Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERH Gene

Aliases for ERH Gene

  • Enhancer Of Rudimentary Homolog (Drosophila) 2 3
  • Enhancer Of Rudimentary (Drosophila) Homolog 2
  • Enhancer Of Rudimentary Homolog 3
  • DROER 3

External Ids for ERH Gene

Previous GeneCards Identifiers for ERH Gene

  • GC14M067352
  • GC14M063643
  • GC14M067836
  • GC14M068916
  • GC14M069846
  • GC14M050015

Summaries for ERH Gene

GeneCards Summary for ERH Gene

ERH (Enhancer Of Rudimentary Homolog (Drosophila)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ERH Gene

  • May have a role in the cell cycle

Gene Wiki entry for ERH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERH Gene

Genomics for ERH Gene

Regulatory Elements for ERH Gene

Genomic Location for ERH Gene

69,380,123 bp from pter
69,398,627 bp from pter
18,505 bases
Minus strand

Genomic View for ERH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERH Gene

Proteins for ERH Gene

  • Protein details for ERH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Enhancer of rudimentary homolog
    Protein Accession:
    Secondary Accessions:
    • B2R5H2
    • P70659
    • Q14259

    Protein attributes for ERH Gene

    104 amino acids
    Molecular mass:
    12259 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with POLDIP3.

    Three dimensional structures from OCA and Proteopedia for ERH Gene

neXtProt entry for ERH Gene

Proteomics data for ERH Gene at MOPED

Post-translational modifications for ERH Gene

  • Ubiquitination at Lys12, Lys41, Lys84, and Lys90
  • Modification sites at PhosphoSitePlus

Other Protein References for ERH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERH Gene

Domains for ERH Gene

Protein Domains for ERH Gene


Suggested Antigen Peptide Sequences for ERH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P84090
  • Belongs to the E(R) family.
genes like me logo Genes that share domains with ERH: view

No data available for Gene Families for ERH Gene

Function for ERH Gene

Molecular function for ERH Gene

GENATLAS Biochemistry: Drosophila enhancer of the rudimentary gene DROER,homolog,ubiquitously expressed
UniProtKB/Swiss-Prot Function: May have a role in the cell cycle

Gene Ontology (GO) - Molecular Function for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ERH: view
genes like me logo Genes that share phenotypes with ERH: view

Animal Model Products

CRISPR Products

miRNA for ERH Gene

miRTarBase miRNAs that target ERH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ERH Gene

Localization for ERH Gene

Subcellular locations from

Jensen Localization Image for ERH Gene COMPARTMENTS Subcellular localization image for ERH gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with ERH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ERH Gene

Pathways for ERH Gene

SuperPathways for ERH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 9074495
GO:0006213 pyrimidine nucleoside metabolic process TAS 8786099
GO:0006221 pyrimidine nucleotide biosynthetic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ERH: view

No data available for Pathways by source for ERH Gene

Transcripts for ERH Gene

mRNA/cDNA for ERH Gene

Unigene Clusters for ERH Gene

Enhancer of rudimentary homolog (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERH

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP3: - -

Relevant External Links for ERH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERH Gene

mRNA expression in normal human tissues for ERH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERH Gene

SOURCE GeneReport for Unigene cluster for ERH Gene Hs.509791

mRNA Expression by UniProt/SwissProt for ERH Gene

Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expressions with ERH: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ERH Gene

Orthologs for ERH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERH 35
  • 100 (n)
  • 100 (a)
ERH 36
  • 100 (a)
(Bos Taurus)
Mammalia ERH 35
  • 95.51 (n)
  • 100 (a)
ERH 36
  • 100 (a)
(Canis familiaris)
Mammalia ERH 35
  • 95.51 (n)
  • 100 (a)
ERH 36
  • 67 (a)
(Mus musculus)
Mammalia Erh 35
  • 92.95 (n)
  • 100 (a)
Erh 16
Erh 36
  • 100 (a)
(Monodelphis domestica)
Mammalia ERH 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia ERH 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Erh 35
  • 92.95 (n)
  • 99.04 (a)
(Gallus gallus)
Aves ERH 35
  • 84.62 (n)
  • 98.08 (a)
ERH 36
  • 99 (a)
(Anolis carolinensis)
Reptilia ERH 36
  • 99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4423 35
tropical clawed frog
(Silurana tropicalis)
Amphibia erh 35
  • 83.33 (n)
  • 100 (a)
Str.6458 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12367 35
(Danio rerio)
Actinopterygii e(r) 35
erh 35
  • 83.65 (n)
  • 99.04 (a)
erh 36
  • 99 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000515 35
  • 67 (n)
  • 78.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta e(r) 35
  • 67.68 (n)
  • 79.8 (a)
e(r) 36
  • 76 (a)
e(r) 37
  • 79 (a)
(Caenorhabditis elegans)
Secernentea F35G12.11 36
  • 33 (a)
T21C9.4 35
  • 53.06 (n)
  • 56.12 (a)
T21C9.4 36
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ER 35
  • 51.33 (n)
  • 45 (a)
(Oryza sativa)
Liliopsida Os02g0611450 35
  • 53.54 (n)
  • 45.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5461 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5915 36
  • 85 (a)
Species with no ortholog for ERH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERH Gene

Gene Tree for ERH (if available)
Gene Tree for ERH (if available)

Paralogs for ERH Gene Pseudogenes for ERH Gene

genes like me logo Genes that share paralogs with ERH: view

No data available for Paralogs for ERH Gene

Variants for ERH Gene

Sequence variations from dbSNP and Humsavar for ERH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs959242 -- 69,383,411(-) GGTCC(A/G)TTTTT intron-variant
rs1054482 -- 69,380,339(-) TTCTT(C/T)TTTTT utr-variant-3-prime
rs1054551 -- 69,380,217(-) CCCTT(C/T)TTCAA utr-variant-3-prime
rs1275672 -- 69,388,837(+) AACTT(C/T)ATAAA intron-variant
rs1290035 -- 69,390,142(+) ctccc(C/T)cagat intron-variant

Relevant External Links for ERH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ERH Gene

Disorders for ERH Gene

No disorders were found for ERH Gene.

No data available for UniProtKB/Swiss-Prot for ERH Gene

Publications for ERH Gene

  1. Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene. (PMID: 8786099) Isomura M. … Nakamura Y. (Genomics 1996) 2 3 4 23
  2. The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. (PMID: 9074495) Gelsthorpe M. … Tsubota S.I. (Gene 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. (PMID: 15794639) Wan C. … Rose R.B. (Biochemistry 2005) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ERH Gene

Sources for ERH Gene

Back to Top