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Aliases for ERH Gene

Aliases for ERH Gene

  • ERH, MRNA Splicing And Mitosis Factor 2 3 5
  • Enhancer Of Rudimentary (Drosophila) Homolog 2
  • Enhancer Of Rudimentary Homolog (Drosophila) 2
  • Enhancer Of Rudimentary Homolog 3
  • DROER 3

External Ids for ERH Gene

Previous GeneCards Identifiers for ERH Gene

  • GC14M067352
  • GC14M063643
  • GC14M067836
  • GC14M068916
  • GC14M069846
  • GC14M050015

Summaries for ERH Gene

GeneCards Summary for ERH Gene

ERH (ERH, MRNA Splicing And Mitosis Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ERH Gene

  • May have a role in the cell cycle.

Gene Wiki entry for ERH Gene

Additional gene information for ERH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERH Gene

Genomics for ERH Gene

GeneHancer (GH) Regulatory Elements for ERH Gene

Promoters and enhancers for ERH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069396 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 566 -0.3 -304 4.5 PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ERH SLC39A9 SRSF5 DDX18P1 DCAF5 RPL7AP6 GALNT16 PLEKHD1
GH14I069190 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 +206.9 206889 1.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF766 E2F8 EXD2 SRSF5 DCAF5 ERH DDX18P1 ENSG00000258957 LOC105370550
GH14I069267 Enhancer 0.9 Ensembl ENCODE 24.6 +130.1 130142 2.6 ZSCAN4 YBX1 GLI4 CDC5L ZKSCAN1 ZNF664 ZFHX2 CTBP1 ZNF207 EGR2 ERH SRSF5 RPL7AP6 DDX18P1 SUSD6 DCAF5 EXD2 SLC39A9 GALNT16 ACTN1
GH14I069715 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -319.5 -319474 5 SMAD1 NFIB MZF1 ZNF195 RAD21 ZNF121 ZNF350 ATF7 RCOR1 RUNX3 SRSF5 EXD2 ADAM21 ERH SUSD6 ADAM20 ADAM20P1 ENSG00000258957 PIR54293
GH14I070358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -960.8 -960773 2 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 COX16 GC14P070361 RNU2-51P SRSF5 MED6 SUSD6 RPL7AP6 ADAM20P1 PTTG4P ERH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERH gene promoter:

Genomic Locations for ERH Gene

Genomic Locations for ERH Gene
chr14:69,380,123-69,398,627
(GRCh38/hg38)
Size:
18,505 bases
Orientation:
Minus strand
chr14:69,846,840-69,865,344
(GRCh37/hg19)

Genomic View for ERH Gene

Genes around ERH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERH Gene

Proteins for ERH Gene

  • Protein details for ERH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84090-ERH_HUMAN
    Recommended name:
    Enhancer of rudimentary homolog
    Protein Accession:
    P84090
    Secondary Accessions:
    • B2R5H2
    • P70659
    • Q14259

    Protein attributes for ERH Gene

    Size:
    104 amino acids
    Molecular mass:
    12259 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with POLDIP3. Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for ERH Gene

neXtProt entry for ERH Gene

Post-translational modifications for ERH Gene

  • Ubiquitination at Lys41, posLast=8484, and posLast=9090

Other Protein References for ERH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERH Gene

Domains & Families for ERH Gene

Gene Families for ERH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84090

UniProtKB/Swiss-Prot:

ERH_HUMAN :
  • Belongs to the E(R) family.
Family:
  • Belongs to the E(R) family.
genes like me logo Genes that share domains with ERH: view

Function for ERH Gene

Molecular function for ERH Gene

GENATLAS Biochemistry:
Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in the cell cycle.

Gene Ontology (GO) - Molecular Function for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 21516116
GO:0008327 methyl-CpG binding IDA 25284789
genes like me logo Genes that share ontologies with ERH: view
genes like me logo Genes that share phenotypes with ERH: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERH Gene

Localization for ERH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERH gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030496 midbody IDA 15166316
GO:0034709 methylosome IDA 25284789
genes like me logo Genes that share ontologies with ERH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ERH Gene

Pathways & Interactions for ERH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9074495
GO:0006213 pyrimidine nucleoside metabolic process TAS 8786099
GO:0006221 pyrimidine nucleotide biosynthetic process IEA --
GO:0007049 cell cycle IEA --
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with ERH: view

No data available for Pathways by source and SIGNOR curated interactions for ERH Gene

Drugs & Compounds for ERH Gene

No Compound Related Data Available

Transcripts for ERH Gene

Unigene Clusters for ERH Gene

Enhancer of rudimentary homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:
SP3: - -

Relevant External Links for ERH Gene

GeneLoc Exon Structure for
ERH
ECgene alternative splicing isoforms for
ERH

Expression for ERH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERH Gene

This gene is overexpressed in NK cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERH Gene



Protein tissue co-expression partners for ERH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERH Gene:

ERH

SOURCE GeneReport for Unigene cluster for ERH Gene:

Hs.509791

mRNA Expression by UniProt/SwissProt for ERH Gene:

P84090-ERH_HUMAN
Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for ERH Gene

  • Kidney(4.3)
  • Pancreas(3.3)
  • Eye(2.7)
  • Liver(2.6)
  • Lung(2.5)
  • Blood(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ERH: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERH Gene

Orthologs for ERH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERH 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia ERH 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERH 33 34
  • 95.51 (n)
dog
(Canis familiaris)
Mammalia ERH 33 34
  • 95.51 (n)
mouse
(Mus musculus)
Mammalia Erh 33 16 34
  • 92.95 (n)
rat
(Rattus norvegicus)
Mammalia Erh 33
  • 92.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERH 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERH 33 34
  • 84.62 (n)
lizard
(Anolis carolinensis)
Reptilia ERH 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia erh 33
  • 83.33 (n)
Str.6458 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4423 33
zebrafish
(Danio rerio)
Actinopterygii erh 33 34
  • 83.65 (n)
e(r) 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12367 33
fruit fly
(Drosophila melanogaster)
Insecta e(r) 35 33 34
  • 67.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000515 33
  • 67 (n)
worm
(Caenorhabditis elegans)
Secernentea T21C9.4 33 34
  • 53.06 (n)
F35G12.11 34
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ER 33
  • 51.33 (n)
rice
(Oryza sativa)
Liliopsida Os02g0611450 33
  • 53.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5915 34
  • 85 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5461 33
Species where no ortholog for ERH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERH Gene

ENSEMBL:
Gene Tree for ERH (if available)
TreeFam:
Gene Tree for ERH (if available)

Paralogs for ERH Gene

Pseudogenes.org Pseudogenes for ERH Gene

genes like me logo Genes that share paralogs with ERH: view

No data available for Paralogs for ERH Gene

Variants for ERH Gene

Sequence variations from dbSNP and Humsavar for ERH Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000002856 -- 69,381,483(-) T/C intron_variant
rs1000200655 -- 69,397,360(-) C/T intron_variant
rs1000614845 -- 69,397,586(-) C/T intron_variant
rs1000639166 -- 69,391,510(-) T/G intron_variant
rs1000755381 -- 69,386,116(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERH Gene

Variant ID Type Subtype PubMed ID
esv3634836 CNV gain 21293372

Variation tolerance for ERH Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERH Gene

Disorders for ERH Gene

No disorders were found for ERH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERH Gene

Publications for ERH Gene

  1. Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PMID: 8786099) Isomura M … Nakamura Y (Genomics 1996) 2 3 4 22 58
  2. The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PMID: 9074495) Gelsthorpe M … Tsubota SI (Gene 1997) 2 3 4 58
  3. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. (PMID: 25284789) Takai H … Akiyama T (Cell reports 2014) 3 4 58
  4. Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. (PMID: 23236152) Weng MT … Luo J (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 58
  5. Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. (PMID: 15794639) Wan C … Rose RB (Biochemistry 2005) 3 4 58

Products for ERH Gene

Sources for ERH Gene

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