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ERLEC1 Gene

protein-coding   GIFtS: 56
GCID: GC02P054015

Endoplasmic Reticulum Lectin 1

(Previous name: chromosome 2 open reading frame 30)
(Previous symbol: C2orf30)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Endoplasmic Reticulum Lectin 11 2     CL249362
C2orf301 2 3 5     CL250842
Erlectin 11 2     HEL1172
XTP3TPB2 3     XTP3-B2
ER Lectin2 3     Cancer Invasion And Metastasis-Related2
XTP3-Transactivated Gene B Protein2 3     Epididymis Luminal Protein 1172
Chromosome 2 Open Reading Frame 301     XTP3-Transactivated Protein B2
CIM2     Erlectin3

External Ids:    HGNC: 252221   Entrez Gene: 272482   Ensembl: ENSG000000689127   OMIM: 6112295   UniProtKB: Q96DZ13   

Export aliases for ERLEC1 gene to outside databases

Previous GC identifers: GC02P053867 GC02P053748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERLEC1 Gene:
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This
protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated
ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a
manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A
related pseudogene has been identified on chromosome 21. (provided by RefSeq, Aug 2011)

GeneCards Summary for ERLEC1 Gene:
ERLEC1 (endoplasmic reticulum lectin 1) is a protein-coding gene. Diseases associated with ERLEC1 include malaria. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is OS9.

UniProtKB/Swiss-Prot: ERLEC_HUMAN, Q96DZ1
Function: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in
endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both
non-glycosylated proteins and glycoproteins

Gene Wiki entry for ERLEC1 (C2orf30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ERLEC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidERLEC1 promoter sequence
   Search Chromatin IP Primers for ERLEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERLEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.2   Ensembl cytogenetic band:  2p16.2   HGNC cytogenetic band: 2p16

ERLEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERLEC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P054015:  view genomic region     (about GC identifiers)

Start:
54,014,068 bp from pter      End:
54,046,495 bp from pter
Size:
32,428 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ERLEC_HUMAN, Q96DZ1 (See protein sequence)
Recommended Name: Endoplasmic reticulum lectin 1 precursor  
Size: 483 amino acids; 54858 Da
Subunit: May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via
PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5
Secondary accessions: B2RDB4 B5MC72 O95901 Q6UWN7 Q9NUY7 Q9UQL4
Alternative splicing: 3 isoforms:  Q96DZ1-1   Q96DZ1-2   Q96DZ1-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ERLEC1: NX_Q96DZ1

Explore proteomics data for ERLEC1 at MOPED

Post-translational modifications: 

  • Isoform 1 and isoform 2 are N-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ERLEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120869.1  NP_001120870.1  NP_056516.2  

    ENSEMBL proteins: 
     ENSP00000385629   ENSP00000185150   ENSP00000367485  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009011 Man6P_isomerase_rcpt-bd_dom
     IPR012913 PRKCSH

    Graphical View of Domain Structure for InterPro Entry Q96DZ1

    ProtoNet protein and cluster: Q96DZ1

    1 Blocks protein domain: IPB012913 Glucosidase II beta subunit-like

    UniProtKB/Swiss-Prot: ERLEC_HUMAN, Q96DZ1
    Similarity: Contains 2 PRKCSH domains


    ERLEC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERLEC_HUMAN, Q96DZ1
    Function: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in
    endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both
    non-glycosylated proteins and glycoproteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA16531414
    GO:0005515protein binding IPI16531414
         
    ERLEC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ERLEC1:
     Decreased TP53 protein express  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERLEC1
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    miRNA
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    Block miRNA regulation of human, mouse, rat ERLEC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERLEC1 (see all 23):
    hsa-miR-140-5p hsa-miR-4288 hsa-miR-128 hsa-miR-488 hsa-miR-632 hsa-miR-346 hsa-miR-3167 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidERLEC1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ERLEC1

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    GenScript: all cDNA clones in your preferred vector (see all 3): ERLEC1 (NM_001127398)
    Sino Biological Human cDNA Clone for ERLEC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERLEC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERLEC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERLEC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERLEC_HUMAN, Q96DZ1: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    cytosol1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IDA16531414

    ERLEC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERLEC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ERLEC1):
        Protein processing in endoplasmic reticulum


    ERLEC1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERLEC1
    Interactions:

        Search GeneGlobe Interaction Network for ERLEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERLEC1 (Q96DZ12, 3 ENSP000001851504) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1AP194382, 3, ENSP000001627494MINT-49337 I2D: score=2 STRING: ENSP00000162749
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    LIPEQ054693I2D: score=2 
    ASGR2ENSP000003471404STRING: ENSP00000347140
    HSP90B1ENSP000002997674STRING: ENSP00000299767
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IDA18502753

    ERLEC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERLEC1 (ERLEC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ERLEC1 gene (3 alternative transcripts): 
    NM_001127397.2  NM_001127398.2  NM_015701.4  

    Unigene Cluster for ERLEC1:

    Endoplasmic reticulum lectin 1
    Hs.438336  [show with all ESTs]
    Unigene Representative Sequence: NM_015701
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494373 ENST00000405123 ENST00000185150(uc002rxl.3 uc002rxm.3)
    ENST00000378239(uc002rxn.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ERLEC1 (see all 23):
    hsa-miR-140-5p hsa-miR-4288 hsa-miR-128 hsa-miR-488 hsa-miR-632 hsa-miR-346 hsa-miR-3167 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidERLEC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ERLEC1
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    OriGene qPCR primer pairs and template standards for ERLEC1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERLEC1
      QuantiTect SYBR Green Assays in human, mouse, rat ERLEC1
      QuantiFast Probe-based Assays in human, mouse, rat ERLEC1

    Additional mRNA sequence: 

    AF131743.1 AF131849.1 AK001913.1 AK315477.1 AY358717.1 AY453410.1 BC013129.1 BC022228.1 

    16 DOTS entries:

    DT.454783  DT.100879573  DT.100726163  DT.40279012  DT.120956248  DT.100879576  DT.120956301  DT.40119338 
    DT.95154973  DT.100791649  DT.100839623  DT.100879561  DT.100879571  DT.92040309  DT.92439657  DT.99954574 

    Selected AceView cDNA sequences (see all 391):

    AF131743 CR623209 AI811580 CB134199 AY453410 AA115000 AI089654 AA825232 
    CB135414 BM353999 AA714676 NM_015701 BM929601 AI861865 AA505836 AA687108 
    CD674201 AA418175 CB137868 BF590730 AA909072 AW893811 T35324 CR601764 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ERLEC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:        -                                                                                       
    SP2:        -                                               -                                       
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ERLEC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERLEC1 expression in normal human tissues (normalized intensities)      ERLEC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTTGTCC
    ERLEC1 Expression
    About this image


    ERLEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ERLEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERLEC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438336
        Custom PCR Arrays for ERLEC1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ERLEC1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erlec11 , 5 endoplasmic reticulum lectin 11, 5 91.03(n)1
    96.48(a)1
      11 (18.18 cM)5
    667531  NM_025745.31  NP_080021.31 
     309307745 
    chicken
    (Gallus gallus)
    Aves ERLEC11 endoplasmic reticulum lectin 1 75.62(n)
    79.86(a)
      101751309  XM_004940126.1  XP_004940183.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERLEC16
    endoplasmic reticulum lectin 1
    76(a)
    1 ↔ 1
    1(263028254-263051797)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.220202 Xenopus laevis transcribed sequence with weak similarity more 76.54(n)    CB558691.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3092 sbcb309 73.29(n)   368331  BC044498.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67661 CG6766 45.62(n)
    35.1(a)
      34619  NM_135693.1  NP_609537.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y105E8A.21 CELE_Y105E8A.2 47.15(n)
    36.22(a)
      173298  NM_170934.4  NP_740930.2 


    ENSEMBL Gene Tree for ERLEC1 (if available)
    TreeFam Gene Tree for ERLEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERLEC1 gene
    OS92  
    1 SIMAP similar gene for ERLEC1 using alignment to 1 protein entry:     ERLEC_HUMAN:
    OS9

    ERLEC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ERLEC1
    PGOHUM00000239144


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERLEC1 (see all 730)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167963901,2
    C,F--53880078(+) TCCCTG/AGCCTC 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs129962731,2
    C,H--53880256(+) TCCTCA/CCAGAA 3 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 420
    rs129964751,2
    C,H--53880267(+) GTCTCC/TTCTGA 3 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs129964761,2
    H--53880269(+) CTCCTC/TTGACT 3 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1817187541,2
    --53880303(+) TACAGG/TTATTG 3 -- us2k10--------
    rs129963171,2
    C,H--53880320(+) ACATAA/CCCTTA 3 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs1409019461,2
    --53880398(+) ATCAGC/TTCTAT 3 -- us2k10--------
    rs1498322751,2
    --53880493(+) TCTTTC/TCCTTC 3 -- us2k10--------
    rs1114898951,2
    C--53880535(+) AAAAA-/ATTGAC 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs667160851,2
    C--53880536(+) ATGCT-/AAAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ERLEC1 (54014068 - 54046495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ERLEC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834058CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611229    OMIM disorders: --

    1 disease for ERLEC1:    About MalaCards
    malaria


    ERLEC1 for disorders           About GeneDecksing


    Export disorders for ERLEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERLEC1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ERLEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2, 3 Christianson J.C.... Kopito R.R. (Nat. Cell Biol. 2008)
    2. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. (PubMed id 16531414)1, 2, 3 Cruciat C.-M.... Niehrs C. (J. Biol. Chem. 2006)
    3. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)1, 2 Hosokawa N.... Nagata K. (J. Biol. Chem. 2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    10. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27248 HGNC: 25222 AceView: C2orf30 Ensembl:ENSG00000068912 euGenes: HUgn27248
    ECgene: ERLEC1 Kegg: 27248 H-InvDB: ERLEC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERLEC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERLEC1 gene:
    Search GeneIP for patents involving ERLEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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