Function: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5-TNAAGGTCA-3. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
UniProtKB/Swiss-Prot Induction: Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.

Gene Ontology (GO) - Molecular Function for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding TAS 9286700
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ESRRA: view
genes like me logo Genes that share phenotypes with ESRRA: view

Animal Models for ESRRA Gene

MGI Knock Outs for ESRRA:

miRNA for ESRRA Gene

Targeting motifs for ESRRA Gene
HOMER Transcription Factor Regulatory Elements motif ESRRA
  • Consensus sequence: CAAAGGTCAG Submotif: canonical Cell Type: HepG2 GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ESRRA Gene

Localization for ESRRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRRA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESRRA Gene COMPARTMENTS Subcellular localization image for ESRRA gene
Compartment Confidence
nucleus 5
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with ESRRA: view

Pathways for ESRRA Gene

genes like me logo Genes that share pathways with ESRRA: view

Gene Ontology (GO) - Biological Process for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IMP 23836911
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with ESRRA: view

Compounds for ESRRA Gene

(5) Tocris Compounds for ESRRA Gene

Compound Action Cas Number
(Z)-4-Hydroxytamoxifen Metabolite of tamoxifen (Cat. No. 0999) [68047-06-3]
DPN Highly potent ERbeta agonist [1428-67-7]
ICI 182,780 Estrogen receptor antagonist [129453-61-8]
PHTPP Selective ERbeta antagonist [805239-56-9]
PPT Subtype-selective ERalpha agonist [263717-53-9]

(2) Drugbank Compounds for ESRRA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
target
Troglitazone
97322-87-7 target inverse agonist

(5) IUPHAR Ligand for ESRRA Gene

Ligand Type Action Affinity Pubmed IDs
cyclohexylmethyl-(1-p-tolyl-1H-indol-3-ylmethyl)-amine Agonist Inverse agonist 6.7
XCT790 Antagonist Antagonist 6.1
genistein Activator None
7,4-dihydroxyisoflavone Activator None
5,7-dihydroxy-4-methoxyisoflavone Agonist Agonist

(17) Novoseek inferred chemical compound relationships for ESRRA Gene

Compound -log(P) Hits PubMed IDs
estrogen 77 118
fulvestrant 67.5 4
biochanin a 67.2 1
diethylstilbestrol 51.8 1
daidzein 48.4 1
genes like me logo Genes that share compounds with ESRRA: view

Transcripts for ESRRA Gene

Unigene Clusters for ESRRA Gene

Estrogen-related receptor alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESRRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for ESRRA Gene

GeneLoc Exon Structure for
ESRRA
ECgene alternative splicing isoforms for
ESRRA

Expression for ESRRA Gene

mRNA expression in normal human tissues for ESRRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESRRA Gene

This gene is overexpressed in Muscle - Skeletal (5.2) and Heart - Left Ventricle (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ESRRA Gene

SOURCE GeneReport for Unigene cluster for ESRRA Gene Hs.110849

genes like me logo Genes that share expressions with ESRRA: view

No data available for mRNA Expression by UniProt/SwissProt for ESRRA Gene

Orthologs for ESRRA Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ESRRA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ESRRA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESRRA 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esrra 16
Esrra 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESRRA 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10209 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12278 35
zebrafish
(Danio rerio)
Actinopterygii esrra 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ERR 36
  • 34 (a)
OneToMany
ERR 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for ESRRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESRRA Gene

ENSEMBL:
Gene Tree for ESRRA (if available)
TreeFam:
Gene Tree for ESRRA (if available)

Paralogs for ESRRA Gene

Paralogs for ESRRA Gene

Pseudogenes.org Pseudogenes for ESRRA Gene

genes like me logo Genes that share paralogs with ESRRA: view

Variants for ESRRA Gene

Sequence variations from dbSNP and Humsavar for ESRRA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs493052 -- 64,310,908(+) TTCCC(A/G)CTCTG intron-variant
rs546538 -- 64,307,860(+) TGTTA(A/T)TTTCC intron-variant
rs620645 -- 64,312,952(+) aggac(A/G)taggt intron-variant
rs650008 -- 64,314,965(+) GTGCG(C/T)TTGCT intron-variant
rs663597 -- 64,307,867(+) TTTCC(A/C)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ESRRA Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897685 CNV Loss 21882294
dgv1168n71 CNV Loss 21882294
nsv357 CNV Insertion 18451855

Relevant External Links for ESRRA Gene

HapMap Linkage Disequilibrium report
ESRRA
Human Gene Mutation Database (HGMD)
ESRRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESRRA Gene

Disorders for ESRRA Gene

(12) Novoseek inferred disease relationships for ESRRA Gene

Disease -log(P) Hits PubMed IDs
endometrial carcinoma 54.8 16
metabolic disorder 46.9 7
breast cancer 43.7 34
endometrial cancer 30.3 16
breast carcinoma 23.2 7

Relevant External Links for ESRRA

Genetic Association Database (GAD)
ESRRA
Human Genome Epidemiology (HuGE) Navigator
ESRRA
genes like me logo Genes that share disorders with ESRRA: view

No data available for UniProtKB/Swiss-Prot for ESRRA Gene

Publications for ESRRA Gene

  1. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. (PMID: 9271417) Sladek R. … Giguere V. (Mol. Cell. Biol. 1997) 3 4 23
  2. The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). (PMID: 12522104) Schreiber S.N. … Kralli A. (J. Biol. Chem. 2003) 3 4 23
  3. Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha. (PMID: 15337744) Kallen J. … Fournier B. (J. Biol. Chem. 2004) 3 4 23
  4. A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters. (PMID: 16150865) Barry J.B. … Giguere V. (Mol. Endocrinol. 2006) 3 4 23
  5. A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. (PMID: 15883633) Laflamme N. … Rousseau F. (J. Bone Miner. Res. 2005) 3 23 48

Products for ESRRA Gene

  • Addgene plasmids for ESRRA

Sources for ESRRA Gene

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