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ESR2 Gene

protein-coding   GIFtS: 70
GCID: GC14M064550

Estrogen Receptor 2 (ER Beta)

  See ESR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Estrogen Receptor 2 (ER Beta)1 2     Erb2
Nuclear Receptor Subfamily 3 Group A Member 22 3     Estrogen Nuclear Receptor Beta Variant A2
ESTRB2 3     Estrogen Nuclear Receptor Beta Variant B2
NR3A22 3     Estrogen Receptor Beta2
ER-BETA2     Estrogen Receptor Beta 42
ESR-BETA2     ER-beta3
ESRB2     

External Ids:    HGNC: 34681   Entrez Gene: 21002   Ensembl: ENSG000001400097   OMIM: 6016635   UniProtKB: Q927313   

Export aliases for ESR2 gene to outside databases

Previous GC identifers: GC14M062021 GC14M058487 GC14M062683 GC14M062685 GC14M063621 GC14M063763 GC14M064693 GC14M044866


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ESR2 Gene:
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription
factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is
localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the
encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription.
Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively
spliced transcript variants of this gene have been described, but the full-length nature of some of these
variants has not been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ESR2 Gene:
ESR2 (estrogen receptor 2 (ER beta)) is a protein-coding gene. Diseases associated with ESR2 include serous cystadenocarcinoma, and gender identity disorder. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates
expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform
beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of
ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in
the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at
elevated temperature is more gradual

summary for ESR2 Gene:
Estrogen controls many cellular processes including growth, differentiation and function of the reproductive
system. In females, estrogen's main targets are the ovaries, uterus, vagina and mammary glands. In the male,
target organs are the testes, prostate and epididymis. Estrogen is also responsible for the growth and
maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen
exerts most of its actions via estrogen receptors (ER). Estrogen receptors are ligand-activated
transcription factors belonging to the nuclear hormone receptor superfamily. Today, two estrogen receptors
are known, ERalpha and ERbeta. ERalpha protein is highly homologous to ERbeta protein, especially in the DNA
and ligand binding domains, although divergence exists in the N-terminal transactivation domain. Both
receptors interact with the same DNA response element and show a similar ligand binding profile. Upon ligand
binding estrogen receptors undergo a conformational change allowing spontaneous dimerization to form either
homo- or heterodimers. As a dimer, the estrogen receptor binds to the estrogen response element (ERE) in the
promoter region of target genes. ERalpha and ERbeta which are present in a broad spectrum of tissues.

Gene Wiki entry for ESR2 (Estrogen receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ESR2 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ESR2 promoter sequence
   Search Chromatin IP Primers for ESR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q21-q22

ESR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESR2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064550:  view genomic region     (about GC identifiers)

Start:
64,550,950 bp from pter      End:
64,805,268 bp from pter
Size:
254,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731 (See protein sequence)
Recommended Name: Estrogen receptor beta  
Size: 530 amino acids; 59216 Da
Subunit: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6
coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C.
Isoform beta-2/cx preferentially forms a heterodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1.
Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the
presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including
cyclin-D1/CCND1 AP-1 promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2
Sequence caution: Sequence=CAA67555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for ESR2 (see all 30):
1L2J (3D)        1NDE (3D)        1QKM (3D)        1U3Q (3D)        1U3R (3D)        1U3S (3D)    
Secondary accessions: A8K8K5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31
Q9UEV6 Q9UHD3 Q9UQK9
Alternative splicing: 8 isoforms:  Q92731-1   Q92731-2   Q92731-3   Q92731-4   Q92731-5   Q92731-6   Q92731-7   Q92731-8   
(Does not form homodimers)

Explore the universe of human proteins at neXtProt for ESR2: NX_Q92731

Explore proteomics data for ESR2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-87 and Ser-105 recruits NCOA11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ESR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035365.1  NP_001201831.1  NP_001201832.1  NP_001258805.1  NP_001258806.1  NP_001428.1  

    ENSEMBL proteins: 
     ENSP00000452485   ENSP00000450699   ENSP00000351412   ENSP00000450488   ENSP00000345616  
     ENSP00000452426   ENSP00000451582   ENSP00000343925   ENSP00000441792   ENSP00000335551  
     ENSP00000350427   ENSP00000267525  
    Reactome Protein details: Q92731

    ESR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ESR2
    OriGene Protein Over-expression Lysate for ESR2
    OriGene MassSpec for ESR2
    OriGene Custom Protein Services for ESR2
    GenScript Custom Purified and Recombinant Proteins Services for ESR2
    Novus Biologicals ESR2 Proteins
    Novus Biologicals ESR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ESR2 

    ESR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ESR2
    R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
    OriGene Antibodies for ESR2
    OriGene Custom Antibody Services for ESR2
    Novus Biologicals ESR2 Antibodies
    Abcam antibodies for ESR2 (P03372, Q92731)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ESR2
    LSBio Antibodies in human, mouse, rat for ESR2

    ESR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ESR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ESR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ESR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Estrogen receptor-beta
    3A. Estrogen receptors

    Selected InterPro protein domains (see all 8):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR024178 Oest_rcpt/oest-rel_rcp
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry Q92731

    ProtoNet protein and cluster: Q92731

    1 Blocks protein domain: IPB001723 Steroid hormone receptor signature

    UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with ESR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ESR2_HUMAN, Q92731
    Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates
    expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform
    beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of
    ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in
    the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at
    elevated temperature is more gradual

         Genatlas biochemistry entry for ESR2:
    estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced isoforms (hER beta
    1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine leiomyomata,see ULCR14

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA15345745
    GO:0003677DNA binding TAS9636657
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8769313
    GO:0003707steroid hormone receptor activity TAS10749889
    GO:0003713transcription coactivator activity TAS8769313
         
    Find genes that share ontologies with ESR2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ESR2:
     Increased G1 DNA content  Increased cell death in breast  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Esr2) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with ESR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ESR2: Esr2tm1.2Pcn Esr2tm1Aghe Esr2tm1Psh Esr2tm1Mma Esr2tm1Unc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ESR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ESR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ESR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ESR2:
    hsa-mir-335-5p (MIRT017943), hsa-mir-92a-3p (MIRT004563)

    Block miRNA regulation of human, mouse, rat ESR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ESR2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ESR2
    Predesigned siRNA for gene silencing in human, mouse, rat ESR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ESR2

    Clone
    Products:
         
    OriGene clones in human, mouse for ESR2 (see all 19)
    OriGene ORF clones in mouse, rat for ESR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
    Sino Biological Human cDNA Clone for ESR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2
    Addgene plasmids for ESR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ESR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ESR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ESR2_HUMAN, Q92731: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    extracellular4
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS9671811
    GO:0005634nucleus TAS11181953
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA15024130

    Find genes that share ontologies with ESR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ESR2 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3ERK Signaling
    ERK Signaling0.61
    4GPCR Pathway
    Estrogen Pathway0.55
    5Chks in Checkpoint Regulation
    Estrogen-mediated S-Phase Entry0.55


    Find genes that share SuperPaths with ESR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ESR2
        TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ESR2 (see all 6)
        ERK Signaling
    Estrogen-mediated S-Phase Entry
    eNOS Signaling
    Estrogen Pathway
    MNAR-PELP1 and Estrogen Receptor Interaction

    2 GeneGo (Thomson Reuters) Pathways for ESR2
        Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5 BioSystems Pathways for ESR2
        Nuclear Receptors
    SIDS Susceptibility Pathways
    Ovarian Infertility Genes
    Integrated Pancreatic Cancer Pathway
    Plasma membrane estrogen receptor signaling


    1 Reactome Pathway for ESR2
        Nuclear Receptor transcription pathway

    1 PharmGKB Pathway for ESR2
        Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for ESR2):
        Estrogen signaling pathway
    Prolactin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ESR2 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Breast Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ESR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ESR2 (Q927311, 3 ENSP000003439254) via UniProtKB, MINT, STRING, and/or I2D (see all 453) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    HIST1H4FP628053I2D: score=1 
    HIST1H4HP628053I2D: score=1 
    HIST1H4IP628053I2D: score=1 
    HIST1H4JP628053I2D: score=1 
    HIST1H4KP628053I2D: score=1 
    HIST2H4AP628053I2D: score=1 
    HIST2H4BP628053I2D: score=1 
    HIST4H4P628053I2D: score=1 
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    ENSG00000234475P081073I2D: score=1 
    ENSG00000235941P081073I2D: score=1 
    HSPA1AP081073I2D: score=1 
    HSPA1BP081073I2D: score=1 
    ENSG00000235650P622693, ENSP000004161104I2D: score=1 STRING: ENSP00000416110
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    RPS18P622693I2D: score=1 
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    ENSG00000227460Q96PV03, ENSP000004142594I2D: score=1 STRING: ENSP00000414259
    PPP5CP530411, 3, ENSP000000124434EBI-78505,EBI-716663 I2D: score=1 STRING: ENSP00000012443
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    NCOA1Q157883, ENSP000003209404I2D: score=5 STRING: ENSP00000320940
    MED1Q156483, ENSP000003006514I2D: score=4 STRING: ENSP00000300651
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=4 STRING: ENSP00000361066
    NCOA6Q146863, ENSP000003518944I2D: score=4 STRING: ENSP00000351894
    RBM39Q144983, ENSP000002533634I2D: score=4 STRING: ENSP00000253363
    SP1P080473, ENSP000003293574I2D: score=4 STRING: ENSP00000329357
    BCAS2O759343, ENSP000003585544I2D: score=3 STRING: ENSP00000358554
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=3 STRING: ENSP00000352137
    PPARGC1AQ9UBK23, ENSP000002648674I2D: score=3 STRING: ENSP00000264867
    STAT5AP422293, ENSP000003412084I2D: score=3 STRING: ENSP00000341208
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    MAPK11Q157593, ENSP000003336854I2D: score=2 STRING: ENSP00000333685
    MED16Q9Y2X03, ENSP000003256124I2D: score=2 STRING: ENSP00000325612
    MED17Q9NVC63, ENSP000002518714I2D: score=2 STRING: ENSP00000251871
    MED23Q9ULK43, ENSP000003570474I2D: score=2 STRING: ENSP00000357047
    NCOR2Q9Y6183, ENSP000003485514I2D: score=2 STRING: ENSP00000348551
    PIAS1O759253, ENSP000002496364I2D: score=2 STRING: ENSP00000249636
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    ZBTB17Q131053, ENSP000003648954I2D: score=2 STRING: ENSP00000364895
    ACAD11Q709F03, ENSP000002649904I2D: score=1 STRING: ENSP00000264990
    ACSM2BQ68CK63, ENSP000003274534I2D: score=1 STRING: ENSP00000327453
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    ANAPC5Q9UJX43, ENSP000002618194I2D: score=1 STRING: ENSP00000261819
    ANKFY1Q9P2R33, ENSP000003433624I2D: score=1 STRING: ENSP00000343362
    BCLAF1Q9NYF83, ENSP000000311354I2D: score=1 STRING: ENSP00000031135
    C19orf68Q86XI83, ENSP000003313634I2D: score=1 STRING: ENSP00000331363
    CCNCP248633, ENSP000003582224I2D: score=1 STRING: ENSP00000358222
    CDC16Q130423, ENSP000003485544I2D: score=1 STRING: ENSP00000348554
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    CNTRLQ7Z7A13, ENSP000002383414I2D: score=1 STRING: ENSP00000238341
    COPB2P356063, ENSP000003294194I2D: score=1 STRING: ENSP00000329419
    COPG2Q9UBF23, ENSP000003939124I2D: score=1 STRING: ENSP00000393912
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    CSE1LP550603, ENSP000002629824I2D: score=1 STRING: ENSP00000262982
    CTTNQ142473, ENSP000003018434I2D: score=1 STRING: ENSP00000301843
    CWC27Q6UX043, ENSP000003704604I2D: score=1 STRING: ENSP00000370460
    DAP3P513983, ENSP000003416924I2D: score=1 STRING: ENSP00000341692
    DBN1Q166433, ENSP000002923854I2D: score=1 STRING: ENSP00000292385
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    PTCD3Q96EY73, ENSP000002546304I2D: score=1 STRING: ENSP00000254630
    PTPN23Q9H3S73, ENSP000002655624I2D: score=1 STRING: ENSP00000265562
    PURAQ005773, ENSP000003327064I2D: score=1 STRING: ENSP00000332706
    RALYQ9UKM93, ENSP000002461944I2D: score=1 STRING: ENSP00000246194
    RBM10P981753, ENSP000003668294I2D: score=1 STRING: ENSP00000366829
    RBM14Q96PK63, ENSP000003117474I2D: score=1 STRING: ENSP00000311747
    RBM28Q9NW133, ENSP000002230734I2D: score=1 STRING: ENSP00000223073
    RBM43Q6ZSC33, ENSP000003312114I2D: score=1 STRING: ENSP00000331211
    RBM47A0AV963, ENSP000002959714STRING: ENSP00000295971 I2D: score=1 
    RBMXL2O755263, ENSP000003041394I2D: score=1 STRING: ENSP00000304139
    RFC4P352493, ENSP000002962734I2D: score=1 STRING: ENSP00000296273
    RMDN3Q96TC73, ENSP000002603854I2D: score=1 STRING: ENSP00000260385
    RPL10AP629063, ENSP000003630184I2D: score=1 STRING: ENSP00000363018
    RPL18AQ025433, ENSP000002222474I2D: score=1 STRING: ENSP00000222247
    RPL29P479143, ENSP000002941894I2D: score=1 STRING: ENSP00000294189
    RPL36Q9Y3U83, ENSP000002525434I2D: score=1 STRING: ENSP00000252543
    RPL36ALQ969Q03, ENSP000003460124I2D: score=1 STRING: ENSP00000346012
    RPL3LQ929013, ENSP000002686614I2D: score=1 STRING: ENSP00000268661
    RPL7P181243, ENSP000003397954I2D: score=1 STRING: ENSP00000339795
    RPL7AP624243, ENSP000003610764I2D: score=1 STRING: ENSP00000361076
    RPS11P622803, ENSP000002706254I2D: score=1 STRING: ENSP00000270625
    RPS16P622493, ENSP000002514534I2D: score=1 STRING: ENSP00000251453
    RPS17P087083, ENSP000003460454I2D: score=1 STRING: ENSP00000346045
    RPS24P628473, ENSP000004143214I2D: score=1 STRING: ENSP00000414321
    RPS27AP629793, ENSP000002723174I2D: score=1 STRING: ENSP00000272317
    RPS7P620813, ENSP000003390954I2D: score=1 STRING: ENSP00000339095
    RPS9P467813, ENSP000003028964I2D: score=1 STRING: ENSP00000302896
    RRBP1Q9P2E93, ENSP000003540454I2D: score=1 STRING: ENSP00000354045
    RRP12Q5JTH93, ENSP000003600314I2D: score=1 STRING: ENSP00000360031
    SF3B3Q153933, ENSP000003057904I2D: score=1 STRING: ENSP00000305790
    SHROOM3Q8TF723, ENSP000002960434I2D: score=1 STRING: ENSP00000296043
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    SIPA1L2Q9P2F83, ENSP000002628614I2D: score=1 STRING: ENSP00000262861
    SMARCC2Q8TAQ23, ENSP000002670644I2D: score=1 STRING: ENSP00000267064
    SMC1AQ146833, ENSP000003234214I2D: score=1 STRING: ENSP00000323421
    SMTNP538143, ENSP000003515934I2D: score=1 STRING: ENSP00000351593
    SND1Q7KZF43, ENSP000003467624I2D: score=1 STRING: ENSP00000346762
    SPRR1BP225283, ENSP000003064614I2D: score=1 STRING: ENSP00000306461
    SRSF2Q011303, ENSP000003508774I2D: score=1 STRING: ENSP00000350877
    STAU1O957933, ENSP000003609224I2D: score=1 STRING: ENSP00000360922
    SURF6O756833, ENSP000003610924I2D: score=1 STRING: ENSP00000361092
    TAF15Q928043, ENSP000003095584I2D: score=1 STRING: ENSP00000309558
    TCOF1Q134283, ENSP000004068884I2D: score=1 STRING: ENSP00000406888
    TEX10Q9NXF13, ENSP000003640374I2D: score=1 STRING: ENSP00000364037
    TTC21BQ7Z4L53, ENSP000002433444I2D: score=1 STRING: ENSP00000243344
    UBN1Q9NPG33, ENSP000002623764I2D: score=1 STRING: ENSP00000262376
    UBR3Q6ZT123, ENSP000003960684I2D: score=1 STRING: ENSP00000396068
    VIMP086703, ENSP000002242374I2D: score=1 STRING: ENSP00000224237
    VMACQ2NL983, ENSP000003433484I2D: score=1 STRING: ENSP00000343348
    VPS41P497543, ENSP000003094574I2D: score=1 STRING: ENSP00000309457
    ZNF512BQ96KM63, ENSP000002171304I2D: score=1 STRING: ENSP00000217130
    PNRC1Q127963I2D: score=3 
    PNRC2Q9NPJ43I2D: score=3 
    ACTN3Q080433I2D: score=1 
    CWC15Q9P0133I2D: score=1 
    EFTUD2Q150293I2D: score=1 
    EIF3IQ133473I2D: score=1 
    FBLL1A6NHQ23I2D: score=1 
    FTSJ3Q8IY813I2D: score=1 
    H2BFSP570533I2D: score=1 
    LARP1Q6PKG03I2D: score=1 
    MED10Q9BTT43I2D: score=1 
    PSMC5P621953I2D: score=1 
    PWP1Q136103I2D: score=1 
    RPL17P186213I2D: score=1 
    RPS25P628513I2D: score=1 
    C3ENSP000002459074STRING: ENSP00000245907
    ESRRAENSP000000004424STRING: ENSP00000000442
    ESRRBENSP000002615324STRING: ENSP00000261532
    ESRRGENSP000003861714STRING: ENSP00000386171
    HNF4AENSP000003129874STRING: ENSP00000312987
    NR1D1ENSP000002466724STRING: ENSP00000246672
    NR1H2ENSP000002537274STRING: ENSP00000253727
    NR2C1ENSP000003332754STRING: ENSP00000333275
    NR2C2ENSP000003204474STRING: ENSP00000320447
    NR2F1ENSP000003258194STRING: ENSP00000325819
    NR2F6ENSP000002914424STRING: ENSP00000291442
    NR4A1ENSP000002430504STRING: ENSP00000243050
    NR4A2ENSP000003444794STRING: ENSP00000344479
    NR5A1ENSP000003626904STRING: ENSP00000362690
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15345745
    GO:0001541ovarian follicle development IEA--
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated TAS11181953

    Find genes that share ontologies with ESR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ESR2
      Browse compounds at ApexBio 

    Compounds for ESR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (Z)-4-HydroxytamoxifenMetabolite of tamoxifen (Cat. No. 0999)[68047-06-3]
    ICI 182,780 Estrogen receptor antagonist[129453-61-8]
    DPNHighly potent ERbeta agonist[1428-67-7]
    PPTSubtype-selective ERalpha agonist[263717-53-9]
    PHTPPSelective ERbeta antagonist[805239-56-9]

    1 HMDB Compound for ESR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--

    Selected DrugBank Compounds for ESR2 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TamoxifenICI-46474 (see all 3)10540-29-1targetantagonist agonist17158759 20827267 16822624 11752352 16326830 16010412 2011412 17404078
    RaloxifeneLY-139481 (see all 6)84449-90-1targetagonist11861516 10418979 11810032 11752352 12097269 11500849
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0target--17139284 17016423 10592235
    N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide-- --target--17139284 17016423 10592235
    Para-Mercury-Benzenesulfonic Acid-- --target--17139284 17016423 10592235
    Trilostane-- 13647-35-3targetallosteric modulator12209583 16806905 17109615
    4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol-- --target--17139284 17016423
    DiethylstilbestrolDES (see all 10)56-53-1targetagonist15123288 19101832
    Estradiol17beta oestradiol (see all 7)50-28-2targetagonist17464340 2011412
    EstropipateEstropipate (usp) (see all 4)7280-37-7targetagonist17464340 2011412

    Selected IUPHAR Ligands for ESR2 (Estrogen receptor-beta) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    4-hydroxy?aetamoxifen
    AntagonistAntagonist10.69048584
    diethylstilbestrol
    AgonistAgonist9.89048584
    17beta-estradiol
    AgonistAgonist9.349048584
    WAY200070
    AgonistFull agonist8.52 - 915456246
    fulvestrant
    AntagonistAntagonist8.74--
    diarylpropionitril
    AgonistAgonist8.611150164 11708925
    R,R-THC
    AntagonistAntagonist8.449927308 10395487
    estriol
    AgonistAgonist8.49048584
    genistein
    AgonistAgonist8.29048584
    estrone
    AgonistAgonist7.939048584

    Selected Novoseek inferred chemical compound relationships for ESR2 gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 96.1 3585 19800101 (9), 18620727 (7), 12895004 (6), 16214508 (6) (see all 99)
    4-hydroxytamoxifen 85.1 40 17464340 (6), 18663360 (4), 11720858 (2), 16782818 (2) (see all 21)
    estradiol 84.7 197 10601611 (6), 10342855 (4), 19001520 (4), 15345745 (3) (see all 99)
    tamoxifen 81.9 167 16010412 (8), 19744542 (5), 11078914 (4), 17404078 (4) (see all 76)
    fulvestrant 80.1 13 19528477 (2), 19212635 (2), 17923257 (1), 16549430 (1) (see all 7)
    progesterone 80 273 16033082 (5), 17905466 (3), 19200930 (3), 19094096 (2) (see all 99)
    raloxifene 80 38 10076999 (2), 11720858 (2), 15138633 (2), 17962382 (2) (see all 26)
    steroid 76.9 114 10499535 (2), 11775002 (2), 11806710 (2), 12702147 (2) (see all 78)
    genistein 76.1 109 16596234 (5), 19556829 (5), 16513288 (5), 18258689 (4) (see all 51)
    daidzein 73.5 39 14664520 (5), 11431145 (3), 16673816 (2), 16972265 (2) (see all 17)

    4 PharmGKB related drug/compound annotations for ESR2 gene    About this table
    Drug/compound PharmGKB Annotation
    anastrozole
    exemestane
    fulvestrant
    tamoxifen  CA  



    Find genes that share compounds with ESR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for ESR2 gene (7 alternative transcripts): 
    NM_001040275.1  NM_001214902.1  NM_001214903.1  NM_001271876.1  NM_001271877.1  NM_001437.2  NM_001040276.1  

    Unigene Cluster for ESR2:

    Estrogen receptor 2 (ER beta)
    Hs.660607  [show with all ESTs]
    Unigene Representative Sequence: AB006589
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556275 ENST00000554572(uc001xgy.2 uc001xgv.3 uc001xgw.3 uc001xgx.3)
    ENST00000358599(uc001xgz.2) ENST00000555278 ENST00000344288 ENST00000553796
    ENST00000557772 ENST00000555483(uc010aqd.1) ENST00000554520 ENST00000341099(uc010aqb.1 uc010aqc.1 uc001xha.1)
    ENST00000555783 ENST00000542956 ENST00000353772(uc001xgu.3) ENST00000357782
    ENST00000267525
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ESR2
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    OriGene clones in human, mouse for ESR2 (see all 19)
    OriGene ORF clones in mouse, rat for ESR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2
    Addgene plasmids for ESR2 
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    OriGene qPCR primer pairs and template standards for ESR2
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      QuantiTect SYBR Green Assays in human, mouse, rat ESR2
      QuantiFast Probe-based Assays in human, mouse, rat ESR2

    Additional mRNA sequence: 

    AB006589.1 AB006590.1 AF047463.1 AF051427.1 AF051428.1 AF061054.1 AF074598.1 AF074599.1 
    AK292370.1 AY438022.1 BC006461.1 BC024181.2 DQ777076.1 DQ777077.1 DQ838582.1 DQ838583.1 
    HQ692820.1 HQ692821.1 NR_073496.1 NR_073497.1 NR_073505.1 X99101.1 

    11 DOTS entries:

    DT.310701  DT.100751205  DT.102837012  DT.120767971  DT.120767979  DT.40120425  DT.92419264  DT.40125379 
    DT.95367837  DT.91703242  DT.100740263 

    Selected AceView cDNA sequences (see all 316):

    CA867834 AK095241 AI200286 AA814679 AW731703 NM_182913 AW451449 AF435011 
    BM469251 CA423800 BM562970 AY061758 BG110769 AY184204 BP364494 BE856003 
    BQ269694 AA972285 BE673396 BU101582 AK095087 BI914129 CA868590 BM019005 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ESR2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                              -                       -     -     -     -   
    SP3:                    -     -     -     -     -     -     -     -                                               -     -                 -     -     -     -   
    SP4:                                                                                                              -                                             
    SP5:                                                                                            -                                                               

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:  -                     
    SP3:  -                     
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ESR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ESR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACAGTG
    ESR2 Expression
    About this image


    ESR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
             oocyte   
    ESR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ESR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660607

    UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
    Tissue specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain,
    placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also
    found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is
    expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small
    intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4
    is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5
    is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung,
    liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not
    expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ESR2 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Breast Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ESR2
    OriGene qSTAR qPCR primer pairs in human, mouse for ESR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ESR2
    QuantiTect SYBR Green Assays in human, mouse, rat ESR2
    QuantiFast Probe-based Assays in human, mouse, rat ESR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ESR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Esr21 , 5 estrogen receptor 2 (beta)1, 5 84.65(n)1
    88.68(a)1
      12 (33.52 cM)5
    139831  NM_010157.31  NP_034287.31 
     761204195 
    chicken
    (Gallus gallus)
    Aves ESR21 estrogen receptor 2 (ER beta) 74.78(n)
    80.7(a)
      395575  NM_204794.2  NP_990125.1 
    lizard
    (Anolis carolinensis)
    Reptilia ESR26
    estrogen receptor 2 (ER beta)
    70(a)
    1 ↔ 1
    1(1646467-1679450)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC3944602 estrogen receptor beta 79.44(n)    AY310903.1 
    zebrafish
    (Danio rerio)
    Actinopterygii esr2a2 estrogen receptor 2a 77.22(n)   317734  AF516874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ERR6
    estrogen-related receptor
    26(a)
    1 → many
    3L(8176461-8179771)


    ENSEMBL Gene Tree for ESR2 (if available)
    TreeFam Gene Tree for ESR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ESR2 gene
    NR4A32  ESRRA2  NR3C22  NR4A12  PGR2  NR3C12  AR2  NR4A22  
    ESRRB2  ESR12  ESRRG2  
    Selected SIMAP similar genes for ESR2 using alignment to 4 protein entries:     ESR2_HUMAN (see all proteins) (see all similar genes):
    NR3A2    ESR1    NR3C2    HNF4G    NR2C2    HNF4alpha
    NR1I3    VDR    NR3A1    NR5A1    ESRRG    THRB
    NR3B3    ERRgamma    NR1H3    ESRRB    NR3C4    RARG

    Find genes that share paralogs with ESR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ESR2 (see all 2376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161649971,2
    C,F--44866330(+) GCCCCT/CTGTTG 4 -- ds5001 int11Minor allele frequency- C:0.03WA 118
    rs1390048851,2
    --44866383(+) GAGGAC/TAGGCA 4 -- nc-transcript-variantut310--------
    rs12559981,2
    C,F,A,H--44866453(-) CTGTGC/GCTGCC 4 -- ut31 nc-transcript-variant22Minor allele frequency- G:0.39MN EA NA NS WA CSA 3005
    rs582623691,2
    C--44866494(+) CTTCTC/TTGCCA 4 -- nc-transcript-variantut313Minor allele frequency- T:0.08CSA WA EA 239
    rs80186871,2
    C,F,H--44866664(+) ATTGTT/CGGATT 5 -- nc-transcript-variantut31 ds500126Minor allele frequency- C:0.23NA NS EA WA CSA 2485
    rs1146297271,2
    C,F--44866728(+) AACTCT/CTTCTT 5 -- nc-transcript-variantut31 ds50011Minor allele frequency- C:0.02WA 118
    rs284409701,2
    C,F--44866740(+) AAAATT/CATTTT 5 -- nc-transcript-variantut31 ds50012Minor allele frequency- C:0.07NA EA 240
    rs1422199231,2
    --44866752(+) TTCATG/TGATTA 5 -- nc-transcript-variantut31 ds50010--------
    rs9285541,2
    C,F,O,A,H--44866777(-) CTTCAA/GTTTCC 5 -- ut31 ds5001 nc-transcript-variant33Minor allele frequency- G:0.31MN EA NA NS WA CSA 4528
    rs2014852811,2
    --44866797(+) TACCCA/GAGATT 5 -- nc-transcript-variantut31 ds50010--------

    HapMap Linkage Disequilibrium report for ESR2 (64550950 - 64800950 bp, first 250kb of ESR2)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ESR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748782CNV Deletion23290073
    esv2351050CNV Deletion18987734
    esv2748779CNV Deletion23290073
    nsv902021CNV Loss21882294
    nsv1307CNV Loss18451855
    nsv902019CNV Gain21882294
    nsv524908CNV Gain19592680
    nsv456326CNV Gain19166990

    Human Gene Mutation Database (HGMD): ESR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ESR2
    DNA2.0 Custom Variant and Variant Library Synthesis for ESR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601663    OMIM disorders: --

    Selected diseases for ESR2 (see all 22):    
    About MalaCards
    serous cystadenocarcinoma    gender identity disorder    lobular neoplasia    germ cell cancer
    vaginitis    ovarian serous cystadenocarcinoma    progesterone resistance    fallopian tube cancer
    transsexualism    peritoneal mesothelioma    malignant peritoneal mesothelioma    cystadenocarcinoma
    dental fluorosis    ovarian endometriosis    ovarian clear cell adenocarcinoma    enchondroma
    primary pigmented nodular adrenocortical disease    endometriosis    leiomyoma    osteoporosis

    6 diseases from the University of Copenhagen DISEASES database for ESR2:
    Breast cancer     Osteoporosis     Endometrial cancer     Endometriosis
    Prostate cancer     Carcinoma

    Find genes that share disorders with ESR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ESR2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 79 565 14576822 (6), 19463683 (6), 14620916 (5), 18771580 (5) (see all 99)
    endometrial cancer 65.1 37 19438492 (4), 15968319 (4), 12873984 (3), 19758455 (2) (see all 21)
    breast carcinoma 59.9 45 15363297 (4), 20306984 (2), 16327431 (2), 15656884 (2) (see all 27)
    endometrial carcinoma 58 26 15573770 (4), 11109162 (4), 16324249 (3), 17649814 (2) (see all 13)
    prostate cancer 53.7 133 17908481 (6), 16551880 (5), 11752866 (5), 17913855 (5) (see all 59)
    tumors 52.9 503 11042568 (6), 12750263 (6), 11676856 (5), 15257551 (5) (see all 99)
    endometriosis 51.9 44 16210018 (4), 19001520 (4), 19878085 (4), 17336962 (3) (see all 16)
    cancer 48.3 123 12921561 (5), 18085520 (4), 16615154 (4), 11734621 (3) (see all 78)
    osteoporosis 39.5 17 16530497 (2), 10709863 (1), 18172701 (1), 18406312 (1) (see all 12)
    prostatic intraepithelial neoplasia 39.4 6 11438457 (1), 12497580 (1), 19672287 (1)

    Genetic Association Database (GAD): ESR2
    Human Genome Epidemiology (HuGE) Navigator: ESR2 (224 documents)

    Export disorders for ESR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ESR2 gene, integrated from 10 sources (see all 1738):
    (articles sorted by number of sources associating them with ESR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results. (PubMed id 20827267)1, 4, 7 Hayes D.F....Flockhart D.A. (Clin. Pharmacol. Ther. 2010)
    2. ER beta: identification and characterization of a novel human estrogen receptor. (PubMed id 8769313)1, 2, 3 Mosselman S.... Dijkema R. (FEBS Lett. 1996)
    3. Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway. (PubMed id 15862947)1, 2, 9 St-Laurent V.... Tremblay A. (J. Steroid Biochem. Mol. Biol. 2005)
    4. Estrogen receptor polymorphisms and the risk of endometrial cancer. (PubMed id 19438492)1, 4, 9 Ashton K.A....Scott R.J. (BJOG 2009)
    5. Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. (PubMed id 18070128)1, 4, 9 Ashworth J.J....Ashcroft G.S. (Clin. Genet. 2008)
    6. Estrogen receptor beta polymorphism is associated with prostate cancer risk. (PubMed id 16551880)1, 4, 9 Thellenberg-Karlsson C....GrAPnberg H. (Clin. Cancer Res. 2006)
    7. +1730 G/A polymorphism of the estrogen receptor beta gene (ERbeta) may be an important genetic factor predisposing to endometriosis. (PubMed id 19878085)1, 4, 9 Bianco B....Barbosa C.P. (Acta Obstet Gynecol Scand 2009)
    8. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. (PubMed id 17904846)1, 4, 9 Tsezou A....Kitsiou S. (Breast 2008)
    9. Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women. (PubMed id 15272917)1, 4, 9 Westberg L....Eriksson E. (Clin. Endocrinol. (Oxf) 2004)
    10. Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer. (PubMed id 19654868)1, 4, 9 Chae Y.K....Helzlsouer K. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2100 HGNC: 3468 AceView: SYNE2 Ensembl:ENSG00000140009 euGenes: HUgn2100
    ECgene: ESR2 Kegg: 2100 H-InvDB: ESR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ESR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ESR2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Estrogen_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ESR2 gene:
    Search GeneIP for patents involving ESR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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