Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ESAM Gene

Aliases for ESAM Gene

  • Endothelial Cell Adhesion Molecule 2 3 5
  • Endothelial Cell-Selective Adhesion Molecule 3
  • HUEL (C4orf1)-Interacting Protein 3
  • LP4791 Protein 3
  • 2310008D05Rik 3
  • W117m 3

External Ids for ESAM Gene

Previous GeneCards Identifiers for ESAM Gene

  • GC11M126623
  • GC11M126136
  • GC11M124656
  • GC11M124160
  • GC11M124128
  • GC11M124622
  • GC11M120565

Summaries for ESAM Gene

GeneCards Summary for ESAM Gene

ESAM (Endothelial Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGSF11.

UniProtKB/Swiss-Prot for ESAM Gene

  • Can mediate aggregation most likely through a homophilic molecular interaction.

Gene Wiki entry for ESAM Gene

Additional gene information for ESAM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESAM Gene

Genomics for ESAM Gene

Regulatory Elements for ESAM Gene

Enhancers for ESAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H124717 1.4 FANTOM5 Ensembl ENCODE 15.2 +44.4 44393 1 ZNF76 KLF17 FEZF1 BATF GLIS2 ZNF366 SCRT2 ATF7 RUNX3 IKZF2 SPA17 ESAM NRGN ENSG00000255045 VSIG2 SIAE LOC101929340 ROBO3 ROBO4 GC11P124740
GH11H124757 1.5 FANTOM5 ENCODE dbSUPER 13.3 +1.2 1191 6 HDGF ATF1 ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ATF7 RUNX3 ROBO4 ESAM VSIG2 SPA17 NRGN LOC101929340
GH11H124836 1 Ensembl ENCODE 11 -74.8 -74752 1 CTCF ZSCAN4 ZNF384 BATF RAD21 ZFHX2 SMC3 ZNF143 NFE2 KLF7 ROBO3 MSANTD2 LOC100507283 SIAE SPA17 ESAM LOC101929340 VSIG2 ENSG00000255045 NRGN
GH11H124793 0.7 ENCODE 11.7 -31.5 -31533 0 CTCF PKNOX1 ZNF654 NR2F1 TRIM22 ZNF384 RAD21 KLF16 SCRT2 SMC3 ESAM LOC101929340 VSIG2 ENSG00000255045 SIAE SPA17 NRGN ROBO3 LOC100507283 ENSG00000279342
GH11H124768 1 ENCODE dbSUPER 0.4 -8.3 -8285 3 JUN ZNF384 TEAD3 FOSL1 ZFHX2 ZNF316 EGR1 FOS EGR2 SMARCE1 NRGN SIAE SPA17 LOC100507283 MSANTD2 ROBO3 VSIG2 ESAM ENSG00000254509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ESAM on UCSC Golden Path with GeneCards custom track

Promoters for ESAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046439 -273 1601 RB1 SIN3A ARID4B ZNF2 RAD21 ZEB1 EGR1 ZNF143 RCOR1 ATF7

Genomic Location for ESAM Gene

Chromosome:
11
Start:
124,752,583 bp from pter
End:
124,762,327 bp from pter
Size:
9,745 bases
Orientation:
Minus strand

Genomic View for ESAM Gene

Genes around ESAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESAM Gene

Proteins for ESAM Gene

  • Protein details for ESAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AP7-ESAM_HUMAN
    Recommended name:
    Endothelial cell-selective adhesion molecule
    Protein Accession:
    Q96AP7
    Secondary Accessions:
    • B4DVN8
    • Q96T50

    Protein attributes for ESAM Gene

    Size:
    390 amino acids
    Molecular mass:
    41176 Da
    Quaternary structure:
    • Interacts with BAIAP1.

    Alternative splice isoforms for ESAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESAM Gene

Post-translational modifications for ESAM Gene

  • Glycosylation at posLast=108108, posLast=169169, isoforms=2213, and isoforms=2236
  • Modification sites at PhosphoSitePlus

Other Protein References for ESAM Gene

Antibody Products

No data available for DME Specific Peptides for ESAM Gene

Domains & Families for ESAM Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ESAM: view

No data available for UniProtKB/Swiss-Prot for ESAM Gene

Function for ESAM Gene

Molecular function for ESAM Gene

UniProtKB/Swiss-Prot Function:
Can mediate aggregation most likely through a homophilic molecular interaction.
genes like me logo Genes that share phenotypes with ESAM: view

Animal Models for ESAM Gene

MGI Knock Outs for ESAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for ESAM

CRISPR Products

miRNA for ESAM Gene

miRTarBase miRNAs that target ESAM

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESAM
  • Applied Biological Materials Clones for ESAM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESAM Gene

Localization for ESAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESAM Gene

Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESAM gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ESAM: view

Pathways & Interactions for ESAM Gene

genes like me logo Genes that share pathways with ESAM: view

Pathways by source for ESAM Gene

Interacting Proteins for ESAM Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278927%0d%0a9606.ENSP00000228463%0d%0a9606.ENSP00000264734%0d%0a9606.ENSP00000396304%0d%0a9606.ENSP00000342445%0d%0a9606.ENSP00000356133%0d%0a
Selected Interacting proteins: Q96AP7-ESAM_HUMAN ENSP00000278927 for ESAM Gene via IID STRING

Gene Ontology (GO) - Biological Process for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with ESAM: view

No data available for SIGNOR curated interactions for ESAM Gene

Drugs & Compounds for ESAM Gene

No Compound Related Data Available

Transcripts for ESAM Gene

Unigene Clusters for ESAM Gene

Endothelial cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESAM
  • Applied Biological Materials Clones for ESAM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ESAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: -

Relevant External Links for ESAM Gene

GeneLoc Exon Structure for
ESAM
ECgene alternative splicing isoforms for
ESAM

Expression for ESAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ESAM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Platelet (16.8), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ESAM Gene



Protein tissue co-expression partners for ESAM Gene

NURSA nuclear receptor signaling pathways regulating expression of ESAM Gene:

ESAM

SOURCE GeneReport for Unigene cluster for ESAM Gene:

Hs.173840

mRNA Expression by UniProt/SwissProt for ESAM Gene:

Q96AP7-ESAM_HUMAN
Tissue specificity: Highly expressed in endothelial cells.

Evidence on tissue expression from TISSUES for ESAM Gene

  • Spleen(4.4)
  • Intestine(4.3)
  • Liver(4.3)
  • Nervous system(3.8)
  • Heart(3.4)
  • Lung(3.4)
  • Blood(3.1)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ESAM: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ESAM Gene

Orthologs for ESAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ESAM 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ESAM 33 34
  • 83.89 (n)
cow
(Bos Taurus)
Mammalia ESAM 33 34
  • 82.91 (n)
rat
(Rattus norvegicus)
Mammalia Esam 33
  • 78.13 (n)
mouse
(Mus musculus)
Mammalia Esam 33 16 34
  • 78.12 (n)
oppossum
(Monodelphis domestica)
Mammalia ESAM 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESAM 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ESAM 33 34
  • 55.49 (n)
lizard
(Anolis carolinensis)
Reptilia ESAM 34
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esam 33
  • 52.12 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562934 33
  • 50.35 (n)
esamb 34
  • 36 (a)
OneToMany
esama 34
  • 35 (a)
OneToMany
Species where no ortholog for ESAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESAM Gene

ENSEMBL:
Gene Tree for ESAM (if available)
TreeFam:
Gene Tree for ESAM (if available)

Paralogs for ESAM Gene

(1) SIMAP similar genes for ESAM Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ESAM Gene

genes like me logo Genes that share paralogs with ESAM: view

Variants for ESAM Gene

Sequence variations from dbSNP and Humsavar for ESAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000088138 -- 124,764,272(+) TGACC(A/G)TAAAG intron-variant, upstream-variant-2KB
rs1000496097 -- 124,757,502(+) TCTGG(A/G)GTAAA intron-variant, upstream-variant-2KB
rs1000650208 -- 124,757,228(+) GAGTT(C/T)AAGAC intron-variant, upstream-variant-2KB
rs1000783278 -- 124,755,928(+) AGAAG(A/G)CACCG intron-variant
rs1001000467 -- 124,763,278(+) AATTG(A/C)ATTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ESAM Gene

Variant ID Type Subtype PubMed ID
nsv556487 CNV loss 21841781

Variation tolerance for ESAM Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ESAM Gene

Human Gene Mutation Database (HGMD)
ESAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ESAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESAM Gene

Disorders for ESAM Gene

Relevant External Links for ESAM

Genetic Association Database (GAD)
ESAM
Human Genome Epidemiology (HuGE) Navigator
ESAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ESAM

No disorders were found for ESAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESAM Gene

Publications for ESAM Gene

  1. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. (PMID: 11279107) Hirata Ki … Quertermous T (The Journal of biological chemistry 2001) 2 3 4 60
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ESAM Gene

  • Addgene plasmids for ESAM

Sources for ESAM Gene

Content
Loading form....