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Aliases for ERI1 Gene

Aliases for ERI1 Gene

  • Exoribonuclease 1 2 3 2
  • Histone MRNA 3-End-Specific Exoribonuclease 3 4
  • Three Prime Histone MRNA Exonuclease 1 2 3
  • Histone MRNA 3-Exonuclease 1 3 4
  • 3-5 Exonuclease ERI1 3 4
  • Protein 3hExo 3 4
  • Eri-1 Homolog 3 4
  • THEX1 3 4
  • HEXO 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 1 3
  • Histone MRNA 3 End-Specific Exonuclease 3
  • Three Prime MRNA Exonuclease 1 3
  • 3-5 Exoribonuclease 1 3
  • 3 Exoribonuclease 3
  • EC 3.1.-.- 4
  • 3HEXO 3
  • 3EXO 4

External Ids for ERI1 Gene

Previous Symbols for ERI1 Gene

  • THEX1

Summaries for ERI1 Gene

GeneCards Summary for ERI1 Gene

ERI1 (Exoribonuclease 1) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. GO annotations related to this gene include rRNA binding and 3-5 exonuclease activity. An important paralog of this gene is ERI3.

UniProtKB/Swiss-Prot for ERI1 Gene

  • RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERI1 Gene

Genomics for ERI1 Gene

Genomic Location for ERI1 Gene

Start:
9,002,147 bp from pter
End:
9,116,746 bp from pter
Size:
114,600 bases
Orientation:
Plus strand

Genomic View for ERI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI1 Gene

Regulatory Elements for ERI1 Gene

Proteins for ERI1 Gene

  • Protein details for ERI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV48-ERI1_HUMAN
    Recommended name:
    3-5 exoribonuclease 1
    Protein Accession:
    Q8IV48
    Secondary Accessions:
    • A8K4U7
    • Q9NSX3

    Protein attributes for ERI1 Gene

    Size:
    349 amino acids
    Molecular mass:
    40064 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3-end of histone mRNAs.
    SequenceCaution:
    • Sequence=CAB70871.2; Type=Erroneous termination; Positions=159; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=CAB70871.2; Type=Frameshift; Positions=117; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERI1 Gene

neXtProt entry for ERI1 Gene

Proteomics data for ERI1 Gene at MOPED

Post-translational modifications for ERI1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys67 and Lys269

Other Protein References for ERI1 Gene

No data available for DME Specific Peptides for ERI1 Gene

Domains for ERI1 Gene

Gene Families for ERI1 Gene

HGNC:
  • ERI :Enhanced RNAi three prime mRNA exonucleases

Protein Domains for ERI1 Gene

UniProtKB/Swiss-Prot:

ERI1_HUMAN
Domain:
  • The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3-end histone mRNA exonuclease activity:
    • Q8IV48
  • Contains 1 exonuclease domain.:
    • Q8IV48
  • Contains 1 SAP domain.:
    • Q8IV48
genes like me logo Genes that share domains with ERI1: view

Function for ERI1 Gene

Molecular function for ERI1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Although it can bind simultaneously with SLBP to the 3-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.
UniProtKB/Swiss-Prot Function: RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Enzyme Numbers (IUBMB) for ERI1 Gene

Gene Ontology (GO) - Molecular Function for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IBA --
GO:0003676 nucleic acid binding --
GO:0004527 exonuclease activity --
GO:0008408 3-5 exonuclease activity IDA 14536070
GO:0019843 rRNA binding ISS --
genes like me logo Genes that share ontologies with ERI1: view
genes like me logo Genes that share phenotypes with ERI1: view

Animal Models for ERI1 Gene

MGI Knock Outs for ERI1:

miRNA for ERI1 Gene

miRTarBase miRNAs that target ERI1

No data available for Transcription Factor Targeting and HOMER Transcription for ERI1 Gene

Localization for ERI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERI1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERI1 Gene COMPARTMENTS Subcellular localization image for ERI1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
GO:0071204 histone pre-mRNA 3end processing complex ISS --
genes like me logo Genes that share ontologies with ERI1: view

Pathways for ERI1 Gene

genes like me logo Genes that share pathways with ERI1: view

Pathways by source for ERI1 Gene

2 Cell Signaling Technology pathways for ERI1 Gene

Gene Ontology (GO) - Biological Process for ERI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0031047 gene silencing by RNA IEA --
GO:0031125 rRNA 3-end processing ISS --
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
GO:0090305 nucleic acid phosphodiester bond hydrolysis --
genes like me logo Genes that share ontologies with ERI1: view

Compounds for ERI1 Gene

(1) HMDB Compounds for ERI1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with ERI1: view

Transcripts for ERI1 Gene

Unigene Clusters for ERI1 Gene

Exoribonuclease 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERI1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:

Relevant External Links for ERI1 Gene

GeneLoc Exon Structure for
ERI1
ECgene alternative splicing isoforms for
ERI1

Expression for ERI1 Gene

mRNA expression in normal human tissues for ERI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERI1 Gene

SOURCE GeneReport for Unigene cluster for ERI1 Gene Hs.20000

genes like me logo Genes that share expressions with ERI1: view

Orthologs for ERI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERI1 36
  • 99.52 (n)
  • 99.43 (a)
ERI1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 87 (a)
OneToMany
ERI1 36
  • 86.91 (n)
  • 86.25 (a)
THEX1 37
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ERI1 36
  • 89.97 (n)
  • 91.98 (a)
ERI1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eri1 36
  • 82.42 (n)
  • 84.06 (a)
Eri1 16
Eri1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERI1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERI1 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eri1 36
  • 83.86 (n)
  • 85.22 (a)
chicken
(Gallus gallus)
Aves ERI1 36
  • 73.92 (n)
  • 79.22 (a)
ERI1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERI1 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8018 36
tropical clawed frog
(Silurana tropicalis)
Amphibia eri1 36
  • 70.77 (n)
  • 77.02 (a)
Str.6568 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6758 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15106 36
eri1 36
  • 66.32 (n)
  • 70.24 (a)
eri1 37
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crn-4 37
  • 21 (a)
ManyToMany
eri-1 36
  • 48.84 (n)
  • 39.59 (a)
eri-1 37
  • 16 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes eri1 36
  • 47.72 (n)
  • 39.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for ERI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERI1 Gene

ENSEMBL:
Gene Tree for ERI1 (if available)
TreeFam:
Gene Tree for ERI1 (if available)

Paralogs for ERI1 Gene

Paralogs for ERI1 Gene

genes like me logo Genes that share paralogs with ERI1: view

Variants for ERI1 Gene

Sequence variations from dbSNP and Humsavar for ERI1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6748 -- 9,033,292(+) TAATA(C/T)GAAAA utr-variant-3-prime
rs7853 -- 9,033,304(+) TACGA(A/G)ATTTT utr-variant-3-prime
rs962909 -- 9,008,562(-) TCCTG(C/T)TAAGT intron-variant
rs1016512 -- 9,024,310(-) TTTGG(A/G)ATTTC intron-variant
rs1025396 -- 9,024,417(-) aaaga(A/G)aagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERI1 Gene

Variant ID Type Subtype PubMed ID
nsv890331 CNV Loss 21882294
nsv831229 CNV Gain+Loss 17160897

Relevant External Links for ERI1 Gene

HapMap Linkage Disequilibrium report
ERI1

Disorders for ERI1 Gene

Relevant External Links for ERI1

Genetic Association Database (GAD)
ERI1
Human Genome Epidemiology (HuGE) Navigator
ERI1
genes like me logo Genes that share disorders with ERI1: view

No data available for UniProtKB/Swiss-Prot for ERI1 Gene

Publications for ERI1 Gene

  1. Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP. (PMID: 15451662) Cheng Y. … Patel D.J. (J. Mol. Biol. 2004) 3 4 23
  2. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. (PMID: 16912046) Yang X.-C. … Dominski Z. (J. Biol. Chem. 2006) 3 4 23
  3. A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. (PMID: 14536070) Dominski Z. … Marzluff W.F. (Mol. Cell 2003) 2 3 4
  4. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. (PMID: 14961122) Kennedy S. … Ruvkun G. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ERI1 Gene

Sources for ERI1 Gene

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