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ESR2 Gene

protein-coding GIFtS: 69

GC14M063763

estrogen receptor 2 (ER beta)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ER-BETA ^²
ER-beta ^³
ESR-BETA ^²
ESRB ^²
ESTRB ^², ³
Erb ^¹, ²
NR3A2 ^¹, ², ³

Descriptions
Nuclear receptor subfamily 3 group A member 2 ^³
estrogen receptor 2 (ER beta) ^²
estrogen receptor beta ^²
estrogen receptor beta 4 ^²

External Ids
HGNC: 3468¹
Entrez Gene: 2100²
UniProtKB: Q92731³
Ensembl: ENSG00000140009⁷

Search outside databases for aliases for ESR2 gene

Previous GC identifers: GC14M062021 GC14M058487 GC14M062683 GC14M062685 GC14M063621

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ESR2:

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor

transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal

ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding

to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that

interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit

the activity of other estrogen receptor family members. Several alternatively spliced transcript

variants of this gene have been described, but the full-length nature of some of these variants

has not been fully characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and

activates expression of reporter genes containing estrogen response elements (ERE) in an

estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very

low ere binding activity resulting in the loss of ligand-dependent transactivation ability.

DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while

in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated

temperature is more gradual

Gene Wiki entry for ESR2 (Estrogen_receptor_beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ESR2 gene

Entrez Gene cytogenetic band: 14q23.2 Ensembl cytogenetic band: 14q23.2 HGNC cytogenetic band: 14q21-q22

ESR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M063763: (about GC identifiers)

Start:	63,763,504 bp from pter
End:	63,875,021 bp from pter
Size:	111,518 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731 (See protein sequence)

Recommended Name: Estrogen receptor beta

Size: 530 amino acids; 59216 Da

Subunit: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5

and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts

with PELP1 and UBE1C. Isoform beta-2/cx preferentially forms a hetereodimer with ESR1 rather than

ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13. Interacts with DNTTIP2. Interacts

with isoform 4 of TXNRD1

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1L2J (3D)

1NDE (3D)

1QKM (3D)

1U3Q (3D)

1U3R (3D)

1U3S (3D)

1U9E (3D)

1X76 (3D)

1X78 (3D)

1X7B (3D)

1X7J (3D)

1YY4 (3D)

1YYE (3D)

1ZAF (3D)

2FSZ (3D)

2GIU (3D)

2I0G (3D)

2JJ3 (3D)

2NV7 (3D)

2QTU (3D)

2Z4B (3D)

Secondary accessions: O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q9UEV6 Q9UHD3

Q9UQK9

Alternative splicing: 8 isoforms: Q92731-1 Q92731-2 Q92731-3 Q92731-4 Q92731-5 Q92731-6 Q92731-7 Q92731-8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001035365.1 NP_001035366.1 NP_001428.1

ENSEMBL proteins:

ENSP00000345616 ENSP00000350427 ENSP00000267525 ENSP00000351412 ENSP00000343925 ENSP00000335551

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ESR2
	Millipore Purified and/or Recombinant ESR2 Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for ESR2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Estrogen Receptor beta, Estrogen Receptor)
	Human Recombinant Proteins from Abnova (ESR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	11181953
GO:0005739	mitochondrion	IDA	15024130

About this table

Antibodies for ESR2:

	Invitrogen Antibodies for ESR2
	Millipore Mono- and Polyclonal Antibodies for the study of ESR2
	Sigma-Aldrich Antibodies for ESR2
	R&D Systems Antibodies for ESR2 (ER beta/NR3A2)
	Antibodies from Abcam (Estrogen Receptor beta, Estrogen Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ESR2)
	Novus Biologicals Antibodies for ESR2

Assays for ESR2:

	Invitrogen Assays for ESR2
	Millipore Kits and Assays for the Analysis of ESR2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92731

ProtoNet protein and cluster: Q92731

1 Blocks protein family: IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ESR2)
		Millipore RNAi Products for the Analysis of ESR2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ESR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001040275

Applied Biosystems Silencer® siRNAs for ESR2

Sigma-Aldrich siRNA and siRNA Panels for ESR2

Sigma-Aldrich shRNA Panels and shRNA for ESR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ESR2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040275
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040275
untagged cDNA clones in CMV expression vector (see all 4): NM_001040275

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001437

UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and

activates expression of reporter genes containing estrogen response elements (ERE) in an

estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very

low ere binding activity resulting in the loss of ligand-dependent transactivation ability.

DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while

in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated

temperature is more gradual

Genatlas biochemistry entry for ESR2:

estrogen receptor beta,steroid/thyroid receptor superfamily,with several alternatively spliced

isoforms (hER beta 1-5),expressed in thymus,spleen,ovary and testis, not rearranged in uterine

leiomyomata,see ULCR14

12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Esr2):

	digestive/alimentary	endocrine/exocrine gland	hearing/vestibular/ear	homeostasis/metabolism
immune system	muscle	nervous system	no phenotypic analysis	renal/urinary system
reproductive system	respiratory system

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	8769313
GO:0003713	transcription coactivator activity	TAS	8769313
GO:0005496	steroid binding	TAS	11181953
GO:0005515	protein binding	IPI	12039952 14764652
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ESR2 (Your Favorite Gene powered by Ingenuity)

Aryl Hydrocarbon Receptor Signaling
Estrogen Receptor Signaling

GeneDecks ESR2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ESR2

5/87 Interacting proteins for ESR2 (ENSP00000343925³ Q92731¹) via UniProtKB, MINT, and/or STRING (see all 87 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP5C	P53041¹	EBI-78505, EBI-716663
PRMT2	P55345¹	EBI-78505, EBI-78458
AKT1	ENSP00000270202³	STRING (score=.981)
NCOA1	ENSP00000320940³	STRING (score=.979)
SRC	ENSP00000362659³	STRING (score=.979)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	11181953
GO:0007165	signal transduction	TAS	8769313 10749889
GO:0007267	cell-cell signaling	TAS	8769313
GO:0030308	negative regulation of cell growth	NAS	11181953

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ESR2

Sigma-Aldrich Small Molecules for ESR2:

Mixed Agonist/Antagonist Activator Antagonist Agonist

Compounds for ESR2 available from Tocris Bioscience

Compound	Action	CAS number
ICI 182,780	Estrogen receptor antagonist	[129453-61-8]
DPN	Highly potent ERbeta agonist	[1428-67-7]
PHTPP	Selective ERbeta antagonist	[805239-56-9]

About this table

10/41 Novoseek chemical compound relationships for ESR2 gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
estradiol	84.39	176	10601611 (6), 10342855 (4), 19001520 (4), 15345745 (3) (see all 99)
progesterone	78.94	223	16033082 (5), 17905466 (3), 19200930 (3), 19094096 (2) (see all 99)
steroid	76.41	101	10499535 (2), 11775002 (2), 11806710 (2), 12702147 (2) (see all 69)
isopropylparaben	71.94	1	11193391 (1)
daidzein	71.09	38	14664520 (5), 11431145 (3), 16673816 (2), 16972265 (2) (see all 17)
coumestrol	70.68	8	14664520 (2), 15579483 (1), 16118406 (1), 15084758 (1) (see all 6)
3-benzylidene camphor	69.76	7	15147785 (2), 15458796 (1), 19150460 (1)
17alpha estradiol	69.37	3	15910780 (1), 15254088 (1), 17713618 (1), 15955889 (1)
isobutylparaben	68.30	2	11193391 (1), 19101832 (1)
4-methylbenzylidene camphor	67.34	12	12765243 (5), 15458796 (1), 15979666 (1), 19150460 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ESR2)
		Millipore RNAi Products for the Analysis of ESR2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ESR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001040275

Sigma-Aldrich siRNA and siRNA Panels for ESR2

Sigma-Aldrich shRNA Panels and shRNA for ESR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040275 NM_001040276 NM_001437

REFSEQ mRNAs for ESR2 gene (3 alternative transcripts):

NM_001040275.1 NM_001040276.1 NM_001437.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040275 NM_001040276 NM_001437

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040275
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040275
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001040275

Additional cDNA sequence:

AB006589.1 AB006590.1 AF047463.1 AF051427.1 AF051428.1 AF060555.1 AF061054.1 AF074598.1

AF074599.1 AK292370.1 AY438022.1 BC006461.1 DQ777076.1 DQ777077.1 DQ838582.1 DQ838583.1

X99101.1 XM_001724440.1

11 DOTS entries:

DT.100751205 DT.310701 DT.102837012 DT.120767971 DT.120767979 DT.40120425 DT.92419264 DT.100740263

DT.40125379 DT.95367837 DT.91703242

24/316 AceView cDNA sequences (see all 316 ):

BE673396 BM562970 BQ057203 BG110769 AA747679 AW451449 CA868590 AY184204

CR619897 BC071873 BX490649 BQ638577 BG222179 BM503281 AY061758 AL117404

AI638206 AA480895 BE673476 BM786454 AL080133 BC042134 AA813160 AW589851

highest scoring ESTs for ESR2:

AB006589 AF061054 BG722442 X99101 AB006590 AF051427 AF051428 AF060555 AF074599 AI917846

Unigene Cluster for ESR2:

Estrogen receptor 2 (ER beta)

Hs.660607 [show with all ESTs]

Unigene Representative Sequence: AB006589

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ESR2 (see all 11 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	·	16c	·	16d	^
SP1:																																					-
SP2:																																					-								-		-		-		-
SP3:							-		-		-		-		-		-		-		-																-		-						-		-		-		-
SP4:																																					-
SP5:																															-

ExUns:	17a	·	17b	·	17c	·	17d
SP1:
SP2:	-
SP3:	-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ESR2

6 Ensembl transcripts including schematic representations:

ENST00000344288 ENST00000357782 ENST00000267525 ENST00000358599 ENST00000341099 ENST00000353772

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ESR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ESR2

¹ / ² / ³

14 probe-sets matching ESR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31437_r_at²^{, 3}	U95-A	1	1.00	1.00	0.81	0.71	AF061055	0.40	0.50	0.45	1
31436_s_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.84	AF061055	0.40	0.50	0.45	1
34431_at²^{, 3}	U95-A	1	1.00	1.00	-0.20	0.26	AF061054	0.80	1.00	0.91	1
1442_at²^{, 3}	U95-A	1	1.00	1.00	0.73	1.48	X99101	0.80	1.00	0.91	1
211120_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB006590	0.60	1.00	0.82	1
211119_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF060555	0.60	1.00	0.82	1
211117_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF124790	0.40	1.00	0.76	1
211118_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF051428	0.60	1.00	0.82	1
210780_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB006589	0.80	1.00	0.91	1
211120_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211119_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211117_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211118_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210780_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCCACAGTG

SOURCE GeneReport for Unigene cluster: Hs.660607
Expression variation in blood from EXPOLDB for ESR2
UniProtKB/Swiss-Prot: ESR2_HUMAN, Q92731
Tissue specificity: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart,
brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary
gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in
colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a
lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary
gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at
a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in
testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung,
liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and
uterus. Not expressed in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ESR2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ESR2¹	--	estrogen receptor 2 (ER beta)	87.23(n) 88.11(a)	403639 XM_860976.1 XP_866069.1
chimpanzee (Pan troglodytes)	ESR2¹	--	estrogen receptor 2 (ER beta)	99.62(n) 99.25(a)	452964 XM_001170268.1 XP_001170268.1
cow (Bos taurus)	ESR2¹	--	estrogen receptor 2 (ER beta)	87.27(n) 89.24(a)	281146 NM_174051.2 NP_776476.1
rat (Rattus norvegicus)	Esr2¹	--	estrogen receptor 2 (ER beta)	85.36(n) 88.66(a)	25149 NM_012754.1 NP_036886.1
mouse (Mus musculus)	Esr2^{1, 5}	12 (33.00 cM)⁵	estrogen receptor 2 (beta)^{1, 5}	84.65(n)¹ 88.68(a)¹	13983¹ NM_207707.1¹ NP_997590.1¹ AB034957⁵ AF063853⁵ (see all 13)

About this table Species with no ortholog for ESR2

ENSEMBL Gene Tree for ESR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ESR2 gene

ESR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/589 NCBI SNPs in ESR2 are shown (see all 589 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 180)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs928554^1,2	A,C,F,H,O	63763948(-)	`CTTCAA/GTTTCC`	2	--	ut3¹		13		MN EA NA EU WA	2575
	rs1271572^1,2	A,C,F,H,O	63831670(-)	`GGGGGG/TTCTCA`	3	--	ng3¹ int¹		9		NA EU EA	694
	rs944459^1,2	A,C,F,H,O	63769111(+)	`AAGTAC/TGCAAT`	3	--	int¹ ng5¹		16		NA EA EU WA MN CSAM	2714
	rs1255998^1,2	A,C,F,H	63763624(-)	`CTGTGC/GCTGCC`	2	--	ut3¹		8		MN EU EA WA NA	2270
	rs8006145^1,2	A,C,F,H	63769203(+)	`CCACAC/AAAGAA`	3	--	int¹ ng5¹		9		MN CSAM EA EU WA	828
	rs8018687^1,2	C,F,H	63763835(+)	`ATTGTT/CGGATT`	2	--	ut3¹		11		NA EU EA WA	966
	rs4986938^1,2	C,F,H	63769569(-)	`TCACAG/AGCTGA`	3	--	int¹ ut3¹		15		MN CSAM EA EU NA	1244
	rs3829768^1,2	C,F	63831347(+)	`AGGTCA/GCTGGG`	3	--	ng3¹ int¹		1		--	100
--	rs8008187^1,2	C	63831558(+)	`CCCCAG/CCAGGA`	3	--	ng3¹ int¹		1		--	100
--	rs3841304^1,2	C	63831676(+)	`CCCCC-/CAGTGT`	3	--	ng3¹ int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ESR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601663

10/93 Novoseek disease relationships for ESR2 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	78.00	485	14576822 (6), 14620916 (5), 16289616 (5), 15254780 (5) (see all 99)
endometrial cancer	63.49	28	15968319 (4), 12873984 (3), 11207052 (2), 11309276 (2) (see all 19)
breast carcinoma	58.69	39	15363297 (4), 16327431 (2), 15374639 (2), 15285303 (2) (see all 25)
endometrial carcinoma	57.78	26	15573770 (4), 11109162 (4), 16324249 (3), 17649814 (2) (see all 13)
prostate cancer	53.18	126	17908481 (6), 16551880 (5), 11752866 (5), 17913855 (5) (see all 54)
tumors	50.87	453	11042568 (6), 12750263 (6), 11676856 (5), 15257551 (5) (see all 99)
endometriosis	50.49	38	16210018 (4), 19001520 (4), 17336962 (3), 17548071 (3) (see all 14)
cancer	46.75	109	12921561 (5), 18085520 (4), 16615154 (4), 11734621 (3) (see all 69)
osteoporosis	41.31	16	16530497 (2), 10709863 (1), 18172701 (1), 18406312 (1) (see all 11)
osteosarcoma	38.09	18	15993498 (2), 15033914 (2), 17947807 (2), 9223441 (1) (see all 12)

About this table

Human Gene Mutation Database: ESR2
Genetic Association Database: ESR2
Human Genome Epidemiology Navigator: ESR2 (143 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1162 PubMed articles for ESR2 gene (see all 1162 ):

ER beta: identification and characterization of a novel human estrogen receptor. (PubMed id 8769313)^{2, 3, 4} Mosselman S.... Dijkema R. (1996)
Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. (PubMed id 16098017)^{1, 3, 6} Fytili P....Tsezou A. (2005)
The RsaI polymorphism in the estrogen receptor-beta gene is associated with male infertility. (PubMed id 15998774)^{1, 3, 6} Aschim E.L....Giwercman Y.L. (2005)
Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. (PubMed id 16261413)^{1, 3, 6} Maguire P....Lindblom A. (2005)
Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status. (PubMed id 15381922)^{1, 3, 6} Almeida S....Hutz M.H. (2005)
Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population. (PubMed id 15193490)^{1, 3, 6} Wang Z....Maruo T. (2004)
Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. (PubMed id 14633679)^{1, 3, 6} Zheng S.L....Gao Y.T. (2003)
Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women. (PubMed id 11397855)^{1, 3, 6} Westberg L....Eriksson E. (2001)
Microsatellite profile in hormonal receptor genes associated with breast cancer. (PubMed id 16317584)^{1, 3, 6} Iobagiu C....Genin C. (2006)
Correlation of estrogen receptor beta gene polymorphisms with spinal bone mineral density in peri- and post-menopausal Greek women. (PubMed id 16125346)^{1, 3, 6} Efstathiadou Z....Tsatsoulis A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2100	HGNC: 3468	AceView: SYNE2	Ensembl:ENSG00000140009	euGenes: HUgn2100
ECgene: ESR2	H-InvDB: ESR2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ESR2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ESR2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ESR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ESR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ESR2		Antibodies for ESR2
	Explore super-pooled esiRNAs		Proteins for ESR2
	Lentivirus-delivered shRNAs for ESR2		Small molecules for ESR2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ESR2)
	Antibodies (ESR2)
	Chimera RNAi (ESR2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Estrogen Receptor beta, Estrogen Receptor)
	Antibodies (Estrogen Receptor beta, Estrogen Receptor)

Search OriGene for ESR2

Tocris compounds for ESR2

	Drugs for ESR2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ESR2

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ESR2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ESR2

Summaries
for ESR2

Genomic Location
for ESR2

Proteins
for ESR2

Protein Domains/
Families
for ESR2

Gene Function
for ESR2

Pathways & Interactions
for ESR2

Drugs & Compounds
for ESR2

Transcripts
for ESR2

Expression
for ESR2

Orthologs
for ESR2

Paralogs
for ESR2

SNPs/Variants
for ESR2

Disorders & Mutations
for ESR2

Medical News
for ESR2

Publications
for ESR2

Search for ESR2

Genome Databases showing ESR2

Other Databases showing ESR2

Specialized Databases showing ESR2

Licensable Technologies
for ESR2

Services
for ESR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ESR2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ESR2

Summariesfor ESR2

Genomic Locationfor ESR2

Proteinsfor ESR2

Protein Domains/Familiesfor ESR2

Gene Functionfor ESR2

Pathways & Interactionsfor ESR2

Drugs & Compoundsfor ESR2

Transcriptsfor ESR2

Expression for ESR2

Orthologsfor ESR2

Paralogsfor ESR2

SNPs/Variantsfor ESR2

Disorders & Mutationsfor ESR2

Medical Newsfor ESR2

Publicationsfor ESR2

Search for ESR2

Genome Databases showing ESR2

Other Databases showing ESR2

Specialized Databases showing ESR2

Licensable Technologiesfor ESR2

Servicesfor ESR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ESR2

Summaries
for ESR2

Genomic Location
for ESR2

Proteins
for ESR2

Protein Domains/
Families
for ESR2

Gene Function
for ESR2

Pathways & Interactions
for ESR2

Drugs & Compounds
for ESR2

Transcripts
for ESR2

Expression
for ESR2

Orthologs
for ESR2

Paralogs
for ESR2

SNPs/Variants
for ESR2

Disorders & Mutations
for ESR2

Medical News
for ESR2

Publications
for ESR2

Licensable Technologies
for ESR2

Services
for ESR2