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ERVW-1 Gene

protein-coding   GIFtS: 41
GCID: GC07M092098

Endogenous Retrovirus Group W, Member 1

(Previous names: endogenous retroviral family W, env(C7), member 1)
(Previous symbol: ERVWE1)
  See ERVW-1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Endogenous Retrovirus Group W, Member 11 2     syncytin1
ERVWE11 2 3 5     ENV2
HERV-7q Envelope Protein1 2 3     ENVW2
Endogenous Retroviral Family W, Env(C7), Member 11 2     HERV-7q2
Envelope Glycoprotein1 2     HERV-W-ENV2
Envelope Protein1 2     HERV7Q2
enverin1 2     HERVWENV2
HERV-Tryptophan Envelope Protein1 2     env-W2
HERV-W Env Glycoprotein1 2     HERV-W_7q21.2 Provirus Ancestral Env Polyprotein2
HERV-W{7q21.1} Provirus Ancestral Env Polyprotein1 2     Human Endogenous Retrovirus W EnvC7-1 Envelope Protein2
syncytin-11 2     Syncytin A2
Endogenous Retrovirus Group W Member 12 3     Env-W3
Envelope Polyprotein GPr732 3     Enverin3
HERV-W Envelope Protein2 3     Syncytin3
HERVW2 5     Syncytin-13

External Ids:    HGNC: 135251   Entrez Gene: 308162   Ensembl: ENSG000002429507   OMIM: 6046595   UniProtKB: Q9UQF03   
ORGUL members:         

Export aliases for ERVW-1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERVW-1 Gene:
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high
levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus
on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein
gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental
syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the
placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin
cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.
Alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Mar 2010)

GeneCards Summary for ERVW-1 Gene:
ERVW-1 (endogenous retrovirus group W, member 1) is a protein-coding gene. Diseases associated with ERVW-1 include choriocarcinoma, and schizophrenia. An important paralog of this gene is ERVFRD-1.

UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This
endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion
during placenta morphogenesis
Function: SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein
(TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to
recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing
these receptors in vitro
Function: The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the
protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and
post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats)
assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region
of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes
(By similarity)

Gene Wiki entry for ERVW-1 (ERVWE1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ERVW-1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ERVW-1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERVW-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.2   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21.2

ERVW-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERVW-1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092098:  view genomic region     (about GC identifiers)

Start:
92,097,694 bp from pter      End:
92,107,300 bp from pter
Size:
9,607 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,426,904-91,436,439     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0 (See protein sequence)
Recommended Name: HERV-W_7q21.2 provirus ancestral Env polyprotein precursor  
Size: 538 amino acids; 59866 Da
Subunit: The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a
labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN
Developmental stage: In placenta, detected at higher level during early pregnancy and at lower level during late
pregnancy
Miscellaneous: Probably involved in the development of multiple sclerosis (MS). MS is a neurodegenerative disease
characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular
areas of the brain. It leads to physical and cognitive disabilities. Viral particles or intracellular RNA of
HERV-W family members have been detected in tissue from patients with multiple sclerosis or schizophrenia
Miscellaneous: Orthologs in Pan troglodytes, Gorilla gorilla, Pongo pygmaeus and Hylobates moloch
Miscellaneous: It can make pseudotypes with HIV-1 virions and confer infectivity. Can also induce cellular
resistance to spleen necrosis virus in vitro
Miscellaneous: HERV-W family subgenomic RNAs have been observed
Miscellaneous: This provirus is intergenic, the closest flanking genes being ODAG and PEX1
Secondary accessions: B2RPD4 O95244 O95245 Q8NHY7 Q9NRZ2 Q9NZG3

Explore the universe of human proteins at neXtProt for ERVW-1: NX_Q9UQF0

Explore proteomics data for ERVW-1 at MOPED

Post-translational modifications: 

  • Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive
    precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM
    proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic
    tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope
    proteins seems to have been lost during evolution1
  • The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to
    participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the
    transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is
    thought to occur upon receptor recognition in order to allow membrane fusion (By similarity)1
  • Glycosylation2 at Asn169, Asn208, Asn214, Asn234, Asn242, Asn281, Asn409
  • Modification sites at PhosphoSitePlus

  • See ERVW-1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124397.1  NP_055405.3  

    ENSEMBL proteins: 
     ENSP00000474984   ENSP00000419945  

    ERVW-1 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ERVW-1 

     
    antibodies-online proteins for ERVW-1 (3 products) 

     
    antibodies-online peptides for ERVW-1

    ERVW-1 Antibody Products:

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    antibodies-online antibodies for ERVW-1 (34 products) 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for ERVW-1 
    antibodies-online kits for ERVW-1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018154 TLV/ENV_coat_polyprotein

    Graphical View of Domain Structure for InterPro Entry Q9UQF0

    ProtoNet protein and cluster: Q9UQF0

    1 Blocks protein domain: IPB002050 ENV polyprotein (coat polyprotein)

    UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
    Domain: The cytoplasmic region is essential for the fusiogenic function
    Domain: The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins.
    Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo
    (By similarity)
    Similarity: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily


    Find genes that share domains with ERVW-1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENW1_HUMAN, Q9UQF0
    Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
    Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This
    endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion
    during placenta morphogenesis
    Function: SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein
    (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to
    recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing
    these receptors in vitro
    Function: The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the
    protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and
    post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats)
    assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region
    of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes
    (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for ERVW-1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENW1_HUMAN, Q9UQF0: Transmembrane protein: Cell membrane; Single-pass type I membrane protein (By similarity)
    ENW1_HUMAN, Q9UQF0: Surface protein: Cell membrane; Peripheral membrane protein (By similarity). Note=The
    surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding
    to TM (By similarity)
    ENW1_HUMAN, Q9UQF0: HERV-W_7q21.2 provirus ancestral Env polyprotein: Virion (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0019031viral envelope IEA--

    Find genes that share ontologies with ERVW-1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERVW-1
    Interactions:

        Search GeneGlobe Interaction Network for ERVW-1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ERVW-1 (Q9UQF03 ENSP000004199454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC1A4P430073, ENSP000002342564I2D: score=1 STRING: ENSP00000234256
    HYAL2Q128913, ENSP000003503874I2D: score=1 STRING: ENSP00000350387
    SLC1A5Q157583I2D: score=1 
    --ENSP000003036234STRING: ENSP00000303623
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006949syncytium formation TAS10693809
    GO:0009653anatomical structure morphogenesis TAS10693809

    Find genes that share ontologies with ERVW-1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERVW-1 (ENW1)

    Selected Novoseek inferred chemical compound relationships for ERVW-1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enfuvirtide 62.3 12 19578246 (3), 15582695 (1), 16912327 (1), 15220433 (1)
    alamos 50.1 2 13678464 (1), 7531216 (1)
    2,2'-dithiodipyridine 38.9 2 15194782 (1)
    gp 130 24.2 2 8388512 (1), 7694060 (1)
    forskolin 14.2 7 12175968 (2), 19091402 (2), 12757936 (1), 19692500 (1) (see all 5)
    asparagine 6.92 2 9223414 (1), 2045792 (1)
    steroid 5.51 3 17066266 (2), 18814240 (1)
    lipid 4.75 17 15956582 (4), 19793805 (4), 17360745 (2), 18081926 (2) (see all 5)
    polysaccharide 2.02 8 20369301 (3), 18330979 (1), 17959660 (1), 7804009 (1) (see all 5)
    glutamate 1.77 1 9811701 (1)



    Find genes that share compounds with ERVW-1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ERVW-1 gene (2 alternative transcripts): 
    NM_001130925.1  NM_014590.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604270 ENST00000603053 ENST00000603704 ENST00000493463(uc022ahe.1)
    ENST00000603252
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ERVW-1

    Selected AceView cDNA sequences (see all 145):

    BX374329 BC030968 CR622175 CR617248 NM_014590 AB079501 BX357209 AB066205 
    AB066659 CR613169 BC041024 CR605851 CR625046 AF072506 BG000981 T39519 
    AA776439 BF993049 BE732673 AB066648 BX378304 BQ024410 BE734284 AB096025 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERVW-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ERVW-1 Expression
    About this image


    ERVW-1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Syncytiotrophoblast-like cells
             placenta   
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
    ERVW-1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERVW-1 Protein Expression

    UniProtKB/Swiss-Prot: ENW1_HUMAN, Q9UQF0
    Tissue specificity: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in
    testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary,
    prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly
    increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ERVW-1 (if available)
    TreeFam Gene Tree for ERVW-1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERVW-1 gene
    ERVFRD-12  
    3 SIMAP similar genes for ERVW-1 using alignment to 1 protein entry:     ENW1_HUMAN:
    ERVWE1    ERVWE2    env

    Find genes that share paralogs with ERVW-1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ENW1_HUMAN, Q9UQF0: All variants have fusogenic properties


    Selected SNPs for ERVW-1 (see all 281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124068181,2
    C--92097199(+) ATTTCA/GGCTCA 2 -- ds50010--------
    rs1455815411,2
    --92097396(+) CCATGC/TGGTGA 2 -- ds50010--------
    rs1863219711,2
    --92097493(+) AGGCAC/GTTAGC 2 -- ds50010--------
    rs102624611,2
    C--92097529(+) agcccA/G/Tattgg 2 -- ds50010--------
    rs1419677741,2
    --92097578(+) GGACAC/TCCTGC 2 -- ds50010--------
    rs1920812641,2
    C--92097584(+) CCTGCA/GTGATC 2 -- ds50010--------
    rs1830518801,2
    --92097585(+) CTGCAG/TGATCC 2 -- ds50010--------
    rs132292551,2
    C,F--92097611(+) agcggC/Tgggtc 2 -- ds50018Minor allele frequency- T:0.34NA WA EA 368
    rs1873866641,2
    C--92097670(+) CAAGCC/TGTAAG 2 -- ds50010--------
    rs1116796251,2
    C--92097744(+) TCCCAC/TACAAA 2 -- ut311Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ERVW-1 (92097694 - 92107300 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ERVW-1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERVW-1
    DNA2.0 Custom Variant and Variant Library Synthesis for ERVW-1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604659    OMIM disorders: --

    2 diseases for ERVW-1:    
    About MalaCards
    choriocarcinoma    schizophrenia


    Find genes that share disorders with ERVW-1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ERVW-1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 88.2 268 10482563 (3), 8139054 (3), 14687493 (2), 16873261 (2) (see all 99)
    jaagsiekte 70.8 3 12596899 (1), 10775607 (1), 19695657 (1)
    leukemia t-cell 69.6 13 1711082 (1), 2072457 (1), 1405724 (1), 9311790 (1) (see all 12)
    aids 58.2 21 9499799 (1), 16873261 (1), 18672260 (1), 19105347 (1) (see all 21)
    lentivirus infections 58.1 1 10933692 (1)
    viremia 57.3 3 17079310 (2), 14722893 (1)
    paraparesis tropical spastic 47.7 3 1540409 (1), 7680300 (1), 8778566 (1)
    htlv-ii infections 47.6 1 7590608 (1)
    sarcoma avian 46.6 2 15367609 (1), 17245447 (1)
    leukemia 46.5 37 2166972 (2), 15026987 (2), 10891403 (2), 1405724 (1) (see all 28)


    Export disorders for ERVW-1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ERVW-1 gene, integrated from 10 sources (see all 484):
    (articles sorted by number of sources associating them with ERVW-1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. (PubMed id 9882319)1, 2, 3, 9 Blond J.-L.... Mallet F. (J. Virol. 1999)
    2. Endogenous retroviruses and multiple sclerosis. II. HERV-7q. (PubMed id 9835022)1, 2, 3 Alliel P.M....Rieger F. (C. R. Acad. Sci. III, Sci. Vie 1998)
    3. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. (PubMed id 15254254)1, 2, 9 Bonnaud B.... Mallet F. (Mol. Biol. Evol. 2004)
    4. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta. (PubMed id 12620933)1, 2, 9 Smallwood A.... Banerjee S. (Biol. Reprod. 2003)
    5. Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family. (PubMed id 10826480)1, 2, 9 Voisset C....Paranhos-Baccala G. (AIDS Res. Hum. Retroviruses 2000)
    6. Syncytin is captive retroviral envelope protein involved in human placental morphogenesis. (PubMed id 10693809)1, 2, 9 Sha M....McCoy J.M. (Nature 2000)
    7. Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope. (PubMed id 15827173)1, 2, 9 Cheynet V.... Mallet F. (J. Virol. 2005)
    8. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. (PubMed id 14557543)1, 2, 9 Blaise S.... Heidmann T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    9. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. (PubMed id 10708449)1, 2, 9 Blond J.-L.... Cosset F.-L. (J. Virol. 2000)
    10. The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus. (PubMed id 12664292)1, 2, 9 Ponferrada V.G.... Wooley D.P. (Arch. Virol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30816 HGNC: 13525 AceView: ERVWE1 Ensembl:ENSG00000242950 euGenes: HUgn30816
    ECgene: ERVW-1 H-InvDB: ERVW-1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ERVW-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERVW-1 Genetics and Cytogenetics in Oncology and Haematology
    Human Endogenous Retrovirus Database (HERVd)http://herv.img.cas.cz/cgi-bin/draw_full_element.cgi?fid=41573
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/050

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERVW-1 gene:
    Search GeneIP for patents involving ERVW-1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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