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Aliases for ESF1 Gene

Aliases for ESF1 Gene

  • ESF1 Nucleolar Pre-RRNA Processing Protein Homolog 2 3 5
  • ABT1-Associated Protein 3 4
  • C20orf6 3 4
  • ABTAP 3 4
  • ESF1, Nucleolar Pre-RRNA Processing Protein, Homolog (S. Cerevisiae) 2
  • ESF1, Nucleolar Pre-RRNA Processing Protein, Homolog 3
  • Chromosome 20 Open Reading Frame 6 2
  • BA526K24.1 3
  • HDCMC28P 3

External Ids for ESF1 Gene

Previous HGNC Symbols for ESF1 Gene

  • C20orf6

Summaries for ESF1 Gene

GeneCards Summary for ESF1 Gene

ESF1 (ESF1 Nucleolar Pre-RRNA Processing Protein Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ESF1 Gene

  • May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).

Gene Wiki entry for ESF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESF1 Gene

Genomics for ESF1 Gene

Regulatory Elements for ESF1 Gene

Enhancers for ESF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ESF1 on UCSC Golden Path with GeneCards custom track

Promoters for ESF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ESF1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ESF1 gene promoter:

Genomic Location for ESF1 Gene

Chromosome:
20
Start:
13,714,322 bp from pter
End:
13,784,933 bp from pter
Size:
70,612 bases
Orientation:
Minus strand

Genomic View for ESF1 Gene

Genes around ESF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESF1 Gene

Proteins for ESF1 Gene

  • Protein details for ESF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H501-ESF1_HUMAN
    Recommended name:
    ESF1 homolog
    Protein Accession:
    Q9H501
    Secondary Accessions:
    • Q86X92
    • Q9H9Q5
    • Q9HA35
    • Q9NX93
    • Q9P1S6

    Protein attributes for ESF1 Gene

    Size:
    851 amino acids
    Molecular mass:
    98796 Da
    Quaternary structure:
    • Interacts with ABT1. Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity).
    SequenceCaution:
    • Sequence=AAF65504.1; Type=Frameshift; Positions=664; Evidence={ECO:0000305}; Sequence=BAA91123.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14167.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ESF1 Gene

Proteomics data for ESF1 Gene at MOPED

Post-translational modifications for ESF1 Gene

  • Ubiquitination at Lys 184
  • Modification sites at PhosphoSitePlus

Other Protein References for ESF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ESF1 Gene

Domains & Families for ESF1 Gene

Protein Domains for ESF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ESF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H501

UniProtKB/Swiss-Prot:

ESF1_HUMAN :
  • Belongs to the ESF1 family.
Family:
  • Belongs to the ESF1 family.
genes like me logo Genes that share domains with ESF1: view

No data available for Gene Families for ESF1 Gene

Function for ESF1 Gene

Molecular function for ESF1 Gene

UniProtKB/Swiss-Prot Function:
May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).
genes like me logo Genes that share phenotypes with ESF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ESF1 Gene

Localization for ESF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESF1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESF1 Gene COMPARTMENTS Subcellular localization image for ESF1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ESF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
genes like me logo Genes that share ontologies with ESF1: view

Pathways & Interactions for ESF1 Gene

SuperPathways for ESF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ESF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ESF1 Gene

Drugs & Compounds for ESF1 Gene

No Compound Related Data Available

Transcripts for ESF1 Gene

mRNA/cDNA for ESF1 Gene

Unigene Clusters for ESF1 Gene

ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESF1 Gene

No ASD Table

Relevant External Links for ESF1 Gene

GeneLoc Exon Structure for
ESF1
ECgene alternative splicing isoforms for
ESF1

Expression for ESF1 Gene

mRNA expression in normal human tissues for ESF1 Gene

Protein differential expression in normal tissues from HIPED for ESF1 Gene

This gene is overexpressed in Breast (14.3), Plasma (14.3), and Pancreas (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ESF1 Gene



SOURCE GeneReport for Unigene cluster for ESF1 Gene Hs.369284

genes like me logo Genes that share expression patterns with ESF1: view

Protein tissue co-expression partners for ESF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ESF1 Gene

Orthologs for ESF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ESF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESF1 35
  • 88.04 (n)
  • 83.65 (a)
ESF1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESF1 35
  • 88.34 (n)
  • 84.28 (a)
ESF1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esf1 35
  • 85.11 (n)
  • 81.47 (a)
Esf1 16
Esf1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESF1 35
  • 95.92 (n)
  • 93.82 (a)
ESF1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esf1 35
  • 84.57 (n)
  • 81.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ESF1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves ESF1 35
  • 69.49 (n)
  • 64.58 (a)
ESF1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESF1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.479 35
zebrafish
(Danio rerio)
Actinopterygii esf1 35
  • 64.7 (n)
  • 65.97 (a)
wufe06g12 35
esf1 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5651 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003294 35
  • 52.41 (n)
  • 45.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11417 35
  • 52.65 (n)
  • 47.29 (a)
CG11417 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F58B3.4 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESF1 36
  • 34 (a)
OneToOne
ESF1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10539 36
  • 42 (a)
OneToOne
Species with no ortholog for ESF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ESF1 Gene

ENSEMBL:
Gene Tree for ESF1 (if available)
TreeFam:
Gene Tree for ESF1 (if available)

Paralogs for ESF1 Gene

Pseudogenes.org Pseudogenes for ESF1 Gene

genes like me logo Genes that share paralogs with ESF1: view

No data available for Paralogs for ESF1 Gene

Variants for ESF1 Gene

Sequence variations from dbSNP and Humsavar for ESF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3180370 - 13,766,794(-) GGAGA(C/T)AGAAG reference, missense
rs6079171 - 13,772,608(+) CTGAA(A/G)GATAT reference, missense
rs34414644 - 13,714,960(-) AGTCC(A/C)TTGAT reference, missense
rs754795 -- 13,762,410(+) AAAGT(A/T)TTTCT intron-variant
rs754796 -- 13,762,651(+) ATTCT(A/G)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ESF1 Gene

Variant ID Type Subtype PubMed ID
nsv912689 CNV Gain 21882294
esv268688 CNV Insertion 20981092
esv272957 CNV Insertion 20981092
esv1607153 CNV Insertion 17803354

Variation tolerance for ESF1 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESF1 Gene

HapMap Linkage Disequilibrium report
ESF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESF1 Gene

Disorders for ESF1 Gene

Relevant External Links for ESF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESF1

No disorders were found for ESF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESF1 Gene

Publications for ESF1 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for ESF1 Gene

Sources for ESF1 Gene

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