Aliases for ESCO1 Gene
External Ids for ESCO1 Gene
Previous GeneCards Identifiers for ESCO1 Gene
ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ESCO1 Gene
ESCO1 (Establishment Of Sister Chromatid Cohesion N-Acetyltransferase 1) is a Protein Coding gene. Diseases associated with ESCO1 include Anonychia Congenita and Roberts Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Cell Cycle, Mitotic. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is ESCO2.
UniProtKB/Swiss-Prot for ESCO1 Gene
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.