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Aliases for ERI3 Gene

Aliases for ERI3 Gene

  • ERI1 Exoribonuclease Family Member 3 2 3 5
  • Prion Protein-Interacting Protein 3 4
  • Prion Interactor 1 3 4
  • PRNPIP 3 4
  • PINT1 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 3
  • Prion Protein Interacting Protein 2
  • ERI1 Exoribonuclease 3 3
  • Exoribonuclease 3 2
  • EC 3.1.-.- 4
  • PRNPIP1 4

External Ids for ERI3 Gene

Previous HGNC Symbols for ERI3 Gene

  • PRNPIP

Previous GeneCards Identifiers for ERI3 Gene

  • GC01M044459
  • GC01M044686
  • GC01M042800

Summaries for ERI3 Gene

GeneCards Summary for ERI3 Gene

ERI3 (ERI1 Exoribonuclease Family Member 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ERI1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERI3 Gene

Genomics for ERI3 Gene

Regulatory Elements for ERI3 Gene

Enhancers for ERI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G044523 2.8 VISTA Ensembl ENCODE dbSUPER 10.1 -169.3 -169256 3.0 PKNOX1 TAL1 TEAD4 ETS1 TCF12 ZFHX2 ZNF316 NCOR1 POLR2A EGR2 RNF220 ERI3 MIR5584
GH01G044325 2.3 Ensembl ENCODE 11.2 +27.4 27396 4.0 FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS ZNF263 SZT2 ZSWIM5 DMAP1 ERI3 LOC101929609 PTCH2 GC01P044305
GH01G044561 2 dbSUPER 11.5 -216.7 -216727 21.5 PKNOX1 ARNT ZNF766 FOS ZNF263 JUNB REST ZNF579 MEF2D ZNF610 ERI3 RNU6-369P RNF220 DMAP1 RPS8 DPH2 BEST4 MIR5584 PIR47647
GH01G044483 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -130.1 -130057 3.2 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 FOS ZNF263 JUNB KAT8 DMAP1 ZSWIM5 RNF220 TOE1 RNU6-369P PTCH2 ERI3 LOC101929609 PLK3 ATP6V0B
GH01G044282 1.5 Ensembl ENCODE dbSUPER 10.5 +71.9 71867 2.7 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 FOS DMAP1 ERI3 SZT2 GC01P044290 ERI3-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERI3 on UCSC Golden Path with GeneCards custom track

Promoters for ERI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005728 79 1201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ARID4B DMAP1 YY1 ZNF766

Genomic Location for ERI3 Gene

Chromosome:
1
Start:
44,221,070 bp from pter
End:
44,355,279 bp from pter
Size:
134,210 bases
Orientation:
Minus strand

Genomic View for ERI3 Gene

Genes around ERI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI3 Gene

Proteins for ERI3 Gene

  • Protein details for ERI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43414-ERI3_HUMAN
    Recommended name:
    ERI1 exoribonuclease 3
    Protein Accession:
    O43414
    Secondary Accessions:
    • B1AK98
    • Q5T2T7
    • Q5T2T9
    • Q5TG35
    • Q9BQA0
    • Q9UEB4

    Protein attributes for ERI3 Gene

    Size:
    337 amino acids
    Molecular mass:
    37238 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PRNP.
    SequenceCaution:
    • Sequence=AAC19158.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERI3 Gene

    Alternative splice isoforms for ERI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERI3 Gene

Post-translational modifications for ERI3 Gene

  • Ubiquitination at Lys321 and isoforms=2, 3331
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERI3 Gene

Domains & Families for ERI3 Gene

No data available for UniProtKB/Swiss-Prot for ERI3 Gene

Function for ERI3 Gene

Enzyme Numbers (IUBMB) for ERI3 Gene

Gene Ontology (GO) - Molecular Function for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ERI3: view

Phenotypes for ERI3 Gene

genes like me logo Genes that share phenotypes with ERI3: view

Animal Model Products

CRISPR Products

miRNA for ERI3 Gene

miRTarBase miRNAs that target ERI3

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERI3 Gene

Localization for ERI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERI3 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERI3 Gene

Pathways & Interactions for ERI3 Gene

No Data Available

Interacting Proteins for ERI3 Gene

Gene Ontology (GO) - Biological Process for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
genes like me logo Genes that share ontologies with ERI3: view

No data available for Pathways by source and SIGNOR curated interactions for ERI3 Gene

Drugs & Compounds for ERI3 Gene

No Compound Related Data Available

Transcripts for ERI3 Gene

Unigene Clusters for ERI3 Gene

ERI1 exoribonuclease family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERI3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ERI3 Gene

GeneLoc Exon Structure for
ERI3
ECgene alternative splicing isoforms for
ERI3

Expression for ERI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERI3 Gene



Protein tissue co-expression partners for ERI3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERI3 Gene:

ERI3

SOURCE GeneReport for Unigene cluster for ERI3 Gene:

Hs.731413

Evidence on tissue expression from TISSUES for ERI3 Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Skin(2.5)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with ERI3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERI3 Gene

Orthologs for ERI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERI3 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia ERI3 34 35
  • 97.73 (n)
cow
(Bos Taurus)
Mammalia ERI3 34 35
  • 96.74 (n)
rat
(Rattus norvegicus)
Mammalia Eri3 34
  • 95.45 (n)
mouse
(Mus musculus)
Mammalia Eri3 34 16 35
  • 93.87 (n)
oppossum
(Monodelphis domestica)
Mammalia ERI3 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERI3 34 35
  • 81.58 (n)
lizard
(Anolis carolinensis)
Reptilia ERI3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eri3 34
  • 73.19 (n)
Str.15577 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1845 34
worm
(Caenorhabditis elegans)
Secernentea CELE_R02D3.8 34
  • 51.66 (n)
R02D3.8 35
  • 38 (a)
OneToMany
M02B7.2 35
  • 36 (a)
OneToMany
Species where no ortholog for ERI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ERI3 Gene

ENSEMBL:
Gene Tree for ERI3 (if available)
TreeFam:
Gene Tree for ERI3 (if available)

Paralogs for ERI3 Gene

Paralogs for ERI3 Gene

(1) SIMAP similar genes for ERI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ERI3: view

Variants for ERI3 Gene

Sequence variations from dbSNP and Humsavar for ERI3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000025757 -- 44,271,058(+) CCTCC(C/T)TGCTA intron-variant
rs1000036743 -- 44,225,304(+) TGTCT(G/T)GCTCT intron-variant
rs1000041562 -- 44,313,707(+) CTTGA(A/T)ATCCA intron-variant
rs1000059905 -- 44,356,209(+) ACCCA(C/T)GTCAT upstream-variant-2KB
rs1000074235 -- 44,314,060(+) CACCA(A/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERI3 Gene

Variant ID Type Subtype PubMed ID
esv24567 CNV loss 19812545
esv3399053 CNV insertion 20981092
esv3585881 CNV loss 21293372
esv998002 CNV deletion 20482838
nsv508011 OTHER sequence alteration 20534489
nsv829715 CNV gain 17160897

Variation tolerance for ERI3 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERI3 Gene

Disorders for ERI3 Gene

Relevant External Links for ERI3

Genetic Association Database (GAD)
ERI3
Human Genome Epidemiology (HuGE) Navigator
ERI3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERI3

No disorders were found for ERI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERI3 Gene

Publications for ERI3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for ERI3 Gene

Sources for ERI3 Gene

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