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ERV3-1 Gene

protein-coding   GIFtS: 34
GCID: GC07M064451

Endogenous Retrovirus Group 3, Member 1

(Previous names: endogenous retroviral sequence 3 (includes zinc finger protein...)
(Previous symbol: ERV3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Endogenous Retrovirus Group 3, Member 11 2     ERV-R2
ERV31 2 3 5     ERVR2
Endogenous Retroviral Sequence 31 2     HERV-R2
ERV-3 Envelope Protein2 3     HERVR2
ERV-R Envelope Protein2 3     envR2
ERV3-1 Envelope Protein2 3     HERV-R_7q21.2 Provirus Ancestral Env Polyprotein2
HERV-R Envelope Protein2 3     Envelope Polyprotein3
Endogenous Retroviral Sequence 3 (Includes Zinc Finger Protein H-Plk/HPF9)1     ERV3 Envelope Protein3

External Ids:    HGNC: 34541   Entrez Gene: 20862   Ensembl: ENSG000002134627   OMIM: 1311705   UniProtKB: Q142643   
ORGUL members:         

Export aliases for ERV3-1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERV3-1 Gene:
The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the
most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates
with the exception of gorillas. Taken together, the observation of genome conservation, the detection of
transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A
functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ERV3-1 Gene:
ERV3-1 (endogenous retrovirus group 3, member 1) is a protein-coding gene. Diseases associated with ERV3-1 include choriocarcinoma, and multiple sclerosis.

UniProtKB/Swiss-Prot: ENR1_HUMAN, Q14264
Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This
endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease
expression of cyclin B1 and increased expression of p21 in vitro
Function: SU mediates receptor recognition (By similarity)
Function: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other
hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane
(By similarity)

Gene Wiki entry for ERV3-1 (ERV3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ERV3-1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ERV3-1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERV3-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.2   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7p12-q11

ERV3-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERV3-1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M064451:  view genomic region     (about GC identifiers)

Start:
64,450,733 bp from pter      End:
64,467,124 bp from pter
Size:
16,392 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 63,788,327-63,804,718     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ENR1_HUMAN, Q14264 (See protein sequence)
Recommended Name: HERV-R_7q21.2 provirus ancestral Env polyprotein precursor  
Size: 604 amino acids; 67942 Da
Subunit: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by
non-covalent interactions or by a labile interchain disulfide bond (By similarity)
Developmental stage: Highly expressed in primitive adrenal cortex and placenta. Expressed at lower level in
developing nervous tissues, tongue, heart, gut, kidney, columna vertebralis and liver
Miscellaneous: HERV-R_7q21.2 genomic and subgenomic RNAs have been observed
Miscellaneous: This provirus is intergenic, the closest flanking genes being ZNF117 and FLJ25037
Caution: CKS-17 sequence does not match the minimal active consensus
Caution: Truncated; premature stop codon upstream of the fusion peptide on TM

Explore the universe of human proteins at neXtProt for ERV3-1: NX_Q14264

Explore proteomics data for ERV3-1 at MOPED

Post-translational modifications: 

  • Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). Has been mainly detected
    in vivo as an 65 kDa unprocessed polyprotein precursor1
  • The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to
    participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the
    transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is
    thought to occur upon receptor recognition in order to allow membrane fusion (By similarity)1
  • Glycosylation2 at Asn64, Asn105, Asn201, Asn316, Asn369, Asn382, Asn399, Asn527, Asn569
  • Modification sites at PhosphoSitePlus

  • See ERV3-1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001007254.2  
    ENSEMBL proteins: 
     ENSP00000391594  

    ERV3-1 Human Recombinant Protein Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018154 TLV/ENV_coat_polyprotein

    Graphical View of Domain Structure for InterPro Entry Q14264

    ProtoNet protein and cluster: Q14264

    1 Blocks protein domain: IPB002050 ENV polyprotein (coat polyprotein)

    UniProtKB/Swiss-Prot: ENR1_HUMAN, Q14264
    Domain: Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic
    peptide, it inhibits immune function in vitro and in vivo (By similarity)
    Similarity: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily


    ERV3-1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENR1_HUMAN, Q14264
    Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.
    Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This
    endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease
    expression of cyclin B1 and increased expression of p21 in vitro
    Function: SU mediates receptor recognition (By similarity)
    Function: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other
    hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    ERV3-1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERV3-1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENR1_HUMAN, Q14264: Virion

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0019031viral envelope IEA--

    ERV3-1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERV3-1
    Interactions:

        Search GeneGlobe Interaction Network for ERV3-1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ERV3-1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERV3-1 (ENR1)

    1 Novoseek inferred chemical compound relationship for ERV3-1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 19.9 3 9465316 (1), 8592062 (1), 9732235 (1)



    ERV3-1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ERV3-1 gene: 
    NM_001007253.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394323(uc011kdr.2) ENST00000528878(uc003tts.2) ENST00000535538

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate ERV3-1
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    Predesigned siRNA for gene silencing in human, mouse, rat ERV3-1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ERV3-1
      QuantiFast Probe-based Assays in human, mouse, rat ERV3-1

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERV3-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ERV3-1 Expression
    About this image


    ERV3-1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    ERV3-1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERV3-1 Protein Expression

    UniProtKB/Swiss-Prot: ENR1_HUMAN, Q14264
    Tissue specificity: Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level
    in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis,
    thymus, thyroid, trachea

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERV3-1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ERV3-1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ERV3-11 endogenous retrovirus group 3, member 1 99.23(n)
    98.18(a)
      100190893  NM_001135588.1  NP_001129060.1 


    ENSEMBL Gene Tree for ERV3-1 (if available)
    TreeFam Gene Tree for ERV3-1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERV3-1 gene

    ERV3-1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ERV3-1
    PGOHUM00000244534 PGOHUM00000237629 PGOHUM00000233575


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ENR1_HUMAN, Q14264: This envelope gene is polymorphic with at least five different alleles. A mutation introducing a
    premature stop codon instead of amino acid 223 is present in approximately 1% of the Caucasian population


    Selected SNPs for ERV3-1 (see all 332)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833200721,2
    C--64453439(+) AAGGCC/TAAGCA 1 -- ut510--------
    rs1424556771,2
    C--64453448(+) CAAAGG/TGACAG 1 -- ut510--------
    rs1876151741,2
    --64453473(+) AATTAA/TTATGA 1 -- ut510--------
    rs1508352891,2
    --64453598(+) GTCTCC/TTCAAG 1 -- ut510--------
    rs1151567381,2
    C,F--64453612(+) CAGCCG/ATGTGT 1 -- ut511Minor allele frequency- A:0.10WA 118
    rs77961441,2
    C,F,A,H--64453615(+) ccgtgC/Tgtgga 1 -- ut5112Minor allele frequency- T:0.15NA WA CSA EA 374
    rs1921454831,2
    C--64453632(+) AGCTTC/TCGGAG 1 -- ut510--------
    rs346360141,2
    C,F--64453634(+) CTTCCG/AGAGTG 1 -- ut519Minor allele frequency- A:0.42NA CSA WA EA 370
    rs766900741,2
    C--64453635(+) TTCCGG/CAGTGA 1 -- ut513Minor allele frequency- C:0.08NA EA 242
    rs768521961,2
    C,F--64453768(+) ATGGAT/AGGATC 1 -- ut511Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for ERV3-1 (64450733 - 64467124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ERV3-1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1147e201CNV Deletion23290073
    esv2422405CNV Duplication17116639
    dgv226e55CNV Loss17911159
    dgv7308n71CNV Gain21882294
    dgv7309n71CNV Gain21882294
    nsv888284CNV Gain21882294
    nsv464518CNV Gain19166990
    nsv517778CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERV3-1
    DNA2.0 Custom Variant and Variant Library Synthesis for ERV3-1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131170    OMIM disorders: --

    10 diseases for ERV3-1:    
    About MalaCards
    choriocarcinoma    multiple sclerosis    prostate adenocarcinoma    rheumatoid arthritis
    arthritis    ovarian cancer    adenocarcinoma    thyroiditis
    prostatitis    breast cancer


    ERV3-1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for ERV3-1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 59.9 2 8707424 (1), 8592062 (1)
    autoimmune diseases 19.6 2 7882554 (1), 8809571 (1)
    rheumatoid arthritis 14.1 2 7882554 (2)
    multiple sclerosis 8.29 2 8871766 (2)
    immunodeficiency 6.32 3 7884857 (1), 9188654 (1)
    tumors 0 7 11410490 (1), 9419968 (1), 9458354 (1)
    cancer 0 2 16443335 (2)


    Export disorders for ERV3-1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERV3-1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with ERV3-1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3. (PubMed id 10427470)1, 2, 9 Rasmussen H.B. and Clausen J. (Dis. Markers 1998)
    2. Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population. (PubMed id 9525678)1, 2, 9 de Parseval N. and Heidmann T. (J. Virol. 1998)
    3. A revised nomenclature for transcribed human endogenous retroviral loci. (PubMed id 21542922)1, 3 Mayer J....Seal R.L. (Mob DNA 2011)
    4. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. (PubMed id 14557543)1, 2 Blaise S.... Heidmann T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. (PubMed id 12970426)1, 2 de Parseval N.... Heidmann T. (J. Virol. 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. (PubMed id 12083821)1, 2 Andersson A.-C.... Larsson E. (Virology 2002)
    8. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo. (PubMed id 10692254)1, 2 Lin L.... Rote N.S. (Placenta 2000)
    9. Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. (PubMed id 7645262)1, 2 Venables P.J.W.... Boyd M.T. (Virology 1995)
    10. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel. (PubMed id 2115127)1, 3 Kato N.... Cohen M. (Mol. Cell. Biol. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2086 HGNC: 3454 Ensembl:ENSG00000213462 euGenes: HUgn2086 ECgene: ERV3-1
    H-InvDB: ERV3-1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERV3-1 Pharmacogenomics, SNPs, Pathways
    Human Endogenous Retrovirus Database (HERVd)http://herv.img.cas.cz/cgi-bin/draw_full_element.cgi?fid=41580

    (Patent information from GeneIP,
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    Patent Information for ERV3-1 gene:
    Search GeneIP for patents involving ERV3-1

    GeneCards and IP:
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