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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERVW-1 Gene

protein-coding   GIFtS: 39
GCID: GC07M092098

endogenous retrovirus group W, member 1

(Previous names: endogenous retroviral family W, env(C7), member 1 )
(Previous symbol: ERVWE1)
 Explore 54 diseases affiliated with
ERVW-1 via
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Biological research products
for ERVW-1    

Aliases
for ERVW-1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Endogenous Retrovirus Group W, Member 11 2     Env-W3
ERVWE11 2 3 5     Envelope Glycoprotein2
HERVW1 2 5     Envelope Protein2
HERV-7q1 2     Enverin3
HERV-W-ENV1 2     HERV-Tryptophan Envelope Protein2
Endogenous Retroviral Family W, Env(C7), Member 11 2     HERV-W Env Glycoprotein2
Endogenous Retrovirus Group W Member 12 3     HERV-W_7q21.2 Provirus Ancestral Env Polyprotein2
Envelope Polyprotein GPr732 3     HERV-W{7q21.1} Provirus Ancestral Env Polyprotein2
HERV-7q Envelope Protein2 3     Human Endogenous Retrovirus W EnvC7-1 Envelope Protein2
HERV-W Envelope Protein2 3     Syncytin A2
HERV-W1     Syncytin-13
ENV2     Env-W3
ENVW2     Enverin3
HERV7Q2     Syncytin3
HERVWENV2     Syncytin-13

External Ids:    HGNC: 135251   Entrez Gene: 308162   Ensembl: ENSG000002429507   OMIM: 6046595   UniProtKB: Q9UQF03   

Export aliases for ERVW-1 gene to outside databases


Summaries
for ERVW-1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ERVW-1:
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels,
suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome
7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears
to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and
is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the
characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface
(SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous
envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta
morphogenesis
Function: SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM)
and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize
the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors
in vitro
Function: The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein
has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin
state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a
trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the
ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By
similarity)

Gene Wiki entry for ERVW-1 (ERVWE1)


Genomic Views
for ERVW-1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ERVW-1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERVW-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.2   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21.2

ERVW-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERVW-1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092098:  view genomic region     (about GC identifiers)

Start:
 92,097,694 bp from pter      End:
 92,107,229 bp from pter
Size:
 9,536 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,426,904-91,436,439     

Proteins
for ERVW-1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0 (See protein sequence)
Recommended Name: HERV-W_7q21.2 provirus ancestral Env polyprotein precursor  
Size: 538 amino acids; 59866 Da
Subunit: The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile
interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN
Subcellular location: Transmembrane protein: Cell membrane; Single-pass type I membrane protein (By similarity)
Subcellular location: Surface protein: Cell membrane; Peripheral membrane protein (By similarity). Note=The surface
protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM (By
similarity)
Subcellular location: HERV-W_7q21.2 provirus ancestral Env polyprotein: Virion (By similarity)
Developmental stage: In placenta, detected at higher level during early pregnancy and at lower level during late
pregnancy
Miscellaneous: Probably involved in the development of multiple sclerosis (MS). MS is a neurodegenerative disease
characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas
of the brain. It leads to physical and cognitive disabilities. Viral particles or intracellular RNA of HERV-W family
members have been detected in tissue from patients with multiple sclerosis or schizophrenia
Miscellaneous: Orthologs in Pan troglodytes, Gorilla gorilla, Pongo pygmaeus and Hylobates moloch
Miscellaneous: It can make pseudotypes with HIV-1 virions and confer infectivity. Can also induce cellular resistance
to spleen necrosis virus in vitro
Miscellaneous: HERV-W family subgenomic RNAs have been observed
Miscellaneous: This provirus is intergenic, the closest flanking genes being ODAG and PEX1
Secondary accessions: B2RPD4 O95244 O95245 Q8NHY7 Q9NRZ2 Q9NZG3

Explore the universe of human proteins at neXtProt for ERVW-1: NX_Q9UQF0

Post-translational modifications:

  • Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive
    • precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM
    proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail
    cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins
    seems to have been lost during evolution1
  • The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate
    • in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein.
    Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor
    recognition in order to allow membrane fusion (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQF0

    • ERVW-1 Protein expression data from MOPED and PaxDb:    About this image 
    ERVW-1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124397.1  NP_055405.3  

    ENSEMBL proteins: 
     ENSP00000419945  

    Human Recombinant Protein Products for ERVW-1: 
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    Uscn Proteins for ERVW-1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0019012virion ----
    GO:0019031viral envelope IEA--

    ERVW-1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ERVW-1

    Protein Domains /
    Families
    for ERVW-1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ERVW-1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018154 TLV/ENV_coat_polyprotein

    Graphical View of Domain Structure for InterPro Entry Q9UQF0

    ProtoNet protein and cluster: Q9UQF0

    1 Blocks protein family: IPB002050 ENV polyprotein (coat polyprotein)

    UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
    Domain: The cytoplasmic region is essential for the fusiogenic function
    Domain: The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic
    peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity)
    Similarity: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily


    Function
    for ERVW-1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENW1_HUMAN, Q9UQF0
    Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
    Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous
    envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta
    morphogenesis
    Function: SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM)
    and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize
    the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors
    in vitro
    Function: The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein
    has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin
    state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a
    trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the
    ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By
    similarity)

    Animal Models:

       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ERVW-1 

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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for ERVW-1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ERVW-1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ERVW-1 (Q9UQF03 ENSP000004199454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC1A4P430073, ENSP000002342564I2D: score=1 STRING: ENSP00000234256
    HYAL2Q128913, ENSP000003503874I2D: score=1 STRING: ENSP00000350387
    SLC1A5Q157583I2D: score=1 
    --ENSP000003036234STRING: ENSP00000303623
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006949syncytium formation TAS10693809
    GO:0009653anatomical structure morphogenesis TAS10693809

    ERVW-1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ERVW-1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ERVW-1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ERVW-1
    10/35 Novoseek chemical compound relationships for ERVW-1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enfuvirtide 62.3 12 19578246 (3), 15582695 (1), 16912327 (1), 15220433 (1)
    alamos 50.1 2 13678464 (1), 7531216 (1)
    2,2'-dithiodipyridine 38.9 2 15194782 (1)
    gp 130 24.2 2 8388512 (1), 7694060 (1)
    forskolin 14.2 7 12175968 (2), 19091402 (2), 12757936 (1), 19692500 (1) (see all 5)
    asparagine 6.92 2 9223414 (1), 2045792 (1)
    steroid 5.51 3 17066266 (2), 18814240 (1)
    lipid 4.75 17 15956582 (4), 19793805 (4), 17360745 (2), 18081926 (2) (see all 5)
    polysaccharide 2.02 8 20369301 (3), 18330979 (1), 17959660 (1), 7804009 (1) (see all 5)
    glutamate 1.77 1 9811701 (1)

    Search CenterWatch for drugs/clinical trials and news about ERVW-1 / ENW1 

    Transcripts
    for ERVW-1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ERVW-1 gene (2 alternative transcripts): 
    NM_001130925.1  NM_014590.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000493463(uc022ahe.1)

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    Clone
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    Primer
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    24/145 AceView cDNA sequences (see all 145):

    BX357209 AB066659 BF993049 T39519 CR605851 BC030968 BG000981 CR625046 
    CR617248 BE732673 BC041024 AB079501 AB066648 AB066205 NM_014590 BX378304 
    BX374329 BQ024410 CR613169 AF072506 AA776439 CR622175 BX389657 AB096022 

    GeneLoc Exon Structure


    Expression
    for ERVW-1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERVW-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    ERVW-1 Expression
    About this image

    ERVW-1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ERVW-1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERVW-1

    UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
    Tissue specificity: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in
    testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate,
    skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the
    brain of individuals with multiple sclerosis, particularly in astrocytes and microglia

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    In Situ
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    Orthologs
    for ERVW-1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ERVW-1 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 22(a)
    		 possible ortholog
    		 1(157882361-157883053)


    ENSEMBL Gene Tree for ERVW-1 (if available)
    TreeFam Gene Tree for ERVW-1 (if available) 

    Paralogs
    for ERVW-1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERVW-1 gene
    ERVFRD-12  
    3 SIMAP similar genes for ERVW-1 using alignment to 1 protein entry:     ENW1_HUMAN:
    ERVWE1    ERVWE2    env

    ERVW-1 for paralogs           About GeneDecksing



    Genomic Variants
    for ERVW-1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
    Polymorphism: All variants have fusogenic properties


    10/217 NCBI SNPs in ERVW-1 are shown (see all 217)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1124068181,2
    		C--92097199(+) ATTTCA/GGCTCA 2 -- ds50010--------
    rs1455815411,2
    		--92097396(+) CCATGC/TGGTGA 2 -- ds50010--------
    rs1863219711,2
    		--92097493(+) AGGCAC/GTTAGC 2 -- ds50010--------
    rs102624611,2
    		C--92097529(+) AGCCCA/G/TATTGG 2 -- ds50010--------
    rs1419677741,2
    		--92097578(+) GGACAC/TCCTGC 2 -- ds50010--------
    rs1920812641,2
    		--92097584(+) CCTGCA/GTGATC 2 -- ds50010--------
    rs1830518801,2
    		--92097585(+) CTGCAG/TGATCC 2 -- ds50010--------
    rs132292551,2
    		C,F--92097611(+) agcggC/Tgggtc 2 -- ds50018Minor allele frequency- T:0.34NA WA EA 368
    rs1873866641,2
    		--92097670(+) CAAGCC/TGTAAG 2 -- ds50010--------
    rs1116796251,2
    		C--92097744(+) TCCCAC/TACAAA 2 -- ut311Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ERVW-1 (92097694 - 92107229 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ERVW-1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ERVW-1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ERVW-1 for disorders           About GeneDecksing

    OMIM gene information: 604659    OMIM disorders: --

    20/54 diseases for ERVW-1 (see all 54):    About MalaCards
    human t-cell leukemia virus type 1    pre-eclampsia    testicular germ cell tumor    germ cell tumor
    herpes simplex    placental choriocarcinoma    bipolar disorder    adult t-cell leukemia
    motor neuron disease    lymphosarcoma    rheumatoid arthritis    megakaryoblastic leukemia
    hellp syndrome    multiple sclerosis    hepatitis c    choriocarcinoma
    stomatitis    seminoma    leukemia/lymphoma    t-cell leukemia

    10/53 Novoseek disease relationships for ERVW-1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 88.2 268 10482563 (3), 8139054 (3), 14687493 (2), 16873261 (2) (see all 99)
    jaagsiekte 70.8 3 12596899 (1), 10775607 (1), 19695657 (1)
    leukemia t-cell 69.6 13 1711082 (1), 2072457 (1), 1405724 (1), 9311790 (1) (see all 12)
    aids 58.2 21 9499799 (1), 16873261 (1), 18672260 (1), 19105347 (1) (see all 21)
    lentivirus infections 58.1 1 10933692 (1)
    viremia 57.3 3 17079310 (2), 14722893 (1)
    paraparesis tropical spastic 47.7 3 1540409 (1), 7680300 (1), 8778566 (1)
    htlv-ii infections 47.6 1 7590608 (1)
    sarcoma avian 46.6 2 15367609 (1), 17245447 (1)
    leukemia 46.5 37 2166972 (2), 15026987 (2), 10891403 (2), 1405724 (1) (see all 28)


    Export disorders for ERVW-1 gene to outside databases

    Publications
    for ERVW-1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERVW-1 gene, integrated from 9 sources (see all 475):
    (articles sorted by number of sources associating them with ERVW-1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. (PubMed id 9882319)1, 2, 3, 9 Blond J.-L.... Mallet F. (1999)
    2. Endogenous retroviruses and multiple sclerosis. II. HERV-7q. (PubMed id 9835022)1, 2, 3 Alliel P.M....Rieger F. (1998)
    3. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. (PubMed id 15254254)1, 2, 9 Bonnaud B.... Mallet F. (2004)
    4. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta. (PubMed id 12620933)1, 2, 9 Smallwood A.... Banerjee S. (2003)
    5. Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family. (PubMed id 10826480)1, 2, 9 Voisset C....Paranhos-Baccala G. (2000)
    6. Syncytin is captive retroviral envelope protein involved in human placental morphogenesis. (PubMed id 10693809)1, 2, 9 Sha M....McCoy J.M. (2000)
    7. Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope. (PubMed id 15827173)1, 2, 9 Cheynet V.... Mallet F. (2005)
    8. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. (PubMed id 14557543)1, 2, 9 Blaise S.... Heidmann T. (2003)
    9. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. (PubMed id 10708449)1, 2, 9 Blond J.-L.... Cosset F.-L. (2000)
    10. The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus. (PubMed id 12664292)1, 2, 9 Ponferrada V.G.... Wooley D.P. (2003)

    External Searches for ERVW-1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ERVW-1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30816 HGNC: 13525 AceView: ERVWE1 Ensembl:ENSG00000242950 euGenes: HUgn30816
    ECgene: ERVW-1 H-InvDB: ERVW-1

    Other Databases showing ERVW-1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ERVW-1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ERVW-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERVW-1 Genetics and Cytogenetics in Oncology and Haematology
    Human Endogenous Retrovirus Database (HERVd)http://herv.img.cas.cz/cgi-bin/draw_full_element.cgi?fid=41573
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt050.shtml

    Intellectual Property
    for ERVW-1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ERVW-1 gene:
    Search GeneIP for patents involving ERVW-1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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