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Aliases for ESAM Gene

Aliases for ESAM Gene

  • Endothelial Cell Adhesion Molecule 2 3
  • Endothelial Cell-Selective Adhesion Molecule 3
  • HUEL (C4orf1)-Interacting Protein 3
  • LP4791 Protein 3
  • 2310008D05Rik 3
  • W117m 3

External Ids for ESAM Gene

Previous GeneCards Identifiers for ESAM Gene

  • GC11M126623
  • GC11M126136
  • GC11M124656
  • GC11M124160
  • GC11M124128
  • GC11M124622
  • GC11M120565

Summaries for ESAM Gene

GeneCards Summary for ESAM Gene

ESAM (Endothelial Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Hemostasis. An important paralog of this gene is VSIG8.

UniProtKB/Swiss-Prot for ESAM Gene

  • Can mediate aggregation most likely through a homophilic molecular interaction.

Gene Wiki entry for ESAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESAM Gene

Genomics for ESAM Gene

Regulatory Elements for ESAM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ESAM Gene

Start:
124,752,583 bp from pter
End:
124,762,327 bp from pter
Size:
9,745 bases
Orientation:
Minus strand

Genomic View for ESAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESAM Gene

Proteins for ESAM Gene

  • Protein details for ESAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AP7-ESAM_HUMAN
    Recommended name:
    Endothelial cell-selective adhesion molecule
    Protein Accession:
    Q96AP7
    Secondary Accessions:
    • B4DVN8
    • Q96T50

    Protein attributes for ESAM Gene

    Size:
    390 amino acids
    Molecular mass:
    41176 Da
    Quaternary structure:
    • Interacts with BAIAP1.

    Alternative splice isoforms for ESAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESAM Gene

Proteomics data for ESAM Gene at MOPED

Post-translational modifications for ESAM Gene

  • Glycosylation at Asn108, Asn169, Asn213, and Asn236
  • Modification sites at PhosphoSitePlus

Other Protein References for ESAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ESAM

No data available for DME Specific Peptides for ESAM Gene

Domains for ESAM Gene

Gene Families for ESAM Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for ESAM Gene

Graphical View of Domain Structure for InterPro Entry

Q96AP7

UniProtKB/Swiss-Prot:

ESAM_HUMAN :
  • Q96AP7
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with ESAM: view

Function for ESAM Gene

Molecular function for ESAM Gene

UniProtKB/Swiss-Prot Function:
Can mediate aggregation most likely through a homophilic molecular interaction.

Gene Ontology (GO) - Molecular Function for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ESAM: view
genes like me logo Genes that share phenotypes with ESAM: view

Animal Models for ESAM Gene

MGI Knock Outs for ESAM:

Animal Model Products

miRNA for ESAM Gene

miRTarBase miRNAs that target ESAM

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ESAM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ESAM Gene

Localization for ESAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESAM Gene

Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESAM Gene COMPARTMENTS Subcellular localization image for ESAM gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ESAM: view

Pathways for ESAM Gene

genes like me logo Genes that share pathways with ESAM: view

Pathways by source for ESAM Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ESAM Gene

Gene Ontology (GO) - Biological Process for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007596 blood coagulation TAS --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with ESAM: view

Transcripts for ESAM Gene

Unigene Clusters for ESAM Gene

Endothelial cell adhesion molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ESAM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ESAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: -

Relevant External Links for ESAM Gene

GeneLoc Exon Structure for
ESAM
ECgene alternative splicing isoforms for
ESAM

Expression for ESAM Gene

mRNA expression in normal human tissues for ESAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ESAM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Platelet (16.8), and Placenta (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ESAM Gene

SOURCE GeneReport for Unigene cluster for ESAM Gene Hs.173840

mRNA Expression by UniProt/SwissProt for ESAM Gene

Q96AP7-ESAM_HUMAN
Tissue specificity: Highly expressed in endothelial cells.
genes like me logo Genes that share expressions with ESAM: view

Expression partners for ESAM Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ESAM Gene

Orthologs for ESAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESAM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESAM 35
  • 82.91 (n)
  • 76.92 (a)
ESAM 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESAM 35
  • 83.89 (n)
  • 80.21 (a)
ESAM 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esam 35
  • 78.12 (n)
  • 72.82 (a)
Esam 16
Esam 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESAM 35
  • 99.66 (n)
  • 99.74 (a)
ESAM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esam 35
  • 78.13 (n)
  • 72.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ESAM 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESAM 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESAM 35
  • 55.49 (n)
  • 49.45 (a)
ESAM 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESAM 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esam 35
  • 52.12 (n)
  • 48.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562934 35
  • 50.35 (n)
  • 45.29 (a)
esama 36
  • 35 (a)
OneToMany
esamb 36
  • 36 (a)
OneToMany
Species with no ortholog for ESAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESAM Gene

ENSEMBL:
Gene Tree for ESAM (if available)
TreeFam:
Gene Tree for ESAM (if available)

Paralogs for ESAM Gene

Paralogs for ESAM Gene

Selected SIMAP similar genes for ESAM Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ESAM Gene

genes like me logo Genes that share paralogs with ESAM: view

Variants for ESAM Gene

Sequence variations from dbSNP and Humsavar for ESAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs557856 -- 124,755,762(-) TAGGC(A/G)TGGCA intron-variant
rs655792 -- 124,754,826(+) aaaat(C/T)ttGTC intron-variant
rs6590090 -- 124,754,958(+) CATTG(C/T)CACTC intron-variant
rs34260836 -- 124,755,186(+) AAAAT(-/G)GGGGA intron-variant
rs34868252 -- 124,754,951(+) AACCT(-/C)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ESAM Gene

Variant ID Type Subtype PubMed ID
dgv1321n71 CNV Loss 21882294

Relevant External Links for ESAM Gene

HapMap Linkage Disequilibrium report
ESAM
Human Gene Mutation Database (HGMD)
ESAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESAM Gene

Disorders for ESAM Gene

(1) University of Copenhagen DISEASES for ESAM Gene

Relevant External Links for ESAM

Genetic Association Database (GAD)
ESAM
Human Genome Epidemiology (HuGE) Navigator
ESAM
genes like me logo Genes that share disorders with ESAM: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ESAM Gene

Publications for ESAM Gene

  1. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. (PMID: 11279107) Hirata K. … Quertermous T. (J. Biol. Chem. 2001) 2 3 4
  2. The novel human HUEL (C4orf1) protein shares homology with the DNA- binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. (PMID: 11906820) Sim D.L.C. … Chow V.T.K. (Int. J. Biochem. Cell Biol. 2002) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for ESAM Gene

Sources for ESAM Gene

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