ERH Gene
protein-coding GIFtS: 52
GCID: GC14M069846
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enhancer of rudimentary homolog (Drosophila)(Previous name: enhancer of rudimentary (Drosophila) homolog )
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Aliases
for ERH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Enhancer Of Rudimentary Homolog (Drosophila)1 2 | | DROER1 2 | | Enhancer Of Rudimentary (Drosophila) Homolog1 | | Enhancer Of Rudimentary Homolog2 |
Export aliases for ERH gene to outside databasesPrevious GC identifers: GC14M067352 GC14M063643 GC14M067836 GC14M068916 GC14M050015 |
Summaries
for ERH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Function: May have a role in the cell cycle
Gene Wiki entry for ERH
|
Genomic Views
for ERH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ERH gene promoter:
GR LHX3b/Lhx3b p300 HNF-1A E2F-1 E2F deltaCREB HNF-1 LHX3a/Lhx3a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ERH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.1|7q34 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1ERH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M069846: view genomic region
(about GC identifiers)
Start:
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69,846,840 bp from pter |
End:
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69,865,344 bp from pter |
Size:
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18,505 bases |
Orientation:
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minus strand |
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Proteins
for ERH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ERH_HUMAN, P84090 (See
protein sequence)Recommended Name: Enhancer of rudimentary homolog Size: 104 amino acids; 12259 Da
Subunit: Homodimer (By similarity). Interacts with POLDIP3
2 PDB 3D structures from  and Proteopedia  for ERH:1W9G (3D)
2NML (3D)
Secondary accessions: B2R5H2 P70659 Q14259Explore the universe of human proteins at neXtProt for ERH: NX_P84090
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P84090
ERH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004441.1
ENSEMBL proteins: ENSP00000451080 ENSP00000450503
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ERH for ontologies About GeneDecksing
ERH Antibody Products:
Assay Products for ERH: |
Protein
Domains /
Families
for ERH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ERH for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P84090ProtoNet protein and cluster: P84090 UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Similarity: Belongs to the E(R) family |
Function
for ERH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Function: May have a role in the cell cycle Genatlas biochemistry entry for ERH:Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ERH (NM_004450) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ERH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERH |
6 GenomeRNAi human phenotypes for ERH:
|
Pathways & Interactions
for ERH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERH
5/64 Interacting proteins for ERH (P840902, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 64)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ERH for ontologies About GeneDecksing
|
Drugs & Compounds
for ERH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ERH
Search CenterWatch for drugs/clinical trials and news about ERH
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Transcripts
for ERH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ERH gene: NM_004450.2 Unigene Cluster for ERH: Enhancer of rudimentary homolog (Drosophila) Hs.509791 [show with all ESTs]Unigene Representative Sequence: BQ9567334 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000557016(uc001xlc.2) ENST00000216520 ENST00000557697 ENST00000555373
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ERH (NM_004450) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ERH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERH |
Additional cDNA sequence: AK130850.1 AK312186.1 BC014301.2 BC071709.1 BT006877.1 CR450298.1 CR542178.1 D85758.1 U66871.1 19 DOTS entries: DT.100033245 DT.100033139 DT.418339 DT.95319046 DT.100815696 DT.120778709 DT.95247009 DT.120778739 DT.120778758 DT.100045840 DT.92441639 DT.95246991 DT.100815690 DT.92441638 DT.95247003 DT.100704839 DT.100815689 DT.101985095 DT.121128839 24/471 AceView cDNA sequences (see all 471): BM717869 BM682215 BQ182459 CR542178 AI927616 CA389518 BQ028613 BM727018 CR450298 CB126653 AI523468 N90271 BM509606 W68100 BM855072 BQ182464 BU951006 AI554751 AI620926 BM851819 BM561361 CD517282 R96136 CD673416
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ERH About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | |
ECgene alternative splicing isoforms for ERH
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Expression
for ERH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ERH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTCAAGAT
About this image
See ERH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ERH
SOURCE GeneReport for Unigene cluster: Hs.509791
UniProtKB/Swiss-Prot: ERH_HUMAN, P84090Tissue specificity: Expressed in all tissues examined
SABiosciences Custom PCR Arrays for ERH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ERH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ERH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERH |
Orthologs
for ERH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for ERH gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for ERH (if available)
TreeFam Gene Tree for ERH (if available) |
Paralogs
for ERH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ERH gene
ERH for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ERH
PGOHUM00000261957 PGOHUM00000243206 PGOHUM00000233594
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Genomic Variants
for ERH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ERH (69846840 - 69865344 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ERH: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ERH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ERH for disorders About GeneDecksing
OMIM gene information: 601191
OMIM disorders: --
6  diseases for ERH: About MalaCardsdental fluorosis retinal perforation metastasis efficiency breast cancer
retinitis malaria
Export disorders for ERH gene to outside databases
|
Publications
for ERH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ERH gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with ERH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PubMed id 8786099)1, 2, 3, 9 Isomura M.... Nakamura Y. (1996)
- The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PubMed id 9074495)1, 2, 3 Gelsthorpe M....Tsubota S.I. (1997)
- Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. (PubMed id 15794639)1, 2 Wan C.... Rose R.B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosacch aromyces pombe. (PubMed id 23145069)1 Krzyzanowski M.K....Kozlowski P. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- Evolutionarily conserved protein ERH controls CENP-E m RNA splicing and is required for the survival of KRAS mutant cancer cells. (PubMed id 23236152)1 Weng M.T....Luo J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Enhancer of rudimentary homolog (ERH) plays an essenti al role in the progression of mitosis by promoting mitotic chromosome alignment. (PubMed id 22704934)1 Fujimura A....Kimura K. (2012)
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External Searches for ERH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ERH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ERH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ERH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ERH gene:
Search GeneIP for patents involving ERH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ERH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ERH | | OriGene shRNA RFP for ERH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ERH | | | OriGene Protein Over-expression Lysate for ERH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ERH | | OriGene 3'-UTR Clone for ERH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ERH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ERH | | OriGene Custom Protein Services for ERH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ERH | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ERH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERH |
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| | | | Search Tocris compounds for ERH |
| |  |  |  |  | | | | | | Recombinant Protein for ERH |
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 | | | ERH Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for ERH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERH |
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