Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERICH3 Gene

Aliases for ERICH3 Gene

  • Glutamate Rich 3 2 3 5
  • C1orf173 3 4
  • Chromosome 1 Open Reading Frame 173 2
  • Glutamate-Rich Protein 3 3
  • Glutamate-Rich 3 2
  • RP11-653A5.1 3

External Ids for ERICH3 Gene

Previous HGNC Symbols for ERICH3 Gene

  • C1orf173

Previous GeneCards Identifiers for ERICH3 Gene

  • GC01M075034

Summaries for ERICH3 Gene

GeneCards Summary for ERICH3 Gene

ERICH3 (Glutamate Rich 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH3 Gene

Genomics for ERICH3 Gene

Regulatory Elements for ERICH3 Gene

Enhancers for ERICH3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G074693 0.4 ENCODE 12.8 -20.1 -20073 1.0 ZNF558 ERICH3 LRRC53 ENSG00000272864 TYW3
GH01G074637 0.3 FANTOM5 12.1 +36.5 36486 0.1 ERICH3 LRRC53 GC01P074675 PIR56552
GH01G074689 0.7 ENCODE 0.4 -16.2 -16234 0.2 SOX13 CTCF FOXA2 SAP130 CEBPG RAD21 RFX5 FOXK2 ZNF143 SMC3 LRRC53 ENSG00000272864 ERICH3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERICH3 on UCSC Golden Path with GeneCards custom track

Promoters for ERICH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008578 137 400 POLR2A SMARCA4 RBBP5

Genomic Location for ERICH3 Gene

Chromosome:
1
Start:
74,568,111 bp from pter
End:
74,673,738 bp from pter
Size:
105,628 bases
Orientation:
Minus strand

Genomic View for ERICH3 Gene

Genes around ERICH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH3 Gene

Proteins for ERICH3 Gene

  • Protein details for ERICH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5RHP9-ERIC3_HUMAN
    Recommended name:
    Glutamate-rich protein 3
    Protein Accession:
    Q5RHP9
    Secondary Accessions:
    • Q68DL8
    • Q6GMR8
    • Q6ZSF9
    • Q8ND41

    Protein attributes for ERICH3 Gene

    Size:
    1530 amino acids
    Molecular mass:
    168466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86994.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERICH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH3 Gene

Post-translational modifications for ERICH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ERICH3 Gene

Domains & Families for ERICH3 Gene

Protein Domains for ERICH3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ERICH3 Gene

Function for ERICH3 Gene

genes like me logo Genes that share phenotypes with ERICH3: view

Animal Model Products

miRNA for ERICH3 Gene

miRTarBase miRNAs that target ERICH3

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERICH3 Gene

Localization for ERICH3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH3 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERICH3 Gene

Pathways & Interactions for ERICH3 Gene

SuperPathways for ERICH3 Gene

No Data Available

Interacting Proteins for ERICH3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322609%0d%0a9606.ENSP00000452871%0d%0a
Selected Interacting proteins: ENSP00000322609 Q5RHP9-ERIC3_HUMAN for ERICH3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ERICH3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH3 Gene

Drugs & Compounds for ERICH3 Gene

(2) Drugs for ERICH3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 512
Escitalopram Approved, Investigational Pharma 0
genes like me logo Genes that share compounds with ERICH3: view

Transcripts for ERICH3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:

Relevant External Links for ERICH3 Gene

GeneLoc Exon Structure for
ERICH3
ECgene alternative splicing isoforms for
ERICH3

Expression for ERICH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH3 Gene

mRNA differential expression in normal tissues according to GTEx for ERICH3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), and Testis (x4.9).

Protein differential expression in normal tissues from HIPED for ERICH3 Gene

This gene is overexpressed in Neutrophil (33.4), Adrenal (17.8), and Testis (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ERICH3 Gene:

ERICH3
genes like me logo Genes that share expression patterns with ERICH3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH3 Gene

Orthologs for ERICH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERICH3 34
  • 98.91 (n)
C1orf173 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERICH3 34
  • 85.45 (n)
C1orf173 35
  • 60 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf173 34
  • 77.71 (n)
C1orf173 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4922501L14Rik 35 34
  • 72.11 (n)
OneToOne
Erich3 16
rat
(Rattus norvegicus)
Mammalia LOC295528 34
  • 69.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf173 35
  • 23 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf173 35
  • 21 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf173 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf173 35
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C8H1orf173 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
Species where no ortholog for ERICH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERICH3 Gene

ENSEMBL:
Gene Tree for ERICH3 (if available)
TreeFam:
Gene Tree for ERICH3 (if available)

Paralogs for ERICH3 Gene

No data available for Paralogs for ERICH3 Gene

Variants for ERICH3 Gene

Sequence variations from dbSNP and Humsavar for ERICH3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000035053 -- 74,673,823(+) GTGAA(A/G)CCAGC intron-variant, upstream-variant-2KB
rs1000234692 -- 74,651,912(+) TAATT(C/T)TGCTC intron-variant
rs1000244483 -- 74,651,538(+) CCTTA(C/T)CCTTT intron-variant
rs1000339832 -- 74,652,234(+) ACAGA(C/T)TTGGT intron-variant
rs1000381648 -- 74,663,093(+) CCAAC(C/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH3 Gene

Variant ID Type Subtype PubMed ID
esv1344845 CNV deletion 17803354
esv1982102 CNV deletion 18987734
esv2669044 CNV deletion 23128226
nsv1002115 CNV gain 25217958
nsv461995 CNV gain 19166990
nsv473205 CNV novel sequence insertion 20440878
nsv546578 CNV gain 21841781
nsv830248 CNV loss 17160897
nsv830259 CNV gain 17160897

Variation tolerance for ERICH3 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.17; 95.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERICH3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH3 Gene

Disorders for ERICH3 Gene

Relevant External Links for ERICH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERICH3

No disorders were found for ERICH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH3 Gene

Publications for ERICH3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for ERICH3 Gene

Sources for ERICH3 Gene

Content
Loading form....