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Aliases for ERICH6 Gene

Aliases for ERICH6 Gene

  • Glutamate Rich 6 2 3 5
  • Family With Sequence Similarity 194, Member A 2 3
  • Glutamate-Rich 6A 2 3
  • Protein FAM194A 3 4
  • C3orf44 3 4
  • FAM194A 3 4
  • Chromosome 3 Open Reading Frame 44 2
  • Glutamate-Rich Protein 6 3
  • Glutamate-Rich 6 2
  • ERICH6A 3

External Ids for ERICH6 Gene

Previous HGNC Symbols for ERICH6 Gene

  • C3orf44
  • FAM194A

Previous GeneCards Identifiers for ERICH6 Gene

  • GC03M150379

Summaries for ERICH6 Gene

GeneCards Summary for ERICH6 Gene

ERICH6 (Glutamate Rich 6) is a Protein Coding gene. An important paralog of this gene is ERICH6B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH6 Gene

Genomics for ERICH6 Gene

Regulatory Elements for ERICH6 Gene

Enhancers for ERICH6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F150724 1.3 FANTOM5 Ensembl ENCODE 12.4 -23.1 -23088 5.6 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZNF121 GATA2 ZNF143 FOS JUNB ERICH6-AS1 SIAH2 ERICH6 SIAH2-AS1 ENSG00000243273 FAM188B2 SNRPCP3 LOC101928105
GH03F150662 1.1 Ensembl 11.9 +41.9 41863 0.2 ZNF316 L3MBTL2 NRF1 MAFG NFE2 EMSY ERICH6 ERICH6-AS1 SELENOT SERP1 ENSG00000243273 FAM188B2 GC03P150627
GH03F150631 0.5 FANTOM5 11.4 +73.4 73354 0.0 FOSL1 SIN3A FOSL2 SELENOT SERP1 ERICH6 ERICH6-AS1 CLRN1 GC03P150627
GH03F150733 1.4 FANTOM5 Ensembl ENCODE 11.3 -34.9 -34851 12.4 PKNOX1 ARNT MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 ZNF143 FOS SIAH2 SIAH2-AS1 ERICH6 ERICH6-AS1 TSC22D2 SERP1 CLRN1 LOC101928105 PIR41342
GH03F150745 0.8 Ensembl ENCODE 11.3 -43.2 -43236 3.6 HDGF HDAC1 MLX DDX20 EBF1 RAD21 RARA ZNF316 GATA3 SCRT2 ERICH6 ERICH6-AS1 SIAH2 PIR41342 LOC105374155
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ERICH6 on UCSC Golden Path with GeneCards custom track

Promoters for ERICH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001376678 663 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 ZNF48 BRCA1 YY1 ZNF207

Genomic Location for ERICH6 Gene

Chromosome:
3
Start:
150,659,882 bp from pter
End:
150,704,563 bp from pter
Size:
44,682 bases
Orientation:
Minus strand

Genomic View for ERICH6 Gene

Genes around ERICH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH6 Gene

Proteins for ERICH6 Gene

  • Protein details for ERICH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0X2-ERIP6_HUMAN
    Recommended name:
    Glutamate-rich protein 6
    Protein Accession:
    Q7L0X2
    Secondary Accessions:
    • Q8N9Y8
    • Q8NCQ6
    • Q8NCZ6

    Protein attributes for ERICH6 Gene

    Size:
    663 amino acids
    Molecular mass:
    75255 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH6 Gene

Post-translational modifications for ERICH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH6 Gene

No data available for DME Specific Peptides for ERICH6 Gene

Domains & Families for ERICH6 Gene

Protein Domains for ERICH6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERICH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L0X2

UniProtKB/Swiss-Prot:

ERIP6_HUMAN :
  • Belongs to the ERICH6 family.
Family:
  • Belongs to the ERICH6 family.
genes like me logo Genes that share domains with ERICH6: view

No data available for Gene Families for ERICH6 Gene

Function for ERICH6 Gene

genes like me logo Genes that share phenotypes with ERICH6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH6 Gene

Localization for ERICH6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ERICH6 Gene

Pathways & Interactions for ERICH6 Gene

SuperPathways for ERICH6 Gene

No Data Available

Interacting Proteins for ERICH6 Gene

Selected Interacting proteins: Q7L0X2-ERIP6_HUMAN for ERICH6 Gene via IID

Symbol External ID(s) Details
HSPB1

Gene Ontology (GO) - Biological Process for ERICH6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH6 Gene

Transcripts for ERICH6 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH6 Gene

No ASD Table

Relevant External Links for ERICH6 Gene

GeneLoc Exon Structure for
ERICH6
ECgene alternative splicing isoforms for
ERICH6

Expression for ERICH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ERICH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERICH6 Gene

This gene is overexpressed in Testis (x42.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH6 Gene



Protein tissue co-expression partners for ERICH6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERICH6 Gene:

ERICH6
genes like me logo Genes that share expression patterns with ERICH6: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERICH6 Gene

Orthologs for ERICH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM194A 34 35
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia FAM194A 34 35
  • 82.91 (n)
cow
(Bos Taurus)
Mammalia FAM194A 34 35
  • 82.64 (n)
rat
(Rattus norvegicus)
Mammalia Fam194a 34
  • 73.77 (n)
mouse
(Mus musculus)
Mammalia Fam194a 34 35
  • 69.93 (n)
Erich6 16
oppossum
(Monodelphis domestica)
Mammalia FAM194A 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM194A 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM194A 34 35
  • 56.05 (n)
lizard
(Anolis carolinensis)
Reptilia FAM194A 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam194a 34
  • 52.16 (n)
Species where no ortholog for ERICH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH6 Gene

ENSEMBL:
Gene Tree for ERICH6 (if available)
TreeFam:
Gene Tree for ERICH6 (if available)

Paralogs for ERICH6 Gene

Paralogs for ERICH6 Gene

genes like me logo Genes that share paralogs with ERICH6: view

Variants for ERICH6 Gene

Sequence variations from dbSNP and Humsavar for ERICH6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10591523 -- 150,702,996(+) AACAG(-/AGAG/GA)AGAGA intron-variant, upstream-variant-2KB
rs10632960 -- 150,701,383(+) ATAAT(-/AA/AAT)GGAAA intron-variant
rs10663389 -- 150,702,801(+) TTAAA(-/TTAAA)CACAA intron-variant, upstream-variant-2KB
rs10663390 -- 150,702,889(+) TATGA(-/GT)GTGTG intron-variant, upstream-variant-2KB
rs10935818 -- 150,689,215(+) TTTAC(C/T)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH6 Gene

Variant ID Type Subtype PubMed ID
esv2672200 CNV deletion 23128226
esv3598162 CNV loss 21293372

Variation tolerance for ERICH6 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH6 Gene

Disorders for ERICH6 Gene

Relevant External Links for ERICH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERICH6

No disorders were found for ERICH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH6 Gene

Publications for ERICH6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ERICH6 Gene

Sources for ERICH6 Gene

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