Aliases for ERLEC1 Gene
External Ids for ERLEC1 Gene
Previous HGNC Symbols for ERLEC1 Gene
Previous GeneCards Identifiers for ERLEC1 Gene
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
GeneCards Summary for ERLEC1 Gene
ERLEC1 (Endoplasmic Reticulum Lectin 1) is a Protein Coding gene. Diseases associated with ERLEC1 include Critical Illness Polyneuropathy and Gastric Leiomyosarcoma. Among its related pathways are Protein processing in endoplasmic reticulum and HIV Life Cycle. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is OS9.
UniProtKB/Swiss-Prot for ERLEC1 Gene
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.