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Aliases for ERVK-5 Gene

Aliases for ERVK-5 Gene

  • Endogenous Retrovirus Group K Member 5 2 3
  • HERV-K_3q12.3 Provirus Ancestral Env Polyprotein 3 4
  • Endogenous Retroviral Sequence K (G2), 5 2 3
  • HERV-K(II) Envelope Protein 3 4
  • Envelope Polyprotein 3 4
  • ERVK5 3 4
  • Endogenous Retrovirus Group K Member 5 Env Polyprotein 3
  • HERV-K_3q12.3 Provirus Ancestral Gag Polyprotein 4
  • Endogenous Retrovirus Group K, Member 5 2
  • HERV-K_3q12.3 Provirus Np9 Protein 4
  • Endogenous Retrovirus K Protein 5 4
  • HERV-K(II) Gag Protein 4
  • HERV-K(II) Np9 Protein 4
  • Gag Polyprotein 4
  • HERV-K(II) 3
  • HERV-KII 3

External Ids for ERVK-5 Gene

Previous HGNC Symbols for ERVK-5 Gene

  • ERVK5

Summaries for ERVK-5 Gene

GeneCards Summary for ERVK-5 Gene

ERVK-5 (Endogenous Retrovirus Group K Member 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and structural molecule activity.

UniProtKB/Swiss-Prot for ERVK-5 Gene

  • Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

  • The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

  • May possess a function in tumorigenesis.

Additional gene information for ERVK-5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERVK-5 Gene

Genomics for ERVK-5 Gene

Genomic Location for ERVK-5 Gene

Chromosome:
3
Orientation:
Unknown strand

Genomic View for ERVK-5 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for ERVK-5 Gene

Proteins for ERVK-5 Gene

  • Protein details for ERVK-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61583-NP5_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 5 Np9 protein
    Protein Accession:
    P61583

    Protein attributes for ERVK-5 Gene

    Size:
    75 amino acids
    Molecular mass:
    8907 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5-end of the env gene. Np9 proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 1 proviral genomes. Np9 proteins share 14 N-terminal amino acids with HERV-K(HML-2) type 2 envelope proteins. The rest of the protein is encoded by a small exon located at the 3 end of the envelope gene. This exon shares the same splice acceptor site and therefore overlaps HERV-K(HML-2) type 2 Rec protein second exon. It is yet translated from an alternate reading frame.
    • Intergenic, closest flanking genes being RPL24 and FLJ23047.
    • Protein expressed at very low level.
  • Protein details for ERVK-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDB8-ENK5_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 5 Env polyprotein
    Protein Accession:
    Q9HDB8

    Protein attributes for ERVK-5 Gene

    Size:
    245 amino acids
    Molecular mass:
    27904 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.
    • Intergenic, closest flanking genes being RPL24 and FLJ23047.
  • Protein details for ERVK-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDB9-GAK5_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 5 Gag polyprotein
    Protein Accession:
    Q9HDB9

    Protein attributes for ERVK-5 Gene

    Size:
    667 amino acids
    Molecular mass:
    73588 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Intergenic, closest flanking genes being RPL24 and FLJ23047.

    Alternative splice isoforms for ERVK-5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERVK-5 Gene

Post-translational modifications for ERVK-5 Gene

  • Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).
  • Specific enzymatic cleavages may yield mature proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ERVK-5 Gene

Domains & Families for ERVK-5 Gene

Suggested Antigen Peptide Sequences for ERVK-5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HDB9

UniProtKB/Swiss-Prot:

GAK5_HUMAN :
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
Domain:
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
Family:
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
  • Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
genes like me logo Genes that share domains with ERVK-5: view

No data available for Gene Families for ERVK-5 Gene

Function for ERVK-5 Gene

Molecular function for ERVK-5 Gene

UniProtKB/Swiss-Prot Function:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot Function:
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot Function:
May possess a function in tumorigenesis.

Gene Ontology (GO) - Molecular Function for ERVK-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005198 structural molecule activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ERVK-5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERVK-5 Gene

Localization for ERVK-5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERVK-5 Gene

Nucleus. Note=When overexpressed. {ECO:0000250}.
Virion.
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ERVK-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0019028 viral capsid IEA --
genes like me logo Genes that share ontologies with ERVK-5: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ERVK-5 Gene

Pathways & Interactions for ERVK-5 Gene

SuperPathways for ERVK-5 Gene

No Data Available

Interacting Proteins for ERVK-5 Gene

Gene Ontology (GO) - Biological Process for ERVK-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ERVK-5: view

No data available for Pathways by source and SIGNOR curated interactions for ERVK-5 Gene

Drugs & Compounds for ERVK-5 Gene

No Compound Related Data Available

Transcripts for ERVK-5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ERVK-5 Gene

No ASD Table

Relevant External Links for ERVK-5 Gene

ECgene alternative splicing isoforms for
ERVK-5

No data available for mRNA/cDNA for ERVK-5 Gene

Expression for ERVK-5 Gene

Protein differential expression in normal tissues from HIPED for ERVK-5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERVK-5 Gene



Protein tissue co-expression partners for ERVK-5 Gene

mRNA Expression by UniProt/SwissProt for ERVK-5 Gene:

P61583-NP5_HUMAN
Tissue specificity: Expressed in lung, placenta, testis, peripheral blood lymphocytes, and teratocarcinoma cell lines.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERVK-5 Gene

Orthologs for ERVK-5 Gene

No data available for Orthologs and Evolution for ERVK-5 Gene

Paralogs for ERVK-5 Gene

(4) SIMAP similar genes for ERVK-5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ERVK-5: view

No data available for Paralogs for ERVK-5 Gene

Variants for ERVK-5 Gene

Relevant External Links for ERVK-5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERVK-5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for ERVK-5 Gene

Disorders for ERVK-5 Gene

No disorders were found for ERVK-5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ERVK-5 Gene

Publications for ERVK-5 Gene

  1. Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping. (PMID: 11401426) Sugimoto J … Jinno Y (Genomics 2001) 2 3 4 60
  2. A revised nomenclature for transcribed human endogenous retroviral loci. (PMID: 21542922) Mayer J … Seal RL (Mobile DNA 2011) 2 3 60
  3. A novel gene from the human endogenous retrovirus K expressed in transformed cells. (PMID: 12060620) Armbruester V … Mueller-Lantzsch N (Clinical cancer research : an official journal of the American Association for Cancer Research 2002) 3 4 60
  4. Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. (PMID: 7983737) Sauter M … Mueller-Lantzsch N (Journal of virology 1995) 3 60

Products for ERVK-5 Gene

Sources for ERVK-5 Gene

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