Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ERO1L Gene

protein-coding   GIFtS: 60
GCID: GC14M053106

ERO1-Like (S. Cerevisiae)

(Previous name: ERO1 (S. cerevisiae)-like)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ERO1-Like (S. Cerevisiae)1 2     ERO1A2
Endoplasmic Oxidoreductin-1-Like Protein2 3     ERO1-Like Protein Alpha2
ERO1-L2 3     oxidoreductin-1-L-alpha2
ERO1-L-alpha2 3     EC 1.8.4.-3
ERO1LA2 5     Oxidoreductin-1-L-alpha3
ERO1 (S. Cerevisiae)-Like1     EC 1.8.48
ERO1-alpha2     

External Ids:    HGNC: 132801   Entrez Gene: 300012   Ensembl: ENSG000001979307   OMIM: 6154355   UniProtKB: Q96HE73   

Export aliases for ERO1L gene to outside databases

Previous GC identifers: GC14M050431 GC14M046904 GC14M051098 GC14M052178 GC14M033269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ERO1L Gene:
ERO1L (ERO1-like (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and protein disulfide isomerase activity. An important paralog of this gene is ERO1LB.

UniProtKB/Swiss-Prot: ERO1A_HUMAN, Q96HE7
Function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes
P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds
of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to
the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins.
Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae,
thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced,
CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1

Gene Wiki entry for ERO1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERO1L gene promoter:
         AhR   Pax-5   HNF-4alpha2   LCR-F1   C/EBPalpha   GATA-1   HNF-4alpha1   AREB6   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidERO1L promoter sequence
   Search Chromatin IP Primers for ERO1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERO1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

ERO1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERO1L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M053106:  view genomic region     (about GC identifiers)

Start:
53,106,634 bp from pter      End:
53,162,618 bp from pter
Size:
55,985 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ERO1A_HUMAN, Q96HE7 (See protein sequence)
Recommended Name: ERO1-like protein alpha precursor  
Size: 468 amino acids; 54393 Da
Cofactor: FAD
Subunit: Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT
2 PDB 3D structures from and Proteopedia for ERO1L:
3AHQ (3D)        3AHR (3D)    
Secondary accessions: A8K9X4 A8MYW1 Q7LD45 Q9P1Q9 Q9UKV6

Explore the universe of human proteins at neXtProt for ERO1L: NX_Q96HE7

Explore proteomics data for ERO1L at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99
    disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397 (By
    similarity). The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131
    (PubMed:23027870)1
  • Glycosylation2 at Asn280, Asn384
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ERO1L (Q96HE7) (see all 17)
     LTRQEIV  IMDCVGC  CDVETID  HLSARYLL 


    See ERO1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055399.1  
    ENSEMBL proteins: 
     ENSP00000379042   ENSP00000451204   ENSP00000452020   ENSP00000450655   ENSP00000452269  
     ENSP00000452093  
    Reactome Protein details: Q96HE7

    ERO1L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ERO1L
    OriGene Protein Over-expression Lysate for ERO1L
    OriGene MassSpec for ERO1L
    OriGene Custom Protein Services for ERO1L
    GenScript Custom Purified and Recombinant Proteins Services for ERO1L
    Novus Biologicals ERO1L Proteins
    Novus Biologicals ERO1L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERO1L

     
    Search eBioscience for Proteins for ERO1L 

    ERO1L Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERO1L
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ERO1L 
    OriGene Antibodies for ERO1L
    OriGene Custom Antibody Services for ERO1L
    Novus Biologicals ERO1L Antibodies
    Abcam antibodies for ERO1L
    Cloud-Clone Corp. Antibodies for ERO1L
    ThermoFisher Antibody for ERO1L
    LSBio Antibodies in human, mouse, rat for ERO1L

    ERO1L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ERO1L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ERO1L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ERO1L
    Cloud-Clone Corp. CLIAs for ERO1L
    Search eBioscience for ELISAs for ERO1L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007266 Ero1

    Graphical View of Domain Structure for InterPro Entry Q96HE7

    ProtoNet protein and cluster: Q96HE7

    UniProtKB/Swiss-Prot: ERO1A_HUMAN, Q96HE7
    Similarity: Belongs to the EROs family


    Find genes that share domains with ERO1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERO1A_HUMAN, Q96HE7
    Function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes
    P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds
    of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to
    the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins.
    Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae,
    thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced,
    CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1
    Enzyme regulation: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in
    the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site
    Cys-94 and Cys-131, and between Cys-99 and Cys-104. Glutathione may be required to regulate its activity in the
    endoplasmic reticulum
    Induction: Stimulated by hypoxia; suggesting that it is regulated via the HIF-pathway

         Enzyme Numbers (IUBMB): EC 1.8.42 EC 1.8.4.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IEA--
    GO:0005515protein binding IPI17170699
    GO:0016491oxidoreductase activity IDA11707400
    GO:0016671oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA--
         
    Find genes that share ontologies with ERO1L           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ero1l):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with ERO1L           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERO1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERO1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERO1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERO1L

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERO1L:
    hsa-mir-98-5p (MIRT027850), hsa-mir-106b-5p (MIRT044365), hsa-let-7b-5p (MIRT032494), hsa-mir-182-5p (MIRT047216), hsa-mir-296-3p (MIRT038460)

    Block miRNA regulation of human, mouse, rat ERO1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERO1L (see all 35):
    hsa-miR-607 hsa-miR-3607-3p hsa-let-7d hsa-miR-500a hsa-miR-3162-5p hsa-miR-1304 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidERO1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERO1L
    Predesigned siRNA for gene silencing in human, mouse, rat ERO1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERO1L

    Clone
    Products:
         
    OriGene clones in human, mouse for ERO1L (see all 8)
    OriGene ORF clones in mouse, rat for ERO1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERO1L (NM_014584)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERO1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERO1L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERO1L
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERO1L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERO1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ERO1A_HUMAN, Q96HE7: Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The
    association with ERP44 is essential for its retention in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10671517
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane TAS10671517
    GO:0043231intracellular membrane-bounded organelle TAS10671517

    Find genes that share ontologies with ERO1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ERO1L About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    2Cellular Senescence
    Cellular responses to stress0.81
    3Insulin receptor recycling
    Vibrio cholerae infection0.40
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with ERO1L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ERO1L
        Cholera Infection

    1 Cell Signaling Technology (CST) Pathway for ERO1L
        Translational Control

    2 Reactome Pathways for ERO1L
        Detoxification of Reactive Oxygen Species
    Insulin processing


    2 Kegg Pathways  (Kegg details for ERO1L):
        Protein processing in endoplasmic reticulum
    Vibrio cholerae infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERO1L: 
              Hypoxia Signaling Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ERO1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERO1L (Q96HE71, 2, 3 ENSP000003790424) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P4HBP072371, 2, 3, ENSP000003278014EBI-2564539,EBI-395883 MINT-8075157 MINT-15901 MINT-8075141 I2D: score=3 STRING: ENSP00000327801
    PDIA3P301011, 2, 3, ENSP000003002894EBI-2564539,EBI-979862 MINT-8075180 MINT-4301212 MINT-4053770 I2D: score=2 STRING: ENSP00000300289
    PDIA4P136672, 3, ENSP000002860914MINT-8075089 I2D: score=1 STRING: ENSP00000286091
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    PDILTQ8N8073, ENSP000003054654I2D: score=1 STRING: ENSP00000305465
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS10671517
    GO:0006464cellular protein modification process TAS10671517
    GO:0009266response to temperature stimulus TAS10671517
    GO:0030968endoplasmic reticulum unfolded protein response IEA--
    GO:0034976response to endoplasmic reticulum stress ISS--

    Find genes that share ontologies with ERO1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERO1L (ERO1A)

    1 HMDB Compound for ERO1L    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ERO1L gene: 
    NM_014584.1  

    Unigene Cluster for ERO1L:

    ERO1-like (S. cerevisiae)
    Hs.592304  [show with all ESTs]
    Unigene Representative Sequence: AF081886
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395686(uc001wzv.3) ENST00000553714 ENST00000554019 ENST00000556039
    ENST00000555069 ENST00000556358 ENST00000556769 ENST00000554251 ENST00000557178
    ENST00000556223
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERO1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERO1L (see all 35):
    hsa-miR-607 hsa-miR-3607-3p hsa-let-7d hsa-miR-500a hsa-miR-3162-5p hsa-miR-1304 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidERO1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERO1L
    Predesigned siRNA for gene silencing in human, mouse, rat ERO1L
    Clone
    Products:
         
    OriGene clones in human, mouse for ERO1L (see all 8)
    OriGene ORF clones in mouse, rat for ERO1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERO1L (NM_014584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERO1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERO1L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ERO1L
    OriGene qSTAR qPCR primer pairs in human, mouse for ERO1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERO1L
      QuantiTect SYBR Green Assays in human, mouse, rat ERO1L
      QuantiFast Probe-based Assays in human, mouse, rat ERO1L

    Additional mRNA sequence: 

    AF081886.1 AF123887.1 AK292839.1 AY358463.1 BC008674.1 BC012941.1 

    11 DOTS entries:

    DT.112831  DT.91775036  DT.101957583  DT.100801529  DT.100827309  DT.91752253  DT.91829768  DT.99934119 
    DT.99958345  DT.99990051  DT.99963826 

    Selected AceView cDNA sequences (see all 285):

    CB052699 BU633641 CA418301 W52261 AI698410 AA478632 CA423551 AA356773 
    CA442946 BM551735 BF196506 BI792332 AI474335 BG236346 CR604913 AU280123 
    BQ776314 CD652368 BM845971 BM761643 CA773350 CR614206 AI803700 BQ020493 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ERO1L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                -                                                                                 
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:              -                 -                                                                                 


    ECgene alternative splicing isoforms for ERO1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ERO1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAATGTC
    ERO1L Expression
    About this image


    ERO1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    ERO1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERO1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592304

    UniProtKB/Swiss-Prot: ERO1A_HUMAN, Q96HE7
    Tissue specificity: Widely expressed at low level. Expressed at high level in upper digestive tract. Highly
    expressed in esophagus. Weakly expressed in stomach and duodenum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERO1L: 
              Hypoxia Signaling Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ERO1L
    OriGene qSTAR qPCR primer pairs in human, mouse for ERO1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERO1L
    QuantiTect SYBR Green Assays in human, mouse, rat ERO1L
    QuantiFast Probe-based Assays in human, mouse, rat ERO1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERO1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ERO1L gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ero1l1 , 5 ERO1-like (S. cerevisiae)1, 5 87.14(n)1
    92.67(a)1
      14 (22.86 cM)5
    505271  NM_015774.31  NP_056589.11 
     452830925 
    chicken
    (Gallus gallus)
    Aves ERO1L1 ERO1-like (S. cerevisiae) 73.23(n)
    78.57(a)
      423585  NM_001277569.1  NP_001264498.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    78(a)
    73(a)
    many → 1
    many → 1
    GL343764.1(1102-26809)
    4(122291522-122293609)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA981561.12   -- 75.48(n)    CA981561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053166.12   -- 71.85(n)   393321  BC053166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ero1L3   -- 46(a)   64A10   --
    worm
    (Caenorhabditis elegans)
    Secernentea ero-16
    Protein ERO-1, isoform c
    36(a)
    1 → many
    I(14664449-14674822) WBGene00001334
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERO11 ERO1 49.3(n)
    38.44(a)
      854909   NP_013576.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERO11 ERO1 51.98(n)
    44.86(a)
      843560  NM_105887.3  NP_177372.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07338001 Os03g0733800 54.34(n)
    47.26(a)
      4334011  NM_001057710.2  NP_001051175.2 


    ENSEMBL Gene Tree for ERO1L (if available)
    TreeFam Gene Tree for ERO1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ERO1L gene
    ERO1LB2  
    1 SIMAP similar gene for ERO1L using alignment to 5 protein entries:     ERO1A_HUMAN (see all proteins):
    ERO1LB

    Find genes that share paralogs with ERO1L           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ERO1L
    PGOHUM00000239763


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ERO1L (see all 1024)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928507531,2
    C--34091364(+) CACGAA/GGTCAG 1 -- int10--------
    rs23578031,2
    C,H--53108116(+) AGATCG/AAGACC 1 -- int16Minor allele frequency- A:0.00NA WA 12
    rs1846482411,2
    --53108248(+) AATGGC/TGTGAA 1 -- int10--------
    rs1888507661,2
    --53108294(+) GCCACC/TGCACT 1 -- int10--------
    rs1913813461,2
    --53108310(+) CTGGGC/TGACAC 1 -- int10--------
    rs775006791,2
    C,F--53108470(+) GAGGAT/CTGACT 1 -- int12Minor allele frequency- C:0.05CSA WA 120
    rs1838223321,2
    --53108583(+) AAAATA/GTACTG 1 -- int10--------
    rs1892765961,2
    --53108680(+) GAAGAA/CGTATA 1 -- ut310--------
    rs1151096031,2
    C,F--53108712(+) CTTAAC/ACACTA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1487210541,2
    --53108893(+) ACTAAC/TGAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ERO1L (53106634 - 53162618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ERO1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832796CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERO1L
    DNA2.0 Custom Variant and Variant Library Synthesis for ERO1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615435    OMIM disorders: --


    Find genes that share disorders with ERO1L           About GenesLikeMe

    Genetic Association Database (GAD): ERO1L
    Human Genome Epidemiology (HuGE) Navigator: ERO1L (1 document)

    Export disorders for ERO1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ERO1L gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ERO1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. (PubMed id 10671517)1, 2, 3, 9 Cabibbo A.... Sitia R. (J. Biol. Chem. 2000)
    2. The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha. (PubMed id 12752442)1, 2, 9 Gess B.... Kurtz A. (Eur. J. Biochem. 2003)
    3. Hyperactivity of the Ero1I+ oxidase elicits endoplasmic reticulum stress but no broad antioxidant response. (PubMed id 23027870)1, 2 Hansen H.G....Ellgaard L. (J. Biol. Chem. 2012)
    4. Crystal structures of human Ero1alpha reveal the mechanisms of regulated and targeted oxidation of PDI. (PubMed id 20834232)1, 2 Inaba K.... Suzuki M. (EMBO J. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation. (PubMed id 18971943)1, 2 Baker K.M....Bulleid N.J. (EMBO J. 2008)
    7. A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells. (PubMed id 18833192)1, 2 Appenzeller-Herzog C....Ellgaard L. (EMBO J. 2008)
    8. PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum. (PubMed id 15475357)1, 2 van Lith M.... Benham A.M. (J. Biol. Chem. 2005)
    9. Two conserved cysteine triads in human Ero1alpha cooperate forefficient disulfide bond formation in the ER. (PubMed id 15136577)1, 2 Bertoli G....Sitia R. (J. Biol. Chem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 30001 HGNC: 13280 AceView: ERO1L Ensembl:ENSG00000197930 euGenes: HUgn30001
    ECgene: ERO1L Kegg: 30001 H-InvDB: ERO1L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ERO1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ERO1L gene:
    Search GeneIP for patents involving ERO1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ERO1L
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ERO1L   OriGene RNAi products in human, mouse, rat for ERO1L  
     OriGene qPCR primer pairs and template standards for ERO1L   OriGene Protein Over-expression Lysate for ERO1L  
     OriGene MassSpec something-or-other for ERO1L   OriGene clones in human, mouse for ERO1L  
     OriGene qSTAR qPCR primer pairs in human, mouse for ERO1L   OriGene Purified Protein for ERO1L  
     OriGene ORF clones in mouse, rat for ERO1L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ERO1L   OriGene Custom Protein Services for ERO1L  

     
     
     Block miRNA regulation of human, mouse, rat ERO1L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ERO1L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERO1L Predesigned siRNA for gene silencing in human, mouse, rat ERO1L
     QuantiFast Probe-based Assays in human, mouse, rat ERO1L QuantiTect SYBR Green Assays in human, mouse, rat ERO1L
     PCR Arrays including human, mouse, rat ERO1L Search Chromatin IP Primers for ERO1L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERO1L  GeneGlobe Interaction Network for ERO1L
     Regulatory tfbs in ERO1L promoter
     GenScript Custom Purified and Recombinant Proteins Services for ERO1L GenScript cDNA clones with any tag delivered in your preferred vector for ERO1L
     GenScript Custom Assay Services for ERO1L GenScript Custom overexpressing Cell Line Services for ERO1L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ERO1L 

     Search Tocris compounds for ERO1L (ERO1A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ERO1L antibodies
     ERO1L proteins
     ERO1L lysates
     Antibodies for ERO1L
     See all of Abcam's Antibodies, Kits and Proteins for ERO1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ERO1L
     Antibodies for ERO1L
     ELISAs for ERO1L
     CLIAs for ERO1L



     Browse ESI BIO Cell Lines and PureStem Progenitors for ERO1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERO1L
     SwitchGear 3'UTR luciferase reporter plasmids for ERO1L
     SwitchGear Promoter luciferase reporter plasmids for ERO1L
     ThermoFisher Antibody for ERO1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERO1L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERO1L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERO1L
     LSBio Antibodies in human, mouse, rat for ERO1L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ERO1L
      Search eBioscience for proteins for ERO1L
      Search eBioscience for elisas for ERO1L
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ERO1L gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4