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Aliases for ERI1 Gene

Aliases for ERI1 Gene

  • Exoribonuclease 1 2 3 2
  • Histone MRNA 3-End-Specific Exoribonuclease 3 4
  • Three Prime Histone MRNA Exonuclease 1 2 3
  • Histone MRNA 3-Exonuclease 1 3 4
  • 3-5 Exonuclease ERI1 3 4
  • Protein 3hExo 3 4
  • Eri-1 Homolog 3 4
  • THEX1 3 4
  • HEXO 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 3
  • Histone MRNA 3 End-Specific Exonuclease 3
  • Three Prime MRNA Exonuclease 1 3
  • 3 Exoribonuclease 3
  • EC 3.1.-.- 4
  • 3HEXO 3
  • 3EXO 4

External Ids for ERI1 Gene

Previous HGNC Symbols for ERI1 Gene

  • THEX1

Previous GeneCards Identifiers for ERI1 Gene

  • GC08P008900
  • GC08P007785

Summaries for ERI1 Gene

GeneCards Summary for ERI1 Gene

ERI1 (Exoribonuclease 1) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. GO annotations related to this gene include nucleic acid binding and ribosome binding. An important paralog of this gene is ERI3.

UniProtKB/Swiss-Prot for ERI1 Gene

  • RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERI1 Gene

Genomics for ERI1 Gene

Regulatory Elements for ERI1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERI1 Gene

Chromosome:
8
Start:
9,002,147 bp from pter
End:
9,116,746 bp from pter
Size:
114,600 bases
Orientation:
Plus strand

Genomic View for ERI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI1 Gene

Proteins for ERI1 Gene

  • Protein details for ERI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV48-ERI1_HUMAN
    Recommended name:
    3-5 exoribonuclease 1
    Protein Accession:
    Q8IV48
    Secondary Accessions:
    • A8K4U7
    • Q9NSX3

    Protein attributes for ERI1 Gene

    Size:
    349 amino acids
    Molecular mass:
    40064 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3-end of histone mRNAs.
    SequenceCaution:
    • Sequence=CAB70871.2; Type=Erroneous termination; Positions=159; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=CAB70871.2; Type=Frameshift; Positions=117; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERI1 Gene

neXtProt entry for ERI1 Gene

Proteomics data for ERI1 Gene at MOPED

Post-translational modifications for ERI1 Gene

  • Ubiquitination at Lys 67 and Lys 269
  • Modification sites at PhosphoSitePlus

Other Protein References for ERI1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERI1 (THEX1)

No data available for DME Specific Peptides for ERI1 Gene

Domains & Families for ERI1 Gene

Gene Families for ERI1 Gene

HGNC:

Protein Domains for ERI1 Gene

Suggested Antigen Peptide Sequences for ERI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV48

UniProtKB/Swiss-Prot:

ERI1_HUMAN :
  • The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3-end histone mRNA exonuclease activity
Domain:
  • The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3-end histone mRNA exonuclease activity
  • Contains 1 exonuclease domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with ERI1: view

Function for ERI1 Gene

Molecular function for ERI1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Although it can bind simultaneously with SLBP to the 3-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.
UniProtKB/Swiss-Prot Function:
RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Enzyme Numbers (IUBMB) for ERI1 Gene

Gene Ontology (GO) - Molecular Function for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IBA --
GO:0003676 nucleic acid binding --
GO:0008408 3-5 exonuclease activity IDA 14536070
GO:0019843 rRNA binding ISS --
GO:0043022 ribosome binding ISS --
genes like me logo Genes that share ontologies with ERI1: view
genes like me logo Genes that share phenotypes with ERI1: view

Animal Models for ERI1 Gene

MGI Knock Outs for ERI1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERI1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ERI1 Gene

Localization for ERI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERI1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERI1 Gene COMPARTMENTS Subcellular localization image for ERI1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
GO:0071204 histone pre-mRNA 3end processing complex ISS --
genes like me logo Genes that share ontologies with ERI1: view

Pathways & Interactions for ERI1 Gene

genes like me logo Genes that share pathways with ERI1: view

Pathways by source for ERI1 Gene

2 Cell Signaling Technology pathways for ERI1 Gene

Gene Ontology (GO) - Biological Process for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000738 DNA catabolic process, exonucleolytic IBA --
GO:0031047 gene silencing by RNA IEA --
GO:0031125 rRNA 3-end processing ISS --
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
genes like me logo Genes that share ontologies with ERI1: view

No data available for SIGNOR curated interactions for ERI1 Gene

Drugs & Compounds for ERI1 Gene

(1) Drugs for ERI1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with ERI1: view

Transcripts for ERI1 Gene

Unigene Clusters for ERI1 Gene

Exoribonuclease 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERI1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:

Relevant External Links for ERI1 Gene

GeneLoc Exon Structure for
ERI1
ECgene alternative splicing isoforms for
ERI1

Expression for ERI1 Gene

mRNA expression in normal human tissues for ERI1 Gene

Protein differential expression in normal tissues from HIPED for ERI1 Gene

This gene is overexpressed in Lung (53.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERI1 Gene



SOURCE GeneReport for Unigene cluster for ERI1 Gene Hs.20000

genes like me logo Genes that share expression patterns with ERI1: view

Protein tissue co-expression partners for ERI1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERI1 Gene

Orthologs for ERI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERI1 35
  • 86.91 (n)
  • 86.25 (a)
-- 36
  • 87 (a)
OneToMany
THEX1 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ERI1 35
  • 89.97 (n)
  • 91.98 (a)
ERI1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eri1 35
  • 82.42 (n)
  • 84.06 (a)
Eri1 16
Eri1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERI1 35
  • 99.52 (n)
  • 99.43 (a)
ERI1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eri1 35
  • 83.86 (n)
  • 85.22 (a)
oppossum
(Monodelphis domestica)
Mammalia ERI1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERI1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERI1 35
  • 73.92 (n)
  • 79.22 (a)
ERI1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERI1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eri1 35
  • 70.77 (n)
  • 77.02 (a)
Str.6568 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8018 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15106 35
eri1 35
  • 66.32 (n)
  • 70.24 (a)
eri1 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6758 35
worm
(Caenorhabditis elegans)
Secernentea eri-1 35
  • 48.84 (n)
  • 39.59 (a)
crn-4 36
  • 21 (a)
ManyToMany
eri-1 36
  • 16 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes eri1 35
  • 47.72 (n)
  • 39.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for ERI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERI1 Gene

ENSEMBL:
Gene Tree for ERI1 (if available)
TreeFam:
Gene Tree for ERI1 (if available)

Paralogs for ERI1 Gene

Paralogs for ERI1 Gene

genes like me logo Genes that share paralogs with ERI1: view

Variants for ERI1 Gene

Sequence variations from dbSNP and Humsavar for ERI1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6748 -- 9,033,292(+) TAATA(C/T)GAAAA utr-variant-3-prime, intron-variant
rs7853 -- 9,033,304(+) TACGA(A/G)ATTTT utr-variant-3-prime, intron-variant
rs895253 -- 9,041,194(+) ACAAC(A/G)TATTA intron-variant
rs895254 -- 9,066,456(-) CACTG(C/G)CCGCT intron-variant
rs920974 -- 9,071,234(-) ATTAC(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERI1 Gene

Variant ID Type Subtype PubMed ID
nsv890331 CNV Loss 21882294
nsv831229 CNV Gain+Loss 17160897

Variation tolerance for ERI1 Gene

Residual Variation Intolerance Score: 16.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERI1 Gene

HapMap Linkage Disequilibrium report
ERI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERI1 Gene

Disorders for ERI1 Gene

Relevant External Links for ERI1

Genetic Association Database (GAD)
ERI1
Human Genome Epidemiology (HuGE) Navigator
ERI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERI1
genes like me logo Genes that share disorders with ERI1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERI1 Gene

Publications for ERI1 Gene

  1. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. (PMID: 16912046) Yang X.-C. … Dominski Z. (J. Biol. Chem. 2006) 23 67
  2. High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse. (PMID: 16004606) Hong J. … Huang W. (Biochem. J. 2005) 23 67
  3. Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP. (PMID: 15451662) Cheng Y. … Patel D.J. (J. Mol. Biol. 2004) 23 67
  4. A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. (PMID: 14536070) Dominski Z. … Marzluff W.F. (Mol. Cell 2003) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for ERI1 Gene

Sources for ERI1 Gene

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