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Aliases for ESRP1 Gene

Aliases for ESRP1 Gene

  • Epithelial Splicing Regulatory Protein 1 2 3 5
  • RNA Binding Motif Protein 35A 2 3
  • RNA-Binding Motif Protein 35A 3 4
  • RNA-Binding Protein 35A 3 4
  • RBM35A 3 4
  • RMB35A 3

External Ids for ESRP1 Gene

Previous HGNC Symbols for ESRP1 Gene

  • RBM35A

Previous GeneCards Identifiers for ESRP1 Gene

  • GC08P095725
  • GC08P095653
  • GC08P090861

Summaries for ESRP1 Gene

Entrez Gene Summary for ESRP1 Gene

  • ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

GeneCards Summary for ESRP1 Gene

ESRP1 (Epithelial Splicing Regulatory Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include nucleic acid binding and mRNA binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for ESRP1 Gene

  • mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRP1 Gene

Genomics for ESRP1 Gene

Regulatory Elements for ESRP1 Gene

Promoters for ESRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ESRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ESRP1 Gene

Chromosome:
8
Start:
94,641,074 bp from pter
End:
94,707,466 bp from pter
Size:
66,393 bases
Orientation:
Plus strand

Genomic View for ESRP1 Gene

Genes around ESRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRP1 Gene

Proteins for ESRP1 Gene

  • Protein details for ESRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXG1-ESRP1_HUMAN
    Recommended name:
    Epithelial splicing regulatory protein 1
    Protein Accession:
    Q6NXG1
    Secondary Accessions:
    • A6NHA8
    • A8MPX1
    • E9PB47
    • Q2M2B0
    • Q499G3
    • Q6PJ86
    • Q9NXL8

    Protein attributes for ESRP1 Gene

    Size:
    681 amino acids
    Molecular mass:
    75585 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90992.1; Type=Frameshift; Positions=512; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESRP1 Gene

    Alternative splice isoforms for ESRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRP1 Gene

Proteomics data for ESRP1 Gene at MOPED

Post-translational modifications for ESRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ESRP1 Gene

Domains & Families for ESRP1 Gene

Gene Families for ESRP1 Gene

Suggested Antigen Peptide Sequences for ESRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NXG1

UniProtKB/Swiss-Prot:

ESRP1_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the ESRP family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the ESRP family.
genes like me logo Genes that share domains with ESRP1: view

Function for ESRP1 Gene

Molecular function for ESRP1 Gene

UniProtKB/Swiss-Prot Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
UniProtKB/Swiss-Prot Induction:
Down-regulated during the epithelial-to-mesenchymal transition (EMT).

Gene Ontology (GO) - Molecular Function for ESRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003729 mRNA binding IDA 19285943
genes like me logo Genes that share ontologies with ESRP1: view
genes like me logo Genes that share phenotypes with ESRP1: view

Animal Models for ESRP1 Gene

MGI Knock Outs for ESRP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESRP1 Gene

Localization for ESRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESRP1 Gene COMPARTMENTS Subcellular localization image for ESRP1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ESRP1 Gene

Pathways & Interactions for ESRP1 Gene

genes like me logo Genes that share pathways with ESRP1: view

Pathways by source for ESRP1 Gene

Gene Ontology (GO) - Biological Process for ESRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IEA --
GO:0043484 regulation of RNA splicing IDA 19285943
genes like me logo Genes that share ontologies with ESRP1: view

No data available for SIGNOR curated interactions for ESRP1 Gene

Drugs & Compounds for ESRP1 Gene

No Compound Related Data Available

Transcripts for ESRP1 Gene

Unigene Clusters for ESRP1 Gene

Epithelial splicing regulatory protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP1: -
SP2: - - -
SP3: - - -
SP4: -
SP5: -
SP6:

Relevant External Links for ESRP1 Gene

GeneLoc Exon Structure for
ESRP1
ECgene alternative splicing isoforms for
ESRP1

Expression for ESRP1 Gene

mRNA expression in normal human tissues for ESRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESRP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.4), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.1), Colon - Transverse (x4.8), and Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for ESRP1 Gene

This gene is overexpressed in Cervix (29.6), Pancreas (14.5), and Lung (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ESRP1 Gene



SOURCE GeneReport for Unigene cluster for ESRP1 Gene Hs.487471

mRNA Expression by UniProt/SwissProt for ESRP1 Gene

Q6NXG1-ESRP1_HUMAN
Tissue specificity: Epithelial cell-specific.
genes like me logo Genes that share expression patterns with ESRP1: view

Protein tissue co-expression partners for ESRP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ESRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESRP1 35
  • 93.8 (n)
  • 97.19 (a)
ESRP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESRP1 35
  • 92.63 (n)
  • 96.24 (a)
ESRP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esrp1 35
  • 90.35 (n)
  • 96.9 (a)
Esrp1 16
Esrp1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESRP1 35
  • 99.66 (n)
  • 100 (a)
ESRP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esrp1 35
  • 90.25 (n)
  • 96.63 (a)
oppossum
(Monodelphis domestica)
Mammalia ESRP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESRP1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESRP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESRP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esrp1 35
  • 76.71 (n)
  • 85.23 (a)
Str.5962 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53361 35
zebrafish
(Danio rerio)
Actinopterygii esrp1 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011722 35
  • 53.46 (n)
  • 54.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta fus 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sym-2 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11821 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10873 36
  • 48 (a)
OneToMany
Species with no ortholog for ESRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ESRP1 Gene

ENSEMBL:
Gene Tree for ESRP1 (if available)
TreeFam:
Gene Tree for ESRP1 (if available)

Paralogs for ESRP1 Gene

Paralogs for ESRP1 Gene

(3) SIMAP similar genes for ESRP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ESRP1 Gene

genes like me logo Genes that share paralogs with ESRP1: view

Variants for ESRP1 Gene

Sequence variations from dbSNP and Humsavar for ESRP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2303454 - 94,662,368(+) GCCTT(A/G)TAGTA nc-transcript-variant, reference, missense
rs11785 -- 94,706,086(+) TGAGC(C/T)AGTGA nc-transcript-variant, utr-variant-3-prime
rs15710 -- 94,706,220(-) GAAAC(A/G)CCTAT nc-transcript-variant, utr-variant-3-prime
rs15726 -- 94,706,305(-) TATAC(A/C/G)AAAAT nc-transcript-variant, utr-variant-3-prime
rs1035745 -- 94,646,480(-) AATCC(A/G)TCCAA intron-variant

Variation tolerance for ESRP1 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESRP1 Gene

HapMap Linkage Disequilibrium report
ESRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ESRP1 Gene

Disorders for ESRP1 Gene

Relevant External Links for ESRP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESRP1

No disorders were found for ESRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESRP1 Gene

Publications for ESRP1 Gene

  1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. (PMID: 19285943) Warzecha C.C. … Carstens R.P. (Mol. Cell 2009) 3 4 67
  2. RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer. (PMID: 19177006) Leontieva O.V. … Ionov Y. (Cell Cycle 2009) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. (PMID: 25143390) Ishii H. … Miyazawa K. (J. Biol. Chem. 2014) 3

Products for ESRP1 Gene

Sources for ESRP1 Gene

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