Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

ESR2 Gene

protein-coding GIFtS: 70
GCID: GC14M064550

Estrogen Receptor 2 (ER Beta)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Estrogen Receptor 2 (ER Beta)¹ ²		Erb²
Nuclear Receptor Subfamily 3 Group A Member 2² ³		Estrogen Nuclear Receptor Beta Variant A²
ESTRB² ³		Estrogen Nuclear Receptor Beta Variant B²
NR3A2² ³		Estrogen Receptor Beta²
ER-BETA²		Estrogen Receptor Beta 4²
ESR-BETA²		ER-beta³
ESRB²

External Ids:	HGNC: 3468¹	Entrez Gene: 2100²	Ensembl: ENSG00000140009⁷	OMIM: 601663⁵	UniProtKB: Q92731³

Export aliases for ESR2 gene to outside databases

Previous GC identifers: GC14M062021 GC14M058487 GC14M062683 GC14M062685 GC14M063621 GC14M063763 GC14M064693 GC14M044866

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ESR2 Gene:

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription

factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is

localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the

encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription.

Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively

spliced transcript variants of this gene have been described, but the full-length nature of some of these

variants has not been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ESR2 Gene:

ESR2 (estrogen receptor 2 (ER beta)) is a protein-coding gene. Diseases associated with ESR2 include serous cystadenocarcinoma, and progesterone-receptor positive breast cancer. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates

expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform

beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of

ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in

the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at

elevated temperature is more gradual

summary for ESR2 Gene:

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive

system. In females, estrogen's main targets are the ovaries, uterus, vagina and mammary glands. In the male,

target organs are the testes, prostate and epididymis. Estrogen is also responsible for the growth and

maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen

exerts most of its actions via estrogen receptors (ER). Estrogen receptors are ligand-activated

transcription factors belonging to the nuclear hormone receptor superfamily. Today, two estrogen receptors

are known, ERalpha and ERbeta. ERalpha protein is highly homologous to ERbeta protein, especially in the DNA

and ligand binding domains, although divergence exists in the N-terminal transactivation domain. Both

receptors interact with the same DNA response element and show a similar ligand binding profile. Upon ligand

binding estrogen receptors undergo a conformational change allowing spontaneous dimerization to form either

homo- or heterodimers. As a dimer, the estrogen receptor binds to the estrogen response element (ERE) in the

promoter region of target genes. ERalpha and ERbeta which are present in a broad spectrum of tissues.

Gene Wiki entry for ESR2 (Estrogen receptor beta) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000014.9 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the ESR2 gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ESR2 promoter sequence

Search Chromatin IP Primers for ESR2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q21-q22

ESR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ESR2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M064550: view genomic region (about GC identifiers)

Start:	64,550,950 bp from pter	End:	64,805,268 bp from pter
Size:	254,319 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731 (See protein sequence)

Recommended Name: Estrogen receptor beta

Size: 530 amino acids; 59216 Da

Subunit: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6

coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C.

Isoform beta-2/cx preferentially forms a heterodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1.

Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the

presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including

cyclin-D1/CCND1 AP-1 promoter. Interacts with DYX1C1 (By similarity). Interacts with PRMT2

Sequence caution: Sequence=CAA67555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Selected PDB 3D structures from and Proteopedia for ESR2 (see all 30):

1L2J (3D)

1NDE (3D)

1QKM (3D)

1U3Q (3D)

1U3R (3D)

1U3S (3D)

Secondary accessions: A8K8K5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31

Q9UEV6 Q9UHD3 Q9UQK9

Alternative splicing: 8 isoforms: Q92731-1 Q92731-2 Q92731-3 Q92731-4 Q92731-5 Q92731-6 Q92731-7 Q92731-8

(Does not form homodimers)

Explore the universe of human proteins at neXtProt for ESR2: NX_Q92731

Explore proteomics data for ESR2 at MOPED

Post-translational modifications:

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ESR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001035365.1 NP_001201831.1 NP_001201832.1 NP_001258805.1 NP_001258806.1 NP_001428.1

ENSEMBL proteins:

ENSP00000452485 ENSP00000450699 ENSP00000351412 ENSP00000450488 ENSP00000345616

ENSP00000452426 ENSP00000451582 ENSP00000343925 ENSP00000441792 ENSP00000335551

ENSP00000350427 ENSP00000267525

Reactome Protein details: Q92731

ESR2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for ESR2 OriGene Protein Over-expression Lysate for ESR2 OriGene MassSpec for ESR2 OriGene Custom Protein Services for ESR2
	GenScript Custom Purified and Recombinant Proteins Services for ESR2
	Novus Biologicals ESR2 Proteins Novus Biologicals ESR2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

ESR2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ESR2
	R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
	OriGene Antibodies for ESR2 OriGene Custom Antibody Services for ESR2
	Novus Biologicals ESR2 Antibodies
	Abcam antibodies for ESR2 (P03372, Q92731)
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for ESR2
	LSBio Antibodies in human, mouse, rat for ESR2

ESR2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ESR2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ESR2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

NR: Nuclear hormone receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Estrogen receptor-beta

3A. Estrogen receptors

Selected InterPro protein domains (see all 8):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR001723 Str_hrmn_rcpt

IPR024178 Oest_rcpt/oest-rel_rcp

IPR013088 Znf_NHR/GATA

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

Graphical View of Domain Structure for InterPro Entry Q92731

ProtoNet protein and cluster: Q92731

1 Blocks protein domain: IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal

ligand-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

ESR2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates

expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform

beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of

ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in

the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at

elevated temperature is more gradual

Genatlas biochemistry entry for ESR2:

estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced isoforms (hER beta

1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine leiomyomata,see ULCR14

Gene Ontology (GO): Selected molecular function terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001046	core promoter sequence-specific DNA binding	IDA	15345745
GO:0003677	DNA binding	TAS	9636657
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8769313
GO:0003707	steroid hormone receptor activity	TAS	10749889
GO:0003713	transcription coactivator activity	TAS	8769313

ESR2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ESR2:

Increased G1 DNA content

Increased cell death in breast

Synthetic lethal with Ras

Selected MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Esr2) (see all 24):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

ESR2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for ESR2: Esr2^tm1.2Pcn Esr2^tm1Aghe Esr2^tm1Psh Esr2^tm1Mma Esr2^tm1Unc

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESR2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ESR2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ESR2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ESR2

miRNA Products:		miRTarBase miRNAs that target ESR2: hsa-mir-335-5p (MIRT017943), hsa-mir-92a-3p (MIRT004563)

		Block miRNA regulation of human, mouse, rat ESR2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ESR2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ESR2
		Predesigned siRNA for gene silencing in human, mouse, rat ESR2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ESR2

Clone Products:		OriGene clones in human, mouse for ESR2 (see all 19) OriGene ORF clones in mouse, rat for ESR2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
		Sino Biological Human cDNA Clone for ESR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ESR2
		Browse ESI BIO Cell Lines and PureStem Progenitors for ESR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

ESR2_HUMAN, Q92731: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
nucleus	5
extracellular	4
plasma membrane	2
cytoskeleton	1
cytosol	1
endoplasmic reticulum	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	9671811
GO:0005634	nucleus	TAS	11181953
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IDA	15024130

ESR2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for ESR2 About (see all 18)

See pathways by source

SuperPath

Contained pathways About

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

0.67

Nuclear Receptors

0.67

Gene Expression

Generic Transcription Pathway

0.40

Gene Expression

0.40

ERK Signaling

ERK Signaling

0.61

GPCR Pathway

Estrogen Pathway

0.55

Chks in Checkpoint Regulation

Estrogen-mediated S-Phase Entry

0.55

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for ESR2

TGF-beta Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ESR2 (see all 6)

	ERK Signaling
	Estrogen-mediated S-Phase Entry
	eNOS Signaling
	Estrogen Pathway
	MNAR-PELP1 and Estrogen Receptor Interaction

2 GeneGo (Thomson Reuters) Pathways for ESR2

	Development Ligand-independent activation of ESR1 and ESR2
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

5 BioSystems Pathways for ESR2

	Nuclear Receptors
	SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Integrated Pancreatic Cancer Pathway
	Plasma membrane estrogen receptor signaling

1 Reactome Pathway for ESR2

Nuclear Receptor transcription pathway

1 PharmGKB Pathway for ESR2

Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics

2 Kegg Pathways (Kegg details for ESR2):

	Estrogen signaling pathway
	Prolactin signaling pathway

ESR2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including ESR2 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Targets in human mouse rat

Breast Cancer in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

Cancer Drug Resistance in human mouse rat

Interactions:

GeneGlobe Interaction Network for ESR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ESR2 (Q92731^{1, 3} ENSP00000343925⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 453)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=1 STRING: ENSP00000348258
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	15345745
GO:0001541	ovarian follicle development	IEA	--
GO:0001764	neuron migration	IEA	--
GO:0006351	transcription, DNA-templated	--	--
GO:0006355	regulation of transcription, DNA-templated	TAS	11181953

ESR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ESR2

Browse compounds at ApexBio

Compounds for ESR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
(Z)-4-Hydroxytamoxifen	Metabolite of tamoxifen (Cat. No. 0999)	[68047-06-3]
ICI 182,780	Estrogen receptor antagonist	[129453-61-8]
DPN	Highly potent ERbeta agonist	[1428-67-7]
PPT	Subtype-selective ERalpha agonist	[263717-53-9]
PHTPP	Selective ERbeta antagonist	[805239-56-9]

1 HMDB Compound for ESR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Estradiol	(+)-3,17b-Estradiol (see all 83)	50-28-2	--

Selected DrugBank Compounds for ESR2 (see all 30) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Tamoxifen	ICI-46474 (see all 3)	10540-29-1	target	antagonist agonist	17158759 20827267 16822624 11752352 16326830 16010412 2011412 17404078
Raloxifene	LY-139481 (see all 6)	84449-90-1	target	agonist	11861516 10418979 11810032 11752352 12097269 11500849
Genistein	4',5, 7-Trihydroxyisoflavone (see all 4)	446-72-0	target	--	17139284 17016423 10592235
N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide	--	--	target	--	17139284 17016423 10592235
Para-Mercury-Benzenesulfonic Acid	--	--	target	--	17139284 17016423 10592235
Trilostane	--	13647-35-3	target	allosteric modulator	12209583 16806905 17109615
4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol	--	--	target	--	17139284 17016423
Diethylstilbestrol	DES (see all 10)	56-53-1	target	agonist	15123288 19101832
Estradiol	17beta oestradiol (see all 7)	50-28-2	target	agonist	17464340 2011412
Estropipate	Estropipate (usp) (see all 4)	7280-37-7	target	agonist	17464340 2011412

Selected IUPHAR Ligands for ESR2 (Estrogen receptor-beta) (see all 14) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
4-hydroxy?aetamoxifen	Antagonist	Antagonist	10.6	9048584
diethylstilbestrol	Agonist	Agonist	9.8	9048584
17beta-estradiol	Agonist	Agonist	9.34	9048584
WAY200070	Agonist	Full agonist	8.52 - 9	15456246
fulvestrant	Antagonist	Antagonist	8.74	--
diarylpropionitril	Agonist	Agonist	8.6	11150164 11708925
R,R-THC	Antagonist	Antagonist	8.44	9927308 10395487
estriol	Agonist	Agonist	8.4	9048584
genistein	Agonist	Agonist	8.2	9048584
estrone	Agonist	Agonist	7.93	9048584

Selected Novoseek inferred chemical compound relationships for ESR2 gene (see all 108) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	96.1	3585	19800101 (9), 18620727 (7), 12895004 (6), 16214508 (6) (see all 99)
4-hydroxytamoxifen	85.1	40	17464340 (6), 18663360 (4), 11720858 (2), 16782818 (2) (see all 21)
estradiol	84.7	197	10601611 (6), 10342855 (4), 19001520 (4), 15345745 (3) (see all 99)
tamoxifen	81.9	167	16010412 (8), 19744542 (5), 11078914 (4), 17404078 (4) (see all 76)
fulvestrant	80.1	13	19528477 (2), 19212635 (2), 17923257 (1), 16549430 (1) (see all 7)
progesterone	80	273	16033082 (5), 17905466 (3), 19200930 (3), 19094096 (2) (see all 99)
raloxifene	80	38	10076999 (2), 11720858 (2), 15138633 (2), 17962382 (2) (see all 26)
steroid	76.9	114	10499535 (2), 11775002 (2), 11806710 (2), 12702147 (2) (see all 78)
genistein	76.1	109	16596234 (5), 19556829 (5), 16513288 (5), 18258689 (4) (see all 51)
daidzein	73.5	39	14664520 (5), 11431145 (3), 16673816 (2), 16972265 (2) (see all 17)

4 PharmGKB related drug/compound annotations for ESR2 gene About this table

Drug/compound	PharmGKB Annotation
exemestane
fulvestrant
letrozole
tamoxifen	CA

ESR2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for ESR2 gene (7 alternative transcripts):

NM_001040275.1 NM_001214902.1 NM_001214903.1 NM_001271876.1 NM_001271877.1 NM_001437.2 NM_001040276.1

Unigene Cluster for ESR2:

Estrogen receptor 2 (ER beta)

Hs.660607 [show with all ESTs]

Unigene Representative Sequence: AB006589

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000556275 ENST00000554572(uc001xgy.2 uc001xgv.3 uc001xgw.3 uc001xgx.3)

ENST00000358599(uc001xgz.2) ENST00000555278 ENST00000344288 ENST00000553796

ENST00000557772 ENST00000555483(uc010aqd.1) ENST00000554520 ENST00000341099(uc010aqb.1 uc010aqc.1 uc001xha.1)

ENST00000555783 ENST00000542956 ENST00000353772(uc001xgu.3) ENST00000357782

ENST00000267525

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat ESR2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ESR2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ESR2
		Predesigned siRNA for gene silencing in human, mouse, rat ESR2

Clone Products:		OriGene clones in human, mouse for ESR2 (see all 19) OriGene ORF clones in mouse, rat for ESR2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ESR2 (NM_001437)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ESR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2

Primer Products:		OriGene qPCR primer pairs and template standards for ESR2 OriGene qSTAR qPCR primer pairs in human, mouse for ESR2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ESR2
		QuantiTect SYBR Green Assays in human, mouse, rat ESR2
		QuantiFast Probe-based Assays in human, mouse, rat ESR2

Additional mRNA sequence:

AB006589.1 AB006590.1 AF047463.1 AF051427.1 AF051428.1 AF061054.1 AF074598.1 AF074599.1

AK292370.1 AY438022.1 BC006461.1 BC024181.2 DQ777076.1 DQ777077.1 DQ838582.1 DQ838583.1

HQ692820.1 HQ692821.1 NR_073496.1 NR_073497.1 NR_073505.1 X99101.1

11 DOTS entries:

DT.310701 DT.100751205 DT.102837012 DT.120767971 DT.120767979 DT.40120425 DT.92419264 DT.40125379

DT.95367837 DT.91703242 DT.100740263

316 AceView cDNA sequences (see top 24):

CA867834 AK095241 AI200286 AA814679 AW731703 NM_182913 AW451449 AF435011

BM469251 CA423800 BM562970 AY061758 BG110769 AY184204 BP364494 BE856003

BQ269694 AA972285 BE673396 BU101582 AK095087 BI914129 CA868590 BM019005

AA813160 AA747808 BX281701 CR749324 AK090430 BE206269 AA747679 NM_182914

AI825282 BX490649 BQ057203 BG222179 BC042134 AW589851 AA761297 BQ638577

BM503281 AB023228 AA255739 CD105945 AL117404 BE673476 AA022760 NM_182910

CR590112 CR619897 CA396270 AI638206 CD671619 NM_015180 AA732541 AK074055

AA480895 NM_182912 BC071873 BX282648 AW119118 AW129591 BM786454 BE018062

AL080133 AK001876 BF846386 BX537642 BI829007 BM903563 BG575717 BF355815

BE795270 CD643620 BE046058 AI684761 BP352378 BQ129370 BP337819 BM725084

BF131729 BM720783 CD104656 BU632199 CA454953 BX437730 CD626838 AW182835

AA480953 AA374977 AF495911 AI823517 BG289009 BU929941 CF529381 AW070844

AW169553 BM676886 AI439267 BU681794 BX491511 BX470633 AW615226 BE872541

AI659558 AI904067 BF431182 AW085911 BX640974 AA811639 AF061055 BF367240

AA279975 AW467019 AW418993 BG390051 BX646332 AW001686 BF590055 AA933693

BG435562 AA765594 AK125715 AY061757 BX648234 AI580349 BM688747 AK128631

AK127612 AI638734 W93156 BI063070 AI824538 BM016719 BC036941 F37417

CD358379 BU753174 CK823599 CD671618 BF378797 AW847737 AW469055 AW271422

BI822595 AI673377 AA811024 BE170446 BM503441 BM923427 AW467066 AW178849

BU741984 AY061759 AL039255 F24149 BM837385 AA251050 BX461684 BG054657

BI752567 BF591977 AY184205 AA318047 AW270074 BG430008 CD654909 BF959645

BI860943 BE772890 AA381290 AI953240 AI280259 AL046592 AU135981 CK823600

CB410470 AF435010 BQ129235 AI978784 AW847612 BX496360 AA953083 BX538095

BM805144 BQ024308 AU158599 AA250744 BI022238 AA996286 AA150681 BI830055

BF934173 AI906055 AI655664 BQ328038 BX490648 AW614217 AA247756 BU659791

AI150637 BE782260 BG287170 AW364874 BX415311 CA454921 W61328 BQ335273

BM768539 AI354604 AA339452 BG401287 AW818260 AW195843 BP359956 AA780200

BG542160 AW995025 AA022624 N21444 BF921021 Z19174 BQ301334 BF352815

Z78307 BI917661 C05280 AA279617 AA229815 AW136001 AA132092 AW242484

BF374651 BF853254 BM174959 BF917273 BG292528 AA249758 AA327640 BE167360

AA533106 AW810225 AA905391 CD579378 BF374760 BU101983 BX470344 BX281929

BF842800 AJ708370 BF369440 BP351238 BF890762 BG001776 CB132568 BG996352

BF354147 CF121891 AA354316 BF379450 AI937095 BG987938 AU156404 BE772872

AA262660 BX951803 BF576565 AA333179 AA521356 BE772767 BG106434 AW854891

BQ349000 BQ368010 AW965335 BE067607 BF939354 W92986 BQ300832 BE710336

AW795637 AI919518 BQ375553 AW444950 AI206899 AW362328 BF332803 AW450778

BF333631 BQ379817 AI685725 BI054526 CB410295 BF755529 BE172224 AA228413

AL046593 BE772877 AA093170 CO247430 BF815061 AI658869 BQ335272 AA150758

BE933733 AW818157 BF913194 BG977778 AI970588 BE772811 AW438813 CD357942

BF833675 BF516511 BF840230 BE930507

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ESR2 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	·	16c	·	16d	^
SP1:																																					-
SP2:																																					-								-		-		-		-
SP3:							-		-		-		-		-		-		-		-																-		-						-		-		-		-
SP4:																																					-
SP5:																															-

ExUns:	17a	·	17b	·	17c	·	17d
SP1:
SP2:	-
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for ESR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

ESR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCCACAGTG

About this image

ESR2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Brain (Nervous System) fully expand to see all 18 entries
Thalamus
Septum

Ovary (Reproductive System) fully expand to see all 2 entries
Granulosa Cells Primary Follicle
oocyte

ESR2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ESR2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.660607

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Tissue specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain,

placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also

found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is

expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small

intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4

is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5

is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung,

liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not

expressed in brain

Pathway & Disease-focused RT² Profiler PCR Arrays including ESR2 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Targets in human mouse rat

Breast Cancer in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

Cancer Drug Resistance in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for ESR2 OriGene qSTAR qPCR primer pairs in human, mouse for ESR2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ESR2
		QuantiTect SYBR Green Assays in human, mouse, rat ESR2
		QuantiFast Probe-based Assays in human, mouse, rat ESR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for ESR2 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Esr2^{1 , 5}	estrogen receptor 2 (beta)^{1, 5}	84.65(n)¹ 88.68(a)¹		12 (33.52 cM)⁵ 13983¹ NM_010157.3¹ NP_034287.3¹ 76120419⁵
chicken (Gallus gallus)	Aves	ESR2¹	estrogen receptor 2 (ER beta)	74.78(n) 80.7(a)		395575 NM_204794.2 NP_990125.1
lizard (Anolis carolinensis)	Reptilia	ESR2⁶	estrogen receptor 2 (ER beta)	70(a)	1 ↔ 1	1(1646467-1679450)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC394460²	estrogen receptor beta	79.44(n)		AY310903.1
zebrafish (Danio rerio)	Actinopterygii	esr2a²	estrogen receptor 2a	77.22(n)		317734 AF516874.1
fruit fly (Drosophila melanogaster)	Insecta	ERR⁶	estrogen-related receptor	26(a)	1 → many	3L(8176461-8179771)

ENSEMBL Gene Tree for ESR2 (if available)
TreeFam Gene Tree for ESR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for ESR2 gene

NR4A3² ESRRA² NR3C2² NR4A1² PGR² NR3C1² AR² NR4A2²

ESRRB² ESR1² ESRRG²

Selected SIMAP similar genes for ESR2 using alignment to 4 protein entries: ESR2_HUMAN (see all proteins) (see all similar genes):

NR3A2 ESR1 NR3C2 HNF4G NR2C2 HNF4alpha

NR1I3 VDR NR3A1 NR5A1 ESRRG THRB

NR3B3 ERRgamma NR1H3 ESRRB NR3C4 RARG

ESR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116164997^1,2	C,F	--	44866330(+)	`GCCCCT/CTGTTG`	4	--	ds500¹ int¹		1		WA	118
rs139004885^1,2		--	44866383(+)	`GAGGAC/TAGGCA`	4	--	nc-transcript-variantut3¹		0	--	--	--	--
rs1255998^1,2	C,F,A,H	--	44866453(-)	`CTGTGC/GCTGCC`	4	--	ut3¹ nc-transcript-variant		22		MN EA NA NS WA CSA	3005
rs58262369^1,2	C	--	44866494(+)	`CTTCTC/TTGCCA`	4	--	nc-transcript-variantut3¹		3		CSA WA EA	239
rs8018687^1,2	C,F,H	--	44866664(+)	`ATTGTT/CGGATT`	5	--	nc-transcript-variantut3¹ ds500¹		26		NA NS EA WA CSA	2485
rs114629727^1,2	C,F	--	44866728(+)	`AACTCT/CTTCTT`	5	--	nc-transcript-variantut3¹ ds500¹		1		WA	118
rs28440970^1,2	C,F	--	44866740(+)	`AAAATT/CATTTT`	5	--	nc-transcript-variantut3¹ ds500¹		2		NA EA	240
rs142219923^1,2		--	44866752(+)	`TTCATG/TGATTA`	5	--	nc-transcript-variantut3¹ ds500¹		0	--	--	--	--
rs928554^1,2	C,F,O,A,H	--	44866777(-)	`CTTCAA/GTTTCC`	5	--	ut3¹ ds500¹ nc-transcript-variant		33		MN EA NA NS WA CSA	4528
rs201485281^1,2		--	44866797(+)	`TACCCA/GAGATT`	5	--	nc-transcript-variantut3¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ESR2 (64550950 - 64800950 bp, first 250kb of ESR2)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for ESR2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2748782	CNV	Deletion	23290073
esv2351050	CNV	Deletion	18987734
esv2748779	CNV	Deletion	23290073
nsv902021	CNV	Loss	21882294
nsv1307	CNV	Loss	18451855
nsv902019	CNV	Gain	21882294
nsv524908	CNV	Gain	19592680
nsv456326	CNV	Gain	19166990

Human Gene Mutation Database (HGMD): ESR2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ESR2

DNA2.0 Custom Variant and Variant Library Synthesis for ESR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 601663 OMIM disorders: --

Selected diseases for ESR2 (see all 182):
About MalaCards

serous cystadenocarcinoma progesterone-receptor positive breast cancer ovarian serous cystadenocarcinoma gender identity disorder

lobular neoplasia ovarian endometriosis germ cell cancer progesterone resistance

cystadenocarcinoma fallopian tube cancer malignant peritoneal mesothelioma ovarian cyst

enchondroma dental fluorosis primary pigmented nodular adrenocortical disease endometriosis

ovarian clear cell adenocarcinoma uterine carcinosarcoma phyllode tumor pulmonary sclerosing hemangioma

6 diseases from the University of Copenhagen DISEASES database for ESR2:

Breast cancer Osteoporosis Endometrial cancer Endometriosis

Prostate cancer Carcinoma

ESR2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for ESR2 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	79	565	14576822 (6), 19463683 (6), 14620916 (5), 18771580 (5) (see all 99)
endometrial cancer	65.1	37	19438492 (4), 15968319 (4), 12873984 (3), 19758455 (2) (see all 21)
breast carcinoma	59.9	45	15363297 (4), 20306984 (2), 16327431 (2), 15656884 (2) (see all 27)
endometrial carcinoma	58	26	15573770 (4), 11109162 (4), 16324249 (3), 17649814 (2) (see all 13)
prostate cancer	53.7	133	17908481 (6), 16551880 (5), 11752866 (5), 17913855 (5) (see all 59)
tumors	52.9	503	11042568 (6), 12750263 (6), 11676856 (5), 15257551 (5) (see all 99)
endometriosis	51.9	44	16210018 (4), 19001520 (4), 19878085 (4), 17336962 (3) (see all 16)
cancer	48.3	123	12921561 (5), 18085520 (4), 16615154 (4), 11734621 (3) (see all 78)
osteoporosis	39.5	17	16530497 (2), 10709863 (1), 18172701 (1), 18406312 (1) (see all 12)
prostatic intraepithelial neoplasia	39.4	6	11438457 (1), 12497580 (1), 19672287 (1)

Genetic Association Database (GAD): ESR2
Human Genome Epidemiology (HuGE) Navigator: ESR2 (224 documents)

Export disorders for ESR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for ESR2 gene, integrated from 10 sources (see all 1738):
(articles sorted by number of sources associating them with ESR2)

Utopia: connect your pdf to the dynamic
world of online information

Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results. (PubMed id 20827267)^{1, 4, 7} Hayes D.F....Flockhart D.A. (Clin. Pharmacol. Ther. 2010)
ER beta: identification and characterization of a novel human estrogen receptor. (PubMed id 8769313)^{1, 2, 3} Mosselman S.... Dijkema R. (FEBS Lett. 1996)
Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway. (PubMed id 15862947)^{1, 2, 9} St-Laurent V.... Tremblay A. (J. Steroid Biochem. Mol. Biol. 2005)
Estrogen receptor polymorphisms and the risk of endometrial cancer. (PubMed id 19438492)^{1, 4, 9} Ashton K.A....Scott R.J. (BJOG 2009)
Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. (PubMed id 18070128)^{1, 4, 9} Ashworth J.J....Ashcroft G.S. (Clin. Genet. 2008)
Estrogen receptor beta polymorphism is associated with prostate cancer risk. (PubMed id 16551880)^{1, 4, 9} Thellenberg-Karlsson C....GrAPnberg H. (Clin. Cancer Res. 2006)
+1730 G/A polymorphism of the estrogen receptor beta gene (ERbeta) may be an important genetic factor predisposing to endometriosis. (PubMed id 19878085)^{1, 4, 9} Bianco B....Barbosa C.P. (Acta Obstet Gynecol Scand 2009)
Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. (PubMed id 17904846)^{1, 4, 9} Tsezou A....Kitsiou S. (Breast 2008)
Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women. (PubMed id 15272917)^{1, 4, 9} Westberg L....Eriksson E. (Clin. Endocrinol. (Oxf) 2004)
Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer. (PubMed id 19654868)^{1, 4, 9} Chae Y.K....Helzlsouer K. (PLoS ONE 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 2100	HGNC: 3468	AceView: SYNE2	Ensembl:ENSG00000140009	euGenes: HUgn2100
ECgene: ESR2	Kegg: 2100	H-InvDB: ESR2

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for ESR2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ESR2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Estrogen_receptor

Intellectual Property for ESR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for ESR2 gene:
Search GeneIP for patents involving ESR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of ESR2
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore genomic analysis products

	Antibodies for ESR2 (ER beta/NR3A2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for ESR2		OriGene RNAi products in human, mouse, rat for ESR2
	OriGene qPCR primer pairs and template standards for ESR2		OriGene Protein Over-expression Lysate for ESR2
	OriGene MassSpec something-or-other for ESR2		OriGene clones in human, mouse for ESR2
	OriGene qSTAR qPCR primer pairs in human, mouse for ESR2		OriGene Purified Protein for ESR2
	OriGene ORF clones in mouse, rat for ESR2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ESR2		OriGene Custom Protein Services for ESR2

	Block miRNA regulation of human, mouse, rat ESR2 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing ESR2
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ESR2		Predesigned siRNA for gene silencing in human, mouse, rat ESR2
	QuantiFast Probe-based Assays in human, mouse, rat ESR2		QuantiTect SYBR Green Assays in human, mouse, rat ESR2
	PCR Arrays including human, mouse, rat ESR2		Search Chromatin IP Primers for ESR2
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat ESR2		GeneGlobe Interaction Network for ESR2
	Regulatory tfbs in ESR2 promoter

	GenScript Custom Purified and Recombinant Proteins Services for ESR2		GenScript cDNA clones with any tag delivered in your preferred vector for ESR2
	GenScript Custom Assay Services for ESR2		GenScript Custom overexpressing Cell Line Services for ESR2
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Tocris compounds for ESR2

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for ESR2
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

	Drugs for ESR2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ESR2 antibodies
	ESR2 proteins
	ESR2 lysates

	Antibodies for ESR2
	See all of Abcam's Antibodies, Kits and Proteins for ESR2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for ESR2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ESR2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ESR2
	SwitchGear Promoter luciferase reporter plasmids for ESR2

ThermoFisher Antibody for ESR2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ESR2

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ESR2
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ESR2

LSBio Antibodies in human, mouse, rat for ESR2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ESR2 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

ESR2 Gene

Estrogen Receptor 2 (ER Beta)

Aliases
for ESR2 gene

Summaries
for ESR2 gene

Genomic Views
for ESR2 gene

Proteins
for ESR2 gene

ESR2 Human Recombinant Protein Products:

ESR2 Antibody Products:

ESR2 Assay Products:

Domains /
Families
for ESR2 gene

Function
for ESR2 gene

Localization
for ESR2 gene

Pathways & Interactions
for ESR2 gene

Drugs & Compounds
for ESR2 gene

Transcripts
for ESR2 gene

Expression
for ESR2 gene

Orthologs
for ESR2 gene

Paralogs
for ESR2 gene

Genomic Variants
for ESR2 gene

Disorders / Diseases
for ESR2 gene

Publications
for ESR2 gene

External Searches for ESR2 gene

Genome Databases showing ESR2 gene

Other Databases showing ESR2 gene

Specialized Databases showing ESR2 gene

Intellectual Property
for ESR2 gene

Products
for ESR2 gene

View Random Gene

Breast Neoplasms
Dementia
LUNG TUMOR
Infertility
Azoospermia
Pituitary Tumors
Endometriosis
dysplasia
Ovarian Cysts
aggressiveness
ADENOCARCINOMA LUNG
COLON CARCINOMA
insulin sensitivity
Liver diseases
Atherosclerosis
Breast Cancer
NSCLC
Schizophrenia
Adenocarcinoma
Seminoma
Cancer
premalignant
Colorectal Carcinoma
Germ Cell Cancer
bone loss
mammary tumor
Shock
Ovarian Cancer
COLON ADENOCARCINOMA
Leiomyoma
Colorectal Cancer
Osteoporosis Postmenopausal
invasive cancer
Uterine leiomyoma
immunodeficiency
ENDOMETRIAL CARCINOMA
Urinary Incontinence Stress
Rheumatoid Arthritis
prostate cancer
Cardiovascular Diseases
Tumors
prostatic adenocarcinoma
Carcinoma Ductal
Necrosis
neoplastic transformation
COLON TUMOR
Prostatic Hyperplasia
Neurodegenerative Diseases
Encephalomyelitis
BREAST CARCINOMA
Sarcoma Endometrial Stromal
Colon Cancer
Parkinson Disease
Hyperplasia
PITUITARY ADENOMA
Occlusion Middle Cerebral Artery
Prolactinoma
Carcinoma
Osteoarthritis
PROSTATE CARCINOMA
Uterine Cancer
Leukemia
Alzheimers Disease
Diabetes Mellitus
ductal breast carcinoma
Osteosarcoma
Osteoporosis
neurodegeneration
Carcinoma Endometrioid
Calcification
Effects Cardiovascular
THYROID PAPILLARY CARCINOMA
Cancer Lung
HEART FAILURE
Coronary Artery Disease
Carcinoma Mucinous
stage prostate cancer
Insulin Resistance
Pancreatic tumor
benign prostatic hyperplasia
Adenoma
Bleeding
OVARIAN CARCINOMA
Prostatic Intraepithelial Neoplasia
Polycystic Ovary Syndrome
Infertility Male
STROKE
Graves Disease
Endometrial Hyperplasia
Breast Diseases
Endometrial Cancer
Arthritis
Choriocarcinoma

GeneCards Plus

Advanced Search

Export list of displayed genes

ESR2 Gene

Estrogen Receptor 2 (ER Beta)

Aliasesfor ESR2 gene

Summariesfor ESR2 gene

Genomic Viewsfor ESR2 gene

Proteinsfor ESR2 gene

ESR2 Human Recombinant Protein Products:

ESR2 Antibody Products:

ESR2 Assay Products:

Domains /Familiesfor ESR2 gene

Functionfor ESR2 gene

Localizationfor ESR2 gene

Pathways & Interactionsfor ESR2 gene

Drugs & Compoundsfor ESR2 gene

Transcriptsfor ESR2 gene

Expression for ESR2 gene

Orthologsfor ESR2 gene

Paralogsfor ESR2 gene

Genomic Variantsfor ESR2 gene

Disorders / Diseasesfor ESR2 gene

Publicationsfor ESR2 gene

External Searches for ESR2 gene

Genome Databases showing ESR2 gene

Other Databases showing ESR2 gene

Specialized Databases showing ESR2 gene

Intellectual Propertyfor ESR2 gene

Productsfor ESR2 gene

View Random Gene

Aliases
for ESR2 gene

Summaries
for ESR2 gene

Genomic Views
for ESR2 gene

Proteins
for ESR2 gene

Domains /
Families
for ESR2 gene

Function
for ESR2 gene

Localization
for ESR2 gene

Pathways & Interactions
for ESR2 gene

Drugs & Compounds
for ESR2 gene

Transcripts
for ESR2 gene

Expression
for ESR2 gene

Orthologs
for ESR2 gene

Paralogs
for ESR2 gene

Genomic Variants
for ESR2 gene

Disorders / Diseases
for ESR2 gene

Publications
for ESR2 gene

Intellectual Property
for ESR2 gene

Products
for ESR2 gene