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Aliases for ERICH4 Gene

Aliases for ERICH4 Gene

  • Glutamate Rich 4 2 3 5
  • C19orf69 3 4
  • Chromosome 19 Open Reading Frame 69 2
  • Glutamate-Rich Protein 4 3
  • Glutamate-Rich 4 2

External Ids for ERICH4 Gene

Previous HGNC Symbols for ERICH4 Gene

  • C19orf69

Previous GeneCards Identifiers for ERICH4 Gene

  • GC19P041950

Summaries for ERICH4 Gene

GeneCards Summary for ERICH4 Gene

ERICH4 (Glutamate Rich 4) is a Protein Coding gene.

Additional gene information for ERICH4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH4 Gene

Genomics for ERICH4 Gene

GeneHancer (GH) Regulatory Elements for ERICH4 Gene

Promoters and enhancers for ERICH4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I041440 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -0.4 -442 3.5 ZNF639 ELF3 KLF1 CLOCK ZC3H11A ELF1 NFIC ZNF366 GLIS1 IKZF1 ERICH4 ENSG00000277136 ZNF526 EXOSC5 ENSG00000269843 SNRPA HNRNPUL1 CCDC97 ZNF574 B3GNT8
GH19I041547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +109.6 109569 10.5 HDGF HDAC1 PKNOX1 SMAD1 ZBTB7B ZNF335 SCRT2 ETV6 IKZF2 RUNX3 CEACAM21 ENSG00000280014 CEACAMP3 DMAC2 ERICH4 EXOSC5 BCKDHA LINC01480 ENSG00000268355 TMEM91
GH19I041529 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +88.3 88288 2.9 PKNOX1 ATF1 GLIS2 ATF7 RUNX3 SP3 JUNB ZNF518A CBX8 GLIS1 ENSG00000268355 PCAT19 ZNF574 DMAC2 ERICH4 CIC LINC01480 NUMBL TGFB1 ARHGEF1
GH19I041376 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.2 -66.5 -66461 1.1 ELF3 ZSCAN4 ARID4B ZNF76 SIN3A FEZF1 DMAP1 ZNF2 ZNF335 POLR2B TMEM91 TGFB1 CCDC97 ERICH4 DMAC2 EXOSC5 ENSG00000277744 BCKDHA ENSG00000255730
GH19I041406 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -34.4 -34418 4.3 FOXA2 FOS ZNF362 CEBPB ZEB2 CEBPA MYC PRDM1 CTCF DRAP1 TMEM91 DMAC2 EXOSC5 TGFB1 B9D2 ERICH4 CCDC97 C19orf54 HNRNPUL1 ARHGEF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERICH4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ERICH4 Gene

Genomic Locations for ERICH4 Gene
chr19:41,443,158-41,444,765
(GRCh38/hg38)
Size:
1,608 bases
Orientation:
Plus strand
chr19:41,949,063-41,950,670
(GRCh37/hg19)

Genomic View for ERICH4 Gene

Genes around ERICH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH4 Gene

Proteins for ERICH4 Gene

  • Protein details for ERICH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGS2-ERIC4_HUMAN
    Recommended name:
    Glutamate-rich protein 4
    Protein Accession:
    A6NGS2

    Protein attributes for ERICH4 Gene

    Size:
    130 amino acids
    Molecular mass:
    14477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ERICH4 Gene

Post-translational modifications for ERICH4 Gene

No Post-translational modifications

Other Protein References for ERICH4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH4 Gene

Domains & Families for ERICH4 Gene

Gene Families for ERICH4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ERICH4 Gene

Function for ERICH4 Gene

Phenotypes From GWAS Catalog for ERICH4 Gene

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH4 Gene

Localization for ERICH4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH4 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERICH4 Gene

Pathways & Interactions for ERICH4 Gene

SuperPathways for ERICH4 Gene

No Data Available

Interacting Proteins for ERICH4 Gene

Gene Ontology (GO) - Biological Process for ERICH4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH4 Gene

Drugs & Compounds for ERICH4 Gene

No Compound Related Data Available

Transcripts for ERICH4 Gene

mRNA/cDNA for ERICH4 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH4 Gene

No ASD Table

Relevant External Links for ERICH4 Gene

GeneLoc Exon Structure for
ERICH4
ECgene alternative splicing isoforms for
ERICH4

Expression for ERICH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH4 Gene

mRNA differential expression in normal tissues according to GTEx for ERICH4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x13.4) and Kidney - Cortex (x12.2).

NURSA nuclear receptor signaling pathways regulating expression of ERICH4 Gene:

ERICH4
genes like me logo Genes that share expression patterns with ERICH4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH4 Gene

Orthologs for ERICH4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ERICH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf69 33
  • 99.67 (n)
C19orf69 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERICH4 33
  • 80.51 (n)
C19orf69 34
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERICH4 33
  • 77.18 (n)
C19orf69 34
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685046 33
  • 74.62 (n)
mouse
(Mus musculus)
Mammalia Gm7092 33 34
  • 74.1 (n)
Erich4 16
Species where no ortholog for ERICH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH4 Gene

ENSEMBL:
Gene Tree for ERICH4 (if available)
TreeFam:
Gene Tree for ERICH4 (if available)

Paralogs for ERICH4 Gene

No data available for Paralogs for ERICH4 Gene

Variants for ERICH4 Gene

Sequence variations from dbSNP and Humsavar for ERICH4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057048 -- 41,443,154(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001058310 -- 41,444,151(+) A/G coding_sequence_variant, missense_variant
rs1001221550 -- 41,441,427(+) C/G upstream_transcript_variant
rs1001405850 -- 41,444,571(+) G/A 3_prime_UTR_variant
rs1001569491 -- 41,441,599(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH4 Gene

Variant ID Type Subtype PubMed ID
esv3644380 CNV loss 21293372

Variation tolerance for ERICH4 Gene

Gene Damage Index Score: 3.09; 50.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERICH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH4 Gene

Disorders for ERICH4 Gene

Additional Disease Information for ERICH4

No disorders were found for ERICH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH4 Gene

Publications for ERICH4 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for ERICH4 Gene

Sources for ERICH4 Gene

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