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ERH Gene

protein-coding   GIFtS: 60

GC14M068916
enhancer of rudimentary homolog (Drosophila)
(Previous name: enhancer of rudimentary (Drosophila) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DROER 1, 2
FLJ27340 2
Descriptions
enhancer of rudimentary (Drosophila) homolog 1
enhancer of rudimentary homolog 2
enhancer of rudimentary homolog (Drosophila) 2
External Ids
HGNC: 34471
Entrez Gene: 20792
UniProtKB: P840903
Ensembl: ENSG000001006327
Search outside databases for aliases for ERH gene

Previous GC identifers: GC14M067352 GC14M063643 GC14M067836

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ERH_HUMAN, P84090
Function: May have a role in the cell cycle

Gene Wiki entry for ERH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ERH gene  

Entrez Gene cytogenetic band: 14q24.1|7q34   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

ERH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068916:     (about GC identifiers)

Start:
68,916,598 bp from pter
End:
68,934,774 bp from pter
Size:
18,177 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ERH_HUMAN, P84090 (See protein sequence)
Recommended Name: Enhancer of rudimentary homolog  
Size: 104 amino acids; 12259 Da
Subunit: Homodimer (By similarity)
PDB structure from and Proteopedia :
1W9G (3D)    2NML (3D)    
Secondary accessions: P70659 Q14259

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004441.1  

    ENSEMBL proteins: 
    ENSP00000216520 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ERH)
    Human Recombinant Proteins from Abnova (ERH)
                  OriGene Purified Recombinant Human Protein: ERH 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for ERH: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ERH
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ERH), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ERH)
    Novus Biologicals Antibodies for ERH

    Assays for ERH: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000781 Enh_rudimentary


       GeneDecks  ERH for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P84090

    ProtoNet protein and cluster: P84090

    UniProtKB/Swiss-Prot: ERH_HUMAN, P84090
    Similarity: Belongs to the E(R) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ERH)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ERH)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004450

                  Applied Biosystems Silencer® siRNAs for ERH

                  Sigma-Aldrich siRNA for ERH  
                         Sigma-Aldrich shRNA for ERH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ERH
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004450
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004450
                                     untagged cDNA clone in CMV expression vector: NM_004450 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004450

    UniProtKB/Swiss-Prot: ERH_HUMAN, P84090
    Function: May have a role in the cell cycle

    Genatlas biochemistry entry for ERH:
    Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  ERH 


    5/16 Interacting proteins for ERH (ENSP000002165203 P840901, 2) via UniProtKB, MINT, and/or STRING (see all 16 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTDP1Q9Y5B02STRING (score=.753) MINT-51652 MINT-51649
    CNBPP626331EBI-711389, EBI-1047529
    EIF1BO607391EBI-711389, EBI-1043343
    ILKQ134181EBI-711389, EBI-747644
    COPS6Q7L5N12MINT-64024
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process TAS9074495
    GO:0006213 pyrimidine nucleoside metabolic process TAS8786099
    GO:0007049 cell cycle IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ERH

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ERH)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ERH)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004450

                  Sigma-Aldrich siRNA for ERH  
                         Sigma-Aldrich shRNA for ERH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004450  

    REFSEQ mRNAs for ERH gene: 

    NM_004450.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004450  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004450
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004450
                                     untagged cDNA clone in CMV expression vector: NM_004450 

    Additional cDNA sequence: 

    AK130850.1 AK312186.1 BC014301.2 BC071709.1 BT006877.1 CR450298.1 CR542178.1 CR618598.1 
    D85758.1 U66871.1 

    19 DOTS entries:

    DT.100033245  DT.100033139  DT.418339  DT.95319046  DT.100815696  DT.120778709  DT.95247009  DT.120778739 
    DT.120778758  DT.100045840  DT.92441639  DT.95246991  DT.100815690  DT.92441638  DT.95247003  DT.100704839 
    DT.100815689  DT.101985095  DT.121128839 

    24/471 AceView cDNA sequences (see all 471 ):

    AA304707 BM717869 AA251041 BF197180 CA421504 CA848811 BQ130635 CA389518 
    BM855072 BQ773898 CR542178 BM832603 CA773307 BM830179 AA991960 BQ614050 
    BM727528 BQ028613 CR618598 BM789786 BU682272 AA565449 BU622711 CA308241 

    highest scoring ESTs for ERH:

    D85758 AA314437 AL708262 AU126581 AV755991 AW238418 AW361524 AW361530 BC014301 BC071709 

    Unigene Cluster for ERH:

    Enhancer of rudimentary homolog (Drosophila)
    Hs.509791  [show with all ESTs]
    Unigene Representative Sequence: BQ956733


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ERH

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                -               
    SP2:                                                
    SP3:                    -           -               

    About this scheme

    ECgene alternative splicing isoforms for ERH

    1 Ensembl transcript including schematic representation:
    ENST00000216520  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ERH expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ERH

    1 / 2 / 3

    3 probe-sets matching ERH gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    39079_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 D85758 1.00 1.00 1.00 1

    200043_at2, 3 U133-B 1 1.00 1.00 -- -- NM_004450 0.60 1.00 0.82 1

    200043_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCCTCAAGAT

    SOURCE GeneReport for Unigene cluster: Hs.509791

    Expression variation in blood from EXPOLDB for ERH

    UniProtKB/Swiss-Prot: ERH_HUMAN, P84090
    Tissue specificity: Expressed in all tissues examined

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ERH gene from 5/15 species (see all 15 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ERH1   -- enhancer of rudimentary homolog (Drosophila) 95.51(n)
    100(a)
    480371  XM_537493.2  XP_537493.2 
    chimpanzee
    (Pan troglodytes)
    ERH1   -- enhancer of rudimentary homolog (Drosophila) 100(n)
    100(a)
    452997  XM_001142504.1  XP_001142504.1 
    cow
    (Bos taurus)
    ERH1   -- enhancer of rudimentary homolog (Drosophila) 95.51(n)
    100(a)
    508901  NM_001034336.1  NP_001029508.1 
    rat
    (Rattus norvegicus)
    Erh1   -- enhancer of rudimentary homolog (Drosophila) 93.27(n)
    100(a)
    681415  XM_001061649.1  XP_001061649.1 
    mouse
    (Mus musculus)
    Erh5
    ENSMUSG000000634121
    125
    enhancer of rudimentary homolog (Drosophila)5
    predicted gene, ENSMUSG000000634121
    92.95(n)1
    100(a)1
    1000427771  XM_001478939.11  XP_001478989.11 
     AK0104515  AK0806175  (see all 21)
    About this table        Species with no ortholog for ERH

    ENSEMBL Gene Tree for ERH
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/79 NCBI SNPs in ERH are shown (see all 79 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 49)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs26043051,2
    H68916706(+) TGAATG/TTTATA 1 -- ut314Minor allele frequency- T:0.00EU EA WA 418
    --
    rs18035441,2
    A68916810(-) TTTCTC/TTTTTT 1 -- ut310--------
    rs9592421,2
    A,C,F,H,O68919881(-) GGTCCA/GTTTTT 1 -- int127Minor allele frequency- T:0.01EA NA NS EU WA 1926
    rs71480161,2
    A,C,F,H68917356(+) CCCAAT/GATGTT 1 -- int17Minor allele frequency- G:0.01EU EA WA NA 552
    rs12756731,2
    A,C,F,H68933066(+) GGAACT/AGAAAT 1 -- int18Minor allele frequency- A:0.30EU EA WA 836
    rs128956201,2
    A,C,F68933596(+) TTTCAG/ATACTT 1 -- int11Minor allele frequency- A:0.40NA 90
    rs71403581,2
    C,F,H68921436(+) ACTACT/GTCAAT 1 -- int18Minor allele frequency- G:0.06EU EA WA 838
    rs177641551,2
    C,F,H68922826(+) TATCAT/CAAGGT 1 -- int111Minor allele frequency- C:0.19NA EU EA WA 978
    rs49027171,2
    C,F,H68930195(+) ctacaA/Ctaaaa 1 -- int14Minor allele frequency- C:0.33EU EA WA 418
    rs125891071,2
    C,F,H68930740(+) TCACTC/TATTAT 1 -- int13Minor allele frequency- T:0.03EU EA 248
    About this table

    HapMap Linkage Disequilibrium images for ERH (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 601191

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for ERH gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2079 HGNC: 3447 AceView: ERH Ensembl:ENSG00000100632 euGenes: HUgn2079
    ECgene: ERH H-InvDB: ERH
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ERH Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ERH:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ERH-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ERH Antibodies for ERH
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ERH Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
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     Recombinant & Natural Proteins  

     Recombinant Proteins (ERH)
     Antibodies (ERH)
     Chimera RNAi (ERH)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ERH)
     Antibodies (ERH)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for ERH




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ERH

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