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Aliases for ERGIC2 Gene

Aliases for ERGIC2 Gene

  • ERGIC And Golgi 2 2 3
  • Erv41 3 4
  • PTX1 3 4
  • CD14 Protein 3
  • CDA14 3
  • Cd002 3

External Ids for ERGIC2 Gene

Previous GeneCards Identifiers for ERGIC2 Gene

  • GC12M029382
  • GC12M029493
  • GC12M029262

Summaries for ERGIC2 Gene

Entrez Gene Summary for ERGIC2 Gene

  • ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ERGIC2 Gene

ERGIC2 (ERGIC And Golgi 2) is a Protein Coding gene. An important paralog of this gene is ERGIC3.

UniProtKB/Swiss-Prot for ERGIC2 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for ERGIC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC2 Gene

Genomics for ERGIC2 Gene

Regulatory Elements for ERGIC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERGIC2 Gene

29,337,352 bp from pter
29,381,210 bp from pter
43,859 bases
Minus strand

Genomic View for ERGIC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ERGIC2 Gene

Proteins for ERGIC2 Gene

  • Protein details for ERGIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NHH6
    • Q53GY2
    • Q8N2Q9
    • Q9BVV9
    • Q9NZA3

    Protein attributes for ERGIC2 Gene

    377 amino acids
    Molecular mass:
    42549 Da
    Quaternary structure:
    • May interact with EEF1A1.
    • Sequence=AAF61208.1; Type=Frameshift; Positions=202, 209, 212; Evidence={ECO:0000305};

neXtProt entry for ERGIC2 Gene

Proteomics data for ERGIC2 Gene at MOPED

Post-translational modifications for ERGIC2 Gene

  • Ubiquitination at Lys 14 and Lys 146
  • Glycosylation at Thr 154 and Asn 212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERGIC2 Gene

Domains & Families for ERGIC2 Gene

Protein Domains for ERGIC2 Gene


Suggested Antigen Peptide Sequences for ERGIC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERGIC family.
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC2: view

No data available for Gene Families for ERGIC2 Gene

Function for ERGIC2 Gene

Molecular function for ERGIC2 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Gene Ontology (GO) - Molecular Function for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17980171
genes like me logo Genes that share ontologies with ERGIC2: view

Phenotypes for ERGIC2 Gene

genes like me logo Genes that share phenotypes with ERGIC2: view

Animal Model Products

miRNA for ERGIC2 Gene

miRTarBase miRNAs that target ERGIC2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERGIC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC2 Gene

Localization for ERGIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC2 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269 PubMed:11445006, ECO:0000269 PubMed:17980171}.

Subcellular locations from

Jensen Localization Image for ERGIC2 Gene COMPARTMENTS Subcellular localization image for ERGIC2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17980171
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 17980171
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

Pathways & Interactions for ERGIC2 Gene

SuperPathways for ERGIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC2 Gene

Drugs & Compounds for ERGIC2 Gene

No Compound Related Data Available

Transcripts for ERGIC2 Gene

Unigene Clusters for ERGIC2 Gene

ERGIC and golgi 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERGIC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP3: - -

Relevant External Links for ERGIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERGIC2 Gene

mRNA expression in normal human tissues for ERGIC2 Gene

Protein differential expression in normal tissues from HIPED for ERGIC2 Gene

This gene is overexpressed in Islet of Langerhans (11.1), Placenta (8.0), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERGIC2 Gene

SOURCE GeneReport for Unigene cluster for ERGIC2 Gene Hs.339453

mRNA Expression by UniProt/SwissProt for ERGIC2 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ERGIC2: view

Protein tissue co-expression partners for ERGIC2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ERGIC2 Gene

Orthologs for ERGIC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERGIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ERGIC2 35
  • 93.19 (n)
  • 94.43 (a)
  • 94 (a)
(Canis familiaris)
Mammalia ERGIC2 35
  • 94.78 (n)
  • 96.29 (a)
  • 96 (a)
(Mus musculus)
Mammalia Ergic2 35
  • 91.42 (n)
  • 95.49 (a)
Ergic2 16
Ergic2 36
  • 95 (a)
(Pan troglodytes)
Mammalia ERGIC2 35
  • 98.74 (n)
  • 97.48 (a)
(Monodelphis domestica)
Mammalia ERGIC2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia ERGIC2 36
  • 89 (a)
(Gallus gallus)
Aves ERGIC2 35
  • 82.22 (n)
  • 88.8 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia ERGIC2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ergic2 35
  • 70.2 (n)
  • 75.5 (a)
MGC75899 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16162 35
(Danio rerio)
Actinopterygii ergic2 35
  • 72.99 (n)
  • 78.88 (a)
zgc64005 35
ergic2 36
  • 78 (a)
ERGIC2 (1 of 2) 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3142 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005044 35
  • 46.15 (n)
  • 40.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4293 35
  • 41.31 (n)
  • 34.87 (a)
CG4293 36
  • 27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER136W 35
  • 41.29 (n)
  • 29.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04950g 35
  • 45.79 (n)
  • 30.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV41 35
  • 46.27 (n)
  • 31.1 (a)
ERV46 36
  • 21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04293 35
  • 41.07 (n)
  • 33.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G5.04c 35
  • 43.45 (n)
  • 32.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3984 36
  • 50 (a)
Species with no ortholog for ERGIC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERGIC2 Gene

Gene Tree for ERGIC2 (if available)
Gene Tree for ERGIC2 (if available)

Paralogs for ERGIC2 Gene

Paralogs for ERGIC2 Gene

genes like me logo Genes that share paralogs with ERGIC2: view

Variants for ERGIC2 Gene

Sequence variations from dbSNP and Humsavar for ERGIC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs996498 -- 29,365,497(+) ctact(A/G)gttat intron-variant
rs1035606 -- 29,356,517(+) CAATA(C/T)AGTTA intron-variant
rs1035607 -- 29,356,580(+) TTTTT(A/C)GGTAA intron-variant
rs1046469 -- 29,340,167(-) GAGGT(A/G)CCATG downstream-variant-500B
rs1156242 -- 29,371,024(+) TACCT(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC2 Gene

Variant ID Type Subtype PubMed ID
esv273443 CNV Insertion 20981092

Variation tolerance for ERGIC2 Gene

Residual Variation Intolerance Score: 27.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERGIC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERGIC2 Gene

Disorders for ERGIC2 Gene

Relevant External Links for ERGIC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ERGIC2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC2 Gene

Publications for ERGIC2 Gene

  1. Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions. (PMID: 19360901) Yin G.N. … Suk K. (J. Neurosci. Res. 2009) 23 67
  2. High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes. (PMID: 18354232) Youn J.H. … Shin J.S. (J. Immunol. 2008) 23 67
  3. High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities. (PMID: 18180316) Nareika A. … Huang Y. (J. Endocrinol. 2008) 23 67
  4. CD14: chaperone or matchmaker? (PMID: 16473824) Finberg R.W. … Kurt-Jones E.A. (Immunity 2006) 23 67
  5. Effects of PTX1 expression on growth and tumorigenicity of the prostate cancer cell line PC-3. (PMID: 12932305) Liu X. … Kwok S.C. (DNA Cell Biol. 2003) 2 67

Products for ERGIC2 Gene

Sources for ERGIC2 Gene

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