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Aliases for ERN2 Gene

Aliases for ERN2 Gene

  • Endoplasmic Reticulum To Nucleus Signaling 2 2 3
  • Endoplasmic Reticulum-To-Nucleus Signaling 2 3 4
  • Inositol-Requiring Protein 2 3 4
  • ER To Nucleus Signalling 2 2 3
  • IRE1-BETA 3 4
  • HIRE2p 3 4
  • IRE1b 3 4
  • Serine/Threonine-Protein Kinase/Endoribonuclease IRE2 3
  • Endoplasmic Reticulum To Nucleus Signalling 2 3
  • IRE1, S. Cerevisiae, Homolog Of 3
  • Inositol-Requiring 1 Beta 3
  • IRE1 Beta 3
  • EC 2.7.11 63
  • IRE2 4

External Ids for ERN2 Gene

Previous GeneCards Identifiers for ERN2 Gene

  • GC16M023110
  • GC16M023789
  • GC16M023617
  • GC16M023668
  • GC16M023684
  • GC16M023609
  • GC16U900517
  • GC16M023701
  • GC16M021791

Summaries for ERN2 Gene

GeneCards Summary for ERN2 Gene

ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and endonuclease activity. An important paralog of this gene is ERN1.

UniProtKB/Swiss-Prot for ERN2 Gene

  • Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERN2 Gene

Genomics for ERN2 Gene

Regulatory Elements for ERN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERN2 Gene

23,690,304 bp from pter
23,713,500 bp from pter
23,197 bases
Minus strand

Genomic View for ERN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERN2 Gene

Proteins for ERN2 Gene

  • Protein details for ERN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase/endoribonuclease IRE2
    Protein Accession:
    Secondary Accessions:
    • Q6ZNC0

    Protein attributes for ERN2 Gene

    926 amino acids
    Molecular mass:
    102480 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAD18455.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ERN2 Gene

Proteomics data for ERN2 Gene at MOPED

Selected DME Specific Peptides for ERN2 Gene

Post-translational modifications for ERN2 Gene

Other Protein References for ERN2 Gene

Domains for ERN2 Gene

Gene Families for ERN2 Gene

Suggested Antigen Peptide Sequences for ERN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q76MJ5
  • Contains 1 KEN domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with ERN2: view

Function for ERN2 Gene

Molecular function for ERN2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity).
UniProtKB/Swiss-Prot Function: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Enzyme Numbers (IUBMB) for ERN2 Gene

Gene Ontology (GO) - Molecular Function for ERN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11175748
GO:0004519 endonuclease activity IDA 11175748
GO:0004540 ribonuclease activity IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11175748
genes like me logo Genes that share ontologies with ERN2: view
genes like me logo Genes that share phenotypes with ERN2: view

Animal Models for ERN2 Gene

MGI Knock Outs for ERN2:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ERN2 Gene

Localization for ERN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERN2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ERN2 Gene COMPARTMENTS Subcellular localization image for ERN2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ERN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0016021 integral component of membrane IEA --
GO:1990604 IRE1-TRAF2-ASK1 complex ISS --
genes like me logo Genes that share ontologies with ERN2: view

Pathways for ERN2 Gene

SuperPathways for ERN2 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for ERN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IDA 11175748
GO:0007050 cell cycle arrest IEA --
genes like me logo Genes that share ontologies with ERN2: view

No data available for Pathways by source for ERN2 Gene

Compounds for ERN2 Gene

(3) HMDB Compounds for ERN2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with ERN2: view

Transcripts for ERN2 Gene

mRNA/cDNA for ERN2 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERN2 Gene

Endoplasmic reticulum to nucleus signaling 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ERN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - -
SP4: -
SP6: -

ExUns: 23 ^ 24 ^ 25a · 25b

Relevant External Links for ERN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERN2 Gene

mRNA expression in normal human tissues for ERN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERN2 Gene

This gene is overexpressed in Colon - Transverse (18.0), Stomach (9.1), Minor Salivary Gland (7.5), Cervix - Endocervix (5.9), and Small Intestine - Terminal Ileum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ERN2 Gene

SOURCE GeneReport for Unigene cluster for ERN2 Gene Hs.592041

genes like me logo Genes that share expressions with ERN2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ERN2 Gene

Orthologs for ERN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERN2 35
  • 99.28 (n)
  • 98.87 (a)
ERN2 36
  • 99 (a)
(Bos Taurus)
Mammalia ERN2 35
  • 86.04 (n)
  • 85.68 (a)
ERN2 36
  • 84 (a)
(Canis familiaris)
Mammalia ERN2 35
  • 86.43 (n)
  • 85.32 (a)
ERN2 36
  • 83 (a)
(Mus musculus)
Mammalia Ern2 35
  • 83.15 (n)
  • 82.78 (a)
Ern2 16
Ern2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia ERN2 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 43 (a)
-- 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Ern2 35
  • 82.21 (n)
  • 81.96 (a)
(Gallus gallus)
Aves ERN1 35
  • 67.28 (n)
  • 63.91 (a)
ERN2 36
  • 56 (a)
(Anolis carolinensis)
Reptilia ERN2 36
  • 54 (a)
(Danio rerio)
Actinopterygii ern2 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ire1 36
  • 31 (a)
ire-1 37
  • 50 (a)
(Caenorhabditis elegans)
Secernentea ire-1 36
  • 35 (a)
ire-1 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRE1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6665 36
  • 16 (a)
Species with no ortholog for ERN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERN2 Gene

Gene Tree for ERN2 (if available)
Gene Tree for ERN2 (if available)

Paralogs for ERN2 Gene

Paralogs for ERN2 Gene

Selected SIMAP similar genes for ERN2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ERN2: view

Variants for ERN2 Gene

Sequence variations from dbSNP and Humsavar for ERN2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26761 -- 23,701,340(+) AAAAA(C/T)ACAGG intron-variant
rs26762 -- 23,701,127(-) AGGGC(A/C)CTTTA intron-variant
rs26763 -- 23,700,862(-) TCTGA(C/T)TTTGC intron-variant
rs26764 -- 23,700,604(+) TCCGG(C/G)TGGCC missense, reference
rs27771 -- 23,695,442(+) GATAA(A/T)GGGAC intron-variant

Relevant External Links for ERN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ERN2 Gene

Disorders for ERN2 Gene

Relevant External Links for ERN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ERN2: view

No data available for UniProtKB/Swiss-Prot for ERN2 Gene

Publications for ERN2 Gene

  1. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. (PMID: 11175748) Iwawaki T. … Kohno K. (Nat. Cell Biol. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. (PMID: 9755171) Wang X.Z. … Ron D. (EMBO J. 1998) 2 3

Products for ERN2 Gene

Sources for ERN2 Gene

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