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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERMAP Gene

protein-coding   GIFtS: 53
GCID: GC01P043256

erythroblast membrane-associated protein (Scianna blood...

(Previous names: Radin blood group, Scianna blood group, erythroblast membrane-associated...)
(Previous symbols: RD, SC)
  Search for ERMAP
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Biological research products
for ERMAP    

Aliases
for ERMAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Erythroblast Membrane-Associated Protein (Scianna Blood Group)1 2     Radin Blood Group1
RD1 2 3 5     Scianna Blood Group1
SC1 2 3 5     PRO28012
Radin Blood Group Antigen2 3     Erythroid Membrane-Associated Protein2
Scianna Blood Group Antigen2 3     Radin Blood Group (Rd)2
Erythroblast Membrane-Associated Protein1     Scianna Blood Group (Sc)2
Erythroblast Membrane-Associated Protein (RD And SC Blood Groups)1     HERMAP1

External Ids:    HGNC: 157431   Entrez Gene: 1146252   Ensembl: ENSG000001640107   OMIM: 6090175   UniProtKB: Q96PL53   

Export aliases for ERMAP gene to outside databases

Previous GC identifers: GC01P042286 GC01P042746 GC01P042697 GC01P042704 GC01P042951 GC01P043055 GC01P041402


Summaries
for ERMAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ERMAP:
The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor,
possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group
system. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5
Function: Possible role as a cell-adhesion or receptor molecule of erythroid cells

Gene Wiki entry for ERMAP


Genomic Views
for ERMAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERMAP gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ERMAP promoter sequence
   Search SABiosciences Chromatin IP Primers for ERMAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERMAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34

ERMAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERMAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043256:  view genomic region     (about GC identifiers)

Start:
 43,282,776 bp from pter      End:
 43,310,660 bp from pter
Size:
 27,885 bases      Orientation:
 plus strand

Proteins
for ERMAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5 (See protein sequence)
Recommended Name: Erythroid membrane-associated protein precursor  
Size: 475 amino acids; 52605 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm
Developmental stage: Expressed in fetal liver blood cells (at protein level). Highly expressed in fetal liver
Sequence caution: Sequence=CAH72716.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DPW8 Q5VV53 Q6DUE0 Q7Z3X0 Q8NCV8 Q8NCW2 Q8NCW3 Q96PL6

Explore the universe of human proteins at neXtProt for ERMAP: NX_Q96PL5

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PL5

    • ERMAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017922.1  NP_061008.2  

    ENSEMBL proteins: 
     ENSP00000361595   ENSP00000361592   ENSP00000332439  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): ERMAP
    OriGene Protein Over-expression Lysate (see all 3): ERMAP
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    Novus Biologicals ERMAP Proteins
    Novus Biologicals ERMAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ERMAP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IDA11549310
    GO:0016021integral to membrane IEA--
    GO:0031410cytoplasmic vesicle IEA--


    ERMAP for ontologies           About GeneDecksing



    ERMAP Antibody Products: 
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    Uscn Antibodies for ERMAP
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    Uscn ELISAs and CLIAs for ERMAP

    Protein Domains /
    Families
    for ERMAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ERMAP for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR001870 B30.2/SPRY
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003879 Butyrophylin
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96PL5

    ProtoNet protein and cluster: Q96PL5

    1 Blocks protein family: IPB003879 Butyrophylin C-terminal DUF signature

    UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for ERMAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5
    Function: Possible role as a cell-adhesion or receptor molecule of erythroid cells

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ERMAP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERMAP
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ERMAP (see all 12):
    hsa-miR-485-5p hsa-miR-30c hsa-miR-30d hsa-miR-551b* hsa-miR-146a* hsa-miR-30a hsa-miR-544 hsa-miR-1255a
    SwitchGear 3'UTR luciferase reporter plasmid: ERMAP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERMAP (see all 4)
    OriGene shRNA RFP: ERMAP
    OriGene siRNA: ERMAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERMAP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ERMAP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERMAP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERMAP (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ERMAP (NM_018538)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERMAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERMAP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ERMAP
    Search LifeMap BioReagents cell lines for ERMAP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERMAP


    Pathways & Interactions
    for ERMAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERMAP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ERMAP (Q96PL53 ENSP000003615924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VASPP505523, ENSP000002459324I2D: score=1 STRING: ENSP00000245932
    About this table

    Drugs & Compounds
    for ERMAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ERMAP
    Search CenterWatch for drugs/clinical trials and news about ERMAP 

    Transcripts
    for ERMAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ERMAP gene (2 alternative transcripts): 
    NM_001017922.1  NM_018538.3  

    Unigene Cluster for ERMAP:

    Erythroblast membrane-associated protein (Scianna blood group)
    Hs.439437  [show with all ESTs]
    Unigene Representative Sequence: NM_001017922
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487556(uc001cid.1) ENST00000372517(uc010ojw.1 uc001cic.1)
    ENST00000470938 ENST00000372514(uc001cie.1) ENST00000328249(uc001cif.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ERMAP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERMAP
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ERMAP (see all 12):
    hsa-miR-485-5p hsa-miR-30c hsa-miR-30d hsa-miR-551b* hsa-miR-146a* hsa-miR-30a hsa-miR-544 hsa-miR-1255a
    SwitchGear 3'UTR luciferase reporter plasmid: ERMAP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERMAP (see all 4)
    OriGene shRNA RFP: ERMAP
    OriGene siRNA: ERMAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERMAP
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERMAP (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ERMAP (NM_018538)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERMAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERMAP 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ERMAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERMAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERMAP

    Additional cDNA sequence: 

    AF119899.1 AF311284.1 AF311285.1 AK056138.1 AK125447.1 AK295704.1 AK314436.1 AY049028.1 
    BC031548.1 BC099703.1 BC099707.1 BC099712.1 BC099713.1 

    10 DOTS entries:

    DT.100710212  DT.97831282  DT.99942774  DT.101979902  DT.422610  DT.121393458  DT.121393469  DT.95367077 
    DT.121393465  DT.121614226 

    24/68 AceView cDNA sequences (see all 68):

    AI914019 AA962640 BG029062 AF311284 AI024447 AI470546 BM993192 AY049028 
    AI608820 AI692760 AI991391 NM_018538 AA364859 AW204350 AK125447 AW953941 
    AW955704 AI031866 AI207452 AK056138 BX507568 BU677758 AI092761 BP377859 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ERMAP (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:              -     -     -     -           -                                       
    SP2:                                            -                                       
    SP3:              -           -     -           -     -     -     -     -               
    SP4:              -     -     -     -                                                   
    SP5:                                -           -                                       


    ECgene alternative splicing isoforms for ERMAP

    Expression
    for ERMAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERMAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGCTGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ERMAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ERMAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERMAP

    SOURCE GeneReport for Unigene cluster: Hs.439437

    UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5
    Tissue specificity: Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and
    to a lower extent in leukocytes, thymus, lymph node and spleen

        SABiosciences Custom PCR Arrays for ERMAP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERMAP

    Orthologs
    for ERMAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ERMAP gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    TRIM586
    		 Uncharacterized protein
    		 46(a)
    30(a)
    		 possible ortholog
    possible ortholog
    		 Un(55646228-55646707)
    19(357482-361459)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.145712 Xenopus laevis transcribed sequence with weak similarity more 81.81(n)    CD363175.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii btr046
    btr026
    (see all 27)    		 bloodthirsty-related gene family, member 2
    (see all 27)    		 22(a)
    22(a)
    (see all 27)    		 many ↔ many
    many ↔ many
    (see all 27)    		 7(16950705-16960473)
    3(47625625-47637219)


    ENSEMBL Gene Tree for ERMAP (if available)
    TreeFam Gene Tree for ERMAP (if available) 

    Paralogs
    for ERMAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERMAP gene
    BTN3A22  BTN2A12  BTNL82  BTN3A32  BTN2A22  HHLA22  CD2762  BTNL102  
    MOG2  BTNL22  BTN3A12  VTCN12  BTN1A12  BTNL92  BTNL32  
    13 SIMAP similar genes for ERMAP using alignment to 3 protein entries:     ERMAP_HUMAN (see all proteins):
    MEFV    TRIM41    TRIM69    TRIM39    TRIM27    TRIM21
    TRIM68    BTN3A3    BTN3A1    BTNL9    BTN2A2    TRIM16L
    TRIM16

    ERMAP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ERMAP
    PGOHUM00000263132


    Genomic Variants
    for ERMAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ERMAP_HUMAN, Q96PL5
    Polymorphism: ERMAP is responsible for the Scianna/Radin blood group system which comprises seven different antigens.
    The Sc1 and Sc2 antigens are resulting from a single variation in position 57; Arg-57 corresponds to the Sc2 antigen
    and Gly-57 to the Sc1 antigen. The Sc2 antigen is rare with an occurrence of less than 1% in the population while Sc1
    is more frequent. Sc3 is not expressed by individuals homozygous for a null allele encoding a truncated protein
    lacking its extracellular part (Sc-3). The Sc4 antigen corresponding to the previously defined Radin blood group
    antigen (Rd) is due to a single variation in position 60; Ala-60 corresponds to Sc4/Rd(+), the antigenic form of the
    protein. Sc4 is found in less than 1% of the population. Sc5/STAR, Sc6/SCER and Sc7/SCAN antigens are due to single
    variations in positions 47, 81 and 35 respectively. Alloantibodies to the low frequency Sc2 and Sc4 antigens are the
    cause of hemolytic disease in the newborn


    10/2573 NCBI SNPs in ERMAP are shown (see all 2573)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs560473161,2
    		C,pathogenic43296492(+) CAGCCG/AAGCTG 4 /K /E mis11Minor allele frequency- A:0.00NA 3386
    rs560252381,2
    		C,Fpathogenic43296522(+) GGCCCG/AGGACG 4 /R /G mis12Minor allele frequency- A:0.00NA EU 4569
    rs561367371,2
    		C,Fpathogenic43296531(+) CGGTAC/GCCAAG 4 P A mis12Minor allele frequency- G:0.00NA EU 4919
    rs339212511,2
    		C,F--41421046(+) AAAGG-/CCCCTGG 1 -- int14Minor allele frequency- CC:0.46NS CSA 98
    rs603018801,2
    		C--43281074(+) AAAAA-/AGCAAT 2 -- int1 us2k11Minor allele frequency- A:0.50NA 2
    rs1857300081,2
    		--43281079(+) AAAAAA/CAAAAA 2 -- int1 us2k10--------
    rs1901860861,2
    		--43281139(+) TAGTTA/TAATAA 2 -- int1 us2k10--------
    rs614447361,2
    		C,--43281291(+) TGCATA/GAAATA 2 -- int1 us2k13Minor allele frequency- G:0.07WA NA 240
    rs1453014831,2
    		C,--43281326(+) TAAAC-/TAAAT 
                TCTTA     		2 -- int1 us2k10--------
    rs1387630741,2
    		--43281382(+) CAAAAC/TAAAAT 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for ERMAP (43282776 - 43310660 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ERMAP: --
    Human Gene Mutation Database (HGMD): ERMAP

    Locus Specific Mutation Databases (LSDB): ERMAP
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ERMAP
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    Disorders / Diseases
    for ERMAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ERMAP for disorders           About MalaCards

    ERMAP for disorders           About GeneDecksing

    OMIM gene information: 609017   
    OMIM disorders: 111750  111620  
    Human Genome Epidemiology (HuGE) Navigator: ERMAP (2 documents)

    Export disorders for ERMAP gene to outside databases

    Publications
    for ERMAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERMAP gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ERMAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human erythroid membrane-associated protein, human ERMAP. (PubMed id 11549310)1, 2, 3 Xu H.... Schueler P.A. (2001)
    2. Scianna antigens including Rd are expressed by ERMAP. (PubMed id 12393480)1, 2, 9 Wagner F.F.... Flegel W.A. (2003)
    3. SCER and SCAN: two novel high-prevalence antigens in the Scianna blood group system. (PubMed id 16371048)1, 2, 9 Flegel W.A.... Wagner F.F. (2005)
    4. STAR: a novel high-prevalence antigen in the Scianna blood group system. (PubMed id 15660834)1, 2, 9 Hue-Roye K.... Reid M.E. (2005)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human ERMAP: an erythroid adhesion/receptor transmembrane protein. (PubMed id 11783959)1, 2 Su Y.-Y.... Chui D.H.K. (2001)
    8. The polymorphism nt 76 in exon 2 of SC is more freque nt in whites than in blacks. (PubMed id 19856728)1, 9 Fuchisawa A....Reid M.E. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. [Expression of human ermap gene in umbilical cord blood mononuclear cells during differentiation and development towards erythroid lineage] (PubMed id 18426659)1 Lin L.D....Liang J.F. (2008)

    External Searches for ERMAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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    Genome Databases showing ERMAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114625 HGNC: 15743 AceView: ERMAP Ensembl:ENSG00000164010 euGenes: HUgn114625
    ECgene: ERMAP H-InvDB: ERMAP

    Other Databases showing ERMAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ERMAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ERMAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERMAP Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=scianna
    SeattleSNPshttp://pga.gs.washington.edu/data/ermap/

    Intellectual Property
    for ERMAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ERMAP gene:
    Search GeneIP for patents involving ERMAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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