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Aliases for ERH Gene

Aliases for ERH Gene

  • Enhancer Of Rudimentary Homolog (Drosophila) 2 3 5
  • Enhancer Of Rudimentary (Drosophila) Homolog 2
  • Enhancer Of Rudimentary Homolog 3
  • DROER 3

External Ids for ERH Gene

Previous GeneCards Identifiers for ERH Gene

  • GC14M067352
  • GC14M063643
  • GC14M067836
  • GC14M068916
  • GC14M069846
  • GC14M050015

Summaries for ERH Gene

GeneCards Summary for ERH Gene

ERH (Enhancer Of Rudimentary Homolog (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ERH Gene

  • May have a role in the cell cycle.

Gene Wiki entry for ERH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERH Gene

Genomics for ERH Gene

Regulatory Elements for ERH Gene

Enhancers for ERH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F068931 1.8 FANTOM5 Ensembl ENCODE 31.6 +452.9 452927 29.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ERH ACTN1 RPL7AP6 CCDC177 ZFP36L1 DCAF5 GALNT16 GC14P068937
GH14F070358 1.2 ENCODE 18.1 -960.8 -960838 1.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC MED6 COX16 RPL7AP6 ERH PTTG4P SUSD6 KRT18P7 SLC8A3 PIR53064
GH14F068722 1.4 Ensembl ENCODE 15.3 +674.8 674758 3.0 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 ERH ENSG00000258623 RNU6-921P GC14M068736 GC14P068694
GH14F069190 1.2 ENCODE 15.3 +206.9 206890 1.7 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 RPL7AP6 ERH DDX18P1 SUSD6 EXD2 ENSG00000258957
GH14F068542 1.7 FANTOM5 Ensembl ENCODE 9.7 +849.1 849103 13.8 PKNOX1 ARID4B FEZF1 BRCA1 GLIS2 KLF7 FOS ZNF263 SP5 NFYC ERH ACTN1 GC14P068551 PIR53204
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERH on UCSC Golden Path with GeneCards custom track

Promoters for ERH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001458460 -1073 5400 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for ERH Gene

69,380,123 bp from pter
69,398,627 bp from pter
18,505 bases
Minus strand

Genomic View for ERH Gene

Genes around ERH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERH Gene

Proteins for ERH Gene

  • Protein details for ERH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Enhancer of rudimentary homolog
    Protein Accession:
    Secondary Accessions:
    • B2R5H2
    • P70659
    • Q14259

    Protein attributes for ERH Gene

    104 amino acids
    Molecular mass:
    12259 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with POLDIP3. Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for ERH Gene

neXtProt entry for ERH Gene

Post-translational modifications for ERH Gene

  • Ubiquitination at Lys 41, Lys 84, and Lys 90
  • Modification sites at PhosphoSitePlus

Other Protein References for ERH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ERH

No data available for DME Specific Peptides for ERH Gene

Domains & Families for ERH Gene

Protein Domains for ERH Gene


Suggested Antigen Peptide Sequences for ERH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the E(R) family.
  • Belongs to the E(R) family.
genes like me logo Genes that share domains with ERH: view

No data available for Gene Families for ERH Gene

Function for ERH Gene

Molecular function for ERH Gene

GENATLAS Biochemistry:
Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in the cell cycle.

Gene Ontology (GO) - Molecular Function for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008327 methyl-CpG binding IDA 25284789
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ERH: view
genes like me logo Genes that share phenotypes with ERH: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERH Gene

Localization for ERH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERH gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030496 midbody IDA 15166316
GO:0034709 methylosome IDA 25284789
genes like me logo Genes that share ontologies with ERH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ERH Gene

Pathways & Interactions for ERH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9074495
GO:0006213 pyrimidine nucleoside metabolic process TAS 8786099
GO:0006221 pyrimidine nucleotide biosynthetic process IEA --
GO:0007049 cell cycle IEA --
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with ERH: view

No data available for Pathways by source and SIGNOR curated interactions for ERH Gene

Transcripts for ERH Gene

Unigene Clusters for ERH Gene

Enhancer of rudimentary homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP3: - -

Relevant External Links for ERH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ERH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERH Gene

This gene is overexpressed in NK cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERH Gene

Protein tissue co-expression partners for ERH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERH Gene:


SOURCE GeneReport for Unigene cluster for ERH Gene:


mRNA Expression by UniProt/SwissProt for ERH Gene:

Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with ERH: view

No data available for mRNA differential expression in normal tissues for ERH Gene

Orthologs for ERH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERH 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia ERH 35
  • 100 (a)
(Bos Taurus)
Mammalia ERH 34 35
  • 95.51 (n)
(Canis familiaris)
Mammalia ERH 34 35
  • 95.51 (n)
(Mus musculus)
Mammalia Erh 34 16 35
  • 92.95 (n)
(Rattus norvegicus)
Mammalia Erh 34
  • 92.95 (n)
(Ornithorhynchus anatinus)
Mammalia ERH 35
  • 56 (a)
(Gallus gallus)
Aves ERH 34 35
  • 84.62 (n)
(Anolis carolinensis)
Reptilia ERH 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia erh 34
  • 83.33 (n)
Str.6458 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4423 34
(Danio rerio)
Actinopterygii erh 34 35
  • 83.65 (n)
e(r) 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12367 34
fruit fly
(Drosophila melanogaster)
Insecta e(r) 36 34 35
  • 67.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000515 34
  • 67 (n)
(Caenorhabditis elegans)
Secernentea T21C9.4 34 35
  • 53.06 (n)
F35G12.11 35
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ER 34
  • 51.33 (n)
(Oryza sativa)
Liliopsida Os02g0611450 34
  • 53.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5915 35
  • 85 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5461 34
Species where no ortholog for ERH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERH Gene

Gene Tree for ERH (if available)
Gene Tree for ERH (if available)

Paralogs for ERH Gene Pseudogenes for ERH Gene

genes like me logo Genes that share paralogs with ERH: view

No data available for Paralogs for ERH Gene

Variants for ERH Gene

Sequence variations from dbSNP and Humsavar for ERH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1054482 -- 69,380,339(-) TTCTT(C/T)TTTTT downstream-variant-500B, utr-variant-3-prime
rs1054551 -- 69,380,217(-) CCCTT(C/T)TTCAA downstream-variant-500B, utr-variant-3-prime
rs10671245 -- 69,394,612(+) AAATA(-/AAAC)AACAA intron-variant
rs111724638 -- 69,395,974(+) CTCAA(C/T)GTGGG intron-variant
rs111840678 -- 69,379,980(+) TAGCT(-/TCACATAAA)TCACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ERH Gene

Variant ID Type Subtype PubMed ID
esv3634836 CNV gain 21293372

Variation tolerance for ERH Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERH Gene

Disorders for ERH Gene

Relevant External Links for ERH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ERH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERH Gene

Publications for ERH Gene

  1. Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PMID: 8786099) Isomura M. … Nakamura Y. (Genomics 1996) 2 3 4 22 64
  2. The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PMID: 9074495) Gelsthorpe M. … Tsubota S.I. (Gene 1997) 2 3 4 64
  3. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H. … Akiyama T. (Cell Rep 2014) 3 4 64
  4. Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. (PMID: 15794639) Wan C. … Rose R.B. (Biochemistry 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ERH Gene

Sources for ERH Gene

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