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Aliases for ERH Gene

Aliases for ERH Gene

  • Enhancer Of Rudimentary Homolog (Drosophila) 2 3 5
  • Enhancer Of Rudimentary (Drosophila) Homolog 2
  • DROER 3

External Ids for ERH Gene

Previous GeneCards Identifiers for ERH Gene

  • GC14M067352
  • GC14M063643
  • GC14M067836
  • GC14M068916
  • GC14M069846
  • GC14M050015

Summaries for ERH Gene

GeneCards Summary for ERH Gene

ERH (Enhancer Of Rudimentary Homolog (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ERH Gene

  • May have a role in the cell cycle.

Gene Wiki entry for ERH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERH Gene

Genomics for ERH Gene

Regulatory Elements for ERH Gene

Enhancers for ERH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERH on UCSC Golden Path with GeneCards custom track

Promoters for ERH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERH on UCSC Golden Path with GeneCards custom track

Genomic Location for ERH Gene

69,380,123 bp from pter
69,398,627 bp from pter
18,505 bases
Minus strand

Genomic View for ERH Gene

Genes around ERH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERH Gene

Proteins for ERH Gene

  • Protein details for ERH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Enhancer of rudimentary homolog
    Protein Accession:
    Secondary Accessions:
    • B2R5H2
    • P70659
    • Q14259

    Protein attributes for ERH Gene

    104 amino acids
    Molecular mass:
    12259 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with POLDIP3. Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with CHTOP (PubMed:25284789).

    Three dimensional structures from OCA and Proteopedia for ERH Gene

neXtProt entry for ERH Gene

Proteomics data for ERH Gene at MOPED

Post-translational modifications for ERH Gene

  • Ubiquitination at Lys 41, Lys 84, and Lys 90
  • Modification sites at PhosphoSitePlus

Other Protein References for ERH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ERH

No data available for DME Specific Peptides for ERH Gene

Domains & Families for ERH Gene

Protein Domains for ERH Gene


Suggested Antigen Peptide Sequences for ERH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the E(R) family.
  • Belongs to the E(R) family.
genes like me logo Genes that share domains with ERH: view

No data available for Gene Families for ERH Gene

Function for ERH Gene

Molecular function for ERH Gene

GENATLAS Biochemistry:
Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in the cell cycle.
genes like me logo Genes that share phenotypes with ERH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERH Gene

Localization for ERH Gene

Subcellular locations from

Jensen Localization Image for ERH Gene COMPARTMENTS Subcellular localization image for ERH gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with ERH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ERH Gene

Pathways & Interactions for ERH Gene

SuperPathways for ERH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
genes like me logo Genes that share ontologies with ERH: view

No data available for Pathways by source and SIGNOR curated interactions for ERH Gene

Drugs & Compounds for ERH Gene

No Compound Related Data Available

Transcripts for ERH Gene

Unigene Clusters for ERH Gene

Enhancer of rudimentary homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP3: - -

Relevant External Links for ERH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERH Gene

mRNA expression in normal human tissues for ERH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERH Gene

This gene is overexpressed in NK cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERH Gene

SOURCE GeneReport for Unigene cluster for ERH Gene Hs.509791

mRNA Expression by UniProt/SwissProt for ERH Gene

Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with ERH: view

Protein tissue co-expression partners for ERH Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ERH Gene

Orthologs for ERH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ERH 35
  • 95.51 (n)
  • 100 (a)
ERH 36
  • 100 (a)
(Canis familiaris)
Mammalia ERH 35
  • 95.51 (n)
  • 100 (a)
ERH 36
  • 67 (a)
(Mus musculus)
Mammalia Erh 35
  • 92.95 (n)
  • 100 (a)
Erh 16
Erh 36
  • 100 (a)
(Pan troglodytes)
Mammalia ERH 35
  • 100 (n)
  • 100 (a)
ERH 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Erh 35
  • 92.95 (n)
  • 99.04 (a)
(Monodelphis domestica)
Mammalia ERH 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia ERH 36
  • 56 (a)
(Gallus gallus)
Aves ERH 35
  • 84.62 (n)
  • 98.08 (a)
ERH 36
  • 99 (a)
(Anolis carolinensis)
Reptilia ERH 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia erh 35
  • 83.33 (n)
  • 100 (a)
Str.6458 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4423 35
(Danio rerio)
Actinopterygii e(r) 35
erh 35
  • 83.65 (n)
  • 99.04 (a)
erh 36
  • 99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12367 35
fruit fly
(Drosophila melanogaster)
Insecta e(r) 37
  • 79 (a)
e(r) 35
  • 67.68 (n)
  • 79.8 (a)
e(r) 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000515 35
  • 67 (n)
  • 78.79 (a)
(Caenorhabditis elegans)
Secernentea T21C9.4 35
  • 53.06 (n)
  • 56.12 (a)
F35G12.11 36
  • 33 (a)
T21C9.4 36
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ER 35
  • 51.33 (n)
  • 45 (a)
(Oryza sativa)
Liliopsida Os02g0611450 35
  • 53.54 (n)
  • 45.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5461 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5915 36
  • 85 (a)
Species with no ortholog for ERH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERH Gene

Gene Tree for ERH (if available)
Gene Tree for ERH (if available)

Paralogs for ERH Gene Pseudogenes for ERH Gene

genes like me logo Genes that share paralogs with ERH: view

No data available for Paralogs for ERH Gene

Variants for ERH Gene

Sequence variations from dbSNP and Humsavar for ERH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1275672 -- 69,388,837(+) AACTT(C/T)ATAAA intron-variant
rs1290035 -- 69,390,142(+) ctccc(C/T)cagat intron-variant
rs7140358 -- 69,384,966(+) ACTAC(G/T)TCAAT intron-variant
rs7143230 -- 69,389,023(+) agtta(C/T)acttt intron-variant
rs3047542 -- 69,394,622(+) ACAAA(-/CAAA)TAAAT intron-variant

Variation tolerance for ERH Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ERH Gene

Disorders for ERH Gene

Relevant External Links for ERH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ERH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERH Gene

Publications for ERH Gene

  1. Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PMID: 8786099) Isomura M. … Nakamura Y. (Genomics 1996) 2 3 4 23 67
  2. The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PMID: 9074495) Gelsthorpe M. … Tsubota S.I. (Gene 1997) 2 3
  3. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  4. Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing. (PMID: 26100022) Kavanaugh G. … Cortez D. (Mol. Cell. Biol. 2015) 3
  5. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3

Products for ERH Gene

Sources for ERH Gene