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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ESR2 Gene

protein-coding   GIFtS: 71
GCID: GC14M064550

estrogen receptor 2 (ER beta)
 Explore 193 diseases affiliated with
ESR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ESR2    

Aliases
for ESR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Estrogen Receptor 2 (ER Beta)1 2     ESRB2
NR3A21 2 3     Estrogen Nuclear Receptor Beta Variant A2
Erb1 2     Estrogen Nuclear Receptor Beta Variant B2
Nuclear Receptor Subfamily 3 Group A Member 22 3     Estrogen Receptor Beta2
ESTRB2 3     Estrogen Receptor Beta 42
ER-BETA2     ER-Beta1
ESR-BETA2     

External Ids:    HGNC: 34681   Entrez Gene: 21002   Ensembl: ENSG000001400097   OMIM: 6016635   UniProtKB: Q927313   

Export aliases for ESR2 gene to outside databases

Previous GC identifers: GC14M062021 GC14M058487 GC14M062683 GC14M062685 GC14M063621 GC14M063763 GC14M064693 GC14M044866


Summaries
for ESR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ESR2:
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription
factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is
localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the
encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some
isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced
transcript variants of this gene have been described, but the full-length nature of some of these variants has not
been fully characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression
of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks
ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent
transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand
while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more
gradual

summary for ESR2:
Estrogen controls many cellular processes including growth, differentiation and function of the reproductive
system. In females, estrogen's main targets are the ovaries, uterus, vagina and mammary glands. In the male,
target organs are the testes, prostate and epididymis. Estrogen is also responsible for the growth and
maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen
exerts most of its actions via estrogen receptors (ER). Estrogen receptors are ligand-activated
transcription factors belonging to the nuclear hormone receptor superfamily. Today, two estrogen receptors
are known, ERalpha and ERbeta. ERalpha protein is highly homologous to ERbeta protein, especially in the DNA
and ligand binding domains, although divergence exists in the N-terminal transactivation domain. Both
receptors interact with the same DNA response element and show a similar ligand binding profile. Upon ligand
binding estrogen receptors undergo a conformational change allowing spontaneous dimerization to form either
homo- or heterodimers. As a dimer, the estrogen receptor binds to the estrogen response element (ERE) in the
promoter region of target genes. ERalpha and ERbeta which are present in a broad spectrum of tissues.

Gene Wiki entry for ESR2 (Estrogen receptor beta)


Genomic Views
for ESR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ESR2 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ESR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ESR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ESR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q21-q22

ESR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESR2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064550:  view genomic region     (about GC identifiers)

Start:
 64,550,950 bp from pter      End:
 64,805,268 bp from pter
Size:
 254,319 bases      Orientation:
 minus strand

Proteins
for ESR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731 (See protein sequence)
Recommended Name: Estrogen receptor beta  
Size: 530 amino acids; 59216 Da
Subunit: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6
coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform
beta-2/cx preferentially forms a heterodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts
with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of
estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1
promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2
Subcellular location: Nucleus
Sequence caution: Sequence=CAA67555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/28 PDB 3D structures from and Proteopedia for ESR2 (see all 28):
1L2J (3D)        1NDE (3D)        1QKM (3D)        1U3Q (3D)        1U3R (3D)        1U3S (3D)    
Secondary accessions: A8K8K5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q9UEV6
Q9UHD3 Q9UQK9
Alternative splicing: 8 isoforms:  Q92731-1   Q92731-2   Q92731-3   Q92731-4   Q92731-5   Q92731-6   Q92731-7   Q92731-8   
(Does not form homodimers)

Explore the universe of human proteins at neXtProt for ESR2: NX_Q92731

Post-translational modifications:

  • Phosphorylation at Ser-87 and Ser-105 recruits NCOA11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92731

    • ESR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001035365.1  NP_001201831.1  NP_001201832.1  NP_001258805.1  NP_001258806.1  NP_001428.1  NP_001035366.1  

    ENSEMBL proteins: 
     ENSP00000452485   ENSP00000450699   ENSP00000351412   ENSP00000450488   ENSP00000345616  
     ENSP00000452426   ENSP00000451582   ENSP00000343925   ENSP00000441792   ENSP00000335551  
     ENSP00000350427   ENSP00000267525  
    Reactome Protein details: Q92731
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ESR2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ESR2
    OriGene Protein Over-expression Lysate (see all 3): ESR2
    OriGene Custom Protein Services for ESR2 
    GenScript Custom Purified and Recombinant Proteins Services for ESR2
    Novus Biologicals ESR2 Proteins
    Novus Biologicals ESR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS9671811
    GO:0005634nucleus TAS11181953
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion IDA15024130


    ESR2 for ontologies           About GeneDecksing



    ESR2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ESR2
    R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
    OriGene Antibodies (see all 3): ESR2
    OriGene Custom Antibody Services for ESR2 
    GenScript Superior Antibodies for ESR2
    Novus Biologicals ESR2 Antibodies
    Abcam antibodies for ESR2 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for ESR2

    Assay Products for ESR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ESR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ESR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ESR2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR024178 Oest_rcpt/oest-rel_rcp
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry Q92731

    ProtoNet protein and cluster: Q92731

    1 Blocks protein family: IPB001723 Steroid hormone receptor signature

    UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding
    domain
    Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for ESR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
    Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression
    of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks
    ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent
    transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand
    while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more
    gradual

         Genatlas biochemistry entry for ESR2:
    estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced isoforms (hER beta
    1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine leiomyomata,see ULCR14

    miRNA
    Products:            		miRTarBase miRNAs that target ESR2:
    hsa-mir-92a (MIRT004563)

    OriGene 3'-UTR Clone (see all 3): ESR2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ESR2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ESR2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ESR2 (see all 7)
    OriGene shRNA RFP: ESR2
    OriGene siRNA: ESR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ESR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ESR2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ESR2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
    Sino Biological Human cDNA Clone for ESR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ESR2
    Search LifeMap BioReagents cell lines for ESR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

    Gene Ontology (GO): 14 molecular function terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA15345745
    GO:0003677DNA binding TAS9636657
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8769313
    GO:0003707steroid hormone receptor activity TAS10749889
    GO:0003713transcription coactivator activity TAS8769313
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity NAS9671811
    GO:0005496steroid binding TAS11181953
    GO:0005515protein binding IPI14764652
    GO:0008270zinc ion binding IEA--
    GO:0019899enzyme binding IPI12039952
    GO:0030284estrogen receptor activity TAS11181953
    GO:0034056estrogen response element binding IDA15345745
    GO:0043565sequence-specific DNA binding ----
    GO:0048019receptor antagonist activity NAS9671811


    ESR2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ESR2:
     Increased G1 DNA content  Increased cell death in breast  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for ESR2: Esr2tm1.2Pcn Esr2tm1Aghe Esr2tm1Psh Esr2tm1Mma Esr2tm1Unc
         15/24 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Esr2) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    ESR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ESR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Ligand-independent activation of ESR1 and ESR2
    		Development_Ligand-independent activation of ESR1 and ESR21.00
    		Development Ligand-independent activation of ESR1 and ESR20.97
    2Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    		Nuclear Receptors0.68
    3Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    4Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    5Development HGF signaling pathway
    		Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR20.15
    		Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR20.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ESR2
        Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    1 R&D Systems Pathway for ESR2
        TGF-beta Signaling Pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ESR2 (see all 6)
        ERK Signaling
    Estrogen-mediated S-Phase Entry
    eNOS Signaling
    Estrogen Pathway
    MNAR-PELP1 and Estrogen Receptor Interaction

    2 GeneGo (Thomson Reuters) Pathways for ESR2
        Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5/6 BioSystems Pathways for ESR2 (see all 6) 
        Nuclear Receptors
    SIDS Susceptibility Pathways
    Ovarian Infertility Genes
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    3        Reactome Pathways for ESR2
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression

    1 PharmGKB Pathway for ESR2
        Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics


    ESR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ESR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/439 Interacting proteins for ESR2 (Q927311, 3 ENSP000003439254) via UniProtKB, MINT, STRING, and/or I2D (see all 439)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15345745
    GO:0001541ovarian follicle development IEA--
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent TAS11181953


    ESR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ESR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ESR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ESR2

    Compounds for ESR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICI 182,780 Estrogen receptor antagonist[129453-61-8]
    FERb 033Potent and selective ERbeta agonist[1111084-78-6]
    ERB 041Potent ERbeta agonist[524684-52-4]
    DPNHighly potent ERbeta agonist[1428-67-7]
    PHTPPSelective ERbeta antagonist[805239-56-9]

    1 HMDB Compound for ESR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--

    10/30 DrugBank Compounds for ESR2 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TamoxifenTamoxifen Citrate (see all 5)10540-29-1targetantagonist agonist17158759 20827267 16822624 11752352 16326830 16010412 2011412 17404078
    RaloxifeneLY-139481 (see all 6)84449-90-1targetagonist11861516 10418979 11810032 11752352 12097269 11500849
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0target--17139284 17016423 10592235
    N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide-- --target--17139284 17016423 10592235
    Para-Mercury-Benzenesulfonic Acid-- --target--17139284 17016423 10592235
    Trilostane-- 13647-35-3targetallosteric modulator12209583 16806905 17109615
    4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol-- --target--17139284 17016423
    DiethylstilbestrolDES (see all 10)56-53-1targetagonist15123288 19101832
    Estradiol17beta oestradiol (see all 7)50-28-2targetagonist17464340 2011412
    EstropipateEstropipate (usp) (see all 4)7280-37-7targetagonist17464340 2011412

    10/108 Novoseek chemical compound relationships for ESR2 gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 96.1 3585 19800101 (9), 18620727 (7), 12895004 (6), 16214508 (6) (see all 99)
    4-hydroxytamoxifen 85.1 40 17464340 (6), 18663360 (4), 11720858 (2), 16782818 (2) (see all 21)
    estradiol 84.7 197 10601611 (6), 10342855 (4), 19001520 (4), 15345745 (3) (see all 99)
    tamoxifen 81.9 167 16010412 (8), 19744542 (5), 11078914 (4), 17404078 (4) (see all 76)
    fulvestrant 80.1 13 19528477 (2), 19212635 (2), 17923257 (1), 16549430 (1) (see all 7)
    progesterone 80 273 16033082 (5), 17905466 (3), 19200930 (3), 19094096 (2) (see all 99)
    raloxifene 80 38 10076999 (2), 11720858 (2), 15138633 (2), 17962382 (2) (see all 26)
    steroid 76.9 114 10499535 (2), 11775002 (2), 11806710 (2), 12702147 (2) (see all 78)
    genistein 76.1 109 16596234 (5), 19556829 (5), 16513288 (5), 18258689 (4) (see all 51)
    daidzein 73.5 39 14664520 (5), 11431145 (3), 16673816 (2), 16972265 (2) (see all 17)

    3 PharmGKB related drug/compound annotations for ESR2 gene
    Drug/compound PharmGKB Annotation
    exemestaneDL  
    fulvestrantDL  
    tamoxifenCA  DL  
    About this table

    Search CenterWatch for drugs/clinical trials and news about ESR2 

    Transcripts
    for ESR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ESR2 gene (7 alternative transcripts): 
    NM_001040275.1  NM_001214902.1  NM_001214903.1  NM_001271876.1  NM_001271877.1  NM_001437.2  NM_001040276.1  

    Unigene Clusters for ESR2:

    Estrogen receptor 2 (ER beta)
    Hs.660607  [show with all ESTs], Hs.734038
    Unigene Representative Sequences: AB006589, AF061055
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556275 ENST00000554572(uc001xgy.2 uc001xgv.3 uc001xgw.3 uc001xgx.3)
    ENST00000358599(uc001xgz.2) ENST00000555278 ENST00000344288 ENST00000553796
    ENST00000557772 ENST00000555483(uc010aqd.1) ENST00000554520 ENST00000341099(uc010aqb.1 uc010aqc.1 uc001xha.1)
    ENST00000555783 ENST00000542956 ENST00000353772(uc001xgu.3) ENST00000357782
    ENST00000267525

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: AF061055.1 

    11 DOTS entries:

    DT.310701  DT.120767971  DT.100751205  DT.95367837  DT.102837012  DT.120767979  DT.40120425  DT.92419264 
    DT.40125379  DT.91703242  DT.100740263 

    24/316 AceView cDNA sequences (see all 316):

    CA868590 AW129591 BC042134 AW119118 BQ057203 AI638206 AA747679 AW589851 
    AL080133 AA972285 BE206269 BE673476 BG222179 AY061758 CD671619 CA423800 
    NM_182912 BM019005 NM_182910 BX282648 AK074055 AK090430 BE673396 BG110769 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ESR2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                              -                       -     -     -     -   
    SP3:                    -     -     -     -     -     -     -     -                                               -     -                 -     -     -     -   
    SP4:                                                                                                              -                                             
    SP5:                                                                                            -                                                               

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:  -                     
    SP3:  -                     
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ESR2

    Expression
    for ESR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ESR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCACAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ESR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ESR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ESR2

    SOURCE GeneReport for Unigene clusters: Hs.660607 Hs.734038

    UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
    Tissue specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta,
    liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine
    bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen,
    thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone
    marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a
    lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta,
    skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus,
    prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ESR2 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Breast Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for ESR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ESR2 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ESR21 estrogen receptor 2 (ER beta) 74.78(n)
    80.7(a)    		   395575  NM_204794.1  NP_990125.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ESR26
    		 --
    		 70(a)
    		 1 ↔ 1
    		 1(1646467-1679104)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia LOC3944602 estrogen receptor beta 79.44(n)    AY310903.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii esr2a2 estrogen receptor 2a 77.22(n)   317734  AF516874.1 


    ENSEMBL Gene Tree for ESR2 (if available)
    TreeFam Gene Tree for ESR2 (if available) 

    Paralogs
    for ESR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ESR2 gene
    ESRRA2  RXRG2  PGR2  ESRRB2  HNF4G2  NR2F62  NR2E12  ESRRG2  
    NR3C22  RXRA2  NR2F12  NR3C12  NR2F22  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/25 SIMAP similar genes for ESR2 using alignment to 5 protein entries:     ESR2_HUMAN (see all proteins) (see all similar genes):
    NR3A2    ESR1    NR3C2    HNF4G    NR2C2    HNF4alpha
    NR1I3    VDR    NR3A1    NR5A1    ESRRG    THRB
    NR3B3    ERRgamma    NR1H3    ESRRB    NR3C4    PGR

    ESR2 for paralogs           About GeneDecksing



    Genomic Variants
    for ESR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1953 NCBI SNPs in ESR2 are shown (see all 1953)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs754924341,2
    		--44865996(+) CTCTAC/TTCTTT 3 -- int10--------
    rs768015701,2
    		--44865998(+) CTACTC/TTTTTT 3 -- int10--------
    rs116229911,2
    		H--44866048(+) tgcggG/Tggccc 3 -- int10--------
    rs582623691,2
    		C,--44866494(+) CTTCTC/TTGCCA 3 -- ut313Minor allele frequency- T:0.08CSA WA EA 239
    rs1146297271,2
    		C,F,--44866728(+) AACTCT/CTTCTT 3 -- ut311Minor allele frequency- C:0.02WA 118
    rs284409701,2
    		C,F,--44866740(+) NNNNTT/CATTTT 3 -- ut312Minor allele frequency- C:0.07NA EA 240
    rs772909751,2
    		C,--44867686(+) TAGACA/GTTAAA 3 -- int12Minor allele frequency- G:0.07CSA WA 120
    rs791988401,2
    		F,--44867972(+) ATTGTA/GCAGTT 3 -- int11Minor allele frequency- G:0.03NA 120
    rs768447841,2
    		F,--44869080(+) ATTAAA/GTGTGA 3 -- int11Minor allele frequency- G:0.06WA 118
    rs753016201,2
    		F,--44869896(+) TTCCCG/ACCTTA 3 -- int11Minor allele frequency- A:0.06WA 118

    HapMap Linkage Disequilibrium report for ESR2 (64550950 - 64800950 bp, first 250kb of ESR2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ESR2
         1 Indel: 45291
    Human Gene Mutation Database (HGMD): ESR2

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    Disorders / Diseases
    for ESR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ESR2 for disorders           About GeneDecksing

    OMIM gene information: 601663    OMIM disorders: --

    20/193 diseases for ESR2 (see all 193):    About MalaCards
    open-angle glaucoma    progesterone-receptor positive breast cancer    estrogen-receptor positive breast cancer    gender identity disorder
    primary pigmented nodular adrenocortical disease    prostatitis    obsessive-compulsive disorder    serous cystadenocarcinoma
    primary open angle glaucoma    deep vein thrombosis    osteoporosis, postmenopausal    graft versus host disease
    ovarian serous cystadenocarcinoma    non-small cell lung carcinoma    sclerosing hemangioma    dental fluorosis
    polycystic ovary syndrome    abdominal aortic aneurysm    multinodular goiter    pulmonary sclerosing hemangioma

    8 diseases from the University of Copenhagen DISEASES database for ESR2:
    Breast cancer     Osteoporosis     Endometrial cancer     Endometriosis
    Prostate cancer     Carcinoma     Ovarian disease     Infertility

    10/93 Novoseek disease relationships for ESR2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 79 565 14576822 (6), 19463683 (6), 14620916 (5), 18771580 (5) (see all 99)
    endometrial cancer 65.1 37 19438492 (4), 15968319 (4), 12873984 (3), 19758455 (2) (see all 21)
    breast carcinoma 59.9 45 15363297 (4), 20306984 (2), 16327431 (2), 15656884 (2) (see all 27)
    endometrial carcinoma 58 26 15573770 (4), 11109162 (4), 16324249 (3), 17649814 (2) (see all 13)
    prostate cancer 53.7 133 17908481 (6), 16551880 (5), 11752866 (5), 17913855 (5) (see all 59)
    tumors 52.9 503 11042568 (6), 12750263 (6), 11676856 (5), 15257551 (5) (see all 99)
    endometriosis 51.9 44 16210018 (4), 19001520 (4), 19878085 (4), 17336962 (3) (see all 16)
    cancer 48.3 123 12921561 (5), 18085520 (4), 16615154 (4), 11734621 (3) (see all 78)
    osteoporosis 39.5 17 16530497 (2), 10709863 (1), 18172701 (1), 18406312 (1) (see all 12)
    prostatic intraepithelial neoplasia 39.4 6 11438457 (1), 12497580 (1), 19672287 (1)

    Genetic Association Database (GAD): ESR2
    Human Genome Epidemiology (HuGE) Navigator: ESR2 (224 documents)

    Export disorders for ESR2 gene to outside databases

    Publications
    for ESR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ESR2 gene, integrated from 9 sources (see all 1676):
    (articles sorted by number of sources associating them with ESR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ER beta: identification and characterization of a novel human estrogen receptor. (PubMed id 8769313)1, 2, 3 Mosselman S.... Dijkema R. (1996)
    2. Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway. (PubMed id 15862947)1, 2, 9 St-Laurent V....Tremblay A. (2005)
    3. Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women. (PubMed id 15272917)1, 4, 9 Westberg L....Eriksson E. (2004)
    4. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. (PubMed id 16261413)1, 4, 9 Maguire P....Lindblom A. (2005)
    5. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. (PubMed id 16098017)1, 4, 9 Fytili P....Tsezou A. (2005)
    6. The RsaI polymorphism in the estrogen receptor-beta gene is associated with male infertility. (PubMed id 15998774)1, 4, 9 Aschim E.L....Giwercman Y.L. (2005)
    7. Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status. (PubMed id 15381922)1, 4, 9 Almeida S....Hutz M.H. (2005)
    8. Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population. (PubMed id 15193490)1, 4, 9 Wang Z....Maruo T. (2004)
    9. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. (PubMed id 14633679)1, 4, 9 Zheng S.L....Gao Y.T. (2003)
    10. Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women. (PubMed id 11397855)1, 4, 9 Westberg L....Eriksson E. (2001)

    External Searches for ESR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ESR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2100 HGNC: 3468 AceView: SYNE2 Ensembl:ENSG00000140009 euGenes: HUgn2100
    ECgene: ESR2 H-InvDB: ESR2

    Other Databases showing ESR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ESR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ESR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ESR2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Estrogen_receptor

    Intellectual Property
    for ESR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ESR2 gene:
    Search GeneIP for patents involving ESR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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