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ERI1 Gene

protein-coding   GIFtS: 55
GCID: GC08P008900

Exoribonuclease 1

(Previous name: three prime histone mRNA exonuclease 1)
(Previous symbol: THEX1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Exoribonuclease 11 2     Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 (C.Elegans)1
THEX11 2 3     3' Exoribonuclease2
Three Prime Histone MRNA Exonuclease 11 2     3'-5' Exoribonuclease 12
Histone MRNA 3'-End-Specific Exoribonuclease2 3     3'HEXO2
Histone MRNA 3'-Exonuclease 12 3     Enhanced RNAi Three Prime MRNA Exonuclease Homolog 12
Protein 3'HExo2 3     Histone MRNA 3' End-Specific Exonuclease2
3'-5' Exonuclease ERI12 3     Three Prime MRNA Exonuclease 12
HEXO2 3     3'EXO3
Eri-1 Homolog2 3     EC 3.1.-.-3

External Ids:    HGNC: 239941   Entrez Gene: 904592   Ensembl: ENSG000001046267   OMIM: 6087395   UniProtKB: Q8IV483   
ORGUL members:         

Export aliases for ERI1 gene to outside databases

Previous GC identifer: GC08P007785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ERI1 Gene:
ERI1 (exoribonuclease 1) is a protein-coding gene. GO annotations related to this gene include 3'-5' exonuclease activity and rRNA binding. An important paralog of this gene is ERI2.

UniProtKB/Swiss-Prot: ERI1_HUMAN, Q8IV48
Function: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an
essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the
histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of
short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi).
Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required
for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop
structure of replication-dependent histone pre-mRNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_077531.5  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERI1 gene promoter:
         ATF-2   Pax-2   POU6F1 (c2)   Pax-2a   HNF-3beta   c-Ets-1   CRE-BP1   RORalpha1   Pax-2b   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidERI1 promoter sequence
   Search Chromatin IP Primers for ERI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

ERI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERI1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P008900:  view genomic region     (about GC identifiers)

Start:
8,859,657 bp from pter      End:
8,974,256 bp from pter
Size:
114,600 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ERI1_HUMAN, Q8IV48 (See protein sequence)
Recommended Name: 3'-5' exoribonuclease 1  
Size: 349 amino acids; 40064 Da
Cofactor: Binds 2 magnesium ions per subunit
Subunit: Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and
YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs (By similarity). Binds to
40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the
stem-loop structure of the 3'-end of histone mRNAs
Sequence caution: Sequence=CAB70871.2; Type=Erroneous termination; Positions=159; Note=Translated as Leu;
Sequence=CAB70871.2; Type=Frameshift; Positions=117;
4 PDB 3D structures from and Proteopedia for ERI1:
1W0H (3D)        1ZBH (3D)        1ZBU (3D)        4L8R (3D)    
Secondary accessions: A8K4U7 Q9NSX3

Explore the universe of human proteins at neXtProt for ERI1: NX_Q8IV48

Explore proteomics data for ERI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67, Lys269
  • Modification sites at PhosphoSitePlus

  • See ERI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_699163.2  
    ENSEMBL proteins: 
     ENSP00000429615   ENSP00000430190   ENSP00000429043   ENSP00000430651   ENSP00000250263  

    ERI1 Human Recombinant Protein Products:

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    Novus Biologicals ERI1 Protein
    Novus Biologicals ERI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERI1

     
    Search eBioscience for Proteins for ERI1 

    ERI1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals ERI1 Antibodies
    Abcam antibodies for ERI1
    Cloud-Clone Corp. Antibodies for ERI1
    ThermoFisher Antibodies for ERI1
    LSBio Antibodies in human, mouse, rat for ERI1

    ERI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ERI1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ERI1
    Cloud-Clone Corp. CLIAs for ERI1
    Search eBioscience for ELISAs for ERI1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ERI: Enhanced RNAi three prime mRNA exonucleases

    4 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR003034 SAP_dom
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV48

    ProtoNet protein and cluster: Q8IV48

    2 Blocks protein domains:
    IPB003034 DNA-binding SAP
    IPB006055 Exonuclease


    UniProtKB/Swiss-Prot: ERI1_HUMAN, Q8IV48
    Domain: The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the
    ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity
    Similarity: Contains 1 exonuclease domain
    Similarity: Contains 1 SAP domain


    Find genes that share domains with ERI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERI1_HUMAN, Q8IV48
    Function: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an
    essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the
    histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of
    short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi).
    Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required
    for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop
    structure of replication-dependent histone pre-mRNAs
    Enzyme regulation: Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of
    SLBP prevents the exonuclease activity

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004527exonuclease activity ----
    GO:00084083'-5' exonuclease activity IDA14536070
    GO:0019843rRNA binding ISS--
    GO:0043022ribosome binding ISS--
         
    Find genes that share ontologies with ERI1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Eri1):
     cellular  growth/size/body  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with ERI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Eri1tm1.2Anse for ERI1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERI1:
    hsa-mir-30c-5p (MIRT047993), hsa-mir-155-5p (MIRT020545)

    Block miRNA regulation of human, mouse, rat ERI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERI1 (see all 58):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-640 hsa-miR-19b-2* hsa-miR-429 hsa-miR-106a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidERI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERI1
    Predesigned siRNA for gene silencing in human, mouse, rat ERI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERI1

    Clone
    Products:
         
    OriGene clones in human, mouse for ERI1 (see all 7)
    OriGene ORF clones in mouse, rat for ERI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERI1 (NM_153332)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERI1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERI1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERI1_HUMAN, Q8IV48: Cytoplasm. Nucleus. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730nucleolus ISS--
    GO:0005737cytoplasm ISS--
    GO:0071204histone pre-mRNA 3'end processing complex ISS--

    Find genes that share ontologies with ERI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with ERI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ERI1
        Chromatin Regulation / Acetylation
    Translational Control


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERI1
    Interactions:

        Search GeneGlobe Interaction Network for ERI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ERI1 (Q8IV483 ENSP000002502634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLBPQ144933, ENSP000004176864I2D: score=1 STRING: ENSP00000417686
    UBCENSP000003448184STRING: ENSP00000344818
    DICER1ENSP000003437454STRING: ENSP00000343745
    FANCMENSP000002674304STRING: ENSP00000267430
    DROSHAENSP000003398454STRING: ENSP00000339845
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031047gene silencing by RNA IEA--
    GO:0031125rRNA 3'-end processing ISS--
    GO:0071044NOT histone mRNA catabolic process IMP18172165
    GO:0090305nucleic acid phosphodiester bond hydrolysis IDA14536070

    Find genes that share ontologies with ERI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERI1

    1 HMDB Compound for ERI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ERI1 gene: 
    NM_153332.3  

    Unigene Cluster for ERI1:

    Exoribonuclease 1
    Hs.20000  [show with all ESTs]
    Unigene Representative Sequence: NM_153332
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523898 ENST00000519292 ENST00000521844 ENST00000520684 ENST00000520332
    ENST00000518663 ENST00000522612 ENST00000522258 ENST00000250263(uc003wsk.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERI1 (see all 58):
    hsa-miR-219-1-3p hsa-miR-302d hsa-miR-520e hsa-miR-640 hsa-miR-19b-2* hsa-miR-429 hsa-miR-106a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidERI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERI1
    Predesigned siRNA for gene silencing in human, mouse, rat ERI1
    Clone
    Products:
         
    OriGene clones in human, mouse for ERI1 (see all 7)
    OriGene ORF clones in mouse, rat for ERI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERI1 (NM_153332)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERI1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ERI1
    OriGene qSTAR qPCR primer pairs in human, mouse for ERI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERI1
      QuantiTect SYBR Green Assays in human, mouse, rat ERI1
      QuantiFast Probe-based Assays in human, mouse, rat ERI1

    Additional mRNA sequence: 

    AK024646.1 AK226180.1 AK291062.1 AK301506.1 AL137679.1 AY310909.1 BC035279.1 

    11 DOTS entries:

    DT.214460  DT.101957634  DT.100788000  DT.100034162  DT.121471129  DT.86835774  DT.86839753  DT.95369395 
    DT.102826518  DT.425684  DT.70101834 

    Selected AceView cDNA sequences (see all 154):

    AI733576 CA425553 BG198861 CB106489 CR593780 AI290582 NM_153332 BC035279 
    AY310909 AL603275 BM148154 AA767531 BE676273 BF507661 AW673720 AA703117 
    AI651283 CF121648 BM924692 AI784638 AA446269 BE779448 AA133358 BX955796 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ERI1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -                 -                                 
    SP2:              -                                                   
    SP3:                                                                  


    ECgene alternative splicing isoforms for ERI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGAAATA
    ERI1 Expression
    About this image


    ERI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ERI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20000
        Custom PCR Arrays for ERI1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ERI1
    OriGene qSTAR qPCR primer pairs in human, mouse for ERI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERI1
    QuantiTect SYBR Green Assays in human, mouse, rat ERI1
    QuantiFast Probe-based Assays in human, mouse, rat ERI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ERI1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eri11 , 5 exoribonuclease 11, 5 82.42(n)1
    84.06(a)1
      8 (21.16 cM)5
    672761  NM_026067.31  NP_080343.41 
     354652655 
    chicken
    (Gallus gallus)
    Aves ERI11 exoribonuclease 1 73.92(n)
    79.22(a)
      422629  NM_001006450.1  NP_001006450.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERI16
    exoribonuclease 1
    77(a)
    1 ↔ 1
    GL343257.1(1169336-1176315)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80182 Xenopus laevis transcribed sequence with moderate similarity more 77.83(n)    BX851631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151062 Transcribed sequence with moderate similarity to protein more 72.68(n)    AL924198.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eri-11 eri-1 48.84(n)
    39.59(a)
      176868  NM_171245.4  NP_741293.1 
    soybean
    (Glycine max)
    eudicotyledons CA851096.12   -- 88.75(n)    CA851096.1 


    ENSEMBL Gene Tree for ERI1 (if available)
    TreeFam Gene Tree for ERI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERI1 gene
    ERI22  ERI32  

    Find genes that share paralogs with ERI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERI1 (see all 1252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817011521,2
    --8858326(+) GCATAC/TTCATA 1 -- us2k10--------
    rs1867745981,2
    --8858375(+) TTTATC/TATTTT 1 -- us2k10--------
    rs1158808731,2
    C,F--8858464(+) CCCTGT/CCACCC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1126671261,2
    C,F--8858645(+) AGAGAG/CTTTTA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1420761991,2
    --8858688(+) CAGAGC/TAGTTT 1 -- us2k10--------
    rs29792651,2
    C,F,A,H--8858717(-) aaagcC/Gttaaa 1 -- us2k116Minor allele frequency- G:0.48NS EA NA WA 992
    rs745288001,2
    C,F--8858766(+) TCTACG/AGTTAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1156484131,2
    C,F--8858777(+) TATATC/GTCACT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1900912661,2
    --8858785(+) ACTAAC/G/TGCATG 1 -- us2k10--------
    rs38924541,2
    C,F--8858787(-) GTCATG/ACCTTA 1 -- us2k11Minor allele frequency- A:0.15WA 118

    HapMap Linkage Disequilibrium report for ERI1 (8859657 - 8974256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ERI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890331CNV Loss21882294
    nsv831229CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERI1
    DNA2.0 Custom Variant and Variant Library Synthesis for ERI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608739    OMIM disorders: --


    Find genes that share disorders with ERI1           About GenesLikeMe

    Genetic Association Database (GAD): ERI1
    Human Genome Epidemiology (HuGE) Navigator: ERI1 (1 document)

    Export disorders for ERI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERI1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ERI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. (PubMed id 14536070)1, 2, 3 Dominski Z.... Marzluff W.F. (Mol. Cell 2003)
    2. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. (PubMed id 16912046)1, 2, 9 Yang X.-C.... Dominski Z. (J. Biol. Chem. 2006)
    3. Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP. (PubMed id 15451662)1, 2, 9 Cheng Y. and Patel D.J. (J. Mol. Biol. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. (PubMed id 14961122)1, 2 Kennedy S.... Ruvkun G. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex. (PubMed id 23329046)1 Tan D....Tong L. (Science 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90459 HGNC: 23994 AceView: 3'HEXO Ensembl:ENSG00000104626 euGenes: HUgn90459
    ECgene: ERI1 H-InvDB: ERI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERI1 gene:
    Search GeneIP for patents involving ERI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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