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Aliases for ERGIC3 Gene

Aliases for ERGIC3 Gene

  • ERGIC And Golgi 3 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-84 3 4
  • Serologically Defined Breast Cancer Antigen 84 2 3
  • C20orf47 3 4
  • SDBCAG84 3 4
  • Erv46 3 4
  • Endoplasmic Reticulum-Localized Protein ERp43 3
  • Chromosome 20 Open Reading Frame 47 2
  • DJ477O4.2 3
  • NY-BR-84 3
  • PRO0989 3
  • CGI-54 3

External Ids for ERGIC3 Gene

Previous HGNC Symbols for ERGIC3 Gene

  • SDBCAG84
  • C20orf47

Previous GeneCards Identifiers for ERGIC3 Gene

  • GC20P033589
  • GC20P034129
  • GC20P030907

Summaries for ERGIC3 Gene

GeneCards Summary for ERGIC3 Gene

ERGIC3 (ERGIC And Golgi 3) is a Protein Coding gene. An important paralog of this gene is ERGIC2.

UniProtKB/Swiss-Prot for ERGIC3 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for ERGIC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC3 Gene

Genomics for ERGIC3 Gene

Regulatory Elements for ERGIC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERGIC3 Gene

Chromosome:
20
Start:
35,542,021 bp from pter
End:
35,557,634 bp from pter
Size:
15,614 bases
Orientation:
Plus strand

Genomic View for ERGIC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERGIC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC3 Gene

Proteins for ERGIC3 Gene

  • Protein details for ERGIC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y282-ERGI3_HUMAN
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 3
    Protein Accession:
    Q9Y282
    Secondary Accessions:
    • Q5JWS3
    • Q6ZWP7
    • Q9H276
    • Q9P1L3

    Protein attributes for ERGIC3 Gene

    Size:
    383 amino acids
    Molecular mass:
    43222 Da
    Quaternary structure:
    • Interacts with ERGIC1/ERGIC32.
    SequenceCaution:
    • Sequence=AAF71038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG48265.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERGIC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERGIC3 Gene

Proteomics data for ERGIC3 Gene at MOPED

Post-translational modifications for ERGIC3 Gene

  • Ubiquitination at Lys 8 and Lys 15
  • Glycosylation at Asn 241 and Asn 266
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ERGIC3 Gene

Domains & Families for ERGIC3 Gene

Protein Domains for ERGIC3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y282

UniProtKB/Swiss-Prot:

ERGI3_HUMAN :
  • Belongs to the ERGIC family.
Family:
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC3: view

No data available for Gene Families for ERGIC3 Gene

Function for ERGIC3 Gene

Molecular function for ERGIC3 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Phenotypes for ERGIC3 Gene

genes like me logo Genes that share phenotypes with ERGIC3: view

Animal Model Products

miRNA for ERGIC3 Gene

miRTarBase miRNAs that target ERGIC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERGIC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC3 Gene

Localization for ERGIC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC3 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERGIC3 Gene COMPARTMENTS Subcellular localization image for ERGIC3 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ERGIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with ERGIC3: view

Pathways & Interactions for ERGIC3 Gene

SuperPathways for ERGIC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC3: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC3 Gene

Drugs & Compounds for ERGIC3 Gene

No Compound Related Data Available

Transcripts for ERGIC3 Gene

Unigene Clusters for ERGIC3 Gene

ERGIC and golgi 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERGIC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC3 Gene

No ASD Table

Relevant External Links for ERGIC3 Gene

GeneLoc Exon Structure for
ERGIC3
ECgene alternative splicing isoforms for
ERGIC3

Expression for ERGIC3 Gene

mRNA expression in normal human tissues for ERGIC3 Gene

Protein differential expression in normal tissues from HIPED for ERGIC3 Gene

This gene is overexpressed in Bone (13.9), Stomach (8.8), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERGIC3 Gene



SOURCE GeneReport for Unigene cluster for ERGIC3 Gene Hs.472558

genes like me logo Genes that share expression patterns with ERGIC3: view

Protein tissue co-expression partners for ERGIC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERGIC3 Gene

Orthologs for ERGIC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERGIC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERGIC3 35
  • 92.08 (n)
  • 97.91 (a)
ERGIC3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERGIC3 35
  • 93.21 (n)
  • 97.68 (a)
ERGIC3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ergic3 35
  • 91.56 (n)
  • 98.17 (a)
Ergic3 16
Ergic3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERGIC3 35
  • 99.83 (n)
  • 100 (a)
ERGIC3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ergic3 35
  • 91.38 (n)
  • 98.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ERGIC3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERGIC3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 90 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ERGIC3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ergic3 35
  • 73.8 (n)
  • 86.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15764 35
zebrafish
(Danio rerio)
Actinopterygii ergic3 35
  • 76.98 (n)
  • 87.63 (a)
zgc55762 35
ergic3 36
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4408 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012144 35
  • 53.75 (n)
  • 46.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7011 35
  • 54.91 (n)
  • 48.61 (a)
CG7011 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea erv-46 35
  • 49.34 (n)
  • 43.27 (a)
erv-46 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV46 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G36050 35
  • 58.78 (n)
  • 54.57 (a)
rice
(Oryza sativa)
Liliopsida Os.22690 35
Os05g0490200 35
  • 55.47 (n)
  • 48.53 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23108 35
corn
(Zea mays)
Liliopsida Zm.13676 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4931 36
  • 56 (a)
OneToOne
Species with no ortholog for ERGIC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ERGIC3 Gene

ENSEMBL:
Gene Tree for ERGIC3 (if available)
TreeFam:
Gene Tree for ERGIC3 (if available)

Paralogs for ERGIC3 Gene

Paralogs for ERGIC3 Gene

genes like me logo Genes that share paralogs with ERGIC3: view

Variants for ERGIC3 Gene

Sequence variations from dbSNP and Humsavar for ERGIC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8825 -- 35,556,975(-) CTCAG(C/T)ACCTG reference, synonymous-codon, nc-transcript-variant
rs224411 -- 35,541,132(+) TTTTT(C/T)AAAAT upstream-variant-2KB
rs224412 -- 35,541,888(+) AGGCC(C/G)GGGCA upstream-variant-2KB
rs224413 -- 35,545,542(+) agctt(A/G)ggcaa intron-variant
rs224414 -- 35,547,515(+) GCTGG(A/C/G/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC3 Gene

Variant ID Type Subtype PubMed ID
nsv3364 CNV Insertion 18451855
nsv517785 CNV Loss 19592680
nsv526796 CNV Loss 19592680

Variation tolerance for ERGIC3 Gene

Residual Variation Intolerance Score: 10.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERGIC3 Gene

HapMap Linkage Disequilibrium report
ERGIC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERGIC3 Gene

Disorders for ERGIC3 Gene

Relevant External Links for ERGIC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERGIC3
genes like me logo Genes that share disorders with ERGIC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC3 Gene

Publications for ERGIC3 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). (PMID: 23212913) Zhang L.Y. … Tang H. (J. Biol. Chem. 2013) 67

Products for ERGIC3 Gene

Sources for ERGIC3 Gene

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