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ERG Gene

protein-coding GIFtS: 68

GC21M038675

v-ets erythroblastosis virus E26 oncogene homolog (avian)
(Previous names: v-ets avian erythroblastosis virus E26 oncogene related, v-ets erythroblastosis virus E26 oncogene like (avian) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
OTTHUMP00000115970 ^²
erg-3 ^¹, ²
ets-related ^²
p55 ^¹, ²

Descriptions
TMPRSS2-ERG prostate cancer specific ^²
Transforming protein ERG ^³
transcriptional regulator ERG (transforming protein ERG) ^², 9
v-ets avian erythroblastosis virus E26 oncogene related ^¹, ²
v-ets erythroblastosis virus E26 oncogene homolog (avian) ^²
v-ets erythroblastosis virus E26 oncogene like ^²
v-ets erythroblastosis virus E26 oncogene like (avian) ^¹

External Ids
HGNC: 3446¹
Entrez Gene: 2078²
UniProtKB: P11308³
Ensembl: ENSG00000157554⁷

Search outside databases for aliases for ERG gene

Previous GC identifers: GC21M036332 GC21M038672

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Function: Transcriptional regulator. May participate in transcriptional regulation through the

recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin

structure

Gene Wiki entry for ERG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.2 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.2

ERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M038675:	GeneLoc	Nature:405,311-319
Start:	38,673,819 bp from pter	25,330,315 bp from centromere
End:	38,955,488 bp from pter	25,609,026 bp from centromere
Size:	281,670 bases	278,712 bases
Orientation:	minus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	M17254
genomic clones:	pS166 to P178O22

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308 (See protein sequence)

Recommended Name: Transcriptional regulator ERG

Size: 486 amino acids; 54608 Da

Subunit: Interacts with SETDB1 (By similarity)

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1SXE (3D)

Secondary accessions: B4DTW5 B4E0T4 Q16113 Q6XXX4 Q6XXX5 Q8IXK9

Alternative splicing: 6 isoforms: P11308-3 P11308-1 P11308-2 P11308-4 P11308-5 P11308-6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001129626.1 NP_001129627.1 NP_004440.1 NP_891548.1

ENSEMBL proteins:

ENSP00000381877 ENSP00000349966 ENSP00000381879 ENSP00000381891 ENSP00000381871 ENSP00000381873

ENSP00000381882 ENSP00000381888 ENSP00000381881 ENSP00000288319

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ERG)
	Human Recombinant Proteins from Abnova (ERG)

OriGene Purified Recombinant Human Proteins (see all 2): ERG

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	8502479

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Antibodies for ERG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ERG
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ERG), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ERG)
	Novus Biologicals Antibodies for ERG

Assays for ERG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11308

ProtoNet protein and cluster: P11308

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ERG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ERG)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_182918

Applied Biosystems Silencer® siRNAs for ERG

Sigma-Aldrich siRNA for ERG

Sigma-Aldrich shRNA Panels and shRNA for ERG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ERG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001136154
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001136154
untagged cDNA clones in CMV expression vector (see all 4): NM_001136154

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001136154

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

Function: Transcriptional regulator. May participate in transcriptional regulation through the

recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin

structure

Genatlas biochemistry entry for ERG:

avian erythroblastosis virus E26 (v-ets) oncogene related protein,rearranged in myeloid leukemia

with translocation t(16;21)(p11;q11) (see FUS) and in Ewing sarcoma with t(21;22) translocation

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Erg):

lethality-prenatal/perinatal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0004871	signal transducer activity	TAS	8502479
GO:0005515	protein binding	IPI	11791185
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for ERG

5/40 Interacting proteins for ERG (ENSP00000288319³ P11308¹) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SETDB1	Q15047¹	STRING (score=.743) EBI-79704, EBI-79691
TNFRSF1A	ENSP00000162749³	STRING (score=.993)
IL1B	ENSP00000263341³	STRING (score=.953)
IL2	ENSP00000226730³	STRING (score=.953)
IL6	ENSP00000258743³	STRING (score=.953)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006468	protein amino acid phosphorylation	TAS	8502479
GO:0007165	signal transduction	TAS	8502479
GO:0007275	multicellular organismal development	TAS	8502479

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ERG

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ERG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ERG)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_182918

Sigma-Aldrich siRNA for ERG

Sigma-Aldrich shRNA Panels and shRNA for ERG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136154 NM_001136155 NM_004449 NM_182918

REFSEQ mRNAs for ERG gene (4 alternative transcripts):

NM_001136154.1 NM_001136155.1 NM_004449.4 NM_182918.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136154 NM_001136155 NM_004449 NM_182918

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001136154
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001136154
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001136154

Additional cDNA sequence:

AK297807.1 AK300395.1 AK301277.1 AK303518.1 AK304662.1 AK309469.1 AY204740.1 AY204741.1

AY204742.1 AY204743.1 BC040168.1 DQ204772.1 DQ204773.2 DQ831522.1 EU090248.1 EU432099.1

FJ423744.1 M21535.1 S72621.1 S72865.1 S77574.1 U17630.1

11 DOTS entries:

DT.91659622 DT.100740571 DT.109790 DT.86849626 DT.102830579 DT.426858 DT.92412828 DT.95310949

DT.91657433 DT.92408249 DT.95310911

24/47 AceView cDNA sequences (see all 47 ):

NM_004449 AU280022 AW772271 BX952555 NM_182918 BQ926242 AY204741 R82102

AI168805 AU185916 AY204740 AY204742 AF015313 AU136709 BX100094 BC040168

R82162 BG259459 CA405791 R82103 BG390291 AI767442 BG388025 BM456833

highest scoring ESTs for ERG:

AI142842 AI351043 AY204741 AY204742 AY204743 M21535 AA181081 AA296657 AA479151 AA872358

Unigene Cluster for ERG:

V-ets erythroblastosis virus E26 oncogene homolog (avian)

Hs.473819 [show with all ESTs]

Unigene Representative Sequence: NM_001136154

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ERG (see all 8 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c
SP1:									-		-		-		-		-														-
SP2:													-		-		-														-								-
SP3:									-		-		-		-		-		-										-		-								-
SP4:									-		-		-		-		-
SP5:															-		-

About this scheme

ECgene alternative splicing isoforms for ERG

10 Ensembl transcripts including schematic representations:

ENST00000398905 ENST00000357391 ENST00000398907 ENST00000398919 ENST00000398897 ENST00000398899

ENST00000398911 ENST00000398916 ENST00000398910 ENST00000288319

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ERG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ERG

¹ / ² / ³

15 probe-sets matching ERG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73161_at²^{, 3}	U95-E	1	1.00	1.00	0.82	0.90	AI142842	0.80	1.00	0.91	1
52138_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.41	AI351043	0.80	1.00	0.91	1
913_at²^{, 3}	U95-A	1	1.00	1.00	0.58	0.63	M21535	0.80	1.00	0.91	1
49092_at²^{, 3}	U95-B	1	1.00	1.00	0.89	0.92	AA706319	0.20	1.00	0.72	1
36383_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.70	M17254	0.20	1.00	0.72	1
914_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.09	M21535	0.80	1.00	0.91	1
2046_at²	U95-A	1	0.88	1.00	0.40	1.42	--	--	--	--	--
213541_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI351043	0.80	1.00	0.91	1
222079_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF739971	0.20	1.00	0.72	1
241926_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA296657	0.60	1.00	0.82	1
211626_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M21535	0.80	1.00	0.91	1
213541_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222079_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241926_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211626_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ERG for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.473819
Expression variation in blood from EXPOLDB for ERG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ERG gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ERG¹	--	v-ets erythroblastosis virus E26 oncogene homolog (avian)	99.72(n) 100(a)	473995 XM_001170722.1 XP_001170722.1
cow (Bos taurus)	ERG¹	--	v-ets erythroblastosis virus E26 oncogene homolog (avian)	91.86(n) 97.29(a)	535231 XM_866386.2 XP_871479.1
rat (Rattus norvegicus)	Erg¹	--	avian erythroblastosis virus E-26 (v-ets) oncogene more	89.23(n) 97.36(a)	170909 NM_133397.1 NP_596888.1
mouse (Mus musculus)	Erg^{1, 5}	16 (69.10 cM)⁵	avian erythroblastosis virus E-26 (v-ets) oncogene more^{1, 5}	89.54(n)¹ 96.65(a)¹	13876¹ NM_133659.2¹ NP_598420.1¹ AB073078⁵ AB073079⁵ (see all 13)
chicken (Gallus gallus)	ERG¹	--	v-ets erythroblastosis virus E26 oncogene	85.22(n) 95.61(a)	374146 NM_204280.1 NP_989611.1

About this table Species with no ortholog for ERG

ENSEMBL Gene Tree for ERG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ERG gene

FEV² ETV2² FLI1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1870 NCBI SNPs in ERG are shown (see all 1870 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 712)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2836354^1,2	A,C,F,H,O	38675245(+)	`GCTAGT/CGAATC`	4	--	ut3¹		18	NA EA EU WA	2976
	rs2836442^1,2	A,C,F,H,O	38792912(+)	`AACACA/GAAAAA`	2	--	ng3¹ int¹		12	NA EU EA WA	998
	rs764482^1,2	A,C,F,H	38955531(-)	`TCGCTG/CCGGGA`	2	--	ut5¹		9	NS MN EA	576
	rs2836352^1,2	C,F,H,O	38673825(+)	`TTGGTG/ATATTT`	4	--	ut3¹		8	NA EU EA WA	579
	rs2836444^1,2	C,F,H,O	38793305(+)	`CTCAAT/CAGGCG`	2	--	ng3¹ int¹		9	NA EU EA WA	652
	rs2836443^1,2	C,F,H,O	38793146(+)	`AGGTCG/TGTTTT`	2	--	int¹ ng3¹		13	NA EU EA WA	1072
	rs6517463^1,2	A,C,F,H	38674543(+)	`CTGGAC/TTGGGG`	4	--	ut3¹		4	EU EA WA	412
	rs2836441^1,2	C,F,H,O	38792180(+)	`AATGCA/GATCAA`	3	--	int¹ ut5¹		12	NA EU EA WA	1002
	rs2836353^1,2	C,F,H	38675216(+)	`AAGGGA/CTAGCC`	4	--	ut3¹		14	NA EA EU WA	2380
	rs3787906^1,2	C,F,H	38793738(+)	`CAGAAC/TCTAAG`	2	--	int¹ ng3¹		12	EA NA EU WA	2484

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HapMap Linkage Disequilibrium images for ERG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 165080

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308

A chromosomal aberration involving ERG is a cause of Erwing sarcoma [MIM:133450].

Translocation t(21;22)(q22;q12) with ERW

A chromosomal aberration involving ERG is a cause of acute myeloid leukemia (AML).

Translocation t(16;21)(p11;q22) with FUS

8 Novoseek disease relationships for ERG gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ewings sarcoma	73.60	5	8187069 (1), 8076344 (1), 12907633 (1), 7533529 (1) (see all 5)
liposarcoma myxoid	71.59	1	7566973 (1)
erythroblastosis	69.36	1	2149958 (1), 17646667 (1)
myeloid leukemia	61.76	4	8234289 (1), 8187069 (1), 10779324 (1), 8545449 (1)
leukemia	38.76	5	17646667 (2), 16275934 (2), 2149958 (1), 2250910 (1)
down syndrome	31.30	1	9315229 (1)
cancer	0.00	3	16275934 (2), 8076344 (1)
tumors	0.00	1	9071576 (1)

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1 PharmGKB disease relationship for ERG gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database: ERG
Human Genome Epidemiology Navigator: ERG (23 documents)
Tumor Gene Database: ERG

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/96 PubMed articles for ERG gene (see all 96 ):

ERG gene is translocated in an Ewing's sarcoma cell line. (PubMed id 8076344)^{1, 3, 4} Dunn T.... Viola M.V. (1994)
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. (PubMed id 8187069)^{1, 3, 4} Ichikawa H.... Ohki M. (1994)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. (PubMed id 14693372)^{3, 4} Owczarek C.M.... Hertzog P.J. (2004)
Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women. (PubMed id 11472898)^{3, 6} Lau E.M....Woo J. (2001)
Differentially spliced erg-3 product functions as a transcriptional activator. (PubMed id 8290279)^{3, 4} Prasad D.D.... Reddy E.S. (1994)
The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. (PubMed id 3274086)^{2, 3} Rao V.N....Reddy E.S. (1988)
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. (PubMed id 3299708)^{3, 4} Rao V.N.... Reddy P. (1987)
The erg gene: a human gene related to the ets oncogene. (PubMed id 3476934)^{3, 4} Reddy E.S.P.... Papas T.S. (1987)
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. (PubMed id 16275934)^{1, 3} Marcucci G....Bloomfield C.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2078	HGNC: 3446	AceView: ERG	Ensembl:ENSG00000157554	euGenes: HUgn2078
ECgene: ERG	H-InvDB: ERG

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ERG	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ERG
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ERG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ERG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ERG		Antibodies for ERG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ERG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ERG)
	Antibodies (ERG)
	Chimera RNAi (ERG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ERG)
	Antibodies (ERG)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ERG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ERG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ERG Gene at Home site.
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ERG Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ERG

Summaries
for ERG

Genomic Location
for ERG

Proteins
for ERG

Protein Domains/
Families
for ERG

Gene Function
for ERG

Pathways & Interactions
for ERG

Drugs & Compounds
for ERG

Transcripts
for ERG

Expression
for ERG

Orthologs
for ERG

Paralogs
for ERG

SNPs/Variants
for ERG

Disorders & Mutations
for ERG

Medical News
for ERG

Publications
for ERG

Search for ERG

Genome Databases showing ERG

Other Databases showing ERG

Specialized Databases showing ERG

Licensable Technologies
for ERG

Services
for ERG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ERG Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ERG

Summariesfor ERG

Genomic Locationfor ERG

Proteinsfor ERG

Protein Domains/Familiesfor ERG

Gene Functionfor ERG

Pathways & Interactionsfor ERG

Drugs & Compoundsfor ERG

Transcriptsfor ERG

Expression for ERG

Orthologsfor ERG

Paralogsfor ERG

SNPs/Variantsfor ERG

Disorders & Mutationsfor ERG

Medical Newsfor ERG

Publicationsfor ERG

Search for ERG

Genome Databases showing ERG

Other Databases showing ERG

Specialized Databases showing ERG

Licensable Technologiesfor ERG

Servicesfor ERG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ERG

Summaries
for ERG

Genomic Location
for ERG

Proteins
for ERG

Protein Domains/
Families
for ERG

Gene Function
for ERG

Pathways & Interactions
for ERG

Drugs & Compounds
for ERG

Transcripts
for ERG

Expression
for ERG

Orthologs
for ERG

Paralogs
for ERG

SNPs/Variants
for ERG

Disorders & Mutations
for ERG

Medical News
for ERG

Publications
for ERG

Licensable Technologies
for ERG

Services
for ERG