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ESRP2 Gene

protein-coding   GIFtS: 49
GCID: GC16M068263

Epithelial Splicing Regulatory Protein 2

(Previous name: RNA binding motif protein 35B)
(Previous symbol: RBM35B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epithelial Splicing Regulatory Protein 21 2
RBM35B1 2 3 5
RNA Binding Motif Protein 35B1 2
RNA-Binding Motif Protein 35B2 3
RNA-Binding Protein 35B2 3
RNA Binding Motif Protein 35A2

External Ids:    HGNC: 261521   Entrez Gene: 800042   Ensembl: ENSG000001030677   OMIM: 6129605   UniProtKB: Q9H6T03   

Export aliases for ESRP2 gene to outside databases

Previous GC identifers: GC16M066821 GC16M068259 GC16M054135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ESRP2 Gene:
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 (PubMed 19285943)).(supplied
by OMIM, Aug 2009)

GeneCards Summary for ESRP2 Gene:
ESRP2 (epithelial splicing regulatory protein 2) is a protein-coding gene. GO annotations related to this gene include mRNA binding and nucleotide binding. An important paralog of this gene is RBM12B.

UniProtKB/Swiss-Prot: ESRP2_HUMAN, Q9H6T0
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically
regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing
of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal
transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the
ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ESRP2 gene promoter:
         GR   Nkx2-5   NF-E2 p45   C/EBPalpha   SREBP-1a   COMP1   Zic1   GR-alpha   Zic3   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ESRP2 promoter sequence
   Search Chromatin IP Primers for ESRP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

ESRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESRP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068263:  view genomic region     (about GC identifiers)

Start:
68,262,450 bp from pter      End:
68,272,005 bp from pter
Size:
9,556 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ESRP2_HUMAN, Q9H6T0 (See protein sequence)
Recommended Name: Epithelial splicing regulatory protein 2  
Size: 727 amino acids; 78401 Da
Sequence caution: Sequence=AAL55761.1; Type=Frameshift; Positions=370; Sequence=BAB15275.1; Type=Erroneous
initiation;
Secondary accessions: Q8N6H8 Q8WZ15 Q9H6I4
Alternative splicing: 2 isoforms:  Q9H6T0-1   Q9H6T0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ESRP2: NX_Q9H6T0

Explore proteomics data for ESRP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ESRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079215.2  
    ENSEMBL proteins: 
     ENSP00000454554   ENSP00000418748   ENSP00000463237   ENSP00000463770   ENSP00000461970  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H6T0

    ProtoNet protein and cluster: Q9H6T0

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: ESRP2_HUMAN, Q9H6T0
    Similarity: Belongs to the ESRP family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with ESRP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ESRP2_HUMAN, Q9H6T0
    Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically
    regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing
    of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal
    transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the
    ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2
    Induction: Down-regulated during the epithelial-to-mesenchymal transition (EMT)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IDA19285943
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ESRP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ESRP2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESRP2
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    miRNA
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    miRTarBase miRNAs that target ESRP2:
    hsa-mir-98-5p (MIRT027684), hsa-mir-125b-5p (MIRT046044)

    Block miRNA regulation of human, mouse, rat ESRP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ESRP2 (see all 42):
    hsa-miR-411* hsa-miR-3685 hsa-miR-4307 hsa-miR-379* hsa-miR-4328 hsa-miR-15a hsa-miR-578 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidESRP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ESRP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ESRP2_HUMAN, Q9H6T0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    mitochondrion4
    cytosol3
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005813centrosome ----

    Find genes that share ontologies with ESRP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ESRP2
    Interactions:

        Search GeneGlobe Interaction Network for ESRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ESRP2 (ENSP000004187484) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIAENSP000002167974STRING: ENSP00000216797
    EGFRENSP000002754934STRING: ENSP00000275493
    ERBB2ENSP000002695714STRING: ENSP00000269571
    ERBB4ENSP000003422354STRING: ENSP00000342235
    ERBB3ENSP000002671014STRING: ENSP00000267101
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0043484regulation of RNA splicing IDA19285943

    Find genes that share ontologies with ESRP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ESRP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ESRP2 gene: 
    NM_024939.2  

    Unigene Cluster for ESRP2:

    Epithelial splicing regulatory protein 2
    Hs.592053  [show with all ESTs]
    Unigene Representative Sequence: NM_024939
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565858(uc002evp.1) ENST00000251366 ENST00000473183(uc002evq.1 uc010cfa.1)
    ENST00000566774 ENST00000565213 ENST00000562738 ENST00000562567 ENST00000569964
    ENST00000563159 ENST00000564465 ENST00000564382 ENST00000562724
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ESRP2 (see all 42):
    hsa-miR-411* hsa-miR-3685 hsa-miR-4307 hsa-miR-379* hsa-miR-4328 hsa-miR-15a hsa-miR-578 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidESRP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ESRP2
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    GenScript: all cDNA clones in your preferred vector: ESRP2 (NM_024939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESRP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESRP2
    Primer
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    OriGene qPCR primer pairs and template standards for ESRP2
    OriGene qSTAR qPCR primer pairs in human, mouse for ESRP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ESRP2
      QuantiTect SYBR Green Assays in human, mouse, rat ESRP2
      QuantiFast Probe-based Assays in human, mouse, rat ESRP2

    Additional mRNA sequence: 

    AF289577.1 AK025571.1 AK025901.1 BC030146.2 BC052309.1 BC069241.1 

    14 DOTS entries:

    DT.92435502  DT.99986182  DT.100787641  DT.446664  DT.92435505  DT.97847233  DT.95148464  DT.120665116 
    DT.101956551  DT.120665157  DT.91967324  DT.95148463  DT.95285247  DT.120665086 

    Selected AceView cDNA sequences (see all 92):

    AI149458 AW873122 BF591247 BC069241 AI288958 AK025571 CB164690 BM827260 
    BC030146 CR592167 AA421326 BC052309 BU943912 NM_024939 CK429275 BM768820 
    BP357272 AW591552 CB216923 T72068 AW014794 AW439187 CK903473 AI347333 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ESRP2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                          -     -                       -           -                             -                                                         
    SP2:                          -     -                       -           -           -                 -                                                         
    SP3:                          -     -                       -           -                                                                                       
    SP4:                                                        -           -           -                                                                           
    SP5:        -                 -     -                                                                                                                           


    ECgene alternative splicing isoforms for ESRP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ESRP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGTCCTT
    ESRP2 Expression
    About this image


    ESRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Collecting Duct System
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Eye (Sensory Organs)
             Corneal Epithelium
    ESRP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ESRP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592053

    UniProtKB/Swiss-Prot: ESRP2_HUMAN, Q9H6T0
    Tissue specificity: Epithelial cell-specific

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    QuantiFast Probe-based Assays in human, mouse, rat ESRP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESRP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ESRP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Esrp21 , 5 epithelial splicing regulatory protein 21, 5 88.28(n)1
    93.31(a)1
      8 (53.10 cM)5
    774111  NM_176838.21  NP_789808.11 
     1061303195 
    chicken
    (Gallus gallus)
    Aves ESRP21 epithelial splicing regulatory protein 2 66.28(n)
    71.01(a)
      415710  NM_001030566.1  NP_001025737.1 
    lizard
    (Anolis carolinensis)
    Reptilia ESRP26
    epithelial splicing regulatory protein 2
    66(a)
    1 ↔ 1
    LGc(6350352-6414271)
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb4042 sbcb404 74.02(n)   321244  BC045439.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fus1 fusilli 53.03(n)
    47.89(a)
      44095  NM_001169690.1  NP_001163161.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sym-21 sym-2 48.52(n)
    43.96(a)
      174461  NM_063559.6  NP_495960.2 


    ENSEMBL Gene Tree for ESRP2 (if available)
    TreeFam Gene Tree for ESRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ESRP2 gene
    RBM12B2  HNRNPH32  ESRP12  HNRNPH22  GRSF12  HNRNPH12  HNRNPF2  RBM122  
    1 SIMAP similar gene for ESRP2 using alignment to 4 protein entries:     ESRP2_HUMAN (see all proteins):
    ESRP1

    Find genes that share paralogs with ESRP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ESRP2 (see all 255)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920040301,2
    --68263942(+) CAGCCA/CTTGTC 1 -- ut310--------
    rs1834494711,2
    --68264059(+) GTGCTG/TGTCTT 1 -- ut310--------
    rs1877874831,2
    C--68264087(+) ATGTTC/TGCCGA 1 -- ut310--------
    rs1913161901,2
    C--68264094(+) CCGAGA/GATATC 1 -- ut310--------
    rs37437371,2
    C,H--68264201(+) CTGGTG/ATAGTC 2 /Y syn1 ese310Minor allele frequency- A:0.02EA NA NS 2058
    rs626375601,2
    C,F--68264209(+) GTCATC/GAGCGG 2 H D mis12Minor allele frequency- G:0.01NS NA 4608
    rs353559981,2
    C,F--68264212(+) ATCAGC/TGGGTA 2 T A mis16Minor allele frequency- T:0.02NA WA EU 6053
    rs799026141,2
    C--68264213(+) TCAGCA/GGGTAG 2 P syn10--------
    rs2011094971,2
    --68264263(+) AGACCC/TGCCAG 1 -- int10--------
    rs2003442651,2
    C--68264309(+) GAAGAC/TGCTGA 2 I V mis10--------

    HapMap Linkage Disequilibrium report for ESRP2 (68262450 - 68272005 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ESRP2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ESRP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ESRP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612960    OMIM disorders: --


    Find genes that share disorders with ESRP2           About GenesLikeMe


    Export disorders for ESRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ESRP2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ESRP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PubMed id 19285943)1, 2 Warzecha C.C.... Carstens R.P. (Mol. Cell 2009)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. (PubMed id 22354987)1 Dittmar K.A....Carstens R.P. (Mol. Cell. Biol. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80004 HGNC: 26152 AceView: FLJ21918 Ensembl:ENSG00000103067 euGenes: HUgn80004
    ECgene: ESRP2 H-InvDB: ESRP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ESRP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ESRP2 gene:
    Search GeneIP for patents involving ESRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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