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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERG Gene

protein-coding   GIFtS: 62
GCID: GC21M039751

V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog

(Previous name: v-ets avian erythroblastosis virus E26 oncogene related)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog1 2     ets-related2
V-Ets Avian Erythroblastosis Virus E26 Oncogene Related1 2     p552
Transcriptional Regulator ERG (Transforming Protein ERG)2 11     TMPRSS2/ERG Fusion2
V-Ets Erythroblastosis Virus E26 Oncogene Like1 2     Transcriptional Regulator ERG2
TMPRSS2-ERG Prostate Cancer Specific1     V-Ets Erythroblastosis Virus E26 Oncogene Homolog2
erg-32     Transforming Protein ERG3

External Ids:    HGNC: 34461   Entrez Gene: 20782   Ensembl: ENSG000001575547   OMIM: 1650805   UniProtKB: P113083   

Export aliases for ERG gene to outside databases

Previous GC identifers: GC21M036332 GC21M038672 GC21M038675 GC21M025221


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERG Gene:
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All
members of this family are key regulators of embryonic development, cell proliferation, differentiation,
angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus.
It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of
chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular
cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells.
This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as
TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified. (provided by
RefSeq, Jan 2012)

GeneCards Summary for ERG Gene: 
ERG (v-ets avian erythroblastosis virus E26 oncogene homolog) is a protein-coding gene. Diseases associated with ERG include peripheral primitive neuroectodermal tumor, and branch retinal artery occlusion, and among its related super-pathways are Integrated Cancer pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of
SETDB1 histone methyltransferase and subsequent modification of local chromatin structure

Gene Wiki entry for ERG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERG gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERG promoter sequence

   Search SABiosciences Chromatin IP Primers for ERG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
ERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERG gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M039751:   GeneLoc Nature:405,311-319
Start:
39,751,949 bp from pter       25,330,315 bp from centromere
End:
40,033,704 bp from pter 25,609,026 bp from centromere
Size:
281,756 bases 278,712 bases
Orientation:
minus strand plus strand

Whole chromosome sequencing:
cDNA sequence: M17254
genomic clones: pS166 to P178O22


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308 (See protein sequence)
Recommended Name: Transcriptional regulator ERG  
Size: 486 amino acids; 54608 Da
Subunit: Interacts with SETDB1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
mRNAs
1 PDB 3D structure from and Proteopedia for ERG:
1SXE (3D)    
Secondary accessions: B4DTW5 B4E0T4 Q16113 Q6XXX4 Q6XXX5 Q8IXK9
Alternative splicing: 6 isoforms:  P11308-3   P11308-1   P11308-2   P11308-4   P11308-5   P11308-6   

Explore the universe of human proteins at neXtProt for ERG: NX_P11308

Explore proteomics data for ERG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11308

  • ERG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ERG Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001129626.1  NP_001129627.1  NP_001230357.1  NP_001230358.1  NP_001230361.1  NP_004440.1  NP_891548.1  

    ENSEMBL proteins: 
     ENSP00000381877   ENSP00000381879   ENSP00000288319   ENSP00000381871   ENSP00000381882  
     ENSP00000414150   ENSP00000381881   ENSP00000396268   ENSP00000381891   ENSP00000394694  
     ENSP00000415659  

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    Novus Biologicals ERG Proteins
    Novus Biologicals ERG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERG 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661

    ERG for ontologies           About GeneDecksing



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    ThermoFisher Antibody for ERG
    LSBio Antibodies in human, mouse, rat for ERG 

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    Cloud-Clone Corp. CLIAs for ERG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry P11308

    ProtoNet protein and cluster: P11308

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ERG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERG_HUMAN, P11308
    Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of
    SETDB1 histone methyltransferase and subsequent modification of local chromatin structure

         Genatlas biochemistry entry for ERG:
    avian erythroblastosis virus E26 (v-ets) oncogene related protein,rearranged in myeloid leukemia with
    translocation t(16;21)(p11;q11) (see FUS) and in Ewing sarcoma with t(21;22) translocation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8502479
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity TAS8502479
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    ERG for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Erg):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  normal 

    ERG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ERG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ERG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERG 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidERG 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of ERG 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ERG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Prostate Cancer
    Prostate Cancer0.32
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ERG
        Prostate Cancer


    1         Kegg Pathway  (Kegg details for ERG):
        Transcriptional misregulation in cancer


    ERG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for ERG (P113081, 2, 3 ENSP000003818914) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 2, 3, ENSP000003638224EBI-79704,EBI-608057 MINT-8388488 I2D: score=3 STRING: ENSP00000363822
    EZH2Q159102, 3, ENSP000003201474MINT-8388497 I2D: score=1 STRING: ENSP00000320147
    ETS2P150363, ENSP000003533444I2D: score=3 STRING: ENSP00000353344
    SETDB1Q150473, ENSP000003579654I2D: score=3 STRING: ENSP00000357965
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006468protein phosphorylation TAS8502479
    GO:0007165signal transduction TAS8502479
    GO:0007275multicellular organismal development TAS8502479

    ERG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ERG

    Search CenterWatch for drugs/clinical trials and news about ERG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ERG gene (8 alternative transcripts): 
    NM_001136154.1  NM_001136155.1  NM_001243428.1  NM_001243429.1  NM_001243432.1  NM_004449.4  NM_182918.3  NM_001243433.1  

    Unigene Cluster for ERG:

    V-ets erythroblastosis virus E26 oncogene homolog (avian)
    Hs.473819  [show with all ESTs]
    Unigene Representative Sequence: NM_001243428
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398905 ENST00000398907 ENST00000288319(uc002yxa.3 uc011aek.2)
    ENST00000398897 ENST00000398911(uc010gnv.3 uc010gnx.3) ENST00000417133(uc010gnw.3)
    ENST00000398910 ENST00000453032 ENST00000398919 ENST00000481609(uc010gny.1)
    ENST00000492833 ENST00000468474(uc002yxc.4) ENST00000473107 ENST00000485493(uc010gnz.3)
    ENST00000442448(uc021wjd.1 uc011ael.2 uc002yxb.3) ENST00000429727(uc011aem.1)


    miRNA
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    hsa-miR-361-5p hsa-miR-3146 hsa-miR-200a hsa-miR-128 hsa-miR-1258 hsa-miR-30d hsa-miR-219-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidERG 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERG

    Additional mRNA sequence: 

    AK297807.1 AK300395.1 AK301277.1 AK303518.1 AK304662.1 AK309469.1 AY204740.1 AY204741.1 
    AY204742.1 AY204743.1 BC040168.1 DQ204772.1 DQ204773.2 DQ831522.1 EU090248.1 FJ423744.1 
    M21535.1 S77574.1 U17630.1 

    10 DOTS entries:

    DT.91659622  DT.100740571  DT.109790  DT.86849626  DT.102830579  DT.426858  DT.95310949  DT.95310911 
    DT.91657433  DT.92412828 

    24/47 AceView cDNA sequences (see all 47):

    AU185916 BQ926242 AU136709 BX952555 AY204740 BC040168 R82102 AU280022 
    NM_004449 AY204741 AF015313 AY204742 BX100094 AW772271 NM_182918 AI168805 
    R82162 CA405791 BM456833 AI767442 BG388025 BI712083 BG259459 CB269538 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ERG (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                          -     -     -     -     -                                         -                                             
    SP2:                                      -     -     -                                         -                       -                     
    SP3:                          -     -     -     -     -     -                             -     -                       -                     
    SP4:                          -     -     -     -     -                                                                                       
    SP5:                                            -     -                                                                                       


    ECgene alternative splicing isoforms for ERG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERG expression in normal human tissues (normalized intensities)      ERG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ERG Expression
    About this image


    ERG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             Articular Cartilage Cells Zeugopod Articular Cartilage
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
             sensory organ/nose/nasal septum   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Medulla Oblongata
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Interzone Cells Autopod Synovial Joint
             limb/hindlimb   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             Human corneal endothelial cells
             sensory organ/eye/cornea   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human corneal endothelial cells
             cd31+ cells   

    See ERG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERG

    SOURCE GeneReport for Unigene cluster: Hs.473819
        SABiosciences Expression via Pathway-Focused PCR Array including ERG: 
              Prostate Cancer in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ERG gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erg1 , 5 avian erythroblastosis virus E-26 (v-ets) oncogene more1, 5 89.85(n)1
    97.12(a)1
      16 (56.04 cM)5
    138761  NM_133659.21  NP_598420.11 
     953591695 
    chicken
    (Gallus gallus)
    Aves ERG1 v-ets erythroblastosis virus E26 oncogene homolog (avian) 84.84(n)
    95.18(a)
      374146  NM_204280.1  NP_989611.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERG6
    --
    --
    93(a)
    56(a)
    1 ↔ 1
    possible ortholog
    3(140169440-140264337)
    GL343514.1(326230-363273)
    African clawed frog
    (Xenopus laevis)
    Amphibia erg-A2 v-ets erythroblastosis virus E26 oncogene like 81.47(n)    AJ224125.1 
    zebrafish
    (Danio rerio)
    Actinopterygii erg1 v-ets erythroblastosis virus E26 oncogene like (avian) 71.11(n)
    71.6(a)
      494073  NM_001008616.1  NP_001008616.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets65A3 DNA binding 62(a)
    (best of 2)
      65A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea C42D8.43 DNA-binding protein 78(a)   X(5114542-5116802)   --


    ENSEMBL Gene Tree for ERG (if available)
    TreeFam Gene Tree for ERG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERG gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  ELK12  FEV2  ETV42  ETV22  FLI12  ELK32  
    9 SIMAP similar genes for ERG using alignment to 6 protein entries:     ERG_HUMAN (see all proteins):
    NDRG1-ERG fusion    TLS-ERG    erg    EWSR1/FLI1 fusion    ETV2    EWS-Fli1
    FLI1    ELK3    FEV

    ERG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6452 SNPs in ERG are shown (see all 6452)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010466101,2
    Cuntested130320104(+) ACAGGA/C/GGTGTT 7 -- int11EU 1309
    rs285796081,2
    C,F--25228495(+) TCTATT/GTTTTT 7 -- int1 trp32Minor allele frequency- G:0.25NA WA 4
    rs676901721,2
    C--25265735(+) ACAAA-/AAAAG 
            
    AAAGA
    7 -- int10--------
    rs560006651,2
    C--25271214(+) TGTGTA/GTATAT 7 -- int10--------
    rs1425999651,2
    --25271266(+) TATATA/GTGTGT 7 -- int10--------
    rs2013703561,2
    C--25271291(+) TGTGT-/GCATATA 7 -- int10--------
    rs123296411,2
    C,A--25271292(+) gtgtgT/Catata 7 -- int13Minor allele frequency- C:0.20WA CSA 5
    rs130468731,2
    F--25271315(+) gtgtgC/Tatata 7 -- int12Minor allele frequency- T:0.33NA 6
    rs1419310581,2
    C--25271315(+) GTGTG-/TATATAT 7 -- int10--------
    rs1387357511,2
    C--25308892(+) TGTTG-/CCTC  
     AAACAAA
    CCTCC
    7 -- int10--------

    HapMap Linkage Disequilibrium report for ERG (39751949 - 40001949 bp, first 250kb of ERG)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ERG (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2852CNV Deletion18987735
    esv2264168CNV Deletion18987734
    esv2723416CNV Deletion23290073
    esv2723418CNV Deletion23290073
    esv2672087CNV Deletion23128226
    esv2723419CNV Deletion23290073
    esv2658330CNV Deletion23128226
    esv2667140CNV Deletion23128226
    nsv3515CNV Insertion18451855
    esv2629526CNV Insertion19546169

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing ERG:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing ERG
    DNA2.0 Custom Variant and Variant Library Synthesis for ERG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165080    OMIM disorders: --

    UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone
    and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group
    of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural
    tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the
    tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration
    involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1
  • Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation
    t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4

  • 20/30 diseases for ERG (see all 30):    About MalaCards
    peripheral primitive neuroectodermal tumor    branch retinal artery occlusion    prostate small cell carcinoma    acute myeloid leukemia with t translocation
    mn1    myeloid leukemia    small cell carcinoma    liposarcoma
    retinal artery occlusion    acute myeloid leukemia    myxoid liposarcoma    prostate cancer
    familial prostate cancer    primitive neuroectodermal tumor    sarcoma    prostatitis
    cerebrovascular accident    down syndrome    leukemia    prostate adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ERG:
    Cerebrovascular accident

    ERG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for ERG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 76.5 2 2149958 (1), 20014889 (1), 17646667 (1)
    ewings sarcoma 74.6 6 8187069 (1), 8076344 (1), 12907633 (1), 7533529 (1) (see all 6)
    liposarcoma myxoid 70.7 1 7566973 (1)
    myeloid leukemia 60.9 4 8234289 (1), 8187069 (1), 10779324 (1), 8545449 (1)
    leukemia 41 6 17646667 (2), 16275934 (2), 2149958 (1), 19666492 (1) (see all 5)
    down syndrome 30.2 1 9315229 (1)
    cancer 4.97 4 16275934 (2), 8076344 (1), 19666492 (1)
    tumors 0.826 1 9071576 (1)

    Genetic Association Database (GAD): ERG
    Human Genome Epidemiology (HuGE) Navigator: ERG (33 documents)
    Tumor Gene Database (TGDB): ERG

    Export disorders for ERG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERG gene, integrated from 9 sources (see all 225):
    (articles sorted by number of sources associating them with ERG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). (PubMed id 16303180)1, 2, 9 Moore S.D....Dal Cin P. (2006)
    2. ERG gene is translocated in an Ewing's sarcoma cell line. (PubMed id 8076344)1, 2, 9 Dunn T.... Viola M.V. (1994)
    3. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. (PubMed id 8187069)1, 2, 9 Ichikawa H.... Ohki M. (1994)
    4. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (2011)
    5. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. (PubMed id 20662065)1, 4 Clancy R.M....Buyon J.P. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Genetic variation in the upstream region of ERG and prostate cancer. (PubMed id 19205910)1, 4 LindstrAPm S....Wiklund F. (2009)
    8. Utility of incorporating genetic variants for the early detection of prostate cancer. (PubMed id 19223501)1, 4 Nam R.K....Narod S.A. (2009)
    9. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    10. Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer. (PubMed id 18694509)1, 4 FitzGerald L.M....Huntsman D.G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2078 HGNC: 3446 AceView: ERG Ensembl:ENSG00000157554 euGenes: HUgn2078
    ECgene: ERG Kegg: 2078 H-InvDB: ERG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ERG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ERG gene:
    Search GeneIP for patents involving ERG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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