Aliases for ERLEC1 Gene
External Ids for ERLEC1 Gene
Previous HGNC Symbols for ERLEC1 Gene
Previous GeneCards Identifiers for ERLEC1 Gene
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
GeneCards Summary for ERLEC1 Gene
ERLEC1 (Endoplasmic Reticulum Lectin 1) is a Protein Coding gene. Diseases associated with ERLEC1 include gastric leiomyosarcoma and alcohol-induced mental disorder. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is OS9.
UniProtKB/Swiss-Prot for ERLEC1 Gene
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.