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Aliases for ERGIC3 Gene

Aliases for ERGIC3 Gene

  • ERGIC And Golgi 3 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-84 3 4
  • Serologically Defined Breast Cancer Antigen 84 2 3
  • C20orf47 3 4
  • SDBCAG84 3 4
  • Erv46 3 4
  • Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 3
  • Endoplasmic Reticulum-Localized Protein ERp43 3
  • Chromosome 20 Open Reading Frame 47 2
  • DJ477O4.2 3
  • NY-BR-84 3
  • C2orf47 3
  • PRO0989 3
  • CGI-54 3

External Ids for ERGIC3 Gene

Previous HGNC Symbols for ERGIC3 Gene

  • SDBCAG84
  • C20orf47

Previous GeneCards Identifiers for ERGIC3 Gene

  • GC20P033589
  • GC20P034129
  • GC20P030907

Summaries for ERGIC3 Gene

GeneCards Summary for ERGIC3 Gene

ERGIC3 (ERGIC And Golgi 3) is a Protein Coding gene. An important paralog of this gene is ERGIC2.

UniProtKB/Swiss-Prot for ERGIC3 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for ERGIC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC3 Gene

Genomics for ERGIC3 Gene

Regulatory Elements for ERGIC3 Gene

Enhancers for ERGIC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G035489 0.8 ENCODE 5 -51.0 -51045 2.8 TBP PKNOX1 WRNIP1 SIN3A ZBTB40 ZNF121 EGR1 ELK1 SCRT2 RELB RPL36P4 ERGIC3 LOC102725201 CEP250
GH20G035539 1.6 FANTOM5 Ensembl ENCODE 0.7 -2.1 -2074 0.7 HDGF PKNOX1 ARNT ARID4B ZNF48 TCF12 GLIS2 ZNF143 FOS SP3 RPL36P4 ERGIC3 C20orf173
GH20G035541 1.1 ENCODE 0.7 +0.1 79 1.8 HDGF CREB3L1 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF143 KLF13 DEK ERGIC3 PIR52983
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERGIC3 on UCSC Golden Path with GeneCards custom track

Promoters for ERGIC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136579 79 1001 HDGF CREB3L1 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF143 KLF13 DEK

Genomic Location for ERGIC3 Gene

35,542,021 bp from pter
35,557,634 bp from pter
15,614 bases
Plus strand

Genomic View for ERGIC3 Gene

Genes around ERGIC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERGIC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERGIC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC3 Gene

Proteins for ERGIC3 Gene

  • Protein details for ERGIC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5JWS3
    • Q6ZWP7
    • Q9H276
    • Q9P1L3

    Protein attributes for ERGIC3 Gene

    383 amino acids
    Molecular mass:
    43222 Da
    Quaternary structure:
    • Interacts with ERGIC1/ERGIC32.
    • Sequence=AAF71038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG48265.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERGIC3 Gene


neXtProt entry for ERGIC3 Gene

Post-translational modifications for ERGIC3 Gene

  • Ubiquitination at isoforms=2, 38 and isoforms=2, 315
  • Glycosylation at Asn241 and isoforms=3266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERGIC3 Gene

Domains & Families for ERGIC3 Gene

Protein Domains for ERGIC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERGIC family.
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC3: view

No data available for Gene Families for ERGIC3 Gene

Function for ERGIC3 Gene

Molecular function for ERGIC3 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.
genes like me logo Genes that share phenotypes with ERGIC3: view

Animal Model Products

CRISPR Products

miRNA for ERGIC3 Gene

miRTarBase miRNAs that target ERGIC3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC3 Gene

Localization for ERGIC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC3 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERGIC3 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ERGIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with ERGIC3: view

Pathways & Interactions for ERGIC3 Gene

SuperPathways for ERGIC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC3: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC3 Gene

Drugs & Compounds for ERGIC3 Gene

No Compound Related Data Available

Transcripts for ERGIC3 Gene

Unigene Clusters for ERGIC3 Gene

ERGIC and golgi 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC3 Gene

No ASD Table

Relevant External Links for ERGIC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERGIC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERGIC3 Gene

Protein differential expression in normal tissues from HIPED for ERGIC3 Gene

This gene is overexpressed in Bone (13.9), Stomach (8.8), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERGIC3 Gene

Protein tissue co-expression partners for ERGIC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERGIC3 Gene:


SOURCE GeneReport for Unigene cluster for ERGIC3 Gene:


Evidence on tissue expression from TISSUES for ERGIC3 Gene

  • Nervous system(4.9)
  • Skin(4.7)
  • Liver(4.6)
  • Intestine(4.5)
  • Lung(3.6)
  • Kidney(2.8)
  • Eye(2.5)
  • Pancreas(2.3)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ERGIC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERGIC3 Gene

Orthologs for ERGIC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERGIC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERGIC3 34 35
  • 99.83 (n)
(Canis familiaris)
Mammalia ERGIC3 34 35
  • 93.21 (n)
(Bos Taurus)
Mammalia ERGIC3 34 35
  • 92.08 (n)
(Mus musculus)
Mammalia Ergic3 34 16 35
  • 91.56 (n)
(Rattus norvegicus)
Mammalia Ergic3 34
  • 91.38 (n)
(Ornithorhynchus anatinus)
Mammalia ERGIC3 35
  • 91 (a)
(Monodelphis domestica)
Mammalia ERGIC3 35
  • 90 (a)
(Gallus gallus)
Aves -- 35
  • 90 (a)
-- 35
  • 84 (a)
-- 35
  • 82 (a)
(Anolis carolinensis)
Reptilia ERGIC3 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ergic3 34
  • 73.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15764 34
(Danio rerio)
Actinopterygii ergic3 34 35
  • 76.98 (n)
zgc55762 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4408 34
fruit fly
(Drosophila melanogaster)
Insecta CG7011 34 35
  • 54.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012144 34
  • 53.75 (n)
(Caenorhabditis elegans)
Secernentea erv-46 34 35
  • 49.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV46 35
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G36050 34
  • 58.78 (n)
(Oryza sativa)
Liliopsida Os05g0490200 34
  • 55.47 (n)
Os.22690 34
(Triticum aestivum)
Liliopsida Ta.23108 34
(Zea mays)
Liliopsida Zm.13676 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4931 35
  • 56 (a)
Species where no ortholog for ERGIC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ERGIC3 Gene

Gene Tree for ERGIC3 (if available)
Gene Tree for ERGIC3 (if available)

Paralogs for ERGIC3 Gene

Paralogs for ERGIC3 Gene

genes like me logo Genes that share paralogs with ERGIC3: view

Variants for ERGIC3 Gene

Sequence variations from dbSNP and Humsavar for ERGIC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036553 A colorectal cancer sample
rs1000255695 -- 35,540,665(+) GTGTT(A/G)CCCAG upstream-variant-2KB
rs1000332778 -- 35,556,787(+) GGCTG(A/C)GGCCA intron-variant
rs1000435338 -- 35,546,795(+) GTTGA(A/G)TTTTG intron-variant
rs1000540351 -- 35,553,689(+) GAGGA(C/G/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC3 Gene

Variant ID Type Subtype PubMed ID
nsv1062839 CNV loss 25217958
nsv3364 CNV insertion 18451855
nsv517785 CNV loss 19592680
nsv526796 CNV loss 19592680

Variation tolerance for ERGIC3 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERGIC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERGIC3 Gene

Disorders for ERGIC3 Gene

Relevant External Links for ERGIC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ERGIC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC3 Gene

Publications for ERGIC3 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L. … Hauri H.-P. (J. Biol. Chem. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for ERGIC3 Gene

Sources for ERGIC3 Gene

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