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Aliases for ERVK-6 Gene

Aliases for ERVK-6 Gene

  • Endogenous Retrovirus Group K Member 6 2 3
  • HERV-K_7p22.1 Provirus Ancestral Env Polyprotein 2 3 4
  • HERV-K_7p22.1 Provirus Ancestral Pol Protein 2 3 4
  • HERV-K_7p22.1 Provirus Ancestral Pro Protein 2 3 4
  • HERV-K_7p22.1 Provirus Rec Protein 2 3 4
  • HERV-K(C7) Envelope Protein 2 3 4
  • HERV-K108 Envelope Protein 2 3 4
  • Endogenous Retrovirus Group K, Member 6 2 3
  • Endogenous Retroviral Sequence K, 6 2 3
  • HERV-K(HML-2.HOM) Envelope Protein 3 4
  • Envelope Polyprotein 3 4
  • HERV-K (HML-2.HOM) 2 3
  • Rev-Like Protein 3 4
  • Rev/Rex Homolog 3 4
  • EnvK2 Protein 3 4
  • ERVK6 3 4
  • K-Rev 3 4
  • C-Orf 3 4
  • CORF 3 4
  • Endogenous Retrovirus Group K Member 6 Env Polyprotein 3
  • HERV-K_7p22.1 Provirus Ancestral Gag Polyprotein 4
  • Endogenous Retrovirus K Protein 6 4
  • HERV-K(HML-2.HOM) Gag Protein 4
  • HERV-K(HML-2.HOM) Pol Protein 4
  • HERV-K(HML-2.HOM) Pro Protein 4
  • HERV-K(HML-2.HOM) Rec Protein 4
  • Central Open Reading Frame 4
  • HERV-K(C7) Gag Protein 4
  • HERV-K(C7) Pol Protein 4
  • HERV-K(C7) Pro Protein 4
  • HERV-K(C7) Rec Protein 4
  • Envelope Glycoprotein 3
  • HERV-K108 Gag Protein 4
  • HERV-K108 Pol Protein 4
  • HERV-K108 Pro Protein 4
  • HERV-K108 Rec Protein 4
  • Envelope Protein 3
  • Gag Polyprotein 4
  • EC 3.4.23.50 4
  • Proteinase 4
  • HERV-K(C7) 3
  • HERV-K108 3
  • EC 3.4.23 63
  • Protease 4
  • PR 4

External Ids for ERVK-6 Gene

Previous HGNC Symbols for ERVK-6 Gene

  • ERVK6

Summaries for ERVK-6 Gene

GeneCards Summary for ERVK-6 Gene

ERVK-6 (Endogenous Retrovirus Group K Member 6) is a Protein Coding gene. Diseases associated with ERVK-6 include hiv-1. GO annotations related to this gene include nucleic acid binding and structural molecule activity.

  • Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

  • SU mediates receptor recognition.

  • TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

  • The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

  • Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.

  • Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.

  • Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.

Gene Wiki entry for ERVK-6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERVK-6 Gene

Genomics for ERVK-6 Gene

Genomic Location for ERVK-6 Gene

Chromosome:
7
Orientation:
Unknown strand

Genomic View for ERVK-6 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for ERVK-6 Gene

Proteins for ERVK-6 Gene

  • Protein details for ERVK-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69383-REC6_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 6 Rec protein
    Protein Accession:
    Q69383

    Protein attributes for ERVK-6 Gene

    Size:
    105 amino acids
    Molecular mass:
    11828 Da
    Quaternary structure:
    • Forms homodimers, homotrimers, and homotetramers via a C-terminal domain. Associates with XPO1 and with ZNF145.
    Miscellaneous:
    • Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.
    • Has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HML-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3 part of the proviral genome.
    • This Rec protein is encoded by a human specific provirus.
    • Two proviruses inserted as tandem repeats in most of individuals tested. Both proviral genomes encode identical Rec proteins.
  • Protein details for ERVK-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69384-ENK6_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 6 Env polyprotein
    Protein Accession:
    Q69384
    Secondary Accessions:
    • Q8TD93
    • Q9UBU4
    • Q9YNA5
    • Q9YNA9

    Protein attributes for ERVK-6 Gene

    Size:
    699 amino acids
    Molecular mass:
    79218 Da
    Quaternary structure:
    • The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).
    Miscellaneous:
    • ERVK-6 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.
    • Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as provirus 41574. The centromeric copy is referred here as provirus 41575.
    SequenceCaution:
    • Sequence=CAA76880.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA76886.1; Type=Erroneous initiation; Evidence={ECO:0000305};
  • Protein details for ERVK-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LDI9-GAK6_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 6 Gag polyprotein
    Protein Accession:
    Q7LDI9
    Secondary Accessions:
    • Q9UKH5
    • Q9Y6I1
    • Q9YNA6
    • Q9YNB0

    Protein attributes for ERVK-6 Gene

    Size:
    666 amino acids
    Molecular mass:
    74079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD51797.1; Type=Frameshift; Positions=666; Note=Occurs within the codons for the last amino acids in the Gag and Pro open reading frames.; Evidence={ECO:0000305}; Sequence=AC072054; Type=Erroneous termination; Positions=179; Note=Translated as Arg. Provirus 41574.; Evidence={ECO:0000305}; Sequence=AC072054; Type=Erroneous termination; Positions=365; Note=Translated as Gln. Provirus 41575.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERVK-6 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for ERVK-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR3-POK6_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 6 Pol protein
    Protein Accession:
    Q9BXR3
    Secondary Accessions:
    • Q6KH04
    • Q9BXR4
    • Q9UKH5
    • Q9UP31
    • Q9WIK9
    • Q9WJR4

    Protein attributes for ERVK-6 Gene

    Size:
    956 amino acids
    Molecular mass:
    107688 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Exact N-terminus of this protein has not been formally described.
    • This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein precursors. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.
    • Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as provirus 41574. The centromeric copy is referred here as provirus 41575.
    SequenceCaution:
    • Sequence=AAD51797.1; Type=Frameshift; Positions=Several; Note=A -1 frameshift presumed to occur at the N-terminus at the Pro-Pol gene boundary.; Evidence={ECO:0000305}; Sequence=CAA76879.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA76885.1; Type=Erroneous initiation; Evidence={ECO:0000305};
  • Protein details for ERVK-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I0-VPK6_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 6 Pro protein
    Protein Accession:
    Q9Y6I0
    Secondary Accessions:
    • Q9UKH5

    Protein attributes for ERVK-6 Gene

    Size:
    156 amino acids
    Molecular mass:
    16972 Da
    Quaternary structure:
    • Active as a homodimer.
    Miscellaneous:
    • Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as provirus 41574. The centromeric copy is referred here as provirus 41575.
    SequenceCaution:
    • Sequence=AAD21096.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF88166.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERVK-6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERVK-6 Gene

Proteomics data for ERVK-6 Gene at MOPED

Selected DME Specific Peptides for ERVK-6 Gene

Post-translational modifications for ERVK-6 Gene

  • Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.
  • Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).
  • Specific enzymatic cleavages may yield mature proteins.
  • Cleavage sites that yield the mature proteins remain to be determined.
  • Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).
  • Glycosylation at Asn 100, Asn 128, Asn 153, Asn 274, Asn 355, Asn 372, Asn 461, Asn 507, Asn 554, Asn 566, and Asn 585
  • Modification sites at PhosphoSitePlus

Domains & Families for ERVK-6 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LDI9

UniProtKB/Swiss-Prot:

VPK6_HUMAN :
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
  • Contains 2 CCHC-type zinc fingers.
Domain:
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
  • The LPQG and YXDD motifs are catalytically important and conserved among many retroviruses.
  • Contains 1 integrase catalytic domain.
  • Contains 1 integrase-type DNA-binding domain.
  • Contains 1 reverse transcriptase domain.
  • Contains 1 RNase H domain.
  • Contains 1 G-patch domain.
  • Contains 1 peptidase A2 domain.
Family:
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
  • Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
  • Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
  • Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
Similarity:
  • Contains 2 CCHC-type zinc fingers.
  • Contains 1 integrase-type zinc finger.
genes like me logo Genes that share domains with ERVK-6: view

No data available for Gene Families for ERVK-6 Gene

Function for ERVK-6 Gene

Molecular function for ERVK-6 Gene

UniProtKB/Swiss-Prot Function:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.
UniProtKB/Swiss-Prot Function:
SU mediates receptor recognition.
UniProtKB/Swiss-Prot Function:
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
UniProtKB/Swiss-Prot Function:
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to 5-phosphomonoester.
UniProtKB/Swiss-Prot Function:
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot Function:
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.
UniProtKB/Swiss-Prot CatalyticActivity:
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY- -PIVQ-cleavage site.
UniProtKB/Swiss-Prot Function:
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.

Enzyme Numbers (IUBMB) for ERVK-6 Gene

Gene Ontology (GO) - Molecular Function for ERVK-6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0003964 RNA-directed DNA polymerase activity IEA --
genes like me logo Genes that share ontologies with ERVK-6: view

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERVK-6 Gene

Localization for ERVK-6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERVK-6 Gene

Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.
Transmembrane protein: Cell membrane; Single-pass type I membrane protein.
Surface protein: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.
Endogenous retrovirus group K member 6 Env polyprotein: Virion.
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ERVK-6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019028 viral capsid IEA --
genes like me logo Genes that share ontologies with ERVK-6: view

No data available for Subcellular locations from COMPARTMENTS for ERVK-6 Gene

Pathways & Interactions for ERVK-6 Gene

SuperPathways for ERVK-6 Gene

No Data Available

Interacting Proteins for ERVK-6 Gene

Gene Ontology (GO) - Biological Process for ERVK-6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006278 RNA-dependent DNA biosynthetic process IEA --
GO:0006310 DNA recombination IEA --
GO:0006508 proteolysis IEA --
GO:0015074 DNA integration IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ERVK-6: view

No data available for Pathways by source and SIGNOR curated interactions for ERVK-6 Gene

Drugs & Compounds for ERVK-6 Gene

(63) Drugs for ERVK-6 Gene - From: Novoseek, HMDB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Darunavir Approved Pharma HIV-1 protease inhibitor 198
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 398
Lamivudine Approved, Investigational Pharma Nucleoside analog reverse transcriptase inhibitor 594
Lopinavir Approved Pharma HIV protease inhibitor,highly potent 342
Nevirapine Approved Pharma 222

(47) Additional Compounds for ERVK-6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ERVK-6: view

Transcripts for ERVK-6 Gene

mRNA/cDNA for ERVK-6 Gene

(1) REFSEQ mRNAs :

Alternative Splicing Database (ASD) splice patterns (SP) for ERVK-6 Gene

No ASD Table

Relevant External Links for ERVK-6 Gene

ECgene alternative splicing isoforms for
ERVK-6

Expression for ERVK-6 Gene

Protein differential expression in normal tissues from HIPED for ERVK-6 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERVK-6 Gene



mRNA Expression by UniProt/SwissProt for ERVK-6 Gene

Q69383-REC6_HUMAN
Tissue specificity: Expressed in testis, and peripheral blood lymphocytes.

Protein tissue co-expression partners for ERVK-6 Gene

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ERVK-6 Gene

Orthologs for ERVK-6 Gene

No data available for Orthologs and Evolution for ERVK-6 Gene

Paralogs for ERVK-6 Gene

(1) SIMAP similar genes for ERVK-6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ERVK-6: view

No data available for Paralogs for ERVK-6 Gene

Variants for ERVK-6 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for ERVK-6 Gene

Disorders for ERVK-6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ERVK-6 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ERVK-6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERVK-6
genes like me logo Genes that share disorders with ERVK-6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERVK-6 Gene

Publications for ERVK-6 Gene

  1. Genomic organization of the human endogenous retrovirus HERV-K(HML- 2.HOM) (ERVK6) on chromosome 7. (PMID: 11401447) Reus K. … Meese E.U. (Genomics 2001) 2 3 4 67
  2. A revised nomenclature for transcribed human endogenous retroviral loci. (PMID: 21542922) Mayer J. … Seal R.L. (Mob DNA 2011) 2 3
  3. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. (PMID: 10469592) Barbulescu M. … Lenz J. (Curr. Biol. 1999) 3 23
  4. An almost-intact human endogenous retrovirus K on human chromosome 7. (PMID: 10080172) Mayer J. … Meese E.U. (Nat. Genet. 1999) 2 3
  5. Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells. (PMID: 9060628) Toenjes R.R. … Kurth R. (J. Virol. 1997) 3 23

Products for ERVK-6 Gene

Sources for ERVK-6 Gene

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