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Aliases for ESRG Gene

Subcategory (RNA class) for ESRG Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for ESRG Gene

  • Embryonic Stem Cell Related (Non-Protein Coding) 2 3 5
  • HESRG 3 4
  • Human Embryonic Stem Cell Related Gene 2
  • Embryonic Stem Cell Related Protein 3
  • Human Embryonic Stem Cell Related 3
  • HES Cell-Related Gene Protein 4

External Ids for ESRG Gene

Previous GeneCards Identifiers for ESRG Gene

  • GC03M054714

Summaries for ESRG Gene

GeneCards Summary for ESRG Gene

ESRG (Embryonic Stem Cell Related (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with ESRG include Brain Germinoma.

Additional gene information for ESRG Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRG Gene

Genomics for ESRG Gene

GeneHancer (GH) Regulatory Elements for ESRG Gene

Promoters and enhancers for ESRG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I054640 Enhancer 0.5 ENCODE 560.9 -2.0 -1963 3.4 GATA3 POU5F1 SIN3A EZH2 ESRG GC03P054663 CACNA2D3
GH03I054639 Enhancer 0.2 ENCODE 550.8 0.0 -42 0.1 ESRG GC03P054663 CACNA2D3
GH03I054629 Enhancer 0.5 ENCODE 22.8 +9.7 9720 2.2 POLR2A SCRT2 POU5F1 FOS ESRG GC03P054626 CACNA2D3
GH03I054755 Enhancer 0.5 Ensembl ENCODE 22.4 -116.4 -116424 2.3 FOS ESRG GC03M054667 GC03M054844 CACNA2D3
GH03I054628 Enhancer 0.4 FANTOM5 8.7 +11.1 11132 0.3 POLR2A SCRT2 ESRG GC03P054626 CACNA2D3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ESRG on UCSC Golden Path with GeneCards custom track

Genomic Locations for ESRG Gene

Genomic Locations for ESRG Gene
7,736 bases
Minus strand

Genomic View for ESRG Gene

Genes around ESRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRG Gene

Proteins for ESRG Gene

  • Protein details for ESRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Embryonic stem cell-related gene protein
    Protein Accession:

    Protein attributes for ESRG Gene

    222 amino acids
    Molecular mass:
    24186 Da
    Quaternary structure:
    No Data Available
    • Sequence=ABD92927.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for ESRG Gene

Post-translational modifications for ESRG Gene

No Post-translational modifications

No data available for DME Specific Peptides for ESRG Gene

Domains & Families for ESRG Gene

Gene Families for ESRG Gene

Protein Domains for ESRG Gene


Suggested Antigen Peptide Sequences for ESRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ESRG: view

No data available for UniProtKB/Swiss-Prot for ESRG Gene

Function for ESRG Gene

Molecular function for ESRG Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated during differentiation of ES cells.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ESRG Gene

Localization for ESRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRG Gene

Gene Ontology (GO) - Cellular Components for ESRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23628413
genes like me logo Genes that share ontologies with ESRG: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ESRG Gene

Pathways & Interactions for ESRG Gene

No Data Available

Interacting Proteins for ESRG Gene

Gene Ontology (GO) - Biological Process for ESRG Gene


No data available for Pathways by source and SIGNOR curated interactions for ESRG Gene

Drugs & Compounds for ESRG Gene

No Compound Related Data Available

Transcripts for ESRG Gene

mRNA/cDNA for ESRG Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ESRG Gene

Embryonic stem cell related (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESRG Gene

No ASD Table

Relevant External Links for ESRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ESRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESRG Gene

mRNA differential expression in normal tissues according to GTEx for ESRG Gene

This gene is overexpressed in Cervix - Ectocervix (x21.7) and Vagina (x15.1).

NURSA nuclear receptor signaling pathways regulating expression of ESRG Gene:


SOURCE GeneReport for Unigene cluster for ESRG Gene:


mRNA Expression by UniProt/SwissProt for ESRG Gene:

Tissue specificity: Expressed only in fetal ovary and in undifferentiated ES cells.
genes like me logo Genes that share expression patterns with ESRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ESRG Gene

Orthologs for ESRG Gene

Evolution for ESRG Gene

Gene Tree for ESRG (if available)
Gene Tree for ESRG (if available)

No data available for Orthologs for ESRG Gene

Paralogs for ESRG Gene

No data available for Paralogs for ESRG Gene

Variants for ESRG Gene

Sequence variations from dbSNP and Humsavar for ESRG Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000295210 -- 54,639,730(-) G/A non_coding_transcript_variant
rs1000319794 -- 54,634,555(-) G/T non_coding_transcript_variant
rs1000412212 -- 54,639,449(-) A/G non_coding_transcript_variant
rs1000438377 -- 54,634,341(-) G/A/T intron_variant
rs1001057815 -- 54,635,667(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ESRG Gene

Variant ID Type Subtype PubMed ID
esv3596185 CNV loss 21293372
nsv1014595 CNV loss 25217958
nsv517851 CNV gain 19592680
nsv525644 CNV gain 19592680
nsv834700 CNV gain 17160897

Additional Variant Information for ESRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ESRG Gene

Disorders for ESRG Gene

MalaCards: The human disease database

(1) MalaCards diseases for ESRG Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain germinoma
  • germinoma of the brain
- elite association - COSMIC cancer census association via MalaCards
Search ESRG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ESRG

genes like me logo Genes that share disorders with ESRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ESRG Gene

Publications for ESRG Gene

  1. Transcriptional profiling of human embryonic stem cells and embryoid bodies identifies HESRG, a novel stem cell gene. (PMID: 17803967) Zhao M … Yao K (Biochemical and biophysical research communications 2007) 2 3 4 58
  2. Identification, expression and subcellular localization of ESRG. (PMID: 23628413) Li G … Jiang X (Biochemical and biophysical research communications 2013) 3 4 58
  3. HESRG: a novel biomarker for intracranial germinoma and embryonal carcinoma. (PMID: 21861197) Wanggou S … Ren C (Journal of neuro-oncology 2012) 2 3 58
  4. Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. (PMID: 25317556) Wang J … Izsvák Z (Nature 2014) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for ESRG Gene

Sources for ESRG Gene

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