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Aliases for ERI3 Gene

Aliases for ERI3 Gene

  • ERI1 Exoribonuclease Family Member 3 2 3 5
  • Prion Protein-Interacting Protein 3 4
  • Prion Interactor 1 3 4
  • PRNPIP 3 4
  • PINT1 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 3
  • Prion Protein Interacting Protein 2
  • Exoribonuclease 3 2
  • EC 3.1.-.- 4
  • PRNPIP1 4

External Ids for ERI3 Gene

Previous HGNC Symbols for ERI3 Gene

  • PRNPIP

Previous GeneCards Identifiers for ERI3 Gene

  • GC01M044459
  • GC01M044686
  • GC01M042800

Summaries for ERI3 Gene

GeneCards Summary for ERI3 Gene

ERI3 (ERI1 Exoribonuclease Family Member 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ERI1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERI3 Gene

Genomics for ERI3 Gene

Regulatory Elements for ERI3 Gene

Promoters for ERI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERI3 Gene

Chromosome:
1
Start:
44,221,070 bp from pter
End:
44,355,279 bp from pter
Size:
134,210 bases
Orientation:
Minus strand

Genomic View for ERI3 Gene

Genes around ERI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI3 Gene

Proteins for ERI3 Gene

  • Protein details for ERI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43414-ERI3_HUMAN
    Recommended name:
    ERI1 exoribonuclease 3
    Protein Accession:
    O43414
    Secondary Accessions:
    • B1AK98
    • Q5T2T7
    • Q5T2T9
    • Q5TG35
    • Q9BQA0
    • Q9UEB4

    Protein attributes for ERI3 Gene

    Size:
    337 amino acids
    Molecular mass:
    37238 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PRNP.
    SequenceCaution:
    • Sequence=AAC19158.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERI3 Gene

    Alternative splice isoforms for ERI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERI3 Gene

Proteomics data for ERI3 Gene at MOPED

Post-translational modifications for ERI3 Gene

  • Ubiquitination at Lys 321 and Lys 331
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERI3 Gene

Domains & Families for ERI3 Gene

Gene Families for ERI3 Gene

Protein Domains for ERI3 Gene

Graphical View of Domain Structure for InterPro Entry

O43414

UniProtKB/Swiss-Prot:

ERI3_HUMAN :
  • Contains 1 exonuclease domain.
Domain:
  • Contains 1 exonuclease domain.
genes like me logo Genes that share domains with ERI3: view

Function for ERI3 Gene

Enzyme Numbers (IUBMB) for ERI3 Gene

Gene Ontology (GO) - Molecular Function for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ERI3: view

Phenotypes for ERI3 Gene

genes like me logo Genes that share phenotypes with ERI3: view

Animal Model Products

miRNA for ERI3 Gene

miRTarBase miRNAs that target ERI3

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERI3 Gene

Localization for ERI3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERI3 Gene COMPARTMENTS Subcellular localization image for ERI3 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERI3 Gene

Pathways & Interactions for ERI3 Gene

SuperPathways for ERI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ERI3: view

No data available for Pathways by source and SIGNOR curated interactions for ERI3 Gene

Drugs & Compounds for ERI3 Gene

No Compound Related Data Available

Transcripts for ERI3 Gene

Unigene Clusters for ERI3 Gene

ERI1 exoribonuclease family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERI3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ERI3 Gene

GeneLoc Exon Structure for
ERI3
ECgene alternative splicing isoforms for
ERI3

Expression for ERI3 Gene

mRNA expression in normal human tissues for ERI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERI3 Gene



SOURCE GeneReport for Unigene cluster for ERI3 Gene Hs.731413

genes like me logo Genes that share expression patterns with ERI3: view

Protein tissue co-expression partners for ERI3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERI3 Gene

Orthologs for ERI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERI3 36
  • 100 (a)
OneToOne
ERI3 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ERI3 36
  • 99 (a)
OneToOne
ERI3 35
  • 96.74 (n)
  • 98.81 (a)
dog
(Canis familiaris)
Mammalia ERI3 35
  • 97.73 (n)
  • 98.81 (a)
ERI3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eri3 36
  • 98 (a)
OneToOne
Eri3 16
Eri3 35
  • 93.87 (n)
  • 97.92 (a)
oppossum
(Monodelphis domestica)
Mammalia ERI3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eri3 35
  • 95.45 (n)
  • 98.81 (a)
chicken
(Gallus gallus)
Aves ERI3 35
  • 81.58 (n)
  • 86.84 (a)
ERI3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERI3 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1845 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eri3 35
  • 73.19 (n)
  • 76.45 (a)
Str.15577 35
worm
(Caenorhabditis elegans)
Secernentea M02B7.2 36
  • 36 (a)
OneToMany
R02D3.8 36
  • 38 (a)
OneToMany
CELE_R02D3.8 35
  • 51.66 (n)
  • 48.17 (a)
Species with no ortholog for ERI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ERI3 Gene

ENSEMBL:
Gene Tree for ERI3 (if available)
TreeFam:
Gene Tree for ERI3 (if available)

Paralogs for ERI3 Gene

Paralogs for ERI3 Gene

(1) SIMAP similar genes for ERI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ERI3: view

Variants for ERI3 Gene

Sequence variations from dbSNP and Humsavar for ERI3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4958 -- 44,310,688(+) CTAGA(G/T)GCCTG intron-variant
rs188973 -- 44,275,986(-) agcag(C/T)ctgag intron-variant
rs161724 -- 44,315,664(+) GTGGC(C/T)CAGTA intron-variant
rs161725 -- 44,314,650(+) TGGTC(C/T)GCTAA intron-variant
rs161726 -- 44,314,319(+) AAAAA(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERI3 Gene

Variant ID Type Subtype PubMed ID
esv998002 CNV Deletion 20482838
nsv508011 CNV Loss 20534489
esv269527 CNV Insertion 20981092
nsv829715 CNV Gain 17160897
esv24567 CNV Loss 19812545

Variation tolerance for ERI3 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERI3 Gene

HapMap Linkage Disequilibrium report
ERI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERI3 Gene

Disorders for ERI3 Gene

Relevant External Links for ERI3

Genetic Association Database (GAD)
ERI3
Human Genome Epidemiology (HuGE) Navigator
ERI3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERI3

No disorders were found for ERI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERI3 Gene

Publications for ERI3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for ERI3 Gene

Sources for ERI3 Gene

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