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Aliases for ESM1 Gene

Aliases for ESM1 Gene

  • Endothelial Cell-Specific Molecule 1 2 3
  • ESM-1 3 4
  • Endocan 3

External Ids for ESM1 Gene

Previous GeneCards Identifiers for ESM1 Gene

  • GC05M054436
  • GC05M055702
  • GC05M054244
  • GC05M054289
  • GC05M054309
  • GC05M051247

Summaries for ESM1 Gene

Entrez Gene Summary for ESM1 Gene

  • This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ESM1 Gene

ESM1 (Endothelial Cell-Specific Molecule 1) is a Protein Coding gene. Among its related pathways are Gastric cancer network 1. GO annotations related to this gene include integrin binding and hepatocyte growth factor receptor binding.

UniProtKB/Swiss-Prot for ESM1 Gene

  • Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

Gene Wiki entry for ESM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESM1 Gene

Genomics for ESM1 Gene

Regulatory Elements for ESM1 Gene

Genomic Location for ESM1 Gene

Chromosome:
5
Start:
54,977,864 bp from pter
End:
55,022,671 bp from pter
Size:
44,808 bases
Orientation:
Minus strand

Genomic View for ESM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESM1 Gene

Proteins for ESM1 Gene

  • Protein details for ESM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ30-ESM1_HUMAN
    Recommended name:
    Endothelial cell-specific molecule 1
    Protein Accession:
    Q9NQ30
    Secondary Accessions:
    • B2R4G3
    • Q15330
    • Q3V4E3
    • Q96ES3

    Protein attributes for ESM1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20095 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for ESM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESM1 Gene

Proteomics data for ESM1 Gene at MOPED

Post-translational modifications for ESM1 Gene

Other Protein References for ESM1 Gene

Antibody Products

No data available for DME Specific Peptides for ESM1 Gene

Domains & Families for ESM1 Gene

Protein Domains for ESM1 Gene

Suggested Antigen Peptide Sequences for ESM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ30

UniProtKB/Swiss-Prot:

ESM1_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
Domain:
  • Contains 1 IGFBP N-terminal domain.
genes like me logo Genes that share domains with ESM1: view

No data available for Gene Families for ESM1 Gene

Function for ESM1 Gene

Molecular function for ESM1 Gene

GENATLAS Biochemistry:
endothelial cell-specific molecule 1,restrictively expressed in lung tissue,regulated by TNF,IL1B and IFNG
UniProtKB/Swiss-Prot Function:
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
UniProtKB/Swiss-Prot Induction:
By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4

Gene Ontology (GO) - Molecular Function for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005171 hepatocyte growth factor receptor binding IPI 11590178
GO:0005178 integrin binding IPI 11544294
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with ESM1: view

Phenotypes for ESM1 Gene

genes like me logo Genes that share phenotypes with ESM1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ESM1 Gene

Localization for ESM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESM1 Gene COMPARTMENTS Subcellular localization image for ESM1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ESM1: view

Pathways & Interactions for ESM1 Gene

SuperPathways for ESM1 Gene

Superpath Contained pathways
1 Gastric cancer network 1
genes like me logo Genes that share pathways with ESM1: view

Pathways by source for ESM1 Gene

1 BioSystems pathway for ESM1 Gene

Interacting Proteins for ESM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370812%0d%0a9606.ENSP00000303242%0d%0a9606.ENSP00000349252%0d%0a
Selected Interacting proteins: Q9NQ30-ESM1_HUMAN ENSP00000370812 for ESM1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001558 regulation of cell growth IEA --
GO:0002040 sprouting angiogenesis IMP 20616313
GO:0008284 positive regulation of cell proliferation IDA 11590178
GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway IDA 11590178
genes like me logo Genes that share ontologies with ESM1: view

No data available for SIGNOR curated interactions for ESM1 Gene

Drugs & Compounds for ESM1 Gene

No Compound Related Data Available

Transcripts for ESM1 Gene

Unigene Clusters for ESM1 Gene

Endothelial cell-specific molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ESM1 Gene

GeneLoc Exon Structure for
ESM1
ECgene alternative splicing isoforms for
ESM1

Expression for ESM1 Gene

mRNA expression in normal human tissues for ESM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESM1 Gene

This gene is overexpressed in Kidney - Cortex (x9.5), Lung (x9.1), and Minor Salivary Gland (x7.6).

Protein differential expression in normal tissues from HIPED for ESM1 Gene

This gene is overexpressed in Blymphocyte (35.1), Tlymphocyte (21.0), and Neutrophil (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ESM1 Gene



SOURCE GeneReport for Unigene cluster for ESM1 Gene Hs.129944

mRNA Expression by UniProt/SwissProt for ESM1 Gene

Q9NQ30-ESM1_HUMAN
Tissue specificity: Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney
genes like me logo Genes that share expression patterns with ESM1: view

Protein tissue co-expression partners for ESM1 Gene

Primer Products

In Situ Assay Products

Orthologs for ESM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESM1 35
  • 84.88 (n)
  • 80.87 (a)
ESM1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESM1 35
  • 83.24 (n)
  • 85.38 (a)
ESM1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esm1 35
  • 80.87 (n)
  • 75.41 (a)
Esm1 16
Esm1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESM1 35
  • 99.82 (n)
  • 100 (a)
ESM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esm1 35
  • 79.23 (n)
  • 74.86 (a)
oppossum
(Monodelphis domestica)
Mammalia ESM1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESM1 35
  • 74.32 (n)
  • 74.32 (a)
ESM1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESM1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esm1 35
  • 69.8 (n)
  • 70.59 (a)
zebrafish
(Danio rerio)
Actinopterygii esm1 35
  • 56.48 (n)
  • 53.5 (a)
esm1 36
  • 47 (a)
OneToOne
Species with no ortholog for ESM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESM1 Gene

ENSEMBL:
Gene Tree for ESM1 (if available)
TreeFam:
Gene Tree for ESM1 (if available)

Paralogs for ESM1 Gene

(1) SIMAP similar genes for ESM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ESM1: view

No data available for Paralogs for ESM1 Gene

Variants for ESM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ESM1 Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV Gain 17160897

Variation tolerance for ESM1 Gene

Residual Variation Intolerance Score: 51.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESM1 Gene

HapMap Linkage Disequilibrium report
ESM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ESM1 Gene

Disorders for ESM1 Gene

Relevant External Links for ESM1

Genetic Association Database (GAD)
ESM1
Human Genome Epidemiology (HuGE) Navigator
ESM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESM1
genes like me logo Genes that share disorders with ESM1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESM1 Gene

Publications for ESM1 Gene

  1. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. (PMID: 8702785) Lassalle P. … Tonnel A.-B. (J. Biol. Chem. 1996) 2 23 67
  2. Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. (PMID: 11025405) Bechard D. … Lassalle P. (J. Vasc. Res. 2000) 23 67
  3. Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: Comparative effects of amlodipine and valsartan. (PMID: 25390761) CelA+k T. … GrassA+ G. (Blood Press. 2014) 67
  4. Endothelial cell-specific molecule-1: a potential serum marker for gastric cancer. (PMID: 25056533) Lv Z. … Zhao D. (Tumour Biol. 2014) 67
  5. Endocan elicits severe vascular inflammatory responses in vitro and in vivo. (PMID: 24446198) Lee W. … Bae J.S. (J. Cell. Physiol. 2014) 67

Products for ESM1 Gene

Sources for ESM1 Gene

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