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Aliases for ERVW-1 Gene

Aliases for ERVW-1 Gene

  • Endogenous Retrovirus Group W, Member 1 2 3
  • HERV-7q Envelope Protein 2 3 4
  • Enverin 2 3 4
  • ERVWE1 3 4 6
  • HERV-W{7q21.1} Provirus Ancestral Env Polyprotein 2 3
  • Endogenous Retroviral Family W, Env(C7), Member 1 2 3
  • HERV-W_7q21.2 Provirus Ancestral Env Polyprotein 3 4
  • Endogenous Retrovirus Group W Member 1 3 4
  • HERV-Tryptophan Envelope Protein 2 3
  • Envelope Polyprotein GPr73 3 4
  • HERV-W Env Glycoprotein 2 3
  • HERV-W Envelope Protein 3 4
  • Envelope Glycoprotein 2 3
  • Envelope Protein 2 3
  • Syncytin-1 2 3
  • Syncytin 2 4
  • Env-W 3 4
  • HERVW 3 6
  • Human Endogenous Retrovirus W EnvC7-1 Envelope Protein 3
  • Syncytin A 3
  • HERV-W-ENV 3
  • HERVWENV 3
  • HERV-7q 3
  • HERV7Q 3
  • ENVW 3
  • Env 3

External Ids for ERVW-1 Gene

Previous Symbols for ERVW-1 Gene

  • ERVWE1

Summaries for ERVW-1 Gene

Entrez Gene Summary for ERVW-1 Gene

  • Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ERVW-1 Gene

ERVW-1 (Endogenous Retrovirus Group W, Member 1) is a Protein Coding gene. Diseases associated with ERVW-1 include choriocarcinoma and hiv-1. An important paralog of this gene is ERVFRD-1.

UniProtKB/Swiss-Prot for ERVW-1 Gene

  • This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).

  • Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes

Gene Wiki entry for ERVW-1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERVW-1 Gene

Genomics for ERVW-1 Gene

Genomic Location for ERVW-1 Gene

Start:
92,468,380 bp from pter
End:
92,477,986 bp from pter
Size:
9,607 bases
Orientation:
Minus strand

Genomic View for ERVW-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERVW-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERVW-1 Gene

No data available for Regulatory Elements for ERVW-1 Gene

Proteins for ERVW-1 Gene

  • Protein details for ERVW-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQF0-SYCY1_HUMAN
    Recommended name:
    Syncytin-1
    Protein Accession:
    Q9UQF0
    Secondary Accessions:
    • B2RPD4
    • O95244
    • O95245
    • Q8NHY7
    • Q9NRZ2
    • Q9NZG3

    Protein attributes for ERVW-1 Gene

    Size:
    538 amino acids
    Molecular mass:
    59866 Da
    Quaternary structure:
    • The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN.
    Miscellaneous:
    • HERV-W family subgenomic RNAs have been observed
    • It can make pseudotypes with HIV-1 virions and confer infectivity. Can also induce cellular resistance to spleen necrosis virus in vitro
    • Orthologs in Pan troglodytes, Gorilla gorilla, Pongo pygmaeus and Hylobates moloch
    • Probably involved in the development of multiple sclerosis (MS). MS is a neurodegenerative disease characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. It leads to physical and cognitive disabilities. Viral particles or intracellular RNA of HERV-W family members have been detected in tissue from patients with multiple sclerosis or schizophrenia
    • The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit
    • This provirus is intergenic, the closest flanking genes being ODAG and PEX1

neXtProt entry for ERVW-1 Gene

Proteomics data for ERVW-1 Gene at MOPED

Post-translational modifications for ERVW-1 Gene

  • Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.
  • The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn169, Asn208, Asn214, Asn234, Asn242, Asn281, and Asn409

Other Protein References for ERVW-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERVW-1 Gene

Domains for ERVW-1 Gene

Protein Domains for ERVW-1 Gene

Suggested Antigen Peptide Sequences for ERVW-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQF0

UniProtKB/Swiss-Prot:

SYCY1_HUMAN
Domain:
  • The cytoplasmic region is essential for the fusiogenic function:
    • Q9UQF0
  • The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity).:
    • Q9UQF0
Family:
  • Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.:
    • Q9UQF0
genes like me logo Genes that share domains with ERVW-1: view

No data available for Gene Families for ERVW-1 Gene

Function for ERVW-1 Gene

Molecular function for ERVW-1 Gene

UniProtKB/Swiss-Prot Function: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
UniProtKB/Swiss-Prot Function: Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ERVW-1 Gene

Localization for ERVW-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERVW-1 Gene

Transmembrane protein: Cell membrane; Single-pass type I membrane protein.
Surface protein: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.
Syncytin-1: Virion.

Gene Ontology (GO) - Cellular Components for ERVW-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019031 viral envelope IEA --
genes like me logo Genes that share ontologies with ERVW-1: view

No data available for Subcellular locations from COMPARTMENTS for ERVW-1 Gene

Pathways for ERVW-1 Gene

SuperPathways for ERVW-1 Gene

No Data Available

Interacting Proteins for ERVW-1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000419945%0d%0a9606.ENSP00000444408%0d%0a9606.ENSP00000234256%0d%0a
Selected Interacting proteins: ENSP00000419945 Q9UQF0-SYCY1_HUMAN for ERVW-1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ERVW-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006949 syncytium formation IDA 23492904
GO:0009653 anatomical structure morphogenesis TAS 10693809
genes like me logo Genes that share ontologies with ERVW-1: view

No data available for Pathways by source for ERVW-1 Gene

Compounds for ERVW-1 Gene

(35) Novoseek inferred chemical compound relationships for ERVW-1 Gene

Compound -log(P) Hits PubMed IDs
enfuvirtide 62.3 6
alamos 50.1 2
2,2-dithiodipyridine 38.9 1
gp 130 24.2 2
forskolin 14.2 7
genes like me logo Genes that share compounds with ERVW-1: view

Transcripts for ERVW-1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ERVW-1 Gene

No ASD Table

Relevant External Links for ERVW-1 Gene

GeneLoc Exon Structure for
ERVW-1
ECgene alternative splicing isoforms for
ERVW-1

Expression for ERVW-1 Gene

mRNA expression in normal human tissues for ERVW-1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERVW-1 Gene

This gene is overexpressed in Testis (31.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ERVW-1 Gene

mRNA Expression by UniProt/SwissProt for ERVW-1 Gene

Q9UQF0-SYCY1_HUMAN
Tissue specificity: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
genes like me logo Genes that share expressions with ERVW-1: view

Orthologs for ERVW-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ERVW-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC102154491 35
  • 51.5 (n)
  • 44.66 (a)
mouse
(Mus musculus)
Mammalia BC035947 36
  • 12 (a)
ManyToMany
Syna 36
  • 21 (a)
ManyToMany
Synb 36
  • 22 (a)
ManyToMany
SYNB 36
  • 22 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
OneToMany
-- 36
  • 9 (a)
OneToMany
Species with no ortholog for ERVW-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERVW-1 Gene

ENSEMBL:
Gene Tree for ERVW-1 (if available)
TreeFam:
Gene Tree for ERVW-1 (if available)

Paralogs for ERVW-1 Gene

Paralogs for ERVW-1 Gene

Selected SIMAP similar genes for ERVW-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ERVW-1: view

Variants for ERVW-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ERVW-1 Gene

Q9UQF0-SYCY1_HUMAN
All variants have fusogenic properties

Sequence variations from dbSNP and Humsavar for ERVW-1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1130933 -- 92,468,714(-) TGAGA(G/T)GGGGG utr-variant-3-prime
rs1143396 -- 92,468,791(-) TACTA(C/T)GCCCC reference, missense
rs4727276 -- 92,478,438(+) AGTGG(C/G)AGATG upstream-variant-2KB
rs6979519 -- 92,471,942(+) ctagc(C/T)gagca intron-variant, upstream-variant-2KB
rs7797676 -- 92,472,889(+) agagc(A/G)cttgg intron-variant, upstream-variant-2KB

Relevant External Links for ERVW-1 Gene

HapMap Linkage Disequilibrium report
ERVW-1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ERVW-1 Gene

Disorders for ERVW-1 Gene

(53) Novoseek inferred disease relationships for ERVW-1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 88.2 122
jaagsiekte 70.8 3
leukemia t-cell 69.6 12
aids 58.2 21
lentivirus infections 58.1 1
genes like me logo Genes that share disorders with ERVW-1: view

No data available for UniProtKB/Swiss-Prot for ERVW-1 Gene

Publications for ERVW-1 Gene

  1. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. (PMID: 9882319) Blond J.-L. … Mallet F. (J. Virol. 1999) 2 3 4 23
  2. Syncytin is captive retroviral envelope protein involved in human placental morphogenesis. (PMID: 10693809) Sha M. … McCoy J.M. (Nature 2000) 3 4 23
  3. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. (PMID: 10708449) Blond J.-L. … Cosset F.-L. (J. Virol. 2000) 3 4 23
  4. Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family. (PMID: 10826480) Voisset C. … Paranhos-Baccala G. (AIDS Res. Hum. Retroviruses 2000) 3 4 23
  5. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. (PMID: 14557543) Blaise S. … Heidmann T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23

Products for ERVW-1 Gene

Sources for ERVW-1 Gene

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