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Aliases for ESRP2 Gene

Aliases for ESRP2 Gene

  • Epithelial Splicing Regulatory Protein 2 2 3 5
  • RNA-Binding Motif Protein 35B 3 4
  • RNA-Binding Protein 35B 3 4
  • RBM35B 3 4
  • RNA Binding Motif Protein 35A 3
  • RNA Binding Motif Protein 35B 2

External Ids for ESRP2 Gene

Previous HGNC Symbols for ESRP2 Gene

  • RBM35B

Previous GeneCards Identifiers for ESRP2 Gene

  • GC16M066821
  • GC16M068259
  • GC16M054135
  • GC16M068263

Summaries for ESRP2 Gene

Entrez Gene Summary for ESRP2 Gene

  • ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

GeneCards Summary for ESRP2 Gene

ESRP2 (Epithelial Splicing Regulatory Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and mRNA Capping. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ESRP1.

UniProtKB/Swiss-Prot for ESRP2 Gene

  • mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Additional gene information for ESRP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRP2 Gene

Genomics for ESRP2 Gene

Regulatory Elements for ESRP2 Gene

Enhancers for ESRP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H068201 0.8 ENCODE dbSUPER 11.4 +36.1 36148 1 ZNF121 SCRT1 SCRT2 FEZF1 ZNF623 ZNF781 ZNF697 ZFP90 ESRP2 PLA2G15 SLC7A6 SLC7A6OS PRMT7 ENSG00000279621 RPS12P27
GH16H068200 0.8 dbSUPER 11.4 +37.4 37373 0 PKNOX1 FOXA2 EBF1 ZBTB40 FOSL1 FOS ATF7 IKZF2 SMARCE1 JUNB ESRP2 PLA2G15 SLC7A6 SLC7A6OS PRMT7 ENSG00000262514 ENSG00000279621
GH16H068210 0.7 ENCODE dbSUPER 12 +26.8 26794 1 JUNB ETV6 PRDM4 PRMT7 DUS2 ESRP2 PLA2G15 SLC7A6 NFATC3 SLC7A6OS EDC4 DPEP2 GC16P068209
GH16H068233 1.8 FANTOM5 ENCODE dbSUPER 1.9 +2.2 2227 5 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CTCF ENSG00000270165 DUS2 SNTB2 PRMT7 RANBP10 CHTF8 ENSG00000263276 EDC4 ENSG00000262514
GH16H068951 0.8 ENCODE dbSUPER 3.7 -714.3 -714309 1 PKNOX1 JUND POLR2A ZNF18 SNTB2 ENSG00000200164 RNU4-36P ENSG00000252443 WWP2 CDH1 ESRP2 ENSG00000260999 GC16M069007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ESRP2 on UCSC Golden Path with GeneCards custom track

Promoters for ESRP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087250 502 801 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143

Genomic Location for ESRP2 Gene

Chromosome:
16
Start:
68,228,547 bp from pter
End:
68,238,102 bp from pter
Size:
9,556 bases
Orientation:
Minus strand

Genomic View for ESRP2 Gene

Genes around ESRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRP2 Gene

Proteins for ESRP2 Gene

  • Protein details for ESRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6T0-ESRP2_HUMAN
    Recommended name:
    Epithelial splicing regulatory protein 2
    Protein Accession:
    Q9H6T0
    Secondary Accessions:
    • Q8N6H8
    • Q8WZ15
    • Q9H6I4

    Protein attributes for ESRP2 Gene

    Size:
    727 amino acids
    Molecular mass:
    78401 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55761.1; Type=Frameshift; Positions=370; Evidence={ECO:0000305}; Sequence=BAB15275.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ESRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRP2 Gene

Post-translational modifications for ESRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ESRP2 Gene

Domains & Families for ESRP2 Gene

Gene Families for ESRP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ESRP2 Gene

Suggested Antigen Peptide Sequences for ESRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6T0

UniProtKB/Swiss-Prot:

ESRP2_HUMAN :
  • Belongs to the ESRP family.
Family:
  • Belongs to the ESRP family.
genes like me logo Genes that share domains with ESRP2: view

Function for ESRP2 Gene

Molecular function for ESRP2 Gene

UniProtKB/Swiss-Prot Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
UniProtKB/Swiss-Prot Induction:
Down-regulated during the epithelial-to-mesenchymal transition (EMT).

Gene Ontology (GO) - Molecular Function for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003729 mRNA binding IDA 19285943
genes like me logo Genes that share ontologies with ESRP2: view
genes like me logo Genes that share phenotypes with ESRP2: view

Animal Models for ESRP2 Gene

MGI Knock Outs for ESRP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ESRP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESRP2 Gene

Localization for ESRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESRP2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19285943
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ESRP2: view

Pathways & Interactions for ESRP2 Gene

genes like me logo Genes that share pathways with ESRP2: view

Pathways by source for ESRP2 Gene

Gene Ontology (GO) - Biological Process for ESRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0043484 regulation of RNA splicing IEA,IDA 19285943
genes like me logo Genes that share ontologies with ESRP2: view

No data available for SIGNOR curated interactions for ESRP2 Gene

Drugs & Compounds for ESRP2 Gene

No Compound Related Data Available

Transcripts for ESRP2 Gene

Unigene Clusters for ESRP2 Gene

Epithelial splicing regulatory protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ESRP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ESRP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for ESRP2 Gene

GeneLoc Exon Structure for
ESRP2
ECgene alternative splicing isoforms for
ESRP2

Expression for ESRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESRP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.8) and Liver (x5.4).

Protein differential expression in normal tissues from HIPED for ESRP2 Gene

This gene is overexpressed in Esophagus (23.4), Pancreas (22.3), and Placenta (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ESRP2 Gene



Protein tissue co-expression partners for ESRP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ESRP2 Gene:

ESRP2

SOURCE GeneReport for Unigene cluster for ESRP2 Gene:

Hs.592053

mRNA Expression by UniProt/SwissProt for ESRP2 Gene:

Q9H6T0-ESRP2_HUMAN
Tissue specificity: Epithelial cell-specific.

Evidence on tissue expression from TISSUES for ESRP2 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with ESRP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ESRP2 Gene

Orthologs for ESRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ESRP2 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ESRP2 33 34
  • 91.07 (n)
cow
(Bos Taurus)
Mammalia ESRP2 33 34
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Esrp2 34 16 33
  • 88.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esrp2 33
  • 87.87 (n)
oppossum
(Monodelphis domestica)
Mammalia ESRP2 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESRP2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESRP2 33 34
  • 66.28 (n)
lizard
(Anolis carolinensis)
Reptilia ESRP2 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii esrp2 33 34
  • 65.05 (n)
sbcb404 33
fruit fly
(Drosophila melanogaster)
Insecta fus 33 34
  • 53.03 (n)
worm
(Caenorhabditis elegans)
Secernentea sym-2 33 34
  • 48.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10873 34
  • 45 (a)
OneToMany
Species where no ortholog for ESRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ESRP2 Gene

ENSEMBL:
Gene Tree for ESRP2 (if available)
TreeFam:
Gene Tree for ESRP2 (if available)

Paralogs for ESRP2 Gene

Paralogs for ESRP2 Gene

(1) SIMAP similar genes for ESRP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ESRP2: view

Variants for ESRP2 Gene

Sequence variations from dbSNP and Humsavar for ESRP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000446676 -- 68,230,144(+) ACCAG(A/G)TTGAG utr-variant-3-prime
rs1000492569 -- 68,236,881(+) AACGG(G/T)CCTGG upstream-variant-2KB
rs1000934696 -- 68,230,611(+) CGAGA(C/G)CTGTT intron-variant
rs1000949812 -- 68,236,993(+) GCTAG(C/T)GTTGA upstream-variant-2KB
rs1001123353 -- 68,236,675(+) ATCAG(C/T)GTTGT upstream-variant-2KB

Variation tolerance for ESRP2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ESRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ESRP2 Gene

Disorders for ESRP2 Gene

Relevant External Links for ESRP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESRP2

No disorders were found for ESRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESRP2 Gene

Publications for ESRP2 Gene

  1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PMID: 19285943) Warzecha CC … Carstens RP (Molecular cell 2009) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for ESRP2 Gene

Sources for ESRP2 Gene

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