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Aliases for ERICH5 Gene

Aliases for ERICH5 Gene

  • Glutamate Rich 5 2 3 5
  • C8orf47 3 4
  • Chromosome 8 Open Reading Frame 47 2
  • Glutamate-Rich Protein 5 3
  • Glutamate-Rich 5 2

External Ids for ERICH5 Gene

Previous HGNC Symbols for ERICH5 Gene

  • C8orf47

Previous GeneCards Identifiers for ERICH5 Gene

  • GC08P099077

Summaries for ERICH5 Gene

GeneCards Summary for ERICH5 Gene

ERICH5 (Glutamate Rich 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH5 Gene

Genomics for ERICH5 Gene

Regulatory Elements for ERICH5 Gene

Enhancers for ERICH5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G098001 1.4 Ensembl ENCODE dbSUPER 10.8 -62.2 -62218 1.4 PKNOX1 KLF17 SIN3A FEZF1 ZNF2 RAD21 YY1 RFX5 ZNF335 ZNF366 MATN2 RPS23P1 ERICH5 ENSG00000202399 LAPTM4B ENSG00000245970 GC08P097993 GC08M098021
GH08G097931 1.3 ENCODE dbSUPER 11 -131.1 -131121 3.0 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF766 ZNF143 FOS SP3 NFYC ENSG00000245970 ERICH5 MATN2 GC08M097916 GC08P097993
GH08G097949 1.3 Ensembl ENCODE dbSUPER 10.4 -112.9 -112850 3.2 NFIB ZFP64 SIN3A FEZF1 RAD21 YY1 ZNF366 FOS CEBPB ZEB2 ERICH5 GC08M097916 GC08P097993
GH08G098085 1.1 Ensembl ENCODE 11.8 +21.5 21480 0.4 PKNOX1 ARID4B SIN3A FEZF1 RAD21 RARA SCRT2 ZNF207 ZNF263 ZNF654 ERICH5 RIDA POP1 MATN2 RPS23P1 RPL30 SNORA72 ENSG00000245970 GC08P098099
GH08G097994 1.1 Ensembl ENCODE dbSUPER 10.7 -68.1 -68146 2.8 JUND MYNN KLF17 FOS RAD21 NFE2L2 NR2F2 MATN2 RPS23P1 ERICH5 LAPTM4B ENSG00000202399 ENSG00000245970 GC08P097993 GC08M098021
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERICH5 on UCSC Golden Path with GeneCards custom track

Promoters for ERICH5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227631 489 800 ZSCAN4 ZNF76 SIN3A GLI4 ZNF2 GLIS2 ZNF366 SCRT2 EGR2 ZNF263

Genomic Location for ERICH5 Gene

Chromosome:
8
Start:
98,064,311 bp from pter
End:
98,093,610 bp from pter
Size:
29,300 bases
Orientation:
Plus strand

Genomic View for ERICH5 Gene

Genes around ERICH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH5 Gene

Proteins for ERICH5 Gene

  • Protein details for ERICH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P6B1-ERIC5_HUMAN
    Recommended name:
    Glutamate-rich protein 5
    Protein Accession:
    Q6P6B1
    Secondary Accessions:
    • G3V1K4
    • Q8N1L8

    Protein attributes for ERICH5 Gene

    Size:
    374 amino acids
    Molecular mass:
    39936 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH5 Gene

Post-translational modifications for ERICH5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH5 Gene

Domains & Families for ERICH5 Gene

Protein Domains for ERICH5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH5: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ERICH5 Gene

Function for ERICH5 Gene

genes like me logo Genes that share phenotypes with ERICH5: view

Animal Model Products

CRISPR Products

miRNA for ERICH5 Gene

miRTarBase miRNAs that target ERICH5

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERICH5 Gene

Localization for ERICH5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH5 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERICH5 Gene

Pathways & Interactions for ERICH5 Gene

SuperPathways for ERICH5 Gene

No Data Available

Interacting Proteins for ERICH5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315614%0d%0a9606.ENSP00000241502%0d%0a
Selected Interacting proteins: ENSP00000315614 Q6P6B1-ERIC5_HUMAN for ERICH5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ERICH5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH5 Gene

Drugs & Compounds for ERICH5 Gene

No Compound Related Data Available

Transcripts for ERICH5 Gene

mRNA/cDNA for ERICH5 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH5 Gene

No ASD Table

Relevant External Links for ERICH5 Gene

GeneLoc Exon Structure for
ERICH5
ECgene alternative splicing isoforms for
ERICH5

Expression for ERICH5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH5 Gene

mRNA differential expression in normal tissues according to GTEx for ERICH5 Gene

This gene is overexpressed in Pancreas (x13.3) and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for ERICH5 Gene

This gene is overexpressed in Islet of Langerhans (32.5) and Pancreas (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERICH5 Gene



Protein tissue co-expression partners for ERICH5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH5 Gene:

ERICH5
genes like me logo Genes that share expression patterns with ERICH5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH5 Gene

Orthologs for ERICH5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ERICH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf47 34
  • 99.47 (n)
C8orf47 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERICH5 34
  • 80.23 (n)
C8orf47 35
  • 62 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERICH5 34
  • 76.79 (n)
C14H8orf47 35
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC030476 34 35
  • 71.85 (n)
Erich5 16
rat
(Rattus norvegicus)
Mammalia LOC681820 34
  • 71.12 (n)
oppossum
(Monodelphis domestica)
Mammalia C8orf47 35
  • 33 (a)
OneToOne
Species where no ortholog for ERICH5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH5 Gene

ENSEMBL:
Gene Tree for ERICH5 (if available)
TreeFam:
Gene Tree for ERICH5 (if available)

Paralogs for ERICH5 Gene

No data available for Paralogs for ERICH5 Gene

Variants for ERICH5 Gene

Sequence variations from dbSNP and Humsavar for ERICH5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000145755 -- 98,078,957(+) CCTGC(C/T)AGAAG intron-variant
rs1000213073 -- 98,079,176(+) TTTTT(C/T)TTTTT intron-variant
rs1000243952 -- 98,065,428(+) GTGGT(C/T)ATCAC intron-variant
rs1000360422 -- 98,065,131(+) GCAAT(A/C)TCAGC intron-variant
rs1000393561 -- 98,072,492(+) AATTA(A/C/G)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH5 Gene

Variant ID Type Subtype PubMed ID
dgv250n6 CNV deletion 16902084
esv2663748 CNV deletion 23128226
esv2737347 CNV deletion 23290073
esv3618145 CNV loss 21293372
nsv1031795 CNV loss 25217958
nsv1142535 CNV tandem duplication 24896259
nsv398164 CNV deletion 16902084
nsv465745 CNV gain 19166990
nsv465746 CNV gain 19166990
nsv465747 CNV gain 19166990
nsv611805 CNV gain 21841781
nsv611806 CNV gain 21841781
nsv611807 CNV gain 21841781
nsv831405 CNV gain 17160897

Variation tolerance for ERICH5 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH5 Gene

Disorders for ERICH5 Gene

Relevant External Links for ERICH5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERICH5

No disorders were found for ERICH5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH5 Gene

Publications for ERICH5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg M.E. … Hakonarson H. (Nat. Genet. 2010) 3 64

Products for ERICH5 Gene

Sources for ERICH5 Gene

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