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Aliases for ERICH3 Gene

Aliases for ERICH3 Gene

  • Glutamate Rich 3 2 3 5
  • Glutamate-Rich 3 2 3
  • C1orf173 3 4
  • Chromosome 1 Open Reading Frame 173 2
  • RP11-653A5.1 3

External Ids for ERICH3 Gene

Previous HGNC Symbols for ERICH3 Gene

  • C1orf173

Previous GeneCards Identifiers for ERICH3 Gene

  • GC01M075034

Summaries for ERICH3 Gene

GeneCards Summary for ERICH3 Gene

ERICH3 (Glutamate Rich 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH3 Gene

Genomics for ERICH3 Gene

Regulatory Elements for ERICH3 Gene

Enhancers for ERICH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERICH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERICH3 Gene

Chromosome:
1
Start:
74,568,111 bp from pter
End:
74,673,738 bp from pter
Size:
105,628 bases
Orientation:
Minus strand

Genomic View for ERICH3 Gene

Genes around ERICH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH3 Gene

Proteins for ERICH3 Gene

  • Protein details for ERICH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5RHP9-ERIC3_HUMAN
    Recommended name:
    Glutamate-rich protein 3
    Protein Accession:
    Q5RHP9
    Secondary Accessions:
    • Q68DL8
    • Q6GMR8
    • Q6ZSF9
    • Q8ND41

    Protein attributes for ERICH3 Gene

    Size:
    1530 amino acids
    Molecular mass:
    168466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86994.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERICH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH3 Gene

Proteomics data for ERICH3 Gene at MOPED

Post-translational modifications for ERICH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH3 Gene

Domains & Families for ERICH3 Gene

Protein Domains for ERICH3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ERICH3 Gene

Function for ERICH3 Gene

genes like me logo Genes that share phenotypes with ERICH3: view

Animal Model Products

miRNA for ERICH3 Gene

miRTarBase miRNAs that target ERICH3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERICH3 Gene

Localization for ERICH3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ERICH3 Gene

Pathways & Interactions for ERICH3 Gene

SuperPathways for ERICH3 Gene

No Data Available

Interacting Proteins for ERICH3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322609%0d%0a9606.ENSP00000452871%0d%0a
Selected Interacting proteins: Q5RHP9-ERIC3_HUMAN ENSP00000322609 for ERICH3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ERICH3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH3 Gene

Drugs & Compounds for ERICH3 Gene

No Compound Related Data Available

Transcripts for ERICH3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:

Relevant External Links for ERICH3 Gene

GeneLoc Exon Structure for
ERICH3
ECgene alternative splicing isoforms for
ERICH3

Expression for ERICH3 Gene

mRNA expression in normal human tissues for ERICH3 Gene

mRNA differential expression in normal tissues according to GTEx for ERICH3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), and Testis (x4.9).

Protein differential expression in normal tissues from HIPED for ERICH3 Gene

This gene is overexpressed in Neutrophil (33.4), Adrenal (17.8), and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH3 Gene



genes like me logo Genes that share expression patterns with ERICH3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ERICH3 Gene

Orthologs for ERICH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3H1orf173 35
  • 77.71 (n)
  • 64.81 (a)
C1orf173 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERICH3 35
  • 85.45 (n)
  • 79.36 (a)
C1orf173 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERICH3 35
  • 98.91 (n)
  • 97.97 (a)
C1orf173 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC295528 35
  • 69.45 (n)
  • 55.91 (a)
mouse
(Mus musculus)
Mammalia Erich3 16
4922501L14Rik 36
  • 60 (a)
OneToOne
4922501L14Rik 35
  • 72.11 (n)
  • 62.2 (a)
oppossum
(Monodelphis domestica)
Mammalia C1orf173 36
  • 21 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf173 36
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf173 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf173 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C8H1orf173 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for ERICH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERICH3 Gene

ENSEMBL:
Gene Tree for ERICH3 (if available)
TreeFam:
Gene Tree for ERICH3 (if available)

Paralogs for ERICH3 Gene

No data available for Paralogs for ERICH3 Gene

Variants for ERICH3 Gene

Sequence variations from dbSNP and Humsavar for ERICH3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11210490 - 74,631,742(+) ATTTG(C/G)AGCAG reference, missense
VAR_035132 -
VAR_035133 -
VAR_035134 -
rs11580409 - 74,572,544(+) TGCTA(A/C)ATCTA reference, missense

Variation tolerance for ERICH3 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.17; 95.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH3 Gene

HapMap Linkage Disequilibrium report
ERICH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ERICH3 Gene

Disorders for ERICH3 Gene

Relevant External Links for ERICH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERICH3

No disorders were found for ERICH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH3 Gene

Publications for ERICH3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ERICH3 Gene

Sources for ERICH3 Gene

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