ERN1 Gene
protein-coding GIFtS : 67 GCID: GC17 M062120
Endoplasmic Reticulum To Nucleus Signaling 1 ER to nucleus signalling 1 )
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Aliasesfor ERN1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Endoplasmic Reticulum To Nucleus Signaling 1 1 2 IRE1P2 ER To Nucleus Signalling 11 2 Inositol-Requiring 12 Inositol-Requiring Enzyme 11 2 ire1-alpha2 Endoplasmic Reticulum-To-Nucleus Signaling 12 3 Protein Kinase/Endoribonuclease2 Inositol-Requiring Protein 12 3 Serine/Threonine-Protein Kinase/Endoribonuclease IRE12 IRE12 3 Ire1-alpha3 IRE1a2 3 EC 2.7.118 hIRE1p2 3
Export aliases for ERN1 gene to outside databases Previous GC identifers: GC17M061758 GC17M064547 GC17M062461 GC17M062594 GC17M062582 GC17M059474 GC17M057488
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Summariesfor ERN1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ERN1 Gene: The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. (provided by RefSeq, Jul 2008) GeneCards Summary for ERN1 Gene: ERN1 (endoplasmic reticulum to nucleus signaling 1) is a protein-coding gene. Diseases associated with ERN1 include glucose intolerance cytomegalovirus infection related super-pathways are Parkinson's disease and Activation of Chaperone Genes by XBP1(S) . GO annotations related to this gene include endoribonuclease activity and protein serine/threonine kinase activity . An important paralog of this gene is ERN2 . UniProtKB/Swiss-Prot: ERN1_HUMAN, O75460 Function : Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads toenzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis summary
for ERN1 Gene: IRE1 (also known as endoplasmic reticulum to nucleus signaling (ERN) 1) is a transmembrane resident ERprotein that possesses both kinase and endonuclease domains. Both yeast (IRE1) and mammalian (IRE1alpha)homologs are involved in the degradation of misfolded proteins, as part of the unfolded protein response(UPR) pathway. IRE1 (yeast) is involved in the endonucleolytic cleavage of HAC1 mRNA, whereas IRE1alpha(human) catalyzes the splicing of X-box binding protein (XBP) 1 mRNA. XBP1 mRNA splicing triggersupregulation of genes involved in the ERAD pathway, induction of XBP1 expression and the synthesis of ERchaperones. Gene Wiki entry for ERN1 Gene
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Genomic Viewsfor ERN1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NT_010783.15 NC_018928.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ERN1 gene promoter:Nkx2-2 HSF1short Pax-2 HSF1 (long) POU6F1 (c2) Pax-2a ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for ERN1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23 ERN1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M062120: view genomic region
(about GC identifiers )
Start: 62,120,353 bp from pter End:
62,208,179 bp from pter
Size: 87,827 bases Orientation:
minus strand
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Proteinsfor ERN1 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: ERN1_HUMAN, O75460 See
protein sequence )Recommended Name: Size : 977 amino acids; 109735 DaCofactor : MagnesiumSubunit : Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and isrequired for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2
Subcellular location : Endoplasmic reticulum membrane; Single-pass type I membrane protein2 PDB 3D structures from :2HZ6 (3D) 3P23 (3D) Secondary accessions : A1L457 A8K8N8 A8MXS7 Q59EE2Alternative splicing : 2 isoforms : O75460-1 O75460-2 Explore the universe of human proteins at neXtProt for ERN1: NX_O75460 Explore proteomics data for ERN1 at MOPED Post-translational modifications:
UniProtKB: Autophosphorylated UniProtKB: ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_O75460 2 DME Specific Peptides for ERN1 (O75460 ) ERN1 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_001424.3 ENSEMBL proteins: ENSP00000401445 ENSP00000475519 Reactome Protein details: O75460 Human Recombinant Protein Products for ERN1: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing ERN1 Antibody Products: Assay Products for ERN1:
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Protein
Domains /for ERN1 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section IUPHAR Guide to PHARMACOLOGY protein family classification: endoplasmic reticulum to nucleus signaling 1 IRE family 5/8 InterPro protein domains (see all 8 ):
Graphical View of Domain Structure for InterPro Entry O75460 ProtoNet protein and cluster: O75460
3 Blocks protein domains : IPB002372 IPB006567 IPB010513 UniProtKB/Swiss-Prot: ERN1_HUMAN, O75460 Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity : Contains 1 KEN domainSimilarity : Contains 1 protein kinase domainAbout GeneDecksing
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Functionfor ERN1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ERN1_HUMAN, O75460 Function : Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads toenzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : The kinase domain is activated by trans-autophosphorylation. Kinase activity is required foractivation of the endoribonuclease domain Enzyme Number (IUBMB): EC 2.7.11 2
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing Phenotypes: 5 GenomeRNAi human phenotypes for ERN1 :11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ern1) :About GeneDecksing Animal Models: Ern1 tm1Rjk Ern1 tm1Tiw Ern1 tm1Dron Ern1 tm2.2Tiw In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERN1
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Pathways & Interactionsfor ERN1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for ERN1 About See pathways by source SuperPath Contained pathways About 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 2 Activation of Chaperone Genes by XBP1(S) 3 Asparagine N-linked glycosylation 4 Protein processing in endoplasmic reticulum 5 Translational Control
Pathways by source See SuperPaths Show all pathways 1 1 3 3 (Kegg details for ERN1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERN1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/120 Interacting proteins for ERN1 (O75460 1 , 2 , 3 ENSP00000401445 4 via UniProtKB, MINT, STRING , and/or I2D (see all 120 )Interactant Interaction Details GeneCard External ID(s) TAOK3 Q9H2K8 1 , 3 ENSP00000376317 4 EBI-371750,EBI-1384100 I2D:
score=2 STRING: ENSP00000376317 BAX Q07812 1 , 3 ENSP00000293288 4 EBI-371750,EBI-516580 I2D:
score=1 STRING: ENSP00000293288 SYVN1 Q86TM6 2 , 3 ENSP00000366395 4 MINT-6543145 MINT-6543119 I2D:
score=3 STRING: ENSP00000366395 TRAF2 Q12933 1 , 3 ENSP00000247668 4 EBI-371750,EBI-355744 I2D:
score=3 STRING: ENSP00000247668 UBC P0CG48 2 , 3 ENSP00000344818 4 MINT-6543131 I2D:
score=2 STRING: ENSP00000344818
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ERN1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for ERN1 available from Tocris Bioscience About this table Compound Action
CAS
# STF 083010 Inhibits IRE1alpha endonuclease activity [307543-71-1] 4mu8C Inhibits IRE1alpha endoribonuclease activity [14003-96-4]
3 HMDB Compounds for ERN1 About this table 1 DrugBank Compound for ERN1 About this table 10/11 Novoseek inferred chemical compound relationships for ERN1 gene (see all 11 ) About this table ERN1
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Transcriptsfor ERN1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ERN1 gene (2 alternative transcripts): NM_001433.3 NM_152461.2 Unigene Cluster for ERN1:
Endoplasmic reticulum to nucleus signaling 1 Hs.700027 [show with all ESTs ] Unigene Representative Sequence: AB209869 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000433197 (uc002jdz.2 ) ENST00000583077 ENST00000583896 ENST00000579249 ENST00000577567 ENST00000584041 ENST00000583028 ENST00000606895 Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB209869.1 AF059198.1 AK292403.1 BC130405.1 BC130407.1
5 DOTS entries : DT.91785066 DT.70100412
DT.65286901 DT.40127703 DT.91746645 24/97 AceView cDNA sequences (see all 97 ):
AI734969 AA345460 AI792619 CK904766 AI799794 AI081269 AA973421 BX117163 CB990834 BX099892 AI734961 CA311378 AA687888 NM_152461 AW451601 AI972997 AI222941 BE893085 AI733809 D82734 BQ446956 Z38435 AA677373 BI911980 GeneLoc Exon Structure
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Expression for ERN1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ERN1 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CTGGCAGGTGAbout this image
See ERN1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ERN1 SOURCE GeneReport for Unigene cluster: Hs.700027 UniProtKB/Swiss-Prot: ERN1_HUMAN, O75460 Tissue specificity : Ubiquitously expressed. High levels observed in pancreatic tissueSABiosciences Expression via Pathway-Focused PCR Arrays including ERN1 : Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERN1
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Orthologsfor ERN1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ERN1 gene from 8/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Ern11 5
endoplasmic reticulum (ER) to nucleus signalling 11, 5
89.09(n) 1 93.33(a) 1
11 (69.14 cM) 5 78943 1 NM_023913.2 1 NP_076402.1 1 106394650 5
chicken Aves ERN11
endoplasmic reticulum to nucleus signaling 1
64.16(n) 61.55(a)
771230 XM_001234522.2 XP_001234523.2
lizard Reptilia ERN16
endoplasmic reticulum to nucleus signaling 1
79(a)
1 ↔ 1
GL343326.1(424086-513103)
African clawed frog Amphibia BJ065023.12
--
74.39(n)
BJ065023.1
zebrafish Actinopterygii ern21
endoplasmic reticulum to nucleus signaling 2
60.81(n) 61.07(a)
567021 XM_001919315.2 XP_001919350.2
fruit fly Insecta ire-13 1
protein amino acid phosphorylation protein3 1
53(a) 3 55.08(n) 1 49.93(a) 1
92B33 42358 1 NM_001104369.1 1 NP_001097839.1 1
worm Secernentea ire-11
Protein IRE-1
51.37(n) 48.91(a)
174305 NM_063300.5 NP_495701.2
baker's yeast Saccharomycetes IRE16
Serine-threonine kinase and endoribonuclease; tran... 23(a)
1 → many
VIII(258244-261591)
ENSEMBL Gene Tree for ERN1 (if available)TreeFam Gene Tree for ERN1 (if available)
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Paralogsfor ERN1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ERN1 gene ERN2 2 2 SIMAP similar genes for ERN1 using alignment to 1 protein entry: ERN1_HUMAN :ERN2 CDK4 About GeneDecksing
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Genomic Variantsfor ERN1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ERN1 (62120353 - 62208179 bp)
Structural Variations Database of Genomic Variants (DGV) 2 variations for ERN1 : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ERN1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 604033
OMIM disorders : --20/26 (see all 26 ): About MalaCards glucose intolerance cytomegalovirus infection temporal lobe epilepsy cataract malignant glioma insulin resistance ischemia influenza myeloma alzheimer's disease obesity hepatitis b neuroblastoma sarcoma hypoxia cerebritis hepatitis arthritis melanoma thyroiditis Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 3 Novoseek inferred disease relationships for ERN1 gene About this table
Genetic Association Database (GAD): ERN1 Human Genome Epidemiology (HuGE) Navigator: ERN1 (6 documents) Export disorders for ERN1 gene to outside databases
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Publicationsfor ERN1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ERN1 gene, integrated from 9 sources (see all 166 ):(articles sorted by number of sources associating them with ERN1) Utopia : connect your pdf to the dynamic
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. (PubMed id 9637683) 1 , 2 , 3, 9(1998) Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. (PubMed id 12637535) 1 , 2 , 9(2003) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. (PubMed id 11278723) 1 , 2 , 9(2001) PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response. (PubMed id 23103912) 1 , 2 (2012) MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778) 1 , 4(2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 , 4(2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 , 4(2010) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) Tranlational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. (PubMed id 11175748) 1 , 2 (2001) USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PubMed id 19135427) 1 , 9(2009)
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External Searches for ERN1 gene
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Genome Databases showing ERN1 gene
(According to
Entrez Gene ,
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and/or
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Specialized Databases showing ERN1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ERN1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ERN1 gene: ERN1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ERN1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ERN1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ERN1 (IRE1)
Tocris compounds for ERN1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERN1
ThermoFisher Antibody for ERN1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ERN1
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summary
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and Proteopedia 
for ERN1:
