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Aliases for ERO1B Gene

Aliases for ERO1B Gene

  • Endoplasmic Reticulum Oxidoreductase 1 Beta 2 3 5
  • Endoplasmic Reticulum Oxidoreductin-1-Like Protein B 3 4
  • Endoplasmic Reticulum Oxidoreductase Beta 3 4
  • Oxidoreductin-1-L-Beta 3 4
  • ERO1-L-Beta 3 4
  • ERO1LB 3 4
  • Endoplasmic Oxidoreductin-1-Like Protein B 3
  • ERO1-Like Beta (S. Cerevisiae) 2
  • ERO1-Like Protein Beta 3
  • ERO1-Like Beta 3
  • EC 1.8.4.- 4
  • Ero1beta 3
  • EC 1.8.4 61

External Ids for ERO1B Gene

Previous HGNC Symbols for ERO1B Gene

  • ERO1LB

Summaries for ERO1B Gene

GeneCards Summary for ERO1B Gene

ERO1B (Endoplasmic Reticulum Oxidoreductase 1 Beta) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Metabolism of proteins. An important paralog of this gene is ERO1A.

UniProtKB/Swiss-Prot for ERO1B Gene

  • Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

Gene Wiki entry for ERO1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERO1B Gene

Genomics for ERO1B Gene

Regulatory Elements for ERO1B Gene

Enhancers for ERO1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G236280 1.1 ENCODE 15.8 +0.4 369 2.3 HDGF AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 KLF13 SP3 ERO1B GNG4 GGPS1 RNU2-70P
GH01G236470 0.9 dbSUPER 10.2 -189.6 -189635 1.7 PKNOX1 FEZF1 ZNF2 ZNF121 GLIS2 ZNF263 TSHZ1 ZNF488 ZNF518A ZNF610 LGALS8 LGALS8-AS1 ENSG00000273058 ENSG00000230325 GPR137B ERO1B GC01P236477 EDARADD
GH01G236288 0.9 ENCODE 7 -6.5 -6531 1.0 TBP PKNOX1 CBX3 RB1 ARNT RAD21 ZNF121 GATA2 SMAD5 GTF2B LDHAP2 GPR137B HEATR1 LYST ENSG00000230325 ERO1B LOC100130485 EDARADD
GH01G236333 0.7 ENCODE 8.8 -51.4 -51357 0.2 ZFP37 MAX RAD21 GABPA YY1 ZNF121 JUND ZFHX2 ZNF316 ATF3 ERO1B EDARADD LOC100130485
GH01G236302 0.7 ENCODE 7.2 -20.0 -20037 0.2 ZFP37 ZNF394 ZNF398 ZFHX2 ZNF316 ZNF341 ZNF629 SCRT2 ZNF600 PRDM10 ERO1B LOC100130485 EDARADD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERO1B on UCSC Golden Path with GeneCards custom track

Promoters for ERO1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022355 339 1801 HDGF AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 KLF13 SP3

Genomic Location for ERO1B Gene

Chromosome:
1
Start:
236,215,122 bp from pter
End:
236,282,039 bp from pter
Size:
66,918 bases
Orientation:
Minus strand

Genomic View for ERO1B Gene

Genes around ERO1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERO1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERO1B Gene

Proteins for ERO1B Gene

  • Protein details for ERO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YB8-ERO1B_HUMAN
    Recommended name:
    ERO1-like protein beta
    Protein Accession:
    Q86YB8
    Secondary Accessions:
    • B4DF57
    • Q5T1H4
    • Q8IZ11
    • Q9NR62

    Protein attributes for ERO1B Gene

    Size:
    467 amino acids
    Molecular mass:
    53543 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer with ERO1A; disulfide-linked. Also detected as monomer. Homodimers may be somewhat less active than monomers. Interacts with P4HB. Interacts with ERP44.

    Alternative splice isoforms for ERO1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERO1B Gene

Selected DME Specific Peptides for ERO1B Gene

Q86YB8:
  • YVDLLLNPER
  • CLEKRVFY
  • NPERYTGY
  • IMDCVGC
  • IYEENCFKP
  • LTRQEIV
  • DYFRYYKVNLKRPCPFW

Post-translational modifications for ERO1B Gene

  • N-glycosylated.
  • The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond accepts electron from P4HB and funnel them to the active site disulfide Cys-393/Cys-396. The Cys-81/Cys-390 disulfide bond may be critical for structural stability. Two long-range disulfide bonds participate in loose feedback regulation. The Cys-90/Cys-130 disulfide bond may be the predominant regulatory switch to modulate the catalytic activity, while the Cys-100/Cys-262 disulfide bond may play an auxiliary regulatory role.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERO1B Gene

Domains & Families for ERO1B Gene

Protein Domains for ERO1B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86YB8

UniProtKB/Swiss-Prot:

ERO1B_HUMAN :
  • Belongs to the EROs family.
Family:
  • Belongs to the EROs family.
genes like me logo Genes that share domains with ERO1B: view

No data available for Gene Families for ERO1B Gene

Function for ERO1B Gene

Molecular function for ERO1B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Glutathione may be required to regulate its activity in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Function:
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inducers of the unfolded protein response (UPR).

Enzyme Numbers (IUBMB) for ERO1B Gene

Gene Ontology (GO) - Molecular Function for ERO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0005515 protein binding IPI 20802462
GO:0015035 protein disulfide oxidoreductase activity IBA,IEA --
GO:0016491 oxidoreductase activity NAS 10818100
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA --
genes like me logo Genes that share ontologies with ERO1B: view
genes like me logo Genes that share phenotypes with ERO1B: view

Animal Model Products

CRISPR Products

miRNA for ERO1B Gene

miRTarBase miRNAs that target ERO1B

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERO1B Gene

Localization for ERO1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERO1B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERO1B gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ERO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,TAS 10818100
GO:0005789 endoplasmic reticulum membrane IBA,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ERO1B: view

Pathways & Interactions for ERO1B Gene

genes like me logo Genes that share pathways with ERO1B: view

Pathways by source for ERO1B Gene

Gene Ontology (GO) - Biological Process for ERO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 10818100
GO:0006464 cellular protein modification process IBA --
GO:0019471 4-hydroxyproline metabolic process IEA --
GO:0022417 protein maturation by protein folding IEA --
GO:0030070 insulin processing IEA --
genes like me logo Genes that share ontologies with ERO1B: view

No data available for SIGNOR curated interactions for ERO1B Gene

Drugs & Compounds for ERO1B Gene

(2) Drugs for ERO1B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma Target 0
1-Ethyl-Pyrrolidine-2,5-Dione Experimental Pharma Target 0
genes like me logo Genes that share compounds with ERO1B: view

Transcripts for ERO1B Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERO1B Gene

No ASD Table

Relevant External Links for ERO1B Gene

GeneLoc Exon Structure for
ERO1B
ECgene alternative splicing isoforms for
ERO1B

Expression for ERO1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ERO1B Gene:

ERO1B

mRNA Expression by UniProt/SwissProt for ERO1B Gene:

Q86YB8-ERO1B_HUMAN
Tissue specificity: Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.

Evidence on tissue expression from TISSUES for ERO1B Gene

  • Nervous system(4.2)
  • Blood(4.1)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with ERO1B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERO1B Gene

Orthologs for ERO1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERO1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERO1LB 34 35
  • 99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERO1LB 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERO1LB 34 35
  • 93.58 (n)
cow
(Bos Taurus)
Mammalia ERO1LB 34 35
  • 93.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ERO1LB 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ero1lb 34 16 35
  • 87.01 (n)
rat
(Rattus norvegicus)
Mammalia Ero1lb 34
  • 86.04 (n)
chicken
(Gallus gallus)
Aves ERO1LB 34 35
  • 81.98 (n)
lizard
(Anolis carolinensis)
Reptilia ERO1LB 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ero1l 34
  • 77.65 (n)
zebrafish
(Danio rerio)
Actinopterygii ero1lb 34 35
  • 70.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002816 34
  • 54.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ero1L 34 35
  • 53.83 (n)
worm
(Caenorhabditis elegans)
Secernentea ero-1 34 35
  • 53.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERO1 35 37
  • 23 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2978 34
Species where no ortholog for ERO1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERO1B Gene

ENSEMBL:
Gene Tree for ERO1B (if available)
TreeFam:
Gene Tree for ERO1B (if available)

Paralogs for ERO1B Gene

Paralogs for ERO1B Gene

genes like me logo Genes that share paralogs with ERO1B: view

Variants for ERO1B Gene

Sequence variations from dbSNP and Humsavar for ERO1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010399 -- 236,239,530(+) GTTCT(C/T)TACAA intron-variant
rs1000079621 -- 236,268,156(+) AGAGA(C/G)ATGTG intron-variant
rs1000084377 -- 236,232,468(+) AATTT(A/C)AGTCA intron-variant
rs1000115800 -- 236,256,160(+) AGCAA(C/G)AACAG intron-variant
rs1000117536 -- 236,282,517(+) TAGAT(A/G)TGGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ERO1B Gene

Variant ID Type Subtype PubMed ID
dgv156e212 CNV loss 25503493
dgv590n100 CNV gain 25217958
esv1064239 CNV insertion 17803354
esv3578490 CNV loss 25503493
nsv1005877 CNV gain 25217958
nsv1012436 CNV loss 25217958
nsv1122461 CNV deletion 24896259
nsv468450 CNV gain 19166990
nsv522991 CNV loss 19592680
nsv549394 CNV gain 21841781
nsv549400 CNV gain 21841781
nsv827487 CNV loss 20364138
nsv832969 CNV gain 17160897

Variation tolerance for ERO1B Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.56; 93.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERO1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERO1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERO1B Gene

Disorders for ERO1B Gene

Relevant External Links for ERO1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERO1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERO1B

No disorders were found for ERO1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERO1B Gene

Publications for ERO1B Gene

  1. Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. (PMID: 10818100) Pagani M. … Sitia R. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. The endoplasmic reticulum sulfhydryl oxidase Ero1I^ drives efficient oxidative protein folding with loose regulation. (PMID: 21091435) Wang L. … Wang C.C. (Biochem. J. 2011) 2 3 4 64
  3. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PMID: 16263699) Lewandrowski U. … Sickmann A. (Mol. Cell. Proteomics 2006) 3 4 64
  4. Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta. (PMID: 16012172) Dias-Gunasekara S. … Benham A.M. (J. Biol. Chem. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ERO1B Gene

Sources for ERO1B Gene

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