Aliases for ERN1 Gene
Aliases for ERN1 Gene
External Ids for ERN1 Gene
- HGNC: 3449
- Entrez Gene: 2081
- Ensembl: ENSG00000178607
- OMIM: 604033
- UniProtKB: O75460
Previous GeneCards Identifiers for ERN1 Gene
- GC17M061758
- GC17M064547
- GC17M062461
- GC17M062594
- GC17M062582
- GC17M059474
- GC17M062120
- GC17M057488
- GC17M062122
Summaries for ERN1 Gene
-
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]
GeneCards Summary for ERN1 Gene
ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Chromosome 6Pter-P24 Deletion Syndrome. Among its related pathways are Corticotropin-releasing hormone and Alzheimer's disease. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERN2.
UniProtKB/Swiss-Prot for ERN1 Gene
-
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
-
IRE1 is a transmembrane resident ER protein that possesses both kinase and endonuclease domains. Both yeast (IRE) and mammalian (IRE1alpha) homologs are involved in the degradation of misfolded proteins, as part of the unfolded protein response (UPR) pathway.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERN1 Gene
Genomics for ERN1 Gene
Regulatory Elements for ERN1 Gene
Enhancers for ERN1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ERN1 on UCSC Golden Path with GeneCards custom track
Promoters for ERN1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ERN1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ERN1 gene promoter:
Regulatory Element Products
Genomic Location for ERN1 Gene
- Chromosome:
- 17
- Start:
- 64,039,142 bp from pter
- End:
- 64,130,819 bp from pter
- Size:
- 91,678 bases
- Orientation:
- Minus strand
Genomic View for ERN1 Gene
Genes around ERN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.3 by Ensembl
- 17q24.2 by Entrez Gene
- 17q23 by HGNC
ERN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ERN1 Gene
Proteins for ERN1 Gene
-
Protein details for ERN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75460-ERN1_HUMAN
- Recommended name:
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Protein Accession:
- O75460
- A1L457
- A8K8N8
- A8MXS7
- Q59EE2
Protein attributes for ERN1 Gene
- Size:
- 977 amino acids
- Molecular mass:
- 109735 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.
Three dimensional structures from OCA and Proteopedia for ERN1 Gene
Protein Expression for ERN1 Gene
Post-translational modifications for ERN1 Gene
- ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.
- Autophosphorylated.
- Glycosylation at Asn 176
- Modification sites at PhosphoSitePlus
Other Protein References for ERN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ERN1
- Cell Signaling Technology (CST) Antibodies for ERN1 (IRE1)
- Novus Biologicals Antibodies for ERN1
- Abcam antibodies for ERN2
-
Cloud-Clone Corp. Antibodies for ERN1
- Invitrogen Antibodies for ERN1
- antibodies-online Antibodies for ERN1: See all 163
- GeneTex ERN1 antibody for ERN1
-
Custom Antibody ServicesProSci Antibodies for ERN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ERN1
Protein Products
- EMD Millipore Purified and/or Recombinant ERN1 Protein
-
OriGene Purified Proteins for ERN1
- Search Origene for MassSpec and Protein Over-expression Lysates for ERN1
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- Novus Biologicals proteins for ERN1
- Sino Biological Recombinant Proteins for ERN1
- Sino Biological Cell Lysates for ERN1
-
Cloud-Clone Corp. Proteins for ERN1
- antibodies-online Proteins for ERN1: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ERN1
- Abcam proteins for ERN2
Domains & Families for ERN1 Gene
Gene Families for ERN1 Gene
Protein Domains for ERN1 Gene
Suggested Antigen Peptide Sequences for ERN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75460UniProtKB/Swiss-Prot:
ERN1_HUMAN :- Contains 1 KEN domain.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
- Domain:
-
- Contains 1 KEN domain.
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Function for ERN1 Gene
Molecular function for ERN1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.
- UniProtKB/Swiss-Prot Function:
- Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Enzyme Numbers (IUBMB) for ERN1 Gene
- EC 2.7.11 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 9637683 |
| GO:0004521 | endoribonuclease activity | TAS | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0030544 | Hsp70 protein binding | IPI | 20625543 |
Phenotypes for ERN1 Gene
- MGI mutant phenotypes for ERN1:
-
inferred from 6 alleles
- cellular phenotype
- mortality/aging
- liver/biliary system phenotype
- normal phenotype
- immune system phenotype
- cardiovascular system phenotype
- integument phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for ERN1:
-
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
Animal Models for ERN1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ERN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
- Search ViGene Biosciences for ERN1
CRISPR Products
-
OriGene CRISPR knockouts for ERN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERN1
- GenScript: Design CRISPR guide RNA sequences for ERN1
miRNA for ERN1 Gene
- miRTarBase miRNAs that target ERN1
-
- hsa-let-7a-5p (MIRT052484)
- hsa-mir-199a-5p (MIRT053104)
- hsa-mir-1291 (MIRT053105)
- hsa-mir-192-3p (MIRT441504)
- hsa-mir-107 (MIRT441505)
- hsa-mir-103a-3p (MIRT441506)
- hsa-mir-219b-3p (MIRT441507)
- hsa-mir-1184 (MIRT441508)
- hsa-mir-451b (MIRT441509)
- hsa-mir-186-5p (MIRT441510)
- hsa-mir-4539 (MIRT526814)
- hsa-mir-7158-3p (MIRT526815)
- hsa-mir-649 (MIRT526816)
- hsa-mir-490-3p (MIRT526817)
- hsa-mir-6749-3p (MIRT615323)
- hsa-mir-4680-5p (MIRT615324)
- hsa-mir-5193 (MIRT615325)
- hsa-mir-4667-3p (MIRT615326)
- hsa-mir-6887-3p (MIRT615327)
- hsa-mir-7157-5p (MIRT615328)
- hsa-mir-4310 (MIRT615329)
- hsa-mir-665 (MIRT703850)
- hsa-mir-1273e (MIRT703851)
- hsa-mir-6771-5p (MIRT703852)
- hsa-mir-7160-5p (MIRT703853)
- hsa-mir-4722-5p (MIRT703854)
- hsa-mir-6884-5p (MIRT703855)
- hsa-mir-485-5p (MIRT703856)
- hsa-mir-1827 (MIRT703857)
- hsa-mir-4649-3p (MIRT703858)
- hsa-mir-6746-5p (MIRT703859)
- hsa-mir-4768-3p (MIRT703860)
- hsa-mir-4478 (MIRT703861)
- hsa-mir-4419b (MIRT703862)
- hsa-mir-3929 (MIRT703863)
- hsa-mir-940 (MIRT703864)
- hsa-mir-6893-5p (MIRT703865)
- hsa-mir-6808-5p (MIRT703866)
- hsa-mir-302f (MIRT703867)
- hsa-mir-6891-5p (MIRT703868)
- hsa-mir-3173-3p (MIRT703869)
miRNA Products
- Search ViGene Biosciences for ERN1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for ERN1
- Browse OriGene Inhibitory RNA Products For ERN1
-
ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
Clone Products
- OriGene clones in human for ERN1
- OriGene ORF clones in human,mouse,rat for ERN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ERN1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ERN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ERN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ERN1 Gene
Localization for ERN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ERN1 Gene
- Endoplasmic reticulum membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytosol | 1 |
| extracellular | 1 |
| golgi apparatus | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005637 | nuclear inner membrane | IEA | -- |
| GO:0030176 | integral component of endoplasmic reticulum membrane | IDA | 9637683 |
Pathways & Interactions for ERN1 Gene
More details on SuperPathways for ERN1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Alzheimer's disease | ||
| 2 | Unfolded Protein Response (UPR) | ||
| 3 | Apoptosis Modulation and Signaling |
.31
|
|
| 4 | Protein processing in endoplasmic reticulum | ||
| 5 | Translational Control |
Pathways by source for ERN1 Gene
2 GeneTex pathways for ERN1 Gene
1 Cell Signaling Technology pathway for ERN1 Gene
2 BioSystems pathways for ERN1 Gene
3 Reactome pathways for ERN1 Gene
4 KEGG pathways for ERN1 Gene
Interacting Proteins for ERN1 Gene
Selected Interacting proteins:
O75460-ERN1_HUMAN
ENSP00000401445
for ERN1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006379 | mRNA cleavage | IDA | 21317875 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006468 | protein phosphorylation | IDA | 9637683 |
| GO:0006987 | activation of signaling protein activity involved in unfolded protein response | IDA | 9637683 |
No data available for SIGNOR curated interactions for ERN1 Gene
Drugs & Compounds for ERN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine | Experimental | Pharma | Target | 0 | ||
| Apigenin | Experimental | Pharma | Potentiation, Activator | Protein kinase inhibitor | 0 | |
| Kaempferol | Experimental | Pharma | Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter | 0 | ||
| Quercetin | Experimental | Nutra | Antitumor agent, Non-selective PI 3-kinase inhibitor | 36 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| 4mu8C |
|
14003-96-4 |
|
|
||
| STF 083010 |
|
307543-71-1 |
|
|
(5) Tocris Compounds for ERN1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 4mu8C | Inhibits IRE1alpha endoribonuclease activity | 14003-96-4 |
| Apigenin | Protein kinase inhibitor | 520-36-5 |
| Kaempferol | Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter | 520-18-3 |
| Quercetin | Non-selective PI 3-kinase inhibitor | 117-39-5 |
| STF 083010 | Inhibits IRE1alpha endonuclease activity | 307543-71-1 |
(1) ApexBio Compounds for ERN1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 4μ8C | 14003-96-4 |
Drug Products
- ApexBio compounds for ERN1
Transcripts for ERN1 Gene
mRNA/cDNA for ERN1 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ERN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ERN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERN1
- GenScript: Design CRISPR guide RNA sequences for ERN1
miRNA Products
- Search ViGene Biosciences for ERN1
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for ERN1
- Browse OriGene Inhibitory RNA Products For ERN1
-
ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
Clone Products
- OriGene clones in human for ERN1
- OriGene ORF clones in human,mouse,rat for ERN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ERN1
Flow Cytometry Products
Expression for ERN1 Gene
mRNA differential expression in normal tissues according to GTEx for ERN1 Gene
This gene is overexpressed in Pancreas (x4.2) and Whole Blood (x4.1).
This gene is overexpressed in Plasma (24.9), Heart (15.3), Kidney (13.9), and Adrenal (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERN1 Gene
SOURCE GeneReport for Unigene cluster for ERN1 Gene Hs.700027
mRNA Expression by UniProt/SwissProt for ERN1 Gene
O75460-ERN1_HUMAN
Tissue specificity:
Ubiquitously expressed. High levels observed in pancreatic tissue.
Primer Products
-
OriGene qPCR primer pairs for ERN1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for ERN1 Gene
Orthologs for ERN1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ERN1 35 |
|
||
| ERN1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ERN1 35 |
|
||
| ERN1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ern1 35 |
|
||
| Ern1 16 |
|
||||
| Ern1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ERN1 35 |
|
||
| ERN1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ern1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ERN1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ERN1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC417414 35 |
|
||
| ERN1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ERN1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ern2 35 |
|
||
| Str.12018 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ern2 35 |
|
||
| ern1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | ire-1 37 |
|
|
|
| Ire1 35 |
|
||||
| Ire1 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004176 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ire-1 35 |
|
||
| ire-1 36 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IRE1 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5230 36 |
|
OneToOne |
- Species with no ortholog for ERN1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ERN1 Gene
(2) SIMAP similar genes for ERN1 Gene using alignment to 1 proteins:
Variants for ERN1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040488 | A renal clear cell carcinoma sample | ||||
| rs55869215 | - | 64,057,948(+) | AGACA(C/T)GGTGG | reference, missense | |
| rs186305118 | A lung adenocarcinoma sample | 64,055,926(+) | GCTGG(A/C)GCTGC | reference, missense | |
| VAR_040491 | A gastric adenocarcinoma sample | ||||
| VAR_040492 | - |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.04;
60.54% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ERN1 Gene
Disorders for ERN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 6pter-p24 deletion syndrome |
|
|
Search ERN1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ERN1
No data available for UniProtKB/Swiss-Prot and Genatlas for ERN1 Gene
Publications for ERN1 Gene
- A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. (PMID: 9637683) Tirasophon W. … Kaufman R.J. (Genes Dev. 1998) 2 3 4 23 67
- Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway. (PMID: 18840095) Gjymishka A. … Kilberg M.S. (Biochem. J. 2009) 3 23
- USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PMID: 19135427) Nagai A. … Ichijo H. (Biochem. Biophys. Res. Commun. 2009) 3 23
- Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. (PMID: 19622636) Uemura A. … Yoshida H. (J. Cell. Sci. 2009) 3 23
- Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. (PMID: 18065414) Leclerc D. … Rozen R. (J. Biol. Chem. 2008) 3 23
Products for ERN1 Gene
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- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ERN1
- EMD Millipore Purified and/or Recombinant ERN1 Protein
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Search for Antibodies & Assays
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ERN2
- Abcam proteins for ERN2
- Search for Assays for ERN1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for ERN1
- Cloud-Clone Corp. Proteins for ERN1
- Cloud-Clone Corp Assay Kits for ERN1
- Invitrogen Antibodies for ERN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ERN1
- Addgene plasmids for ERN1
- antibodies-online Antibodies for ERN1: See all 163
- antibodies-online Kits for ERN1: See all 35
- antibodies-online Proteins for ERN1: See all 8
- Search antibodies-online for peptides
- GeneTex ERN1 antibody for ERN1
- Search GeneTex for Proteins for ERN1
- ViGene Biosciences adenoviral particle packaged cDNA for ERN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ERN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ERN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ERN1 gene
- Search ViGene Biosciences for ERN1
- Search ViGene Biosciences for ERN1
- Santa Cruz Biotechnology (SCBT) Antibodies for ERN1
- Search Santa Cruz Biotechnology (SCBT) for ERN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ERN1
- Custom Antibody ServicesProSci Antibodies for ERN1
Sources for ERN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon