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Aliases & Descriptions for ERH
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DROER 1, 2 | | FLJ27340 2 |
| | | Descriptions |
|---|
| enhancer of rudimentary (Drosophila) homolog 1 | | enhancer of rudimentary homolog 2 | | enhancer of rudimentary homolog (Drosophila) 2 |
|
| | Search outside databases for aliases for ERH genePrevious GC identifers: GC14M067352 GC14M063643 GC14M067836 |
Summaries for ERH(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Function: May have a role in the cell cycleGene Wiki entry for ERH |
Genomic Location for ERH
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ERH gene 
Entrez Gene cytogenetic band: 14q24.1|7q34 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1ERH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M068916:
(about GC identifiers)
Start:
|
68,916,598 bp from pter |
End:
|
68,934,774 bp from pter |
Size:
|
18,177 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000014.7 NT_026437.11
| Proteins for ERH
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ERH_HUMAN, P84090 (See
protein sequence)Recommended Name: Enhancer of rudimentary homolog Size: 104 amino acids; 12259 Da
Subunit: Homodimer (By similarity)
PDB structure from and Proteopedia :1W9G (3D)
 2NML (3D)
 
Secondary accessions: P70659 Q14259Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004441.1
ENSEMBL proteins: ENSP00000216520
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: ERH 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ERH: Assays for ERH: | Protein
Domains/ Families for ERH(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P84090
ProtoNet protein and cluster: P84090 UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Similarity: Belongs to the E(R) family | Gene Function for ERH
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004450
Applied Biosystems Silencer® siRNAs for ERH
Sigma-Aldrich siRNA for ERH  Sigma-Aldrich shRNA for ERH  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004450                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004450                                  untagged cDNA clone in CMV expression vector: NM_004450 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004450
UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Function: May have a role in the cell cycleGenatlas biochemistry entry for ERH:Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for ERH
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ERH 
5/16 Interacting proteins for ERH (ENSP000002165203 P840901, 2) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
TAS | 9074495 | | GO:0006213 | pyrimidine nucleoside metabolic process |
TAS | 8786099 | | GO:0007049 | cell cycle |
IEA | -- | About this table
|
Drugs & Compounds for ERH(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ERH
|
Transcripts for ERH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004450
Sigma-Aldrich siRNA for ERH  Sigma-Aldrich shRNA for ERH  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004450 REFSEQ mRNAs for ERH gene: NM_004450.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004450               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004450                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004450                                  untagged cDNA clone in CMV expression vector: NM_004450  Additional cDNA sequence: AK130850.1 AK312186.1 BC014301.2 BC071709.1 BT006877.1 CR450298.1 CR542178.1 CR618598.1 D85758.1 U66871.1 19 DOTS entries: DT.100033245 DT.100033139 DT.418339 DT.95319046 DT.100815696 DT.120778709 DT.95247009 DT.120778739 DT.120778758 DT.100045840 DT.92441639 DT.95246991 DT.100815690 DT.92441638 DT.95247003 DT.100704839 DT.100815689 DT.101985095 DT.121128839 24/471 AceView cDNA sequences (see all 471
):AA304707 BM717869 AA251041 BF197180 CA421504 CA848811 BQ130635 CA389518 BM855072 BQ773898 CR542178 BM832603 CA773307 BM830179 AA991960 BQ614050 BM727528 BQ028613 CR618598 BM789786 BU682272 AA565449 BU622711 CA308241
highest scoring ESTs for ERH:D85758 AA314437 AL708262 AU126581 AV755991 AW238418 AW361524 AW361530 BC014301 BC071709 Unigene Cluster for ERH: Enhancer of rudimentary homolog (Drosophila) Hs.509791 [show with all ESTs]Unigene Representative Sequence: BQ956733
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ERH
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ERH
1 Ensembl transcript including schematic representation: ENST00000216520
|
Expression for ERH
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ERH expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ERH
1 / 2 / 3 3 probe-sets matching ERH gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCCTCAAGAT
SOURCE GeneReport for Unigene cluster: Hs.509791
Expression variation in blood from EXPOLDB for ERH UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Tissue specificity: Expressed in all tissues examined |
Orthologs for ERH
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ERH gene from 5/15 species (see all 15
)
About this table Species with no ortholog for ERH
ENSEMBL Gene Tree for ERH | Paralogs for ERH(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for ERH(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ERH (up to first 250kb)
|
Disorders & Mutations for ERH
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601191
|
Medical News for ERH(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ERH (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for ERH gene (see all 13
):- Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PubMed id 8786099)1, 2, 3, 4 Isomura M.... Nakamura Y. (1996)
- The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PubMed id 9074495)2, 3, 4 Gelsthorpe M....Tsubota S.I. (1997)
- Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. (PubMed id 15794639)3, 4 Wan C.... Rose R.B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Enhancer of the rudimentary gene homologue (ERH) expression pattern in sporadic human breast cancer and normal breast tissue. (PubMed id 18500978)3 Zafrakas M....Dahl E. (2008)
- Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog. (PubMed id 18081865)3 Lukasik A....Kozlowski P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks. (PubMed id 17444515)3 Jin T....Zhang Y.Z. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
|
Search for ERH
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ERH
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ERH
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ERH(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ERH(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ERH:

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Incremental update: 13 Oct 2009
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