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Aliases for ESAM Gene

Aliases for ESAM Gene

  • Endothelial Cell Adhesion Molecule 2 3 5
  • Endothelial Cell-Selective Adhesion Molecule 3
  • HUEL (C4orf1)-Interacting Protein 3
  • LP4791 Protein 3
  • 2310008D05Rik 3
  • W117m 3

External Ids for ESAM Gene

Previous GeneCards Identifiers for ESAM Gene

  • GC11M126623
  • GC11M126136
  • GC11M124656
  • GC11M124160
  • GC11M124128
  • GC11M124622
  • GC11M120565

Summaries for ESAM Gene

GeneCards Summary for ESAM Gene

ESAM (Endothelial Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. An important paralog of this gene is IGSF11.

UniProtKB/Swiss-Prot for ESAM Gene

  • Can mediate aggregation most likely through a homophilic molecular interaction.

Gene Wiki entry for ESAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESAM Gene

Genomics for ESAM Gene

Regulatory Elements for ESAM Gene

Enhancers for ESAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ESAM on UCSC Golden Path with GeneCards custom track

Promoters for ESAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ESAM Gene

Chromosome:
11
Start:
124,752,583 bp from pter
End:
124,762,327 bp from pter
Size:
9,745 bases
Orientation:
Minus strand

Genomic View for ESAM Gene

Genes around ESAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESAM Gene

Proteins for ESAM Gene

  • Protein details for ESAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AP7-ESAM_HUMAN
    Recommended name:
    Endothelial cell-selective adhesion molecule
    Protein Accession:
    Q96AP7
    Secondary Accessions:
    • B4DVN8
    • Q96T50

    Protein attributes for ESAM Gene

    Size:
    390 amino acids
    Molecular mass:
    41176 Da
    Quaternary structure:
    • Interacts with BAIAP1.

    Alternative splice isoforms for ESAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESAM Gene

Post-translational modifications for ESAM Gene

  • Glycosylation at Asn 108, Asn 169, Asn 213, and Asn 236
  • Modification sites at PhosphoSitePlus

Other Protein References for ESAM Gene

Antibody Products

No data available for DME Specific Peptides for ESAM Gene

Domains & Families for ESAM Gene

Protein Domains for ESAM Gene

Graphical View of Domain Structure for InterPro Entry

Q96AP7

UniProtKB/Swiss-Prot:

ESAM_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with ESAM: view

Function for ESAM Gene

Molecular function for ESAM Gene

UniProtKB/Swiss-Prot Function:
Can mediate aggregation most likely through a homophilic molecular interaction.
genes like me logo Genes that share phenotypes with ESAM: view

Animal Models for ESAM Gene

MGI Knock Outs for ESAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for ESAM

CRISPR Products

miRNA for ESAM Gene

miRTarBase miRNAs that target ESAM

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESAM

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESAM Gene

Localization for ESAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESAM Gene

Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESAM Gene COMPARTMENTS Subcellular localization image for ESAM gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ESAM: view

Pathways & Interactions for ESAM Gene

genes like me logo Genes that share pathways with ESAM: view

Pathways by source for ESAM Gene

Interacting Proteins for ESAM Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278927%0d%0a9606.ENSP00000331736%0d%0a9606.ENSP00000236147%0d%0a9606.ENSP00000263686%0d%0a9606.ENSP00000228463%0d%0a9606.ENSP00000398017%0d%0a
Selected Interacting proteins: ENSP00000278927 Q96AP7-ESAM_HUMAN for ESAM Gene via STRING IID

Gene Ontology (GO) - Biological Process for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with ESAM: view

No data available for SIGNOR curated interactions for ESAM Gene

Drugs & Compounds for ESAM Gene

No Compound Related Data Available

Transcripts for ESAM Gene

Unigene Clusters for ESAM Gene

Endothelial cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESAM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ESAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: -

Relevant External Links for ESAM Gene

GeneLoc Exon Structure for
ESAM
ECgene alternative splicing isoforms for
ESAM

Expression for ESAM Gene

mRNA expression in normal human tissues for ESAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ESAM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Platelet (16.8), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ESAM Gene



Protein tissue co-expression partners for ESAM Gene

NURSA nuclear receptor signaling pathways regulating expression of ESAM Gene:

ESAM

SOURCE GeneReport for Unigene cluster for ESAM Gene:

Hs.173840

mRNA Expression by UniProt/SwissProt for ESAM Gene:

Q96AP7-ESAM_HUMAN
Tissue specificity: Highly expressed in endothelial cells.
genes like me logo Genes that share expression patterns with ESAM: view

Primer Products

No data available for mRNA differential expression in normal tissues for ESAM Gene

Orthologs for ESAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESAM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESAM 34
  • 82.91 (n)
  • 76.92 (a)
ESAM 35
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESAM 34
  • 83.89 (n)
  • 80.21 (a)
ESAM 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esam 34
  • 78.12 (n)
  • 72.82 (a)
Esam 16
Esam 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESAM 34
  • 99.66 (n)
  • 99.74 (a)
ESAM 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esam 34
  • 78.13 (n)
  • 72.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ESAM 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESAM 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESAM 34
  • 55.49 (n)
  • 49.45 (a)
ESAM 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESAM 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esam 34
  • 52.12 (n)
  • 48.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562934 34
  • 50.35 (n)
  • 45.29 (a)
esama 35
  • 35 (a)
OneToMany
esamb 35
  • 36 (a)
OneToMany
Species where no ortholog for ESAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESAM Gene

ENSEMBL:
Gene Tree for ESAM (if available)
TreeFam:
Gene Tree for ESAM (if available)

Paralogs for ESAM Gene

(1) SIMAP similar genes for ESAM Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ESAM Gene

genes like me logo Genes that share paralogs with ESAM: view

Variants for ESAM Gene

Sequence variations from dbSNP and Humsavar for ESAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_049872 -
rs34260836 -- 124,755,186(+) AAAAT(-/G)GGGGA intron-variant
rs34961513 -- 124,755,718(+) TCTCC(-/A)AAAAA intron-variant
rs139159038 -- 124,756,648(+) GGAGA(A/C)CCTCC intron-variant, nc-transcript-variant, reference, missense
rs139265422 -- 124,756,271(+) ACAGC(A/G/T)GGCTT intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ESAM Gene

Variant ID Type Subtype PubMed ID
nsv556487 CNV loss 21841781

Variation tolerance for ESAM Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESAM Gene

Human Gene Mutation Database (HGMD)
ESAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ESAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESAM Gene

Disorders for ESAM Gene

Relevant External Links for ESAM

Genetic Association Database (GAD)
ESAM
Human Genome Epidemiology (HuGE) Navigator
ESAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESAM

No disorders were found for ESAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESAM Gene

Publications for ESAM Gene

  1. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. (PMID: 11279107) Hirata K. … Quertermous T. (J. Biol. Chem. 2001) 2 3 4 65
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ESAM Gene

Sources for ESAM Gene

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