Aliases for ESR2 Gene
Aliases for ESR2 Gene
External Ids for ESR2 Gene
- HGNC: 3468
- Entrez Gene: 2100
- Ensembl: ENSG00000140009
- OMIM: 601663
- UniProtKB: Q92731
Previous GeneCards Identifiers for ESR2 Gene
- GC14M062021
- GC14M058487
- GC14M062683
- GC14M062685
- GC14M063621
- GC14M063763
- GC14M064693
- GC14M044866
- GC14M064550
Summaries for ESR2 Gene
-
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ESR2 Gene
ESR2 (Estrogen Receptor 2) is a Protein Coding gene. Diseases associated with ESR2 include Medullary Thyroid Carcinoma, Familial and De Quervain Disease. Among its related pathways are Plasma membrane estrogen receptor signaling and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is ESR1.
UniProtKB/Swiss-Prot for ESR2 Gene
-
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
-
Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal function of the cardiovascular and nervous systems.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESR2 Gene
Genomics for ESR2 Gene
Regulatory Elements for ESR2 Gene
Enhancers for ESR2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G064231 | 1.4 | Ensembl ENCODE dbSUPER | 29.5 | +105.6 | 105607 | 2.0 | HDGF TBP PKNOX1 TBL1XR1 WRNIP1 ZFP64 BMI1 GATA2 SCRT2 FOS | ESR2 MTHFD1 PIR41332 GC14M064323 |
| GH14G064219 | 1 | ENCODE dbSUPER | 30.1 | +117.9 | 117915 | 2.6 | SRF CTCF PKNOX1 USF1 L3MBTL2 MAFG MNT ZNF316 ZFHX2 POLR2A | ESR2 MTHFD1 PIR41332 GC14M064162 |
| GH14G064212 | 1 | ENCODE dbSUPER | 26.3 | +123.8 | 123824 | 4.0 | SIX4 SOX13 CTCF PKNOX1 JUN ZNF335 ZNF121 CTBP1 POLR2A FOSL2 | ESR2 MTHFD1 PIR41332 GC14M064162 |
| GH14G064234 | 1.2 | ENCODE dbSUPER | 21.2 | +103.0 | 103020 | 2.9 | HDGF TBP PKNOX1 TBL1XR1 NFIB SIN3A ZBTB40 ELK1 SCRT2 RCOR1 | ESR2 MTHFD1 LOC102723809 PIR41332 GC14M064323 |
| GH14G064217 | 0.9 | ENCODE dbSUPER | 23.4 | +120.4 | 120370 | 2.3 | PKNOX1 MTA2 NFIA NFIB NR2F1 EP300 NFIC ARID3A ZFHX2 IKZF1 | ESR2 ZBTB25 PIR41332 GC14M064162 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ESR2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ESR2 gene promoter:
Regulatory Element Products
Genomic Location for ESR2 Gene
- Chromosome:
- 14
- Start:
- 64,084,232 bp from pter
- End:
- 64,338,550 bp from pter
- Size:
- 254,319 bases
- Orientation:
- Minus strand
Genomic View for ESR2 Gene
Genes around ESR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.3 by Ensembl
- 14q23.2-q23.3 by Entrez Gene
- 14q23.2-q23.3 by HGNC
ESR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ESR2 Gene
Proteins for ESR2 Gene
-
Protein details for ESR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92731-ESR2_HUMAN
- Recommended name:
- Estrogen receptor beta
- Protein Accession:
- Q92731
- A8K8K5
- G3V5M5
- O60608
- O60685
- O60702
- O60703
- O75583
- O75584
- Q0MWT5
- Q0MWT6
- Q86Z31
- Q9UEV6
- Q9UHD3
- Q9UQK9
Protein attributes for ESR2 Gene
- Size:
- 530 amino acids
- Molecular mass:
- 59216 Da
- Quaternary structure:
-
- Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform 2 preferentially forms a heterodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1 promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.
- SequenceCaution:
-
- Sequence=CAA67555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ESR2 Gene
Protein Expression for ESR2 Gene
Post-translational modifications for ESR2 Gene
- Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ESR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
-
Custom Antibody ServicesOriGene Antibodies for ESR2
- AM21050PU-N
- AM32846PU-N
- AM32846PU-S
- AM32846PU-T
- AP06806PU-N
- AP22965PU-N
- AP23349PU-N
- AP55945PU-N
- AP55945PU-S
- TA309968
- CF801088
- TA801088
- CF801087
- TA801087
- CF801070
- TA801070
- CF801038
- TA801038
- TA590082
- TA352050
- TA352049
- TA349939
- TA332550
- TA327896
- TA327832
- TA324672
- TA324671
- TA324615
- TA311884
- TA311883
- TA311208
- TA309969
- Novus Biologicals Antibodies for ESR2
-
Abcam antibodies for ESR2
-
Cloud-Clone Corp. Antibodies for ESR2
- Invitrogen Antibodies for ESR2
- antibodies-online Antibodies for ESR2: See all 352
- GeneTex ESR2 antibody for ESR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ESR2
Protein Products
-
OriGene Purified Proteins for ESR2
- Search Origene for MassSpec and Protein Over-expression Lysates for ESR2
- Origene Custom Protein Services for ESR2
-
Cloud-Clone Corp. Proteins for ESR2
- antibodies-online Proteins for ESR2: See all 23
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ESR2
-
ProSci Proteins for ESR2
Assay Products
- antibodies-online Kits for ESR2: See all 42
No data available for DME Specific Peptides for ESR2 Gene
Domains & Families for ESR2 Gene
Gene Families for ESR2 Gene
- HGNC:
- IUPHAR :
Protein Domains for ESR2 Gene
Suggested Antigen Peptide Sequences for ESR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92731UniProtKB/Swiss-Prot:
ESR2_HUMAN :- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
- Domain:
-
- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Family:
-
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
Function for ESR2 Gene
Molecular function for ESR2 Gene
- GENATLAS Biochemistry:
- estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced isoforms (hER beta 1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine leiomyomata,see ULCR14
- UniProtKB/Swiss-Prot Function:
- Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001046 | core promoter sequence-specific DNA binding | IDA | 15345745 |
| GO:0003677 | DNA binding | TAS | 9636657 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 8769313 |
| GO:0003707 | steroid hormone receptor activity | TAS | 10749889 |
| GO:0003713 | transcription coactivator activity | TAS | 8769313 |
Phenotypes for ESR2 Gene
- MGI mutant phenotypes for ESR2:
-
inferred from 11 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for ESR2:
Animal Models for ESR2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ESR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ESR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ESR2 gene
- Search ViGene Biosciences for ESR2
CRISPR Products
-
OriGene CRISPR knockouts for ESR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ESR2
- GenScript: Design CRISPR guide RNA sequences for ESR2
miRNA for ESR2 Gene
- miRTarBase miRNAs that target ESR2
-
- hsa-mir-92a-3p (MIRT004563)
- hsa-mir-335-5p (MIRT017943)
- hsa-mir-30a-5p (MIRT054508)
- hsa-mir-6807-5p (MIRT514531)
- hsa-mir-5095 (MIRT514532)
- hsa-mir-7151-3p (MIRT514533)
- hsa-mir-19b-2-5p (MIRT514534)
- hsa-mir-19b-1-5p (MIRT514535)
- hsa-mir-2052 (MIRT514536)
- hsa-mir-19a-5p (MIRT514537)
- hsa-mir-4312 (MIRT514538)
- hsa-mir-3922-3p (MIRT514539)
- hsa-mir-3176 (MIRT514540)
- hsa-mir-3190-5p (MIRT514541)
- hsa-mir-3126-3p (MIRT514542)
- hsa-mir-4438 (MIRT514543)
- hsa-mir-5089-5p (MIRT683370)
- hsa-mir-6726-3p (MIRT683371)
- hsa-mir-203a-5p (MIRT683372)
- hsa-mir-5589-5p (MIRT683373)
- hsa-mir-4731-5p (MIRT683374)
- hsa-mir-6778-3p (MIRT683375)
- hsa-mir-6506-5p (MIRT683376)
- hsa-mir-619-5p (MIRT683377)
- hsa-mir-150-5p (MIRT683378)
- hsa-mir-7107-5p (MIRT683379)
- hsa-mir-1234-3p (MIRT683380)
- hsa-mir-1224-3p (MIRT683381)
- hsa-mir-186-3p (MIRT683382)
- hsa-mir-520h (MIRT683383)
- hsa-mir-520g-3p (MIRT683384)
- hsa-mir-6504-3p (MIRT683385)
- hsa-mir-140-5p (MIRT683386)
- hsa-mir-512-3p (MIRT683387)
- hsa-mir-520e (MIRT683388)
- hsa-mir-520d-3p (MIRT683389)
- hsa-mir-520c-3p (MIRT683390)
- hsa-mir-520b (MIRT683391)
- hsa-mir-520a-3p (MIRT683392)
- hsa-mir-373-3p (MIRT683393)
- hsa-mir-372-3p (MIRT683394)
- hsa-mir-302e (MIRT683395)
- hsa-mir-302d-3p (MIRT683396)
- hsa-mir-302c-3p (MIRT683397)
- hsa-mir-302b-3p (MIRT683398)
- hsa-mir-302a-3p (MIRT683399)
- hsa-mir-93-5p (MIRT683400)
- hsa-mir-526b-3p (MIRT683401)
- hsa-mir-519d-3p (MIRT683402)
- hsa-mir-20b-5p (MIRT683403)
- hsa-mir-20a-5p (MIRT683404)
- hsa-mir-17-5p (MIRT683405)
- hsa-mir-106b-5p (MIRT683406)
- hsa-mir-106a-5p (MIRT683407)
miRNA Products
- Search ViGene Biosciences for ESR2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ESR2
- Browse OriGene Inhibitory RNA Products For ESR2
-
ViGene Biosciences ready-to-package AAV shRNAs for ESR2 gene
Clone Products
-
OriGene ORF clones in human for ESR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ESR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ESR2
- VectorBuilder custom plasmid, inducible vectors for ESR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ESR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ESR2
-
ViGene Biosciences adenoviral particle packaged cDNA for ESR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ESR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ESR2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESR2 Gene
Localization for ESR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ESR2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | TAS | 11181953 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005739 | mitochondrion | IDA | 15024130 |
Pathways & Interactions for ESR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glioma |
.36
|
|
| 2 | Gene Expression |
.48
|
|
| 3 | Nuclear Receptor transcription pathway | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Prolactin Signaling Pathway | ||
Pathways by source for ESR2 Gene
1 Sino Biological pathway for ESR2 Gene
4 BioSystems pathways for ESR2 Gene
3 Reactome pathways for ESR2 Gene
1 PharmGKB pathway for ESR2 Gene
4 KEGG pathways for ESR2 Gene
2 GeneGo (Thomson Reuters) pathways for ESR2 Gene
1 R&D Systems pathway for ESR2 Gene
6 Qiagen pathways for ESR2 Gene
Interacting Proteins for ESR2 Gene
Selected Interacting proteins:
ENSP00000343925
Q92731-ESR2_HUMAN
for ESR2 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 15345745 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 11181953 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0007165 | signal transduction | TAS | 8769313 |
Drugs & Compounds for ESR2 Gene
(146) Drugs for ESR2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Tamoxifen | Approved | Pharma | Antagonist, antagonist, Biomarker, Target, agonist | TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens | 390 | |
| Diethylstilbestrol | Approved | Pharma | Agonist, agonist, Target | 5 | ||
| Estriol | Approved, Vet_approved | Pharma | Agonist, agonist, Target | 0 | ||
| Estradiol | Approved, Investigational, Vet_approved | Pharma | agonist, Target | Sex hormone | 1318 | |
| Fulvestrant | Approved, Investigational | Pharma | Antagonist, inhibitor, antagonist | Estrogen receptor antagonist,high affinity, Hormone therapy | 202 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 17beta-estradiol |
|
Agonist |
|
|||
| 4-hydroxy?aetamoxifen |
|
Antagonist |
|
|||
| N-Desmethyltamoxifen |
|
31750-48-8 | ||||
| ICI 182,780 |
|
129453-61-8 |
|
|
(5) Tocris Compounds for ESR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (Z)-4-Hydroxytamoxifen | Metabolite of tamoxifen (Cat. No. 0999) | 68047-06-3 |
| DPN | Highly potent ERbeta agonist | 1428-67-7 |
| ICI 182,780 | Estrogen receptor antagonist | 129453-61-8 |
| PHTPP | Selective ERbeta antagonist | 805239-56-9 |
| PPT | Subtype-selective ERalpha agonist | 263717-53-9 |
(52) ApexBio Compounds for ESR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (E)-2-Decenoic acid | Fatty acid identified in royal jelly | 334-49-6 |
| (R)-DPN | 524047-78-7 | |
| (R,R)-THC | 138090-06-9 | |
| (Z)-2-decenoic acid | Unsaturated short chain fatty acid for biofilm dispersion | 15790-91-7 |
| (Z)-4-Hydroxytamoxifen | ER modulator, potent and selective | 68047-06-3 |
| Altrenogest | 850-52-2 | |
| Bazedoxifene | Estrogen receptor modulator | 198481-32-2 |
| Bazedoxifene acetate | Estrogen receptor modulator | 198481-33-3 |
| Bazedoxifene HCl | 198480-56-7 | |
| Chlorotrianisene | Estrogen agonist | 569-57-3 |
| Clomiphene citrate | 50-41-9 | |
| Cyclofenil | 2624-43-3 | |
| Diethylstilbestrol | 56-53-1 | |
| DPN | 1428-67-7 | |
| Endoxifen | 112093-28-4 | |
| Equol | 531-95-3 | |
| ERB 041 | 524684-52-4 | |
| Erteberel (LY500307) | 533884-09-2 | |
| Estradiol | Sex hormone | 50-28-2 |
| Estradiol Cypionate | 313-06-4 | |
| Estriol | 50-27-1 | |
| Estrone | Estrogenic hormone | 53-16-7 |
| Estropipate | 7280-37-7 | |
| Ethinyl Estradiol | Oral contraceptive | 57-63-6 |
| Ethisterone | Progestogen hormone | 434-03-7 |
| Ethynodiol diacetate | 297-76-7 | |
| Etonogestrel | 54048-10-1 | |
| FERb 033 | 1111084-78-6 | |
| Fulvestrant | Estrogen receptor antagonist,high affinity | 129453-61-8 |
| G-36 | 1392487-51-2 | |
| Gestodene | 60282-87-3 | |
| GSK 4716 | 101574-65-6 | |
| Hexestrol | 84-16-2 | |
| Medroxyprogesterone acetate | Steroidal progestin | 71-58-9 |
| Megestrol Acetate | Anti-estrogen agent | 595-33-5 |
| Mestranol | Estrogen used in contraceptives | 72-33-3 |
| MPP dihydrochloride | 911295-24-4 | |
| Ospemifene | 128607-22-7 | |
| PHTPP | 805239-56-9 | |
| PPT | 263717-53-9 | |
| Raloxifene HCl | Estrogen receptor (ER) | 82640-04-8 |
| RU 58668 | 151555-47-4 | |
| Tamoxifen | TGF-β modulatory and PKC inhibitory effects | 10540-29-1 |
| Tamoxifen Citrate | Antiestrogen drug | 54965-24-1 |
| Toremifene | Estrogen-receptor modulator | 89778-26-7 |
| Toremifene Citrate | 89778-27-8 | |
| Ulipristal | 159811-51-5 | |
| WAY 200070 | 440122-66-7 | |
| Y 134 | 849662-80-2 | |
| Zearalenone | 17924-92-4 | |
| ZK 164015 | 177583-70-9 | |
| α-Estradiol | 57-91-0 |
Transcripts for ESR2 Gene
mRNA/cDNA for ESR2 Gene
- (15) REFSEQ mRNAs :
- (316) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ESR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ESR2
- GenScript: Design CRISPR guide RNA sequences for ESR2
miRNA Products
- Search ViGene Biosciences for ESR2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ESR2
- Browse OriGene Inhibitory RNA Products For ESR2
-
ViGene Biosciences ready-to-package AAV shRNAs for ESR2 gene
Clone Products
-
OriGene ORF clones in human for ESR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ESR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ESR2
- VectorBuilder custom plasmid, inducible vectors for ESR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ESR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - |
| ExUns: | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | - | ||||||
| SP3: | - | ||||||
| SP4: | |||||||
| SP5: | |||||||
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Expression for ESR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Granulosa Cells Primary Follicle
- oocyte
mRNA differential expression in normal tissues according to GTEx for ESR2 Gene
This gene is overexpressed in Adrenal Gland (x5.6), Ovary (x5.2), and Testis (x4.9).
This gene is overexpressed in Heart (47.1) and Adipocyte (19.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ESR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ESR2 Gene:
ESR2SOURCE GeneReport for Unigene cluster for ESR2 Gene:
Hs.660607mRNA Expression by UniProt/SwissProt for ESR2 Gene:
Q92731-ESR2_HUMAN
Tissue specificity:
Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Evidence on tissue expression from TISSUES for ESR2 Gene
- Nervous system(3.2)
- Blood(2.7)
- Muscle(2.7)
- Heart(2.6)
- Intestine(2.5)
- Kidney(2.4)
- Lung(2.4)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
- Liver(2.2)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for ESR2
-
OriGene qPCR primer pairs and template standards for ESR2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ESR2 Gene
Orthologs for ESR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ESR2 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ESR2 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ESR2 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Esr2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Esr2 16 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ESR2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ESR2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ESR2 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ESR2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | esr2 34 |
|
||
| LOC394460 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | esr2b 35 34 |
|
OneToMany | |
| esr2a 35 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11634 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ERR 35 |
|
OneToMany |
- Species where no ortholog for ESR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ESR2 Gene
Paralogs for ESR2 Gene
(22) SIMAP similar genes for ESR2 Gene using alignment to 4 proteins:
Variants for ESR2 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs184175256 | Likely benign | 64,226,222(+) | TGACT(A/G)ATGTA | downstream-variant-500B, utr-variant-3-prime | |
| rs539694463 | Likely benign | 64,226,246(+) | ACTAC(C/T)GACTT | downstream-variant-500B, utr-variant-3-prime | |
| rs886050608 | Uncertain significance | 64,226,221(+) | TTGAC(G/T)AATGT | downstream-variant-500B, utr-variant-3-prime | |
| rs886050609 | Uncertain significance | 64,226,258(+) | ATAGG(A/G)ATGTT | downstream-variant-500B, utr-variant-3-prime | |
| rs886050610 | Uncertain significance | 64,226,260(+) | AGGGA(A/T)GTTTT | downstream-variant-500B, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2351050 | CNV | deletion | 18987734 |
| esv2748779 | CNV | deletion | 23290073 |
| esv2748782 | CNV | deletion | 23290073 |
| esv3353486 | CNV | insertion | 20981092 |
| esv3567943 | CNV | gain | 25503493 |
| esv3634746 | CNV | loss | 21293372 |
| esv3634750 | CNV | loss | 21293372 |
| nsv1050378 | CNV | gain | 25217958 |
| nsv1069803 | CNV | deletion | 25765185 |
| nsv1307 | CNV | deletion | 18451855 |
| nsv456326 | CNV | gain | 19166990 |
| nsv524908 | CNV | gain | 19592680 |
| nsv564905 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.13;
38.81% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ESR2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESR2 Gene
Disorders for ESR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| medullary thyroid carcinoma, familial |
|
|
| de quervain disease |
|
|
| gender identity disorder |
|
|
| transsexualism |
|
|
| progesterone resistance |
|
|
Search ESR2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ESR2
No data available for UniProtKB/Swiss-Prot and Genatlas for ESR2 Gene
Publications for ESR2 Gene
- Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women. (PMID: 19927160) Zhao T. … Xu H. (J. Hum. Genet. 2010) 3 22 46 64
- Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. (PMID: 20148360) Lin J. … Cook N.R. (Cancer Causes Control 2010) 3 22 46 64
- Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results. (PMID: 20827267) Hayes D.F. … Flockhart D.A. (Clin. Pharmacol. Ther. 2010) 3 25 46 64
- Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. (PMID: 18962445) Hare L. … Harley V.R. (Biol. Psychiatry 2009) 3 22 46 64
- Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy. (PMID: 19082882) Onitilo A.A. … Jin Y. (Breast Cancer Res. Treat. 2009) 3 22 46 64
Products for ESR2 Gene
- R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ESR2
- AM21050PU-N
- AM32846PU-N
- AM32846PU-S
- AM32846PU-T
- AP06806PU-N
- AP22965PU-N
- AP23349PU-N
- AP55945PU-N
- AP55945PU-S
- TA309968
- TA309969
- TA311208
- TA311883
- TA311884
- TA324615
- TA324671
- TA324672
- TA327832
- TA327896
- TA332550
- TA349939
- TA352049
- TA352050
- TA590082
- TA801038
- CF801038
- TA801070
- CF801070
- TA801087
- CF801087
- TA801088
- CF801088
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ESR2
- Search Origene for MassSpec and Protein Over-expression Lysates for ESR2
- Origene Custom Protein Services for ESR2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ESR2
- Browse OriGene Inhibitory RNA Products For ESR2
- OriGene qPCR primer pairs and template standards for ESR2
- OriGene qPCR primer pairs for ESR2
- OriGene CRISPR knockouts for ESR2
- OriGene ORF clones in human for ESR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ESR2
- GenScript: Next-day shipping cDNA ORF clone for ESR2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ESR2
- GenScript Custom Assay Services for ESR2
- GenScript Custom overexpressing Cell Line Services for ESR2
- GenScript: Design CRISPR guide RNA sequences for ESR2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ESR2
- Sino Biological Human cDNA Clone for ESR2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ESR2
- Novus Biologicals proteins and lysates for ESR2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ESR2
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for ESR2
- Cloud-Clone Corp. Proteins for ESR2
- Invitrogen Antibodies for ESR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ESR2
- Addgene plasmids for ESR2
- antibodies-online Antibodies for ESR2: See all 352
- antibodies-online Kits for ESR2: See all 42
- antibodies-online Proteins for ESR2: See all 23
- Search antibodies-online for peptides
- GeneTex ESR2 antibody for ESR2
- Search GeneTex for Proteins for ESR2
- ViGene Biosciences adenoviral particle packaged cDNA for ESR2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ESR2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ESR2 gene
- Search ViGene Biosciences for ESR2
- Santa Cruz Biotechnology (SCBT) Antibodies for ESR2
- Search Santa Cruz Biotechnology (SCBT) for ESR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ESR2
- Search for ESR2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ESR2
- Horizon Cell Lines for ESR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ESR2
- VectorBuilder custom plasmid, inducible vectors for ESR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ESR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ESR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer