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Aliases for ERGIC1 Gene

Aliases for ERGIC1 Gene

  • Endoplasmic Reticulum-Golgi Intermediate Compartment 1 2 3 5
  • Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) 1 2 3
  • ER-Golgi Intermediate Compartment 32 KDa Protein 3 4
  • ERGIC-32 3 4
  • ERGIC32 3 4
  • Endoplasmic Reticulum-Golgi Intermediate Compartment 32 KDa Protein 3
  • KIAA1181 4
  • NET24 3

External Ids for ERGIC1 Gene

Previous GeneCards Identifiers for ERGIC1 Gene

  • GC05P172194
  • GC05P172261
  • GC05P167356

Summaries for ERGIC1 Gene

Entrez Gene Summary for ERGIC1 Gene

  • This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERGIC1 Gene

ERGIC1 (Endoplasmic Reticulum-Golgi Intermediate Compartment 1) is a Protein Coding gene. An important paralog of this gene is ERGIC2.

UniProtKB/Swiss-Prot for ERGIC1 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC1 Gene

Genomics for ERGIC1 Gene

Regulatory Elements for ERGIC1 Gene

Enhancers for ERGIC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERGIC1 on UCSC Golden Path with GeneCards custom track

Promoters for ERGIC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERGIC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERGIC1 Gene

172,834,220 bp from pter
172,952,685 bp from pter
118,466 bases
Plus strand

Genomic View for ERGIC1 Gene

Genes around ERGIC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERGIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERGIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC1 Gene

Proteins for ERGIC1 Gene

  • Protein details for ERGIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9H0L0
    • Q9H2J2
    • Q9ULN9

    Protein attributes for ERGIC1 Gene

    290 amino acids
    Molecular mass:
    32592 Da
    Quaternary structure:
    • Interacts with ERGIC3/ERV46.
    • Sequence=AAG44724.1; Type=Frameshift; Positions=100, 150; Evidence={ECO:0000305}; Sequence=BAA86495.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERGIC1 Gene


neXtProt entry for ERGIC1 Gene

Proteomics data for ERGIC1 Gene at MOPED

Post-translational modifications for ERGIC1 Gene

Other Protein References for ERGIC1 Gene

No data available for DME Specific Peptides for ERGIC1 Gene

Domains & Families for ERGIC1 Gene

Protein Domains for ERGIC1 Gene


Suggested Antigen Peptide Sequences for ERGIC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERGIC family.
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC1: view

No data available for Gene Families for ERGIC1 Gene

Function for ERGIC1 Gene

Molecular function for ERGIC1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.
genes like me logo Genes that share phenotypes with ERGIC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ERGIC1

miRNA for ERGIC1 Gene

miRTarBase miRNAs that target ERGIC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC1 Gene

Localization for ERGIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

Jensen Localization Image for ERGIC1 Gene COMPARTMENTS Subcellular localization image for ERGIC1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ERGIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with ERGIC1: view

Pathways & Interactions for ERGIC1 Gene

SuperPathways for ERGIC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ERGIC1 Gene

Drugs & Compounds for ERGIC1 Gene

No Compound Related Data Available

Transcripts for ERGIC1 Gene

Unigene Clusters for ERGIC1 Gene

Endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: - - - -

ExUns: 15c · 15d

Relevant External Links for ERGIC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERGIC1 Gene

mRNA expression in normal human tissues for ERGIC1 Gene

mRNA differential expression in normal tissues according to GTEx for ERGIC1 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for ERGIC1 Gene

This gene is overexpressed in Nasal epithelium (12.0) and Bone (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERGIC1 Gene

SOURCE GeneReport for Unigene cluster for ERGIC1 Gene Hs.509163

genes like me logo Genes that share expression patterns with ERGIC1: view

Protein tissue co-expression partners for ERGIC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ERGIC1 Gene

Orthologs for ERGIC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERGIC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ERGIC1 35
  • 92.64 (n)
  • 97.59 (a)
  • 97 (a)
(Canis familiaris)
Mammalia ERGIC1 35
  • 91.72 (n)
  • 98.62 (a)
  • 99 (a)
(Mus musculus)
Mammalia Ergic1 35
  • 90.92 (n)
  • 98.97 (a)
Ergic1 16
Ergic1 36
  • 99 (a)
(Pan troglodytes)
Mammalia ERGIC1 35
  • 99.77 (n)
  • 100 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ergic1 35
  • 90.11 (n)
  • 98.28 (a)
(Monodelphis domestica)
Mammalia ERGIC1 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia ERGIC1 36
  • 94 (a)
(Gallus gallus)
Aves ERGIC1 35
  • 81.49 (n)
  • 93.45 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia ERGIC1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485859 35
  • 75.94 (n)
  • 86.62 (a)
Str.15788 35
(Danio rerio)
Actinopterygii ergic1 35
  • 77.85 (n)
  • 89.62 (a)
ergic1 36
  • 90 (a)
(Caenorhabditis elegans)
Secernentea Y102A11A.6 35
  • 57.63 (n)
  • 55.99 (a)
Y102A11A.6 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV46 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2137 36
  • 64 (a)
Species with no ortholog for ERGIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERGIC1 Gene

Gene Tree for ERGIC1 (if available)
Gene Tree for ERGIC1 (if available)

Paralogs for ERGIC1 Gene

Paralogs for ERGIC1 Gene

genes like me logo Genes that share paralogs with ERGIC1: view

Variants for ERGIC1 Gene

Sequence variations from dbSNP and Humsavar for ERGIC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs710107 -- 172,834,540(-) CACAG(A/G)GCGGG intron-variant
rs710108 -- 172,843,169(-) aaact(C/T)ctatt intron-variant
rs710109 -- 172,845,568(-) tttgg(C/T)tcagc intron-variant
rs710110 -- 172,846,061(-) gcttc(C/T)ccaaa intron-variant
rs710111 -- 172,846,084(-) aaggg(C/T)gcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC1 Gene

Variant ID Type Subtype PubMed ID
nsv883114 CNV Loss 21882294
nsv830555 CNV Loss 17160897
nsv515804 CNV Loss 19592680
nsv462532 CNV Loss 19166990
nsv517972 CNV Loss 19592680
esv2731108 CNV Deletion 23290073
esv2658996 CNV Deletion 23128226

Variation tolerance for ERGIC1 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ERGIC1 Gene

Disorders for ERGIC1 Gene

Relevant External Links for ERGIC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ERGIC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC1 Gene

Publications for ERGIC1 Gene

  1. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L. … Hauri H.-P. (J. Biol. Chem. 2004) 2 3 4 67
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ERGIC1 Gene

Sources for ERGIC1 Gene