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Aliases for ESD Gene

Aliases for ESD Gene

  • Esterase D 2 3 4
  • Esterase D/Formylglutathione Hydrolase 2 3
  • Methylumbelliferyl-Acetate Deacetylase 3 4
  • EC 3.1.2.12 4 63
  • FGH 3 4
  • S-Formylglutathione Hydrolase 2
  • Esterase 10 3
  • EC 3.1.1.56 4

External Ids for ESD Gene

Previous GeneCards Identifiers for ESD Gene

  • GC13M045345
  • GC13M041332
  • GC13M046282
  • GC13M045143
  • GC13M046243
  • GC13M047345
  • GC13M028138

Summaries for ESD Gene

Entrez Gene Summary for ESD Gene

  • This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

GeneCards Summary for ESD Gene

ESD (Esterase D) is a Protein Coding gene. Diseases associated with ESD include wilson disease and leukocoria. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include serine-type peptidase activity and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for ESD Gene

  • Serine hydrolase involved in the detoxification of formaldehyde.

Gene Wiki entry for ESD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESD Gene

Genomics for ESD Gene

Regulatory Elements for ESD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ESD Gene

Chromosome:
13
Start:
46,771,256 bp from pter
End:
46,797,681 bp from pter
Size:
26,426 bases
Orientation:
Minus strand

Genomic View for ESD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESD Gene

Proteins for ESD Gene

  • Protein details for ESD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10768-ESTD_HUMAN
    Recommended name:
    S-formylglutathione hydrolase
    Protein Accession:
    P10768
    Secondary Accessions:
    • Q5TBU8
    • Q5TBV0
    • Q5TBV2
    • Q9BVJ2

    Protein attributes for ESD Gene

    Size:
    282 amino acids
    Molecular mass:
    31463 Da
    Quaternary structure:
    • Homodimer
    SequenceCaution:
    • Sequence=CAI12225.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESD Gene

neXtProt entry for ESD Gene

Proteomics data for ESD Gene at MOPED

Selected DME Specific Peptides for ESD Gene

Post-translational modifications for ESD Gene

  • Ubiquitination at Lys 10, Lys 17, Lys 167, Lys 198, and Lys 209
  • Modification sites at PhosphoSitePlus

Other Protein References for ESD Gene

Antibody Products

Domains & Families for ESD Gene

Protein Domains for ESD Gene

Suggested Antigen Peptide Sequences for ESD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10768

UniProtKB/Swiss-Prot:

ESTD_HUMAN :
  • Belongs to the esterase D family.
Family:
  • Belongs to the esterase D family.
genes like me logo Genes that share domains with ESD: view

No data available for Gene Families for ESD Gene

Function for ESD Gene

Molecular function for ESD Gene

GENATLAS Biochemistry:
esterase D
UniProtKB/Swiss-Prot CatalyticActivity:
S-formylglutathione + H(2)O = glutathione + formate.
UniProtKB/Swiss-Prot CatalyticActivity:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
UniProtKB/Swiss-Prot Function:
Serine hydrolase involved in the detoxification of formaldehyde.

Enzyme Numbers (IUBMB) for ESD Gene

Gene Ontology (GO) - Molecular Function for ESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016788 hydrolase activity, acting on ester bonds IDA 19126594
GO:0018738 S-formylglutathione hydrolase activity TAS --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity NAS 3164702
genes like me logo Genes that share ontologies with ESD: view
genes like me logo Genes that share phenotypes with ESD: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ESD

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ESD Gene

Localization for ESD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESD Gene

Cytoplasm. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESD Gene COMPARTMENTS Subcellular localization image for ESD gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ESD: view

Pathways & Interactions for ESD Gene

genes like me logo Genes that share pathways with ESD: view

Pathways by source for ESD Gene

1 KEGG pathway for ESD Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008150 biological_process ND --
GO:0044281 small molecule metabolic process TAS --
GO:0046294 formaldehyde catabolic process IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with ESD: view

No data available for SIGNOR curated interactions for ESD Gene

Drugs & Compounds for ESD Gene

(9) Drugs for ESD Gene - From: NovoSeek, HMDB, ClinicalTrials, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Budesonide Approved Pharma Anti-inflammatory corticosteroid 368
Menthol Approved Pharma Activator 1748
acetic acid Approved Nutra Full agonist, Agonist 80
Formic acid Experimental Pharma 0

(11) Additional Compounds for ESD Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
S-formylglutathione
  • S-Formylglutathione
50409-81-9
4-methylumbelliferone
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 4-Methylumbelliferyl acetate
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-Acetoxy-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
6-phosphogluconate
genes like me logo Genes that share compounds with ESD: view

Transcripts for ESD Gene

Unigene Clusters for ESD Gene

Esterase D:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ESD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ESD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for ESD Gene

GeneLoc Exon Structure for
ESD
ECgene alternative splicing isoforms for
ESD

Expression for ESD Gene

mRNA expression in normal human tissues for ESD Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ESD Gene



SOURCE GeneReport for Unigene cluster for ESD Gene Hs.432491

genes like me logo Genes that share expression patterns with ESD: view

Protein tissue co-expression partners for ESD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ESD Gene

Orthologs for ESD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ESD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESD 35
  • 90.31 (n)
  • 92.2 (a)
ESD 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESD 35
  • 92.67 (n)
  • 96.45 (a)
ESD 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esd 35
  • 87.23 (n)
  • 91.84 (a)
Esd 16
Esd 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESD 35
  • 99.29 (n)
  • 99.65 (a)
ESD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esd 35
  • 87.12 (n)
  • 91.13 (a)
oppossum
(Monodelphis domestica)
Mammalia ESD 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESD 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESD 35
  • 80.02 (n)
  • 83.33 (a)
ESD 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESD 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esd 35
  • 75.65 (n)
  • 80.5 (a)
Str.11945 35
zebrafish
(Danio rerio)
Actinopterygii esd 35
  • 72.7 (n)
  • 80.5 (a)
esd 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4390 37
  • 59 (a)
CG4390 35
  • 57.09 (n)
  • 59.57 (a)
CG4390 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002627 35
  • 57.35 (n)
  • 62.37 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.1 35
  • 56.88 (n)
  • 53.26 (a)
Y48G10A.1 36
  • 53 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL156W 35
  • 50.96 (n)
  • 46.04 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01947g 35
  • 50.72 (n)
  • 48.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YJL068C 35
  • 48.62 (n)
  • 41.52 (a)
-- 36
  • 38 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SFGH 35
  • 57.49 (n)
  • 57.61 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7071 35
barley
(Hordeum vulgare)
Liliopsida Hv.2989 35
rice
(Oryza sativa)
Liliopsida Os01g0939700 35
  • 57.91 (n)
  • 57.55 (a)
corn
(Zea mays)
Liliopsida Zm.3730 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5019 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00173 35
  • 51.67 (n)
  • 51.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1047 36
  • 61 (a)
OneToOne
Species with no ortholog for ESD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ESD Gene

ENSEMBL:
Gene Tree for ESD (if available)
TreeFam:
Gene Tree for ESD (if available)

Paralogs for ESD Gene

Pseudogenes.org Pseudogenes for ESD Gene

genes like me logo Genes that share paralogs with ESD: view

No data available for Paralogs for ESD Gene

Variants for ESD Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ESD Gene

P10768-ESTD_HUMAN
There are two major electrophoretic isotypes. The sequence of the ESD*1 variant is shown

Sequence variations from dbSNP and Humsavar for ESD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_005202 -
VAR_022275 -

Structural Variations from Database of Genomic Variants (DGV) for ESD Gene

Variant ID Type Subtype PubMed ID
nsv900061 CNV Gain 21882294
nsv900062 CNV Gain 21882294

Variation tolerance for ESD Gene

Residual Variation Intolerance Score: 56.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESD Gene

HapMap Linkage Disequilibrium report
ESD

Disorders for ESD Gene

MalaCards: The human disease database

(2) MalaCards diseases for ESD Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
wilson disease
  • hepatolenticular degeneration
leukocoria
  • leucocoria
- elite association
Search ESD in MalaCards View complete list of genes associated with diseases

Relevant External Links for ESD

Genetic Association Database (GAD)
ESD
Human Genome Epidemiology (HuGE) Navigator
ESD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESD
genes like me logo Genes that share disorders with ESD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ESD Gene

Publications for ESD Gene

  1. Physiological role of S-formylglutathione hydrolase in C(1) metabolism of the methylotrophic yeast Candida boidinii. (PMID: 12904537) Yurimoto H. … Kato N. (Microbiology (Reading, Engl.) 2003) 23 25 26 67
  2. Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125. (PMID: 20209484) Alterio V. … De Simone G. (Biopolymers 2010) 23 67
  3. Crystal structure of human esterase D: a potential genetic marker of retinoblastoma. (PMID: 19126594) Wu D. … Liu Z.-J. (FASEB J. 2009) 23 67
  4. Esterase D is essential for protection of Neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells. (PMID: 19527171) Potter A.J. … McEwan A.G. (J. Infect. Dis. 2009) 23 67
  5. [The gene pool of Belgorod oblast population: study of biochemical gene markers in populations of Ukraine and Belarus and the position of the Belgorod population in the Eastern Slavic gene pool system]. (PMID: 18666561) Lependina I.N. … Balanovskaia E.V. (Genetika 2008) 23 67

Products for ESD Gene

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