Aliases for ERP44 Gene
External Ids for ERP44 Gene
Previous HGNC Symbols for ERP44 Gene
Previous GeneCards Identifiers for ERP44 Gene
GeneCards Summary for ERP44 Gene
ERP44 (Endoplasmic Reticulum Protein 44) is a Protein Coding gene. Diseases associated with ERP44 include Multiple Sulfatase Deficiency. Among its related pathways are Immune System and Translational Control. GO annotations related to this gene include calcium ion binding and protein disulfide isomerase activity. An important paralog of this gene is PDIA4.
UniProtKB/Swiss-Prot for ERP44 Gene
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.