Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERMN Gene

Aliases for ERMN Gene

  • Ermin 2 3 5
  • Juxtanodin 2 3 4
  • KIAA1189 2 3 4
  • Ermin, ERM-Like Protein 2 3
  • JN 3 4

External Ids for ERMN Gene

Previous HGNC Symbols for ERMN Gene

  • KIAA1189

Previous GeneCards Identifiers for ERMN Gene

  • GC02M157884
  • GC02M158175
  • GC02M150060

Summaries for ERMN Gene

GeneCards Summary for ERMN Gene

ERMN (Ermin) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding.

UniProtKB/Swiss-Prot for ERMN Gene

  • Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERMN Gene

Genomics for ERMN Gene

Regulatory Elements for ERMN Gene

Enhancers for ERMN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERMN on UCSC Golden Path with GeneCards custom track

Genomic Location for ERMN Gene

Chromosome:
2
Start:
157,318,613 bp from pter
End:
157,327,713 bp from pter
Size:
9,101 bases
Orientation:
Minus strand

Genomic View for ERMN Gene

Genes around ERMN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERMN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERMN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERMN Gene

Proteins for ERMN Gene

  • Protein details for ERMN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAM6-ERMIN_HUMAN
    Recommended name:
    Ermin
    Protein Accession:
    Q8TAM6
    Secondary Accessions:
    • B4DKA6
    • Q9ULN1

    Protein attributes for ERMN Gene

    Size:
    284 amino acids
    Molecular mass:
    32783 Da
    Quaternary structure:
    • Binds actin.
    SequenceCaution:
    • Sequence=BAA86503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERMN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERMN Gene

Proteomics data for ERMN Gene at MOPED

Post-translational modifications for ERMN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ERMN

No data available for DME Specific Peptides for ERMN Gene

Domains & Families for ERMN Gene

Protein Domains for ERMN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERMN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERMN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ERMN Gene

Function for ERMN Gene

Molecular function for ERMN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).

Gene Ontology (GO) - Molecular Function for ERMN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with ERMN: view
genes like me logo Genes that share phenotypes with ERMN: view

Animal Model Products

miRNA for ERMN Gene

miRTarBase miRNAs that target ERMN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERMN Gene

Localization for ERMN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERMN Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERMN Gene COMPARTMENTS Subcellular localization image for ERMN gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ERMN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20934411
GO:0005856 cytoskeleton IEA --
GO:0043025 neuronal cell body IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with ERMN: view

Pathways & Interactions for ERMN Gene

SuperPathways for ERMN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERMN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA,IDA 20934411
genes like me logo Genes that share ontologies with ERMN: view

No data available for Pathways by source and SIGNOR curated interactions for ERMN Gene

Drugs & Compounds for ERMN Gene

No Compound Related Data Available

Transcripts for ERMN Gene

Unigene Clusters for ERMN Gene

Ermin, ERM-like protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERMN Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - -

Relevant External Links for ERMN Gene

GeneLoc Exon Structure for
ERMN
ECgene alternative splicing isoforms for
ERMN

Expression for ERMN Gene

mRNA expression in normal human tissues for ERMN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERMN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x15.4), Brain - Substantia nigra (x8.0), Brain - Hippocampus (x5.8), Brain - Amygdala (x4.6), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ERMN Gene

This gene is overexpressed in Brain (45.6) and Spinal cord (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERMN Gene



SOURCE GeneReport for Unigene cluster for ERMN Gene Hs.443894

mRNA Expression by UniProt/SwissProt for ERMN Gene

Q8TAM6-ERMIN_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain. Expressed at intermediate levels in the lung and liver.
genes like me logo Genes that share expression patterns with ERMN: view

Protein tissue co-expression partners for ERMN Gene

- Elite partner

Primer Products

Orthologs for ERMN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERMN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERMN 35
  • 83.92 (n)
  • 73.4 (a)
ERMN 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERMN 35
  • 84.45 (n)
  • 75.97 (a)
ERMN 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ermn 35
  • 74.13 (n)
  • 61.37 (a)
Ermn 16
Ermn 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERMN 35
  • 99.3 (n)
  • 98.94 (a)
ERMN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ermn 35
  • 72.86 (n)
  • 61.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ERMN 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERMN 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERMN 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERMN 36
  • 43 (a)
OneToOne
Species with no ortholog for ERMN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERMN Gene

ENSEMBL:
Gene Tree for ERMN (if available)
TreeFam:
Gene Tree for ERMN (if available)

Paralogs for ERMN Gene

genes like me logo Genes that share paralogs with ERMN: view

No data available for Paralogs for ERMN Gene

Variants for ERMN Gene

Sequence variations from dbSNP and Humsavar for ERMN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13028288 -- 157,322,039(+) GCTAA(C/G)GAGTA intron-variant
rs13385653 -- 157,324,899(+) CTCTT(C/T)GGATT intron-variant
rs34101932 -- 157,326,483(+) ATTAT(-/T)CGCCA intron-variant, upstream-variant-2KB
rs62175215 -- 157,324,649(+) GTGTA(A/C)AAAAC intron-variant
rs73024611 -- 157,323,814(+) CTTCA(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERMN Gene

Variant ID Type Subtype PubMed ID
nsv834432 CNV Gain 17160897
esv2518040 CNV Deletion 19546169

Variation tolerance for ERMN Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ERMN Gene

Disorders for ERMN Gene

Relevant External Links for ERMN

Genetic Association Database (GAD)
ERMN
Human Genome Epidemiology (HuGE) Navigator
ERMN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERMN

No disorders were found for ERMN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERMN Gene

Publications for ERMN Gene

  1. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. (PMID: 16421295) Brockschnieder D. … Peles E. (J. Neurosci. 2006) 2 3 4 67
  2. Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. (PMID: 16051705) Zhang B. … Liang F. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  3. Human Ermin (hErmin), a new oligodendrocyte-specific cytoskeletal protein related to epileptic seizure. (PMID: 20934411) Wang T. … Zhang B. (Brain Res. 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3

Products for ERMN Gene

Sources for ERMN Gene

Content