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Aliases for ERICH6B Gene

Aliases for ERICH6B Gene

  • Glutamate Rich 6B 2 3 5
  • Family With Sequence Similarity 194, Member B 2 3
  • Protein FAM194B 3 4
  • FAM194B 3 4
  • Glutamate-Rich Protein 6B 3
  • Glutamate-Rich 6B 2

External Ids for ERICH6B Gene

Previous HGNC Symbols for ERICH6B Gene

  • FAM194B

Previous GeneCards Identifiers for ERICH6B Gene

  • GC13M046108

Summaries for ERICH6B Gene

GeneCards Summary for ERICH6B Gene

ERICH6B (Glutamate Rich 6B) is a Protein Coding gene. An important paralog of this gene is ERICH6.

Additional gene information for ERICH6B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH6B Gene

Genomics for ERICH6B Gene

Regulatory Elements for ERICH6B Gene

Enhancers for ERICH6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H044712 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.1 +901.3 901306 3 ZFP64 RAD21 ZNF354C FOS RCOR1 ZNF202 ZNF680 ZC3H11A CEBPB REST GPALPP1 COG3 ERICH6B RN7SL49P TPT1-AS1 RCN1P2 SMARCE1P5 CCDC122 KCTD4 GC13P044709
GH13H046163 1.7 FANTOM5 ENCODE dbSUPER 16.9 -559.1 -559058 21 HDGF PKNOX1 ATF1 SIN3A ZNF2 YY1 TCF12 ZNF766 ELK1 ZNF143 LCP1 ERICH6B COG3 RNU2-6P RUBCNL LRRC63 TPT1-AS1 ZC3H13 RN7SL288P LOC105370192
GH13H045695 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -79.7 -79747 0 PKNOX1 BMI1 BATF EED ATF7 ZSCAN29 RUNX3 IKZF2 CREM SMARCA5 LINC01055 ERICH6B SPERT AKR1B1P4
GH13H044917 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +697.3 697339 2 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 RCN1P2 GPALPP1 RN7SL49P TPT1-AS1 COG3 NUFIP1 TSC22D1 ERICH6B KCTD4 TRE-TTC2-1
GH13H045781 0.9 ENCODE 16.9 -166.2 -166200 1 NFIB ZNF473 INSM2 FEZF1 GLIS2 ZNF366 SCRT2 RCOR1 ZNF362 REST ERICH6B GC13M045757 SIAH3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERICH6B on UCSC Golden Path with GeneCards custom track

Genomic Location for ERICH6B Gene

Chromosome:
13
Start:
45,534,522 bp from pter
End:
45,615,739 bp from pter
Size:
81,218 bases
Orientation:
Minus strand

Genomic View for ERICH6B Gene

Genes around ERICH6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH6B Gene

Proteins for ERICH6B Gene

  • Protein details for ERICH6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0A0-ERI6B_HUMAN
    Recommended name:
    Glutamate-rich protein 6B
    Protein Accession:
    Q5W0A0
    Secondary Accessions:
    • Q96MB5

    Protein attributes for ERICH6B Gene

    Size:
    696 amino acids
    Molecular mass:
    81686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH6B Gene

Post-translational modifications for ERICH6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH6B Gene

Domains & Families for ERICH6B Gene

Gene Families for ERICH6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH6B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERICH6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0A0

UniProtKB/Swiss-Prot:

ERI6B_HUMAN :
  • Belongs to the ERICH6 family.
Family:
  • Belongs to the ERICH6 family.
genes like me logo Genes that share domains with ERICH6B: view

Function for ERICH6B Gene

Phenotypes From GWAS Catalog for ERICH6B Gene

genes like me logo Genes that share phenotypes with ERICH6B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ERICH6B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH6B Gene

Localization for ERICH6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH6B gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ERICH6B Gene

Pathways & Interactions for ERICH6B Gene

SuperPathways for ERICH6B Gene

No Data Available

Interacting Proteins for ERICH6B Gene

Selected Interacting proteins: Q5W0A0-ERI6B_HUMAN for ERICH6B Gene via IID

Symbol External ID(s) Details
CD247

Gene Ontology (GO) - Biological Process for ERICH6B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH6B Gene

Drugs & Compounds for ERICH6B Gene

No Compound Related Data Available

Transcripts for ERICH6B Gene

mRNA/cDNA for ERICH6B Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ERICH6B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3: - -

Relevant External Links for ERICH6B Gene

GeneLoc Exon Structure for
ERICH6B
ECgene alternative splicing isoforms for
ERICH6B

Expression for ERICH6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERICH6B Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for ERICH6B Gene

This gene is overexpressed in Fetal heart (36.3) and Heart (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH6B Gene



Protein tissue co-expression partners for ERICH6B Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH6B Gene:

ERICH6B
genes like me logo Genes that share expression patterns with ERICH6B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH6B Gene

Orthologs for ERICH6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM194B 33 34
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia FAM194B 33 34
  • 68.88 (n)
cow
(Bos Taurus)
Mammalia FAM194B 33
  • 68.28 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911795 33
  • 63.08 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM194B 34
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM194B 34
  • 20 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930564B18Rik 33
Erich6b 16
chicken
(Gallus gallus)
Aves FAM194B 34
  • 20 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM194B 34
  • 46 (a)
OneToOne
Species where no ortholog for ERICH6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH6B Gene

ENSEMBL:
Gene Tree for ERICH6B (if available)
TreeFam:
Gene Tree for ERICH6B (if available)

Paralogs for ERICH6B Gene

Paralogs for ERICH6B Gene

genes like me logo Genes that share paralogs with ERICH6B: view

Variants for ERICH6B Gene

Sequence variations from dbSNP and Humsavar for ERICH6B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000005749 -- 45,571,697(+) TGATC(A/G)TTTGG intron-variant
rs1000091393 -- 45,563,861(+) TGCAG(A/C)CAGTA intron-variant
rs1000144784 -- 45,577,177(+) CATCC(C/T)GAGGG intron-variant
rs1000146192 -- 45,596,332(+) ACTTT(C/T)CCTCC intron-variant
rs1000160051 -- 45,566,383(+) CTCCA(A/G)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH6B Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
dgv325n67 CNV gain 20364138
esv1002062 CNV loss 20482838
esv2747349 CNV deletion 23290073
esv2747350 CNV deletion 23290073
esv275007 CNV loss 21479260
esv3631959 CNV loss 21293372
nsv510583 CNV deletion 20534489
nsv561579 CNV loss 21841781

Variation tolerance for ERICH6B Gene

Gene Damage Index Score: 16.90; 97.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH6B Gene

Disorders for ERICH6B Gene

Relevant External Links for ERICH6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERICH6B

No disorders were found for ERICH6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH6B Gene

Publications for ERICH6B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 60
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ERICH6B Gene

Sources for ERICH6B Gene

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