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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ESR2 Gene

protein-coding GIFtS: 71
GCID: GC14M064550

estrogen receptor 2 (ER beta)

Explore 193 diseases affiliated with
ESR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Estrogen Receptor 2 (ER Beta)¹ ²		ESRB²
NR3A2¹ ² ³		Estrogen Nuclear Receptor Beta Variant A²
Erb¹ ²		Estrogen Nuclear Receptor Beta Variant B²
Nuclear Receptor Subfamily 3 Group A Member 2² ³		Estrogen Receptor Beta²
ESTRB² ³		Estrogen Receptor Beta 4²
ER-BETA²		ER-Beta¹
ESR-BETA²

External Ids:	HGNC: 3468¹	Entrez Gene: 2100²	Ensembl: ENSG00000140009⁷	OMIM: 601663⁵	UniProtKB: Q92731³

Export aliases for ESR2 gene to outside databases

Previous GC identifers: GC14M062021 GC14M058487 GC14M062683 GC14M062685 GC14M063621 GC14M063763 GC14M064693 GC14M044866

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ESR2:

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription

factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is

localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the

encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some

isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced

transcript variants of this gene have been described, but the full-length nature of some of these variants has not

been fully characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression

of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks

ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent

transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand

while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more

gradual

summary for ESR2:

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive

system. In females, estrogen's main targets are the ovaries, uterus, vagina and mammary glands. In the male,

target organs are the testes, prostate and epididymis. Estrogen is also responsible for the growth and

maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen

exerts most of its actions via estrogen receptors (ER). Estrogen receptors are ligand-activated

transcription factors belonging to the nuclear hormone receptor superfamily. Today, two estrogen receptors

are known, ERalpha and ERbeta. ERalpha protein is highly homologous to ERbeta protein, especially in the DNA

and ligand binding domains, although divergence exists in the N-terminal transactivation domain. Both

receptors interact with the same DNA response element and show a similar ligand binding profile. Upon ligand

binding estrogen receptors undergo a conformational change allowing spontaneous dimerization to form either

homo- or heterodimers. As a dimer, the estrogen receptor binds to the estrogen response element (ERE) in the

promoter region of target genes. ERalpha and ERbeta which are present in a broad spectrum of tissues.

Gene Wiki entry for ESR2 (Estrogen receptor beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ESR2 gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ESR2 promoter sequence

Search SABiosciences Chromatin IP Primers for ESR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ESR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q21-q22

ESR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESR2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M064550: view genomic region (about GC identifiers)

Start:	64,550,950 bp from pter	End:	64,805,268 bp from pter
Size:	254,319 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731 (See protein sequence)

Recommended Name: Estrogen receptor beta

Size: 530 amino acids; 59216 Da

Subunit: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6

coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform

beta-2/cx preferentially forms a heterodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts

with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of

estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1

promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2

Subcellular location: Nucleus

Sequence caution: Sequence=CAA67555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

6/28 PDB 3D structures from and Proteopedia for ESR2 (see all 28):

1L2J (3D)

1NDE (3D)

1QKM (3D)

1U3Q (3D)

1U3R (3D)

1U3S (3D)

Secondary accessions: A8K8K5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q9UEV6

Q9UHD3 Q9UQK9

Alternative splicing: 8 isoforms: Q92731-1 Q92731-2 Q92731-3 Q92731-4 Q92731-5 Q92731-6 Q92731-7 Q92731-8

(Does not form homodimers)

Explore the universe of human proteins at neXtProt for ESR2: NX_Q92731

Post-translational modifications:

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92731

ESR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001035365.1 NP_001201831.1 NP_001201832.1 NP_001258805.1 NP_001258806.1 NP_001428.1 NP_001035366.1

ENSEMBL proteins:

ENSP00000452485 ENSP00000450699 ENSP00000351412 ENSP00000450488 ENSP00000345616

ENSP00000452426 ENSP00000451582 ENSP00000343925 ENSP00000441792 ENSP00000335551

ENSP00000350427 ENSP00000267525

Reactome Protein details: Q92731
Human Recombinant Protein Products for ESR2:

	EMD Millipore Purified and/or Recombinant ESR2 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ESR2 OriGene Protein Over-expression Lysate (see all 3): ESR2 OriGene Custom Protein Services for ESR2
	GenScript Custom Purified and Recombinant Proteins Services for ESR2
	Novus Biologicals ESR2 Proteins Novus Biologicals ESR2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	9671811
GO:0005634	nucleus	TAS	11181953
GO:0005654	nucleoplasm	TAS	--
GO:0005739	mitochondrion	IDA	15024130

ESR2 for ontologies About GeneDecksing

ESR2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ESR2
	R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
	OriGene Antibodies (see all 3): ESR2 OriGene Custom Antibody Services for ESR2
	GenScript Superior Antibodies for ESR2
	Novus Biologicals ESR2 Antibodies
	Abcam antibodies for ESR2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ESR2

Assay Products for ESR2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ESR2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ESR2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR001723 Str_hrmn_rcpt

IPR024178 Oest_rcpt/oest-rel_rcp

IPR013088 Znf_NHR/GATA

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

Graphical View of Domain Structure for InterPro Entry Q92731

ProtoNet protein and cluster: Q92731

1 Blocks protein family: IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding

domain

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression

of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks

ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent

transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand

while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more

gradual

Genatlas biochemistry entry for ESR2:

estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced isoforms (hER beta

1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine leiomyomata,see ULCR14

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001046	core promoter sequence-specific DNA binding	IDA	15345745
GO:0003677	DNA binding	TAS	9636657
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8769313
GO:0003707	steroid hormone receptor activity	TAS	10749889
GO:0003713	transcription coactivator activity	TAS	8769313

ESR2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ESR2:

Increased G1 DNA content

Increased cell death in breast

Synthetic lethal with Ras

15/24 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Esr2) (see all 24):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

ESR2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ESR2: Esr2^tm1.2Pcn Esr2^tm1Aghe Esr2^tm1Psh Esr2^tm1Mma Esr2^tm1Unc

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ESR2

miRNA Products:		miRTarBase miRNAs that target ESR2: hsa-mir-92a (MIRT004563)

		OriGene 3'-UTR Clone (see all 3): ESR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ESR2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ESR2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ESR2 (see all 7) OriGene shRNA RFP: ESR2 OriGene siRNA: ESR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ESR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ESR2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ESR2
			Sirion Biotech Customized adenovirus for overexpression of ESR2 Sirion Biotech Customized adenovirus for potent knockdown of ESR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
		Sino Biological Human cDNA Clone for ESR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ESR2
		Search LifeMap BioReagents cell lines for ESR2
		Sirion Biotech Customized stable knockdown cell line services for ESR2 Sirion Biotech Customized inducible knockdown cell line services for ESR2 Sirion Biotech Customized stable overexpressing cell line services for ESR2 Sirion Biotech Customized inducible overexpressing cell line services for ESR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Ligand-independent activation of ESR1 and ESR2

Development_Ligand-independent activation of ESR1 and ESR2

1.00

Development Ligand-independent activation of ESR1 and ESR2

0.97

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Nuclear Receptors

0.68

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Development HGF signaling pathway

Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2

0.15

Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ESR2

	Development Ligand-independent activation of ESR1 and ESR2
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

1 R&D Systems Pathway for ESR2

TGF-beta Signaling Pathways

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ESR2 (see all 6)

	ERK Signaling
	Estrogen-mediated S-Phase Entry
	eNOS Signaling
	Estrogen Pathway
	MNAR-PELP1 and Estrogen Receptor Interaction

2 GeneGo (Thomson Reuters) Pathways for ESR2

	Development Ligand-independent activation of ESR1 and ESR2
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

5/6 BioSystems Pathways for ESR2 (see all 6)

	Nuclear Receptors
	SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway

3 Reactome Pathways for ESR2

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

1 PharmGKB Pathway for ESR2

Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics

ESR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ESR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/439 Interacting proteins for ESR2 (Q92731^{1, 3} ENSP00000343925⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 439)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=1 STRING: ENSP00000348258
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	15345745
GO:0001541	ovarian follicle development	IEA	--
GO:0001764	neuron migration	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	11181953

ESR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ESR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ESR2

Compounds for ESR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
ICI 182,780	Estrogen receptor antagonist	[129453-61-8]
FERb 033	Potent and selective ERbeta agonist	[1111084-78-6]
ERB 041	Potent ERbeta agonist	[524684-52-4]
DPN	Highly potent ERbeta agonist	[1428-67-7]
PHTPP	Selective ERbeta antagonist	[805239-56-9]

1 HMDB Compound for ESR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Estradiol	(+)-3,17b-Estradiol (see all 83)	50-28-2	--

10/30 DrugBank Compounds for ESR2 (see all 30) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Tamoxifen	Tamoxifen Citrate (see all 5)	10540-29-1	target	antagonist agonist	17158759 20827267 16822624 11752352 16326830 16010412 2011412 17404078
Raloxifene	LY-139481 (see all 6)	84449-90-1	target	agonist	11861516 10418979 11810032 11752352 12097269 11500849
Genistein	4',5, 7-Trihydroxyisoflavone (see all 4)	446-72-0	target	--	17139284 17016423 10592235
N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide	--	--	target	--	17139284 17016423 10592235
Para-Mercury-Benzenesulfonic Acid	--	--	target	--	17139284 17016423 10592235
Trilostane	--	13647-35-3	target	allosteric modulator	12209583 16806905 17109615
4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol	--	--	target	--	17139284 17016423
Diethylstilbestrol	DES (see all 10)	56-53-1	target	agonist	15123288 19101832
Estradiol	17beta oestradiol (see all 7)	50-28-2	target	agonist	17464340 2011412
Estropipate	Estropipate (usp) (see all 4)	7280-37-7	target	agonist	17464340 2011412

10/108 Novoseek chemical compound relationships for ESR2 gene (see all 108) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	96.1	3585	19800101 (9), 18620727 (7), 12895004 (6), 16214508 (6) (see all 99)
4-hydroxytamoxifen	85.1	40	17464340 (6), 18663360 (4), 11720858 (2), 16782818 (2) (see all 21)
estradiol	84.7	197	10601611 (6), 10342855 (4), 19001520 (4), 15345745 (3) (see all 99)
tamoxifen	81.9	167	16010412 (8), 19744542 (5), 11078914 (4), 17404078 (4) (see all 76)
fulvestrant	80.1	13	19528477 (2), 19212635 (2), 17923257 (1), 16549430 (1) (see all 7)
progesterone	80	273	16033082 (5), 17905466 (3), 19200930 (3), 19094096 (2) (see all 99)
raloxifene	80	38	10076999 (2), 11720858 (2), 15138633 (2), 17962382 (2) (see all 26)
steroid	76.9	114	10499535 (2), 11775002 (2), 11806710 (2), 12702147 (2) (see all 78)
genistein	76.1	109	16596234 (5), 19556829 (5), 16513288 (5), 18258689 (4) (see all 51)
daidzein	73.5	39	14664520 (5), 11431145 (3), 16673816 (2), 16972265 (2) (see all 17)

3 PharmGKB related drug/compound annotations for ESR2 gene About this table

Drug/compound	PharmGKB Annotation
exemestane	DL
fulvestrant	DL
tamoxifen	CA DL

Search CenterWatch for drugs/clinical trials and news about ESR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ESR2 gene (7 alternative transcripts):

NM_001040275.1 NM_001214902.1 NM_001214903.1 NM_001271876.1 NM_001271877.1 NM_001437.2 NM_001040276.1

Unigene Clusters for ESR2:

Estrogen receptor 2 (ER beta)

Hs.660607 [show with all ESTs], Hs.734038

Unigene Representative Sequences: AB006589, AF061055

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000556275 ENST00000554572(uc001xgy.2 uc001xgv.3 uc001xgw.3 uc001xgx.3)

ENST00000358599(uc001xgz.2) ENST00000555278 ENST00000344288 ENST00000553796

ENST00000557772 ENST00000555483(uc010aqd.1) ENST00000554520 ENST00000341099(uc010aqb.1 uc010aqc.1 uc001xha.1)

ENST00000555783 ENST00000542956 ENST00000353772(uc001xgu.3) ENST00000357782

ENST00000267525

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ESR2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ESR2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ESR2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ESR2 (see all 7) OriGene shRNA RFP: ESR2 OriGene siRNA: ESR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ESR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ESR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ESR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ESR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ESR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ESR2

Additional cDNA sequence: AF061055.1

11 DOTS entries:

DT.310701 DT.120767971 DT.100751205 DT.95367837 DT.102837012 DT.120767979 DT.40120425 DT.92419264

DT.40125379 DT.91703242 DT.100740263

24/316 AceView cDNA sequences (see all 316):

CA868590 AW129591 BC042134 AW119118 BQ057203 AI638206 AA747679 AW589851

AL080133 AA972285 BE206269 BE673476 BG222179 AY061758 CD671619 CA423800

NM_182912 BM019005 NM_182910 BX282648 AK074055 AK090430 BE673396 BG110769

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ESR2 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	·	16c	·	16d	^
SP1:																																					-
SP2:																																					-								-		-		-		-
SP3:							-		-		-		-		-		-		-		-																-		-						-		-		-		-
SP4:																																					-
SP5:																															-

ExUns:	17a	·	17b	·	17c	·	17d
SP1:
SP2:	-
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for ESR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ESR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACAGTG

About this image

ESR2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ESR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ESR2

SOURCE GeneReport for Unigene clusters: Hs.660607 Hs.734038

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Tissue specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta,

liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine

bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen,

thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone

marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a

lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta,

skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus,

prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain

SABiosciences Expression via Pathway-Focused PCR Arrays including ESR2 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Targets in human mouse rat

Breast Cancer in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

Cancer Drug Resistance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ESR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ESR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ESR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ESR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ESR2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ESR2¹	estrogen receptor 2 (ER beta)	74.78(n) 80.7(a)		395575 NM_204794.1 NP_990125.1
lizard (Anolis carolinensis)	Reptilia	ESR2⁶	--	70(a)	1 ↔ 1	1(1646467-1679104)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC394460²	estrogen receptor beta	79.44(n)		AY310903.1
zebrafish (Danio rerio)	Actinopterygii	esr2a²	estrogen receptor 2a	77.22(n)		317734 AF516874.1

ENSEMBL Gene Tree for ESR2 (if available)
TreeFam Gene Tree for ESR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ESR2 gene

ESRRA² RXRG² PGR² ESRRB² HNF4G² NR2F6² NR2E1² ESRRG²

NR3C2² RXRA² NR2F1² NR3C1² NR2F2² AR² ESR1² NR2C1²

HNF4A² NR2C2² RXRB²

18/25 SIMAP similar genes for ESR2 using alignment to 5 protein entries: ESR2_HUMAN (see all proteins) (see all similar genes):

NR3A2 ESR1 NR3C2 HNF4G NR2C2 HNF4alpha

NR1I3 VDR NR3A1 NR5A1 ESRRG THRB

NR3B3 ERRgamma NR1H3 ESRRB NR3C4 PGR

ESR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75492434^1,2		--	44865996(+)	`CTCTAC/TTCTTT`	3	--	int¹		0	--	--	--	--
rs76801570^1,2		--	44865998(+)	`CTACTC/TTTTTT`	3	--	int¹		0	--	--	--	--
rs11622991^1,2	H	--	44866048(+)	`tgcggG/Tggccc`	3	--	int¹		0	--	--	--	--
rs58262369^1,2	C	--	44866494(+)	`CTTCTC/TTGCCA`	3	--	ut3¹		3		CSA WA EA	239
rs114629727^1,2	C,F	--	44866728(+)	`AACTCT/CTTCTT`	3	--	ut3¹		1		WA	118
rs28440970^1,2	C,F	--	44866740(+)	`NNNNTT/CATTTT`	3	--	ut3¹		2		NA EA	240
rs77290975^1,2	C	--	44867686(+)	`TAGACA/GTTAAA`	3	--	int¹		2		CSA WA	120
rs79198840^1,2	F	--	44867972(+)	`ATTGTA/GCAGTT`	3	--	int¹		1		NA	120
rs76844784^1,2	F	--	44869080(+)	`ATTAAA/GTGTGA`	3	--	int¹		1		WA	118
rs75301620^1,2	F	--	44869896(+)	`TTCCCG/ACCTTA`	3	--	int¹		1		WA	118
rs80257824^1,2		--	44870092(+)	`AAAGGC/GATTGC`	3	--	int¹		0	--	--	--	--
rs57296917^1,2	C,F	--	44870810(-)	`CTTGGA/TCAAGT`	3	--	int¹		2		WA	310
rs7159990^1,2	C,H	--	44871392(+)	`ATCAAG/AGCTAT`	3	--	int¹		8		NS EA NA	804
rs78810983^1,2		--	44871582(+)	`GGAAAC/TACTGT`	3	--	int¹		0	--	--	--	--
rs35743760^1,2	C,F	--	44871913(-)	`GGGACT/AGATCA`	4	--	int¹ ds500¹		6		MN NA	528
rs111531403^1,2	C	--	44872380(+)	`CACACT/CGGAGT`	4	--	int¹ ut3¹		2		WA	120
rs58213162^1,2	C	--	44872678(-)	`CTTCGG/AGGTTC`	4	--	int¹		1		--	190
rs57964318^1,2	C,F	--	44872691(-)	`NNNNCG/AGGGAA`	4	--	int¹		2		NA	310
rs944049^1,2	C,H	--	44872764(-)	`TGCACG/AAGCCA`	4	--	int¹		7		NS EA NA	612
rs11851942^1,2	H	--	44872792(+)	`ATTTAG/AGCTCA`	4	--	int¹		4		NS EA	420
rs944048^1,2	H	--	44872825(-)	`ACACAG/CAGGCT`	4	--	int¹		4		NS EA	412
rs61366663^1,2	C,F	--	44872962(-)	`AGGCTT/CGCAGG`	4	--	int¹		2		NA	308
rs56831520^1,2	C,F	--	44873100(-)	`CTCGGG/ATGTGA`	4	--	int¹		1		--	188
rs867442^1,2	C,H	--	44873435(+)	`tgaagG/CaatcT`	4	--	int¹		8		NS EA NA WA	680
rs59566953^1,2	C,F	--	44873565(-)	`AGGCAA/CGTCTA`	4	--	int¹		2		WA	310
rs12432029^1,2	C,F,A,H	--	44873724(+)	`ATTACG/ATTTCC`	5	--	ds500¹ int¹		4		EA NS NA	420
rs17101734^1,2	C,F	--	44873807(+)	`ATCCTT/CAATTT`	5	--	int¹ ds500¹		4		NA WA	260
rs73267844^1,2	C	--	44875380(+)	`GCTCCA/GGCAAC`	5	--	int¹		2		WA	120
rs58126300^1,2		--	44877123(+)	`GAATAG/AGCAAA`	5	--	int¹		3		NA WA	240
rs75388219^1,2	F	--	44877184(+)	`ATAGGG/CAGTGG`	5	--	int¹		1		WA	118
rs17101742^1,2	C	--	44877751(+)	`CTCCCA/GGAAAA`	5	--	int¹		4		NA WA	260
rs60032857^1,2	C	--	44878395(+)	`GTGGCG/ATTTGC`	5	--	int¹		4		NA WA	242
rs76333218^1,2	C	--	44878683(+)	`GTCTCT/CTAATA`	5	--	int¹		2		CSA WA	120
rs75608555^1,2		--	44879601(+)	`CCATCT/GAGCAG`	5	--	int¹		1		NA	120
rs12437103^1,2	C,F,H	--	44879816(+)	`CTTTCA/CTTACA`	5	--	int¹		17		NS EA NA WA	2120
rs8003034^1,2	C,A	--	44880297(+)	`AAAAAG/TTAGCC`	5	--	int¹		3		WA NA CSA	5
rs12897137^1,2	H	--	44880470(+)	`aaaaaA/Ggatag`	5	--	int¹ trp³		4		NS EA	376
rs8013331^1,2	C,F	--	44882309(+)	`tcactA/Gtcatg`	5	--	int¹		1		NA	120
rs7152484^1,2	C	--	44882356(+)	`tcatcG/Tcccac`	5	--	int¹		0	--	--	--	--
rs7151379^1,2	C,F,A,H	--	44882455(+)	`tattcC/Attcct`	5	--	int¹ trp³		21		NS EA NA WA	2166
rs117670667^1,2	C,F	--	44882522(+)	`TGGAGC/TANNNN`	5	--	int¹		1		NA	120
rs55947517^1,2	C,F	--	44882732(+)	`GTACTA/CACAGA`	5	--	int¹		1		NA	120
rs76022560^1,2	C,F	--	44883083(+)	`GTTTCG/ACCCGC`	5	--	int¹		1		WA	118
rs12883967^1,2	H	--	44883413(+)	`gtggaC/Ttaagg`	5	--	int¹		4		NS EA	420
rs79698176^1,2		--	44883801(+)	`AGAACG/AAAATG`	5	--	int¹		1		EA	120
rs11850375^1,2	C,F,H	--	44883959(+)	`GGTTAC/TACCAC`	5	--	int¹		17		NS EA NA WA	2108
rs76869457^1,2	F	--	44884045(+)	`CGCATA/CTCATG`	5	--	int¹		1		NA	120
rs79512176^1,2	F	--	44884240(+)	`CGTTTG/CTGTCC`	5	--	int¹		2		WA EA	238
rs72548761^1,2	C,F	--	44884747(-)	`GCAACC/TTCTAC`	5	--	int¹		1		--	180
rs74458781^1,2	C,F	--	44884954(+)	`TGTCAT/CGCTGC`	5	--	int¹		1		EA	120
rs79935155^1,2		--	44885316(+)	`AGAAAG/AGGTTG`	5	--	int¹		2		CSA WA	120
rs11621314^1,2	C,H	--	44886241(+)	`CTTCAG/AATTCC`	5	--	int¹		4		NS EA	420
rs11621342^1,2	H	--	44886301(+)	`CCCTAG/AATCCA`	5	--	int¹		4		NS EA	414
rs11621345^1,2	H	--	44886341(+)	`CTCCAG/AAGCTA`	5	--	int¹		4		NS EA	416
rs72548762^1,2	C	--	44886365(-)	`GTAAAT/CGGGCA`	5	--	int¹		1		--	186
rs143394299^1,2	C	--	44886873(+)	`TGAACA/GTTAAA`	5	--	int¹		0	--	--	--	--
rs72548756^1,2	C,F	--	44886911(-)	`TTGACT/ATTTTT`	5	--	int¹		2		NA	310
rs72548760^1,2	C,F	--	44887885(-)	`TAAACA/GTTCAA`	5	--	int¹		1		--	190
rs72720399^1,2	F	--	44888173(+)	`GCTGCC/GCAAAG`	5	--	int¹		1		NA	120
rs72548764^1,2	C,F	--	44888412(-)	`AGATAC/AAATCC`	5	--	int¹		2		WA	308
rs17101753^1,2	C,F	--	44888446(+)	`AAAAGG/TAGGAC`	5	--	int¹ trp³		7		NA CSA WA	454
rs111948016^1,2	C	--	44889014(+)	`TTTAAC/TCTCAA`	5	--	int¹		0	--	--	--	--
rs10140457^1,2	C	--	44889228(+)	`CACCAA/CATGTT`	5	--	int¹		5		NA WA	244
rs79500066^1,2	F	--	44889251(+)	`TACCAC/TTCCTA`	5	--	int¹		1		WA	118
rs75027286^1,2	C,F	--	44889772(+)	`AAAACA/GCTCTA`	5	--	int¹		2		WA EA	238
rs72548755^1,2	C	--	44890104(-)	`TGCTTC/TGGAAT`	5	--	int¹		1		--	192
rs199753615^1,2	C	--	44890565(+)	`CAAAAA/CANNNN`	5	--	int¹		0	--	--	--	--
rs199772185^1,2	C	--	44890586(-)	`TTGGTG/TGGTTT`	5	--	int¹		0	--	--	--	--
rs1977487^1,2		--	44890665(-)	`tgtgtA/Gtgtat`	5	--	int¹		0	--	--	--	--
rs202171174^1,2	C	--	44890675(+)	`ACACAC/TACACA`	5	--	int¹		0	--	--	--	--
rs79306444^1,2	F	--	44890968(+)	`TCTGAT/CTGCTT`	5	--	int¹		1		WA	118
rs57470843^1,2		--	44891576(+)	`AAAAAA/CCAAAA`	5	--	int¹		0	--	--	--	--
rs77088374^1,2	F	--	44891578(+)	`AAAACA/GAAAAC`	5	--	int¹		1		NA	120
rs113448117^1,2	C	--	44892007(+)	`TGATCC/TAATCA`	5	--	int¹		0	--	--	--	--
rs61984406^1,2	C	--	44892246(+)	`TGGGAA/TTACAG`	5	--	int¹		2		NA	4
rs7152914^1,2	C	--	44892724(+)	`caggcA/Gtgagc`	5	--	int¹		0	--	--	--	--
rs4462498^1,2	C,H	--	44892932(+)	`GGTTTA/GCCTCT`	5	--	int¹		4		EA NS NA	400
rs2738415^1,2	H	--	44893071(+)	`CAATTC/TCACGG`	5	--	int¹		5		NS EA NA	538
rs66969518^1,2	C,F	--	44893542(-)	`TATTAC/AGNNNN`	5	--	int¹		4		WA NA EA	550
rs11844783^1,2	C,F,H	--	44894531(+)	`GAAAAT/CTATAT`	5	--	int¹		5		NS EA	594
rs113392459^1,2	C,F	--	44894849(+)	`CCTATT/CATCCT`	5	--	int¹		1		WA	118
rs59748760^1,2	C,F	--	44895240(-)	`TGCCCC/TAAGGT`	5	--	int¹		2		NA	308
rs59204191^1,2	C	--	44895259(-)	`TTACAC/GAGATG`	5	--	int¹		3		WA	308
rs59020260^1,2	C,F	--	44895271(-)	`GAAGAC/ACCTGT`	5	--	int¹		2		WA	306
rs57857158^1,2	C	--	44895545(-)	`AGGAAA/GCAATT`	5	--	int¹		1		--	192
rs60771514^1,2	C,F	--	44895611(-)	`ACAGAA/TAATGG`	5	--	int¹		1		--	192
rs12587432^1,2	H	--	44896243(+)	`CCCTAT/ATAAAG`	5	--	int¹		4		NS EA	418
rs75738281^1,2		--	44896317(+)	`GACCCA/GACTCT`	5	--	int¹		1		WA	118
rs78470370^1,2	F	--	44896868(+)	`CACTAC/TGACCT`	5	--	int¹		2		CSA WA	122
rs59160802^1,2	C,F	--	44897532(-)	`GGTTAT/CTAGGT`	5	--	int¹		2		NA	310
rs60630490^1,2	C	--	44897540(-)	`CCAACA/GTGGGT`	5	--	int¹		1		--	190
rs79489572^1,2	C,F	--	44897830(+)	`GATCTC/TTTATC`	5	--	int¹		1		EA	120
rs74840684^1,2		--	44897986(+)	`CTTTGC/TTCAGT`	5	--	int¹		0	--	--	--	--
rs76188947^1,2		--	44898198(+)	`TCTACA/GTTTCC`	5	--	int¹		0	--	--	--	--
rs57378655^1,2	C	--	44898422(-)	`TATTTT/CATTTT`	5	--	int¹		5		NA WA	434
rs57173401^1,2	C	--	44898448(-)	`TCTAGC/TATCTT`	5	--	int¹		1		--	192
rs79321532^1,2		--	44899523(+)	`TTGTTG/AAAGGT`	5	--	int¹		1		NA	120
rs72722305^1,2	C,F	--	44901078(+)	`AATCAT/CAGCTC`	5	--	int¹		1		NA	120
rs79912871^1,2		--	44901207(+)	`GGTCTT/CACTAT`	5	--	int¹		1		NA	120
rs115067383^1,2	C,F	--	44903197(+)	`TCTGAC/TGATAA`	5	--	int¹		1		WA	118
rs7144250^1,2	H	--	44903570(+)	`TAGTAG/AAAGAA`	5	--	int¹ trp³		4		NS EA	412
rs78962806^1,2	C	--	44903735(+)	`TTTTA-/TWATAC`	5	--	int¹		0	--	--	--	--
rs61984411^1,2	C	--	44903860(+)	`GGTGGC/TTCATG`	5	--	int¹		4		NA WA	242
rs112257090^1,2	C	--	44904055(+)	`GAGCCC/TGAGGA`	5	--	int¹		0	--	--	--	--
rs114960802^1,2	C,F	--	44904842(+)	`AAGATA/GTGGCA`	5	--	int¹		1		WA	118
rs12893594^1,2	H	--	44905946(+)	`CATACA/CCATAA`	5	--	int¹		4		NS EA	410
rs12894175^1,2	H	--	44905999(+)	`AAACAG/TAGCAA`	5	--	int¹		4		NS EA	420
rs78151681^1,2	F	--	44906074(+)	`CCAGTC/GTCACC`	5	--	int¹		1		WA	118
rs75350477^1,2	C,F	--	44907959(+)	`CCCAAA/CTCTTC`	5	--	int¹		1		WA	118
rs79716466^1,2		--	44909405(+)	`CAGTGC/TGGAGA`	5	--	int¹		1		WA	118
rs61984412^1,2	C	--	44909588(+)	`AGGACT/AGTCCC`	5	--	int¹		4		NA WA	242
rs79621066^1,2	F	--	44909750(+)	`CTACAC/GATTAG`	5	--	int¹		1		NA	120
rs2026086^1,2		--	44909895(-)	`gctatA/C/Ttggga`	5	--	int¹		0	--	--	--	--
rs117510166^1,2	C,F	--	44910049(+)	`NNNNGT/CGAGCC`	5	--	int¹		1		NA	120
rs6573550^1,2	C,A	--	44910568(+)	`ccccaA/Caagtt`	5	--	int¹		0	--	--	--	--
rs199612728^1,2	C	--	44910588(+)	`TCTTTC/TTTTTT`	5	--	int¹		0	--	--	--	--
rs6573551^1,2	C,F,A	--	44910646(+)	`tggcaT/Cgatct`	5	--	int¹		4		NA WA CSA	7
rs61984413^1,2	C	--	44910748(+)	`CCAGCC/TAATTT`	5	--	int¹		2		NA	4
rs28499370^1,2	C,F	--	44910795(+)	`CCCAAG/CCTGGT`	5	--	int¹		4		NA WA CSA	7
rs28485225^1,2	C,F	--	44910804(+)	`GTCTCG/AAACTC`	5	--	int¹		4		NA WA CSA	7
rs56317344^1,2	C	--	44912066(+)	`TCTTCC/TACAGT`	5	--	int¹		2		WA NA	122
rs12435278^1,2	C,H	--	44912889(+)	`tccttG/Ccatcc`	5	--	int¹		2		NA EA	122
rs75401213^1,2	C	--	44912980(+)	`TTACAT/ACAATA`	5	--	int¹		2		WA	120
rs12435284^1,2	C,F,A,H	--	44913060(+)	`tctcaC/Tggaat`	5	--	int¹		7		NS EA NA	662
rs12435307^1,2	C,F,H	--	44913176(+)	`cagtcC/Gtggct`	5	--	int¹		7		NS EA NA WA	656
rs113370836^1,2	C	--	44913703(+)	`TATCAA/GTTGTA`	5	--	int¹		1		NA	2
rs79272383^1,2	F	--	44913809(+)	`AAACCT/GTCATA`	5	--	int¹		1		EA	120
rs12436020^1,2	C,H	--	44913944(+)	`ttaagA/Gtacat`	5	--	int¹		3		NA WA EA	240
rs72722317^1,2	C,F	--	44915647(+)	`TAAAGA/CGAAGC`	5	--	int¹		2		WA NA	238
rs59216189^1,2	C	--	44915670(+)	`AAAGAT/CANNNN`	5	--	int¹		5		WA CSA NA EA	361
rs77462651^1,2	C	--	44917089(+)	`CTTTGC/AACATT`	5	--	int¹		2		NA	122
rs80164409^1,2	F	--	44917180(+)	`ATTAGC/TTGTAG`	5	--	int¹		1		NA	120
rs78070685^1,2		--	44917249(+)	`AAGAAG/CGATCT`	5	--	int¹		1		NA	120
rs111898097^1,2	C,F	--	44917613(+)	`ACAGGG/ATGAAT`	5	--	int¹		1		WA	118
rs10136955^1,2	C,F,H	--	44917803(+)	`AACTGG/TCAAAG`	5	--	int¹		16		NS EA NA WA CSA	1889
rs74751413^1,2		--	44918211(+)	`CTGATA/CGAACA`	5	--	int¹		0	--	--	--	--
rs34160122^1,2	C	--	44918572(-)	`AGTGAC/AAAATG`	5	--	int¹		5		MN	404
rs111422802^1,2	C	--	44918842(+)	`TCTTCC/TTCAGG`	5	--	int¹		0	--	--	--	--
rs73267884^1,2	C,F	--	44919133(+)	`TACTTT/CGTGTG`	5	--	int¹		3		WA CSA	122
rs76981078^1,2		--	44919473(+)	`TCTAGA/GAAAAA`	5	--	int¹		0	--	--	--	--
rs113329686^1,2	C	--	44919578(+)	`ACTGAC/TATCAT`	5	--	int¹		0	--	--	--	--
rs113524009^1,2	C	--	44920240(+)	`CCAGCT/CTGGGC`	5	--	int¹		1		NA	2
rs10143846^1,2	C,F,H	--	44920497(+)	`AGTCTA/TACAAG`	5	--	int¹		4		NS EA	418
rs59677654^1,2	F	--	44921144(+)	`GCTTCG/ACATGT`	5	--	int¹		2		WA EA	238
rs8020953^1,2	C	--	44924138(+)	`agtctC/Tgcact`	5	--	int¹ us2k¹		0	--	--	--	--
rs112909780^1,2	C	--	44924211(+)	`CAAGCA/GATTCT`	5	--	int¹ us2k¹		0	--	--	--	--
rs10142387^1,2	C	--	44924851(+)	`gaggcC/Tgaggt`	3	--	int¹		0	--	--	--	--
rs111712579^1,2	C	--	44925106(+)	`GAAAAA/CGAAAA`	3	--	int¹		2		WA NA	122
rs77700773^1,2	F	--	44925211(+)	`AGGAAG/TTGAGG`	3	--	int¹		1		NA	120
rs59318135^1,2		--	44925515(+)	`TTGGGT/CTTTAT`	3	--	int¹		2		NA	122
rs73267889^1,2	C	--	44925579(+)	`TTTTAC/GATGGA`	3	--	int¹		4		WA CSA NA	241
rs111730901^1,2	C,F	--	44925887(+)	`CCTGAT/CCAACA`	3	--	int¹		1		WA	118
rs80266272^1,2	C	--	44927356(+)	`TCCAGA/TGACCT`	3	--	int¹		0	--	--	--	--
rs76755040^1,2		--	44927417(+)	`CTGAAT/CTCAGC`	3	--	int¹		1		NA	120
rs3783735^1,2	C	--	44928559(-)	`CTCCCA/GACCTC`	3	--	int¹		1		CSA	1
rs3783734^1,2	C	--	44928628(-)	`ccatgC/Gccggc`	3	--	int¹		0	--	--	--	--
rs112938642^1,2	C	--	44928633(+)	`GCATGA/GTGGCA`	3	--	int¹		0	--	--	--	--
rs111307080^1,2		--	44928662(+)	`TACTCG/AGGAGG`	3	--	int¹		1		CSA	2
rs144893592^1,2	C	--	44929121(+)	`AGAGG-/ATAAGT`	3	--	int¹		0	--	--	--	--
rs61984416^1,2	C,F	--	44929267(+)	`AGATTT/AAAAAA`	3	--	int¹		4		NA WA	242
rs111722049^1,2	C	--	44929682(+)	`AGAGAT/CAGAGT`	3	--	int¹		3		WA CSA NA	123
rs8014219^1,2	C	--	44929770(+)	`ttctcA/Ttgcct`	3	--	int¹		0	--	--	--	--
rs78481919^1,2	F	--	44930119(+)	`TTCTAA/CAATGA`	3	--	int¹		2		WA EA	238
rs72722320^1,2	C,F	--	44930172(+)	`TTGGAT/CAGGAA`	3	--	int¹		2		WA NA	238
rs201051321^1,2	C	--	44930305(-)	`GGCTGG/TTNNNN`	3	--	int¹		0	--	--	--	--
rs7159462^1,2	C,F,H	--	44931415(+)	`TATCCC/TAAGGT`	3	--	int¹		12		NS EA NA	1590
rs1952586^1,2	C,F,A,H	--	44931958(-)	`ATAATA/GATTCA`	3	--	int¹		28		NS NA EA WA CSA	2593
rs113854038^1,2	C	--	44931965(+)	`TTATGC/TGTTCA`	3	--	int¹		1		WA	2
rs61984417^1,2		--	44932051(+)	`GTTATG/TAGTTG`	3	--	int¹		1		NA	2
rs79804609^1,2	C,F	--	44932110(+)	`ATGTAA/GACTGT`	3	--	int¹		1		WA	118
rs113342558^1,2	C	--	44932414(+)	`GTTCTC/TTTCAT`	3	--	int¹		1		WA	2
rs17226046^1,2	C,F,H	--	44932523(+)	`AGTTAC/TGAAAC`	3	--	int¹		20		NA NS EA WA	2434
rs75655276^1,2	F	--	44932726(+)	`GACATT/ACACTT`	3	--	int¹		1		NA	120
rs1887994^1,2	C,F,O,H	--	44933150(-)	`GGAAAG/TTTGGA`	3	--	int¹		19		MN NA NS EA WA	2212
rs79298806^1,2	F	--	44933280(+)	`CGAAGG/AGGCGC`	3	--	int¹		1		WA	118
rs35036378^1,2	C,F	--	44933660(-)	`CGGTCT/GTTAAA`	3	--	ut5¹ int¹		1		--	100
rs34404086^1,2	C,F	--	44933771(-)	`TCGAGG/AGTGCT`	3	--	int¹ us2k¹		2		WA	218
rs3829768^1,2	C,F	--	44934133(+)	`AGGTCA/GCTGGG`	3	--	us2k¹ int¹		5		WA CSA EA	342
rs8008187^1,2	C,F	--	44934344(+)	`CCCCAG/CCAGGA`	3	--	int¹ us2k¹		2		WA	218
rs73267896^1,2	C	--	44934355(+)	`GCCCCG/AGGGTG`	3	--	us2k¹ int¹		1		WA	2
rs200774624^1,2	C	--	44935324(-)	`AGCTGA/TTTTTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs74966429^1,2		--	44935666(+)	`TGCCCC/TGCTTT`	3	--	us2k¹ int¹		1		WA	118
rs10137994^1,2	C	--	44936052(+)	`NNNNCA/GAGGAA`	1	--	int¹		3		WA NA	240
rs10483774^1,2	C,F,H	--	44936138(+)	`AGAAAG/AACAAT`	1	--	int¹		27		NS EA NA WA	2882
rs17226060^1,2	C,F,H	--	44936413(+)	`CCAAAA/GTATCC`	1	--	int¹		21		NA NS EA WA	2436
rs79689385^1,2	F	--	44936521(+)	`AACTTA/GCTAGC`	1	--	int¹		1		NA	120
rs2978380^1,2	H	--	44936773(+)	`TCCCCC/TACAGC`	1	--	int¹		4		NS EA	420
rs76874269^1,2	F	--	44936822(+)	`GACAGC/AGCATG`	1	--	int¹		1		WA	118
rs72722324^1,2	C,F	--	44936941(+)	`TTTCCG/ATAGGA`	1	--	int¹		2		WA NA	238
rs116185142^1,2	C,F	--	44937126(+)	`GTTCTG/AGGATA`	1	--	int¹		1		WA	118
rs79837534^1,2	F	--	44937826(+)	`TCTGCG/ATTGGA`	1	--	int¹		1		WA	118
rs12436302^1,2	C,F,A,H	--	44939025(+)	`GGAATC/TGTTTT`	1	--	int¹		13		NS EA NA WA	1864
rs12436325^1,2	C,F,H	--	44939131(+)	`CTGTTC/GCATGG`	1	--	int¹		7		NS EA NA WA	648
rs61984418^1,2	C	--	44939613(+)	`CAACCG/AGNNNN`	1	--	int¹		3		NA WA	240
rs61984419^1,2		--	44939800(+)	`TCGCTC/TGAGCC`	1	--	int¹		3		NA WA	240
rs61984420^1,2		--	44940094(+)	`CCTCAT/AGCATT`	1	--	int¹		3		NA WA	240
rs72722326^1,2	C,F	--	44940101(+)	`CATTTA/TTCTCT`	1	--	int¹		3		WA NA EA	358
rs35142532^1,2	C	--	44940719(-)	`AGAACG/AAGGGA`	1	--	int¹		6		MN WA	514
rs10047818^1,2	C,F,H	--	44940876(+)	`CGCACA/GTAGAT`	1	--	int¹		9		NS EA MN	814
rs35000350^1,2	C	--	44940913(-)	`CCAAGC/TCTGGG`	1	--	int¹		5		MN	396
rs75846850^1,2		--	44941158(+)	`AGAAGC/GCTTGG`	1	--	int¹		1		WA	118
rs72722327^1,2	C,F	--	44941828(+)	`TCCTGG/AGAATG`	1	--	int¹		2		WA NA	238
rs201342707^1,2	C	--	44942555(+)	`CTCTTG/TTTTTG`	1	--	int¹		0	--	--	--	--
rs72722328^1,2		--	44942756(+)	`ATCCAC/TGTGCA`	1	--	int¹		0	--	--	--	--
rs28858114^1,2	C	--	44944352(+)	`ACCAAT/CCTGGC`	1	--	int¹		2		WA CSA	3
rs28560770^1,2		--	44944744(+)	`AACACA/GGTGAA`	1	--	int¹		0	--	--	--	--
rs79051641^1,2	F	--	44945115(+)	`TCTGTG/ACATAG`	1	--	int¹		1		WA	118
rs2987980^1,2	H	--	44945589(-)	`AGTAGC/TAGAAG`	1	--	int¹		4		NS EA	416
rs28663685^1,2	C	--	44945716(+)	`ACAAAC/TAAAGG`	1	--	int¹		4		WA CSA NA	241
rs72722333^1,2	C,F	--	44946146(+)	`CCACTG/AAAGCC`	1	--	int¹		1		NA	120
rs12323439^1,2	C	--	44946760(+)	`ccaccA/Gcaccg`	1	--	int¹		5		WA CSA NA EA	361
rs77852880^1,2	F	--	44947141(+)	`GGCTTT/CATTGA`	1	--	int¹		2		WA EA	238
rs12436533^1,2	C,F,H	--	44947633(+)	`gtatcT/Ccacaa`	1	--	int¹		5		NS EA	508
rs10136822^1,2	C,F,A,H	--	44947977(+)	`TATGTC/AATAAA`	1	--	int¹		8		NA WA CSA EA	367
rs113592112^1,2	C	--	44948016(+)	`GGTCA-/TTTATC`	1	--	int¹		1		CSA	2
rs10137185^1,2	C,F,A,H	--	44948315(+)	`AGGATC/TAAATA`	1	--	int¹		22		NS EA NA WA CSA	2755
rs12432174^1,2	C,A,H	--	44949546(+)	`AAAaaA/Taataa`	1	--	int¹		0	--	--	--	--
rs79181848^1,2	F	--	44950092(+)	`CTCCTT/ACTTGA`	1	--	int¹		1		WA	118
rs112600825^1,2	C,F	--	44950605(+)	`TAAAAG/TCCTAC`	1	--	int¹		1		WA	118
rs55857324^1,2		--	44950758(+)	`CAGGTA/GTGGTG`	1	--	int¹		0	--	--	--	--
rs73269910^1,2	C	--	44950805(+)	`GATGAG/AAGAAT`	1	--	int¹		1		WA	2
rs72722336^1,2	C,F	--	44951416(+)	`GTCATA/GTATAC`	1	--	int¹		1		NA	120
rs8019025^1,2	C,F,A,H	--	44951976(+)	`agttcA/Gagacc`	1	--	int¹		18		NS EA NA WA CSA	2057
rs73269912^1,2	C	--	44952244(+)	`TAACTG/ATATGG`	1	--	int¹		1		WA	2
rs10139423^1,2	C,F	--	44952340(+)	`AAGTGT/CCAAAC`	1	--	int¹		3		WA CSA	122
rs10142856^1,2	C,F	--	44953060(+)	`aacccA/Gggagg`	1	--	int¹		4		NA WA CSA	7
rs72722337^1,2	C,F	--	44953092(+)	`ATCTCG/ACCACT`	1	--	int¹		1		NA	120
rs57701478^1,2	C	--	44953126(+)	`GGAGAC/TTCTGT`	1	--	int¹		2		NA	122
rs79390726^1,2	C,F	--	44953182(+)	`AAATCC/AACTAT`	1	--	int¹		1		WA	118
rs112593266^1,2	C	--	44953271(+)	`CCAGCA/GTCAAC`	1	--	int¹		0	--	--	--	--
rs76776451^1,2	C,F	--	44953327(+)	`GCTACA/GCAACC`	1	--	int¹		1		WA	118
rs34187403^1,2	C,F,H	--	44953458(+)	`AACTAG/AAAACC`	1	--	int¹		4		NS NA	232
rs10146107^1,2	C,A,H	--	44954151(+)	`aaaaaG/Aaaaaa`	1	--	int¹ trp³		2		NA CSA	3
rs10146464^1,2	C,A,H	--	44954229(+)	`TggacA/Gcggtg`	1	--	int¹		3		NA WA CSA	5
rs111574153^1,2		--	44955303(+)	`AGGCTG/AGAGTG`	1	--	int¹		2		CSA WA	120
rs28811117^1,2	C,F	--	44955544(+)	`AGCCAC/TAGTGC`	1	--	int¹		2		WA NA	238
rs28862689^1,2	C	--	44955545(+)	`GCCACA/GGTGCC`	1	--	int¹		4		CSA WA NA EA	360
rs28871406^1,2	C	--	44955602(+)	`TATCCG/TGATGG`	1	--	int¹		5		WA CSA NA	242
rs7146908^1,2	C,F,H	--	44956963(+)	`AAAATC/GAATGT`	1	--	int¹		9		NS EA NA WA	662
rs111554949^1,2	C	--	44957995(+)	`AAATTC/TTAAAT`	1	--	int¹		1		WA	2
rs61509785^1,2	F	--	44958438(+)	`TACTAG/AAACAA`	1	--	int¹		1		WA	118
rs61516384^1,2	C	--	44958581(+)	`ACAACG/ATAGGA`	1	--	int¹		1		WA	2
rs73269919^1,2	C	--	44958626(+)	`TTTGGG/ATACAA`	1	--	int¹		1		WA	2
rs75516996^1,2	C	--	44958947(+)	`TAGGGA/GACTGC`	1	--	int¹		2		WA	120
rs12434123^1,2	H	--	44959028(+)	`aaatgA/Ctggtg`	1	--	int¹		0	--	--	--	--
rs73269921^1,2	C	--	44959487(+)	`CACGAC/TATTCT`	1	--	int¹		4		WA CSA NA	241
rs73269922^1,2	C	--	44959727(+)	`GGGCAG/ATGAAA`	1	--	int¹		1		WA	2
rs61984422^1,2	C	--	44959829(+)	`AACCCC/TGNNNN`	1	--	int¹		3		NA WA	240
rs201048076^1,2	C	--	44960555(+)	`AGAAGA/CAAAAA`	1	--	int¹		0	--	--	--	--
rs7150300^1,2	C,H	--	44960577(+)	`CTTTTT/ATGGGT`	1	--	int¹		4		NS EA	414
rs28533821^1,2	C	--	44961747(+)	`AGACCT/CTATCT`	1	--	int¹		5		WA CSA NA EA	361
rs113873288^1,2	C	--	44962644(+)	`GACAGC/AGCTTC`	1	--	int¹		1		CSA	1
rs75344118^1,2	F	--	44962703(+)	`ACCTCG/AGCCTC`	1	--	int¹		2		WA EA	238
rs28402888^1,2	C,F	--	44963334(+)	`GAGTGC/TGGTAG`	1	--	int¹		7		NA WA CSA EA	365
rs73269927^1,2	C	--	44963911(+)	`AGTAAG/ACATCT`	1	--	int¹		4		WA CSA NA	241
rs117171778^1,2	C,F	--	44964158(+)	`TCAGAG/TGTTAA`	1	--	int¹		1		NA	120
rs8004284^1,2	C	--	44964790(+)	`TATGAA/CTATTC`	1	--	int¹		4		WA CSA NA	241
rs8005720^1,2	C,F	--	44964793(+)	`NNNNAT/CTCCAC`	1	--	int¹		2		WA NA	238
rs8004907^1,2	C	--	44964894(+)	`ataacG/Atggat`	1	--	int¹		6		WA CSA NA EA	362
rs9788542^1,2	C	--	44964983(+)	`aagacG/Aatgag`	1	--	int¹		4		NA WA EA	242
rs9788467^1,2	C,F	--	44965605(+)

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ESR2 Gene

estrogen receptor 2 (ER beta)

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Export list of displayed genes

ESR2 Gene

estrogen receptor 2 (ER beta)

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Summariesfor ESR2 gene

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Protein Domains /Familiesfor ESR2 gene

Functionfor ESR2 gene

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