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Aliases for ERGIC2 Gene

Aliases for ERGIC2 Gene

  • ERGIC And Golgi 2 2 3 5
  • Erv41 3 4
  • PTX1 3 4
  • Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 2 3
  • CD14 Protein 3
  • CDA14 3
  • Cd002 3

External Ids for ERGIC2 Gene

Previous GeneCards Identifiers for ERGIC2 Gene

  • GC12M029382
  • GC12M029493
  • GC12M029262

Summaries for ERGIC2 Gene

Entrez Gene Summary for ERGIC2 Gene

  • ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ERGIC2 Gene

ERGIC2 (ERGIC And Golgi 2) is a Protein Coding gene. An important paralog of this gene is ERGIC3.

UniProtKB/Swiss-Prot for ERGIC2 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for ERGIC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC2 Gene

Genomics for ERGIC2 Gene

Regulatory Elements for ERGIC2 Gene

Enhancers for ERGIC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G029163 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +213.7 213668 7.5 PKNOX1 ZNF766 GATA2 CBX5 ZNF143 ZNF207 FOS JUNB REST TBX21 LOC100506606 ERGIC2 PIR59479 ENSG00000275278
GH12G029428 1.1 Ensembl ENCODE 10.7 -47.4 -47392 1.2 TBP PKNOX1 RAD21 YY1 GTF3C2 ZNF766 GATA2 POLR3A CBX5 FOS ERGIC2 OVCH1 LOC100506606 PIR60715 GC12P029484
GH12G029319 1.1 FANTOM5 Ensembl ENCODE 10 +60.6 60621 2.4 JUND ZNF680 GATA2 JUN HNF4A FOS ERGIC2 LOC100506606 ENSG00000274315
GH12G029435 0.6 Ensembl 10.7 -54.4 -54368 0.8 L3MBTL2 NR2F1 CEBPB CEBPG ATF2 POLR2H ZNF589 MTA1 ATF3 RBFOX2 ERGIC2 PIR60715 GC12P029484
GH12G029346 0.4 ENCODE 11.2 +34.1 34075 1.1 IKZF1 HNF4A LOC100506606 ERGIC2 ENSG00000273680
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERGIC2 on UCSC Golden Path with GeneCards custom track

Promoters for ERGIC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000050396 210 2400 PKNOX1 CREB3L1 WRNIP1 SIN3A YY1 ZNF766 DEK ZNF263 SP3 ZHX2

Genomic Location for ERGIC2 Gene

Chromosome:
12
Start:
29,337,352 bp from pter
End:
29,381,210 bp from pter
Size:
43,859 bases
Orientation:
Minus strand

Genomic View for ERGIC2 Gene

Genes around ERGIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERGIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERGIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC2 Gene

Proteins for ERGIC2 Gene

  • Protein details for ERGIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RQ1-ERGI2_HUMAN
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    Protein Accession:
    Q96RQ1
    Secondary Accessions:
    • A6NHH6
    • Q53GY2
    • Q8N2Q9
    • Q9BVV9
    • Q9NZA3

    Protein attributes for ERGIC2 Gene

    Size:
    377 amino acids
    Molecular mass:
    42549 Da
    Quaternary structure:
    • May interact with EEF1A1.
    SequenceCaution:
    • Sequence=AAF61208.1; Type=Frameshift; Positions=202, 209, 212; Evidence={ECO:0000305};

neXtProt entry for ERGIC2 Gene

Post-translational modifications for ERGIC2 Gene

  • Ubiquitination at Lys14 and isoforms=146
  • Glycosylation at isoforms=154 and Asn212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERGIC2 Gene

Domains & Families for ERGIC2 Gene

Protein Domains for ERGIC2 Gene

Suggested Antigen Peptide Sequences for ERGIC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RQ1

UniProtKB/Swiss-Prot:

ERGI2_HUMAN :
  • Belongs to the ERGIC family.
Family:
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC2: view

No data available for Gene Families for ERGIC2 Gene

Function for ERGIC2 Gene

Molecular function for ERGIC2 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Gene Ontology (GO) - Molecular Function for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17980171
genes like me logo Genes that share ontologies with ERGIC2: view
genes like me logo Genes that share phenotypes with ERGIC2: view

Animal Model Products

CRISPR Products

miRNA for ERGIC2 Gene

miRTarBase miRNAs that target ERGIC2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC2 Gene

Localization for ERGIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC2 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269 PubMed:11445006, ECO:0000269 PubMed:17980171}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERGIC2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
golgi apparatus 4
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 17980171
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 17980171
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

Pathways & Interactions for ERGIC2 Gene

SuperPathways for ERGIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24768165
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC2 Gene

Drugs & Compounds for ERGIC2 Gene

No Compound Related Data Available

Transcripts for ERGIC2 Gene

Unigene Clusters for ERGIC2 Gene

ERGIC and golgi 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3: - -

Relevant External Links for ERGIC2 Gene

GeneLoc Exon Structure for
ERGIC2
ECgene alternative splicing isoforms for
ERGIC2

Expression for ERGIC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERGIC2 Gene

Protein differential expression in normal tissues from HIPED for ERGIC2 Gene

This gene is overexpressed in Islet of Langerhans (11.1), Placenta (8.0), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERGIC2 Gene



Protein tissue co-expression partners for ERGIC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERGIC2 Gene:

ERGIC2

SOURCE GeneReport for Unigene cluster for ERGIC2 Gene:

Hs.339453

mRNA Expression by UniProt/SwissProt for ERGIC2 Gene:

Q96RQ1-ERGI2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ERGIC2 Gene

  • Liver(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ERGIC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERGIC2 Gene

Orthologs for ERGIC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERGIC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERGIC2 34
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia ERGIC2 34 35
  • 94.78 (n)
cow
(Bos Taurus)
Mammalia ERGIC2 34 35
  • 93.19 (n)
mouse
(Mus musculus)
Mammalia Ergic2 34 16 35
  • 91.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERGIC2 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERGIC2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERGIC2 34 35
  • 82.22 (n)
lizard
(Anolis carolinensis)
Reptilia ERGIC2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ergic2 34
  • 70.2 (n)
MGC75899 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16162 34
zebrafish
(Danio rerio)
Actinopterygii ergic2 34 35
  • 72.99 (n)
ERGIC2 (1 of 2) 35
  • 60 (a)
OneToMany
zgc64005 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3142 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005044 34
  • 46.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4293 34 35
  • 41.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV41 34
  • 46.27 (n)
ERV46 35
  • 21 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04950g 34
  • 45.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER136W 34
  • 41.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3984 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G5.04c 34
  • 43.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04293 34
  • 41.07 (n)
Species where no ortholog for ERGIC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERGIC2 Gene

ENSEMBL:
Gene Tree for ERGIC2 (if available)
TreeFam:
Gene Tree for ERGIC2 (if available)

Paralogs for ERGIC2 Gene

Paralogs for ERGIC2 Gene

genes like me logo Genes that share paralogs with ERGIC2: view

Variants for ERGIC2 Gene

Sequence variations from dbSNP and Humsavar for ERGIC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000037745 -- 29,341,653(+) CAGGT(A/G)TGAGC intron-variant
rs1000145425 -- 29,356,730(+) CAGAG(A/G)ACTAA intron-variant
rs1000202987 -- 29,374,121(+) AAGAA(C/T)GAGTT intron-variant
rs1000212584 -- 29,379,649(+) TTGTA(C/T)GTTTC intron-variant
rs1000244337 -- 29,361,304(+) TCCTG(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC2 Gene

Variant ID Type Subtype PubMed ID
esv3344998 CNV insertion 20981092

Variation tolerance for ERGIC2 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERGIC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERGIC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERGIC2 Gene

Disorders for ERGIC2 Gene

Relevant External Links for ERGIC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERGIC2

No disorders were found for ERGIC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC2 Gene

Publications for ERGIC2 Gene

  1. Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer. (PMID: 11445006) Kwok S.C.M. … Daskal I. (DNA Cell Biol. 2001) 2 3 4 64
  2. The possible interaction of CDA14 and protein elongation factor 1alpha. (PMID: 17980171) Yang Y.F. … Tseng T.L. (Biochim. Biophys. Acta 2008) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L. … Hauri H.-P. (J. Biol. Chem. 2004) 3 4 64

Products for ERGIC2 Gene

Sources for ERGIC2 Gene

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