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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ERG Gene

protein-coding GIFtS: 62
GCID: GC21M039751

v-ets erythroblastosis virus E26 oncogene homolog (avian)

(Previous names: v-ets avian erythroblastosis virus E26 oncogene related,...)

Explore 32 diseases affiliated with
ERG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
V-Ets Erythroblastosis Virus E26 Oncogene Homolog (Avian)¹ ²		Ets-Related¹
Erg-3¹		TMPRSS2/ERG Fusion²
P55¹		Transcriptional Regulator ERG²
V-Ets Avian Erythroblastosis Virus E26 Oncogene Related¹ ²		V-Ets Erythroblastosis Virus E26 Oncogene Like²
Transcriptional Regulator ERG (Transforming Protein ERG)² 11		Transforming Protein ERG³
V-Ets Erythroblastosis Virus E26 Oncogene Like (Avian)¹

External Ids:	HGNC: 3446¹	Entrez Gene: 2078²	Ensembl: ENSG00000157554⁷	OMIM: 165080⁵	UniProtKB: P11308³

Export aliases for ERG gene to outside databases

Previous GC identifers: GC21M036332 GC21M038672 GC21M038675 GC21M025221

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERG:

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All

members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis,

inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS

DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins.

This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also

regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in

chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate

cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript

variants encoding different isoforms have been identified. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1

histone methyltransferase and subsequent modification of local chromatin structure

Gene Wiki entry for ERG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ERG gene promoter:
AML1a ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERG promoter sequence

Search SABiosciences Chromatin IP Primers for ERG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.2 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.2

ERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERG gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M039751:	GeneLoc	Nature:405,311-319
Start:	39,751,949 bp from pter	25,330,315 bp from centromere
End:	40,033,704 bp from pter	25,609,026 bp from centromere
Size:	281,756 bases	278,712 bases
Orientation:	minus strand	plus strand

Whole chromosome sequencing:
cDNA sequence:	M17254
genomic clones:	pS166 to P178O22

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308 (See protein sequence)

Recommended Name: Transcriptional regulator ERG

Size: 486 amino acids; 54608 Da

Subunit: Interacts with SETDB1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4,

DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL,

PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs

Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs

1 PDB 3D structure from and Proteopedia for ERG:

1SXE (3D)

Secondary accessions: B4DTW5 B4E0T4 Q16113 Q6XXX4 Q6XXX5 Q8IXK9

Alternative splicing: 6 isoforms: P11308-3 P11308-1 P11308-2 P11308-4 P11308-5 P11308-6

Explore the universe of human proteins at neXtProt for ERG: NX_P11308

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11308

ERG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001129626.1 NP_001129627.1 NP_001230357.1 NP_001230358.1 NP_001230361.1 NP_004440.1 NP_891548.1

ENSEMBL proteins:

ENSP00000381877 ENSP00000381879 ENSP00000288319 ENSP00000381871 ENSP00000381882

ENSP00000414150 ENSP00000381881 ENSP00000396268 ENSP00000381891 ENSP00000394694

ENSP00000415659

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	Novus Biologicals ERG Proteins Novus Biologicals ERG Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ERG

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0030529	ribonucleoprotein complex	IDA	17289661

ERG for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ERG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ERG for domains About GeneDecksing

4 InterPro domains/families:

IPR000418 Ets_dom

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR003118 Pointed_dom

IPR013761 SAM/pointed

Graphical View of Domain Structure for InterPro Entry P11308

ProtoNet protein and cluster: P11308

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1

histone methyltransferase and subsequent modification of local chromatin structure

Genatlas biochemistry entry for ERG:

avian erythroblastosis virus E26 (v-ets) oncogene related protein,rearranged in myeloid leukemia with translocation

t(16;21)(p11;q11) (see FUS) and in Ewing sarcoma with t(21;22) translocation

miRNA Products:		OriGene 3'-UTR Clone (see all 4): ERG Browse MicroRNA Expression Plasmids
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		hsa-miR-361-5p hsa-miR-3146 hsa-miR-200a hsa-miR-128 hsa-miR-1258 hsa-miR-30d hsa-miR-219-5p hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ERG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERG (see all 7) OriGene shRNA RFP: ERG OriGene siRNA: ERG
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for ERG

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ERG
		Search LifeMap BioReagents cell lines for ERG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERG

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8502479
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	TAS	8502479
GO:0005515	protein binding	IPI	--
GO:0043565	sequence-specific DNA binding	IEA	--

ERG for ontologies About GeneDecksing

Animal Models:
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Erg):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	mortality/aging	nervous system	normal

ERG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ERG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/94 Interacting proteins for ERG (P11308^{1, 2, 3} ENSP00000381891⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275¹^,²^,³, ENSP00000363822⁴	EBI-79704,EBI-608057 MINT-8388488 I2D: score=3 STRING: ENSP00000363822
EZH2	Q15910²^,³, ENSP00000320147⁴	MINT-8388497 I2D: score=1 STRING: ENSP00000320147
ETS2	P15036³, ENSP00000353344⁴	I2D: score=3 STRING: ENSP00000353344
SETDB1	Q15047³, ENSP00000357965⁴	I2D: score=3 STRING: ENSP00000357965
JUN	P05412³, ENSP00000360266⁴	I2D: score=2 STRING: ENSP00000360266

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006468	protein phosphorylation	TAS	8502479
GO:0007165	signal transduction	TAS	8502479
GO:0007275	multicellular organismal development	TAS	8502479
GO:0008283	cell proliferation	TAS	3476934

ERG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ERG
Search CenterWatch for drugs/clinical trials and news about ERG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ERG gene (8 alternative transcripts):

NM_001136154.1 NM_001136155.1 NM_001243428.1 NM_001243429.1 NM_001243432.1 NM_004449.4 NM_182918.3 NM_001243433.1

Unigene Cluster for ERG:

V-ets erythroblastosis virus E26 oncogene homolog (avian)

Hs.473819 [show with all ESTs]

Unigene Representative Sequence: NM_001243428

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398905 ENST00000398907 ENST00000288319(uc002yxa.3 uc011aek.2)

ENST00000398897 ENST00000398911(uc010gnv.3 uc010gnx.3) ENST00000417133(uc010gnw.3)

ENST00000398910 ENST00000453032 ENST00000398919 ENST00000481609(uc010gny.1)

ENST00000492833 ENST00000468474(uc002yxc.4) ENST00000473107 ENST00000485493(uc010gnz.3)

ENST00000442448(uc021wjd.1 uc011ael.2 uc002yxb.3) ENST00000429727(uc011aem.1)

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		8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate ERG (see all 75):
		hsa-miR-361-5p hsa-miR-3146 hsa-miR-200a hsa-miR-128 hsa-miR-1258 hsa-miR-30d hsa-miR-219-5p hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ERG 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERG

Additional cDNA sequence:

AK297807.1 AK300395.1 AK301277.1 AK303518.1 AK304662.1 AK309469.1 AY204740.1 AY204741.1

AY204742.1 AY204743.1 BC040168.1 DQ204772.1 DQ204773.2 DQ831522.1 EU090248.1 FJ423744.1

M21535.1 S77574.1 U17630.1

10 DOTS entries:

DT.91659622 DT.100740571 DT.109790 DT.86849626 DT.102830579 DT.426858 DT.95310949 DT.95310911

DT.91657433 DT.92412828

24/47 AceView cDNA sequences (see all 47):

BX100094 AF015313 NM_004449 AY204742 NM_182918 AY204741 R82162 BQ926242

AU136709 AW772271 AI168805 AY204740 R82102 BC040168 AU185916 BX952555

AU280022 R82103 CA405791 BG259459 BG390291 AI767442 CB269538 BI712083

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ERG (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c
SP1:									-		-		-		-		-														-
SP2:													-		-		-														-								-
SP3:									-		-		-		-		-		-										-		-								-
SP4:									-		-		-		-		-
SP5:															-		-

ECgene alternative splicing isoforms for ERG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ERG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ERG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Autopod Articular Cartilage

Articular Cartilage Cells

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Stylopod Articular Cartilage

Articular Cartilage Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Zeugopod Articular Cartilage

Articular Cartilage Cells

Cartilage

Limb

Autopod Synovial Joint

Interzone Cells

Cartilage

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Limb

Zeugopod Synovial Joint

Interzone Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)

Cartilage

See ERG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ERG

SOURCE GeneReport for Unigene cluster: Hs.473819

SABiosciences Expression via Pathway-Focused PCR Array including ERG:

Prostate Cancer in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ERG gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ERG¹	v-ets erythroblastosis virus E26 oncogene homolog (avian)	84.84(n) 95.18(a)		374146 NM_204280.1 NP_989611.1
lizard (Anolis carolinensis)	Reptilia	ERG⁶ --	--	91(a) 55(a)	1 ↔ 1 possible ortholog	3(140237669-140261749) GL343514.1(326230-339899)
African clawed frog (Xenopus laevis)	Amphibia	erg-A²	v-ets erythroblastosis virus E26 oncogene like	81.47(n)		AJ224125.1
zebrafish (Danio rerio)	Actinopterygii	erg¹	v-ets erythroblastosis virus E26 oncogene like (avian)	71.11(n) 71.6(a)		494073 NM_001008616.1 NP_001008616.1
fruit fly (Drosophila melanogaster)	Insecta	Ets65A³	DNA binding	62(a) (best of 2)		65A6 --
worm (Caenorhabditis elegans)	Secernentea	C42D8.4³	DNA-binding protein	78(a)		X(5114542-5116802) --

ENSEMBL Gene Tree for ERG (if available)
TreeFam Gene Tree for ERG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ERG gene

ELK4² ETV1² ETV3² ERF² ETV5² ETV3L² ETS1² GABPA²

ETS2² ELK1² FEV² ETV4² ETV2² ELK3² FLI1²

9 SIMAP similar genes for ERG using alignment to 6 protein entries: ERG_HUMAN (see all proteins):

NDRG1-ERG fusion TLS-ERG erg FLI1 EWSR1/FLI1 fusion ETV2

EWS-Fli1 ELK3 FEV

ERG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201046610^1,2	C	other	26270419(+)	`ACAGGA/C/GGTGTT`	7	--	int¹		1	EU	1309
rs113352498^1,2	C,	--	25209944(+)	`TTCCTC/AGTTTT`	1	--	int¹		2	NA WA	120
rs76252150^1,2	F,	--	25209991(+)	`ATGACC/GCCTAA`	1	--	int¹		2	NA EA	240
rs76804174^1,2	F,	--	25210051(+)	`ATCATA/TTATGT`	1	--	int¹		1	NA	120
rs4508690^1,2	H	--	25210124(+)	`AAACTC/ACATTA`	1	--	int¹		4	NS EA	418
rs74642731^1,2	F,	--	25212290(+)	`TCATAT/CATGTG`	1	--	int¹		1	WA	118
rs79342343^1,2	F,	--	25212973(+)	`TAAAAC/TTCTTA`	1	--	int¹		1	WA	118
rs35819020^1,2	C,	--	25213919(+)	`TATTAT/ACTGTC`	1	--	int¹		2	NA	122
rs2836347^1,2	O,H	--	25214565(+)	`ATAGCT/ACACAC`	1	--	int¹		5	NA NS EA	429
rs76874996^1,2	F,	--	25215354(+)	`TATTAC/TCATCT`	1	--	int¹		1	EA	120

HapMap Linkage Disequilibrium report for ERG (39751949 - 40001949 bp, first 250kb of ERG)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ERG
5 CNVs: 67786 10601 90775 6136 9328
5 Indels: 79347 12240 103093 46165 41404

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing ERG:

Oncogenes & Tumor Suppressor Genes 384HC

Prostate Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ERG

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ERG for disorders About GeneDecksing

OMIM gene information: 165080 OMIM disorders: --

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small

round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family

of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are

considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form

of the tumors. Note=A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation

t(21;22)(q22;q12) with EWSR1

Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation

t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4

20/32 diseases for ERG (see all 32): About MalaCards

acute myeloid leukemia myeloid leukemia prostate cancer branch retinal artery occlusion

primitive neuroectodermal tumor sarcoma prostatitis leukemia

peripheral primitive neuroectodermal tumor myxoid liposarcoma neuroectodermal tumors retinal artery occlusion

cerebrovascular accident small cell carcinoma liposarcoma prostate small cell carcinoma

acute lymphoblastic leukemia down syndrome megakaryoblastic leukemia lymphoblastic leukemia

1 disease from the University of Copenhagen DISEASES database for ERG:

Cerebrovascular accident

8 Novoseek disease relationships for ERG gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroblastosis	76.5	2	2149958 (1), 20014889 (1), 17646667 (1)
ewings sarcoma	74.6	6	8187069 (1), 8076344 (1), 12907633 (1), 7533529 (1) (see all 6)
liposarcoma myxoid	70.7	1	7566973 (1)
myeloid leukemia	60.9	4	8234289 (1), 8187069 (1), 10779324 (1), 8545449 (1)
leukemia	41	6	17646667 (2), 16275934 (2), 2149958 (1), 19666492 (1) (see all 5)
down syndrome	30.2	1	9315229 (1)
cancer	4.97	4	16275934 (2), 8076344 (1), 19666492 (1)
tumors	0.826	1	9071576 (1)

Genetic Association Database (GAD): ERG
Human Genome Epidemiology (HuGE) Navigator: ERG (33 documents)
Tumor Gene Database (TGDB): ERG

Export disorders for ERG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ERG gene, integrated from 9 sources (see all 197):
(articles sorted by number of sources associating them with ERG)

Utopia: connect your pdf to the dynamic
world of online information

ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). (PubMed id 16303180)^{1, 2, 9} Moore S.D....Dal Cin P. (2006)
ERG gene is translocated in an Ewing's sarcoma cell line. (PubMed id 8076344)^{1, 2, 9} Dunn T.... Viola M.V. (1994)
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. (PubMed id 8187069)^{1, 2, 9} Ichikawa H.... Ohki M. (1994)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. (PubMed id 14693372)^{1, 2} Owczarek C.M.... Hertzog P.J. (2004)
Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women. (PubMed id 11472898)^{1, 4} Lau E.M....Woo J. (2001)
Differentially spliced erg-3 product functions as a transcriptional activator. (PubMed id 8290279)^{1, 2} Prasad D.D.... Reddy E.S. (1994)
The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. (PubMed id 3274086)^{1, 3} Rao V.N....Reddy E.S. (1988)
The erg gene: a human gene related to the ets oncogene. (PubMed id 3476934)^{1, 2} Reddy E.S.P.... Papas T.S. (1987)
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. (PubMed id 3299708)^{1, 2} Rao V.N.... Reddy P. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2078	HGNC: 3446	AceView: ERG	Ensembl:ENSG00000157554	euGenes: HUgn2078
ECgene: ERG	H-InvDB: ERG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ERG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ERG	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ERG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ERG gene:
Search GeneIP for patents involving ERG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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