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Aliases for ESRP2 Gene

Aliases for ESRP2 Gene

  • Epithelial Splicing Regulatory Protein 2 2 3
  • RBM35B 3 4 6
  • RNA Binding Motif Protein 35B 2 3
  • RNA-Binding Motif Protein 35B 3 4
  • RNA-Binding Protein 35B 3 4
  • RNA Binding Motif Protein 35A 3

External Ids for ESRP2 Gene

Previous Symbols for ESRP2 Gene

  • RBM35B

Summaries for ESRP2 Gene

Entrez Gene Summary for ESRP2 Gene

  • ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

GeneCards Summary for ESRP2 Gene

ESRP2 (Epithelial Splicing Regulatory Protein 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and mRNA binding. An important paralog of this gene is HNRNPH1.

UniProtKB/Swiss-Prot for ESRP2 Gene

  • mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRP2 Gene

Genomics for ESRP2 Gene

Genomic Location for ESRP2 Gene

Start:
68,228,547 bp from pter
End:
68,238,102 bp from pter
Size:
9,556 bases
Orientation:
Minus strand

Genomic View for ESRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRP2 Gene

Regulatory Elements for ESRP2 Gene

Proteins for ESRP2 Gene

  • Protein details for ESRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6T0-ESRP2_HUMAN
    Recommended name:
    Epithelial splicing regulatory protein 2
    Protein Accession:
    Q9H6T0
    Secondary Accessions:
    • Q8N6H8
    • Q8WZ15
    • Q9H6I4

    Protein attributes for ESRP2 Gene

    Size:
    727 amino acids
    Molecular mass:
    78401 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55761.1; Type=Frameshift; Positions=370; Evidence={ECO:0000305}; Sequence=BAB15275.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ESRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRP2 Gene

Proteomics data for ESRP2 Gene at MOPED

Post-translational modifications for ESRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ESRP2 Gene

No data available for DME Specific Peptides for ESRP2 Gene

Domains for ESRP2 Gene

Gene Families for ESRP2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for ESRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6T0

UniProtKB/Swiss-Prot:

ESRP2_HUMAN
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.:
    • Q9H6T0
Family:
  • Belongs to the ESRP family.:
    • Q9H6T0
genes like me logo Genes that share domains with ESRP2: view

Function for ESRP2 Gene

Molecular function for ESRP2 Gene

UniProtKB/Swiss-Prot Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
UniProtKB/Swiss-Prot Induction: Down-regulated during the epithelial-to-mesenchymal transition (EMT).

Gene Ontology (GO) - Molecular Function for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003729 mRNA binding IDA 19285943
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ESRP2: view

Phenotypes for ESRP2 Gene

GenomeRNAi human phenotypes for ESRP2:
genes like me logo Genes that share phenotypes with ESRP2: view

miRNA for ESRP2 Gene

miRTarBase miRNAs that target ESRP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ESRP2 Gene

Localization for ESRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESRP2 Gene COMPARTMENTS Subcellular localization image for ESRP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 4
cytosol 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19285943
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ESRP2: view

Pathways for ESRP2 Gene

SuperPathways for ESRP2 Gene

No Data Available

Interacting Proteins for ESRP2 Gene

Gene Ontology (GO) - Biological Process for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0043484 regulation of RNA splicing IDA 19285943
genes like me logo Genes that share ontologies with ESRP2: view

No data available for Pathways by source for ESRP2 Gene

Transcripts for ESRP2 Gene

Unigene Clusters for ESRP2 Gene

Epithelial splicing regulatory protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESRP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for ESRP2 Gene

GeneLoc Exon Structure for
ESRP2
ECgene alternative splicing isoforms for
ESRP2

Expression for ESRP2 Gene

mRNA expression in normal human tissues for ESRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESRP2 Gene

This gene is overexpressed in Esophagus - Mucosa (8.8) and Liver (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ESRP2 Gene

SOURCE GeneReport for Unigene cluster for ESRP2 Gene Hs.592053

mRNA Expression by UniProt/SwissProt for ESRP2 Gene

Q9H6T0-ESRP2_HUMAN
Tissue specificity: Epithelial cell-specific.
genes like me logo Genes that share expressions with ESRP2: view

Orthologs for ESRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ESRP2 35
  • 99.4 (n)
  • 99.16 (a)
ESRP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ESRP2 35
  • 90.82 (n)
  • 94.86 (a)
ESRP2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESRP2 35
  • 91.07 (n)
  • 94.44 (a)
ESRP2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esrp2 35
  • 88.28 (n)
  • 93.31 (a)
Esrp2 16
Esrp2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ESRP2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESRP2 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esrp2 35
  • 87.87 (n)
  • 92.47 (a)
chicken
(Gallus gallus)
Aves ESRP2 35
  • 66.28 (n)
  • 71.01 (a)
ESRP2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESRP2 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii esrp2 35
  • 65.05 (n)
  • 66.72 (a)
esrp2 36
  • 60 (a)
OneToOne
sbcb404 35
fruit fly
(Drosophila melanogaster)
Insecta fus 35
  • 53.03 (n)
  • 47.89 (a)
fus 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sym-2 35
  • 48.52 (n)
  • 43.96 (a)
sym-2 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10873 36
  • 45 (a)
OneToMany
Species with no ortholog for ESRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ESRP2 Gene

ENSEMBL:
Gene Tree for ESRP2 (if available)
TreeFam:
Gene Tree for ESRP2 (if available)

Paralogs for ESRP2 Gene

Paralogs for ESRP2 Gene

Selected SIMAP similar genes for ESRP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ESRP2: view

Variants for ESRP2 Gene

Sequence variations from dbSNP and Humsavar for ESRP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1077737 -- 68,232,548(-) CCCAA(C/T)TGGAC intron-variant
rs3743737 -- 68,230,298(+) CTGGT(A/G)TAGTC reference, synonymous-codon
rs3743738 - 68,231,336(+) GCTCT(A/G)CTGAT reference, missense
rs7184821 -- 68,236,326(+) AGAAC(C/T)CAACC upstream-variant-2KB
rs11649202 -- 68,231,506(+) TGTAC(A/C)CCGTG synonymous-codon, reference

Relevant External Links for ESRP2 Gene

HapMap Linkage Disequilibrium report
ESRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ESRP2 Gene

Disorders for ESRP2 Gene

No disorders were found for ESRP2 Gene.

No data available for UniProtKB/Swiss-Prot for ESRP2 Gene

Publications for ESRP2 Gene

  1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PMID: 19285943) Warzecha C.C. … Carstens R.P. (Mol. Cell 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for ESRP2 Gene

Sources for ESRP2 Gene

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