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Aliases for ERICH6B Gene

Aliases for ERICH6B Gene

  • Glutamate Rich 6B 2 3 5
  • Family With Sequence Similarity 194, Member B 2 3
  • Protein FAM194B 3 4
  • FAM194B 3 4
  • Glutamate-Rich Protein 6B 3
  • Glutamate-Rich 6B 2

External Ids for ERICH6B Gene

Previous HGNC Symbols for ERICH6B Gene

  • FAM194B

Previous GeneCards Identifiers for ERICH6B Gene

  • GC13M046108

Summaries for ERICH6B Gene

GeneCards Summary for ERICH6B Gene

ERICH6B (Glutamate Rich 6B) is a Protein Coding gene. An important paralog of this gene is ERICH6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH6B Gene

Genomics for ERICH6B Gene

Regulatory Elements for ERICH6B Gene

Enhancers for ERICH6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ERICH6B on UCSC Golden Path with GeneCards custom track

Genomic Location for ERICH6B Gene

45,534,522 bp from pter
45,615,739 bp from pter
81,218 bases
Minus strand

Genomic View for ERICH6B Gene

Genes around ERICH6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH6B Gene

Proteins for ERICH6B Gene

  • Protein details for ERICH6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate-rich protein 6B
    Protein Accession:
    Secondary Accessions:
    • Q96MB5

    Protein attributes for ERICH6B Gene

    696 amino acids
    Molecular mass:
    81686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH6B Gene


neXtProt entry for ERICH6B Gene

Post-translational modifications for ERICH6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH6B Gene

Domains & Families for ERICH6B Gene

Protein Domains for ERICH6B Gene


Suggested Antigen Peptide Sequences for ERICH6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERICH6 family.
  • Belongs to the ERICH6 family.
genes like me logo Genes that share domains with ERICH6B: view

No data available for Gene Families for ERICH6B Gene

Function for ERICH6B Gene

genes like me logo Genes that share phenotypes with ERICH6B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH6B Gene

Localization for ERICH6B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ERICH6B Gene

Pathways & Interactions for ERICH6B Gene

SuperPathways for ERICH6B Gene

No Data Available

Interacting Proteins for ERICH6B Gene

Selected Interacting proteins: Q5W0A0-ERI6B_HUMAN for ERICH6B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ERICH6B Gene


No data available for Pathways by source and SIGNOR curated interactions for ERICH6B Gene

Drugs & Compounds for ERICH6B Gene

No Compound Related Data Available

Transcripts for ERICH6B Gene

mRNA/cDNA for ERICH6B Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3: - -

Relevant External Links for ERICH6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERICH6B Gene

mRNA expression in normal human tissues for ERICH6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERICH6B Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for ERICH6B Gene

This gene is overexpressed in Fetal heart (36.3) and Heart (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH6B Gene

Protein tissue co-expression partners for ERICH6B Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH6B Gene:

genes like me logo Genes that share expression patterns with ERICH6B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ERICH6B Gene

Orthologs for ERICH6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH6B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM194B 34
  • 68.28 (n)
  • 55.04 (a)
(Canis familiaris)
Mammalia FAM194B 34
  • 68.88 (n)
  • 52.84 (a)
FAM194B 35
  • 49 (a)
(Mus musculus)
Mammalia 4930564B18Rik 34
Erich6b 16
(Pan troglodytes)
Mammalia FAM194B 34
  • 98.7 (n)
  • 97.77 (a)
FAM194B 35
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100911795 34
  • 63.08 (n)
  • 47.06 (a)
(Monodelphis domestica)
Mammalia FAM194B 35
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia FAM194B 35
  • 20 (a)
(Gallus gallus)
Aves FAM194B 35
  • 20 (a)
(Anolis carolinensis)
Reptilia FAM194B 35
  • 46 (a)
Species where no ortholog for ERICH6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH6B Gene

Gene Tree for ERICH6B (if available)
Gene Tree for ERICH6B (if available)

Paralogs for ERICH6B Gene

Paralogs for ERICH6B Gene

genes like me logo Genes that share paralogs with ERICH6B: view

Variants for ERICH6B Gene

Sequence variations from dbSNP and Humsavar for ERICH6B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs12020217 - 45,596,817(+) TCCTC(A/C)TCCAG intron-variant, upstream-variant-2KB, reference, missense
rs12020731 - 45,596,710(+) ccttc(C/T)ccaga intron-variant, upstream-variant-2KB, reference, missense
rs17066954 - 45,596,486(+) ATATG(A/C/T)TTTCT intron-variant, upstream-variant-2KB, reference, missense
rs3014939 - 45,596,474(+) TTCCT(C/T)TTCTA intron-variant, upstream-variant-2KB, reference, missense
rs11618506 - 45,580,614(+) GAGCC(A/G)GCTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ERICH6B Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
dgv325n67 CNV gain 20364138
esv1002062 CNV loss 20482838
esv2747349 CNV deletion 23290073
esv2747350 CNV deletion 23290073
esv275007 CNV loss 21479260
esv3631959 CNV loss 21293372
nsv510583 CNV deletion 20534489
nsv561579 CNV loss 21841781

Variation tolerance for ERICH6B Gene

Gene Damage Index Score: 16.90; 97.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH6B Gene

Disorders for ERICH6B Gene

Relevant External Links for ERICH6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ERICH6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH6B Gene

Publications for ERICH6B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 65
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 65
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for ERICH6B Gene

Sources for ERICH6B Gene

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