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ERG Gene

protein-coding   GIFtS: 63
GCID: GC21M039751

V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog

(Previous name: v-ets avian erythroblastosis virus E26 oncogene related)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog1 2     ets-related2
V-Ets Avian Erythroblastosis Virus E26 Oncogene Related1 2     p552
Transcriptional Regulator ERG (Transforming Protein ERG)2 11     TMPRSS2/ERG Fusion2
V-Ets Erythroblastosis Virus E26 Oncogene Like1 2     Transcriptional Regulator ERG2
TMPRSS2-ERG Prostate Cancer Specific1     V-Ets Erythroblastosis Virus E26 Oncogene Homolog2
erg-32     Transforming Protein ERG3

External Ids:    HGNC: 34461   Entrez Gene: 20782   Ensembl: ENSG000001575547   OMIM: 1650805   UniProtKB: P113083   

Export aliases for ERG gene to outside databases

Previous GC identifers: GC21M036332 GC21M038672 GC21M038675 GC21M025221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERG Gene:
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All
members of this family are key regulators of embryonic development, cell proliferation, differentiation,
angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus.
It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of
chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular
cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells.
This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as
TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified. (provided by
RefSeq, Jan 2012)

GeneCards Summary for ERG Gene:
ERG (v-ets avian erythroblastosis virus E26 oncogene homolog) is a protein-coding gene. Diseases associated with ERG include extraskeletal ewing sarcoma, and peripheral primitive neuroectodermal tumor. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of
SETDB1 histone methyltransferase and subsequent modification of local chromatin structure

Gene Wiki entry for ERG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERG gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERG promoter sequence

   Search Chromatin IP Primers for ERG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
ERG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERG gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M039751:   GeneLoc Nature:405,311-319
Start:
39,751,949 bp from pter       25,330,315 bp from centromere
End:
40,033,704 bp from pter 25,609,026 bp from centromere
Size:
281,756 bases 278,712 bases
Orientation:
minus strand plus strand

Whole chromosome sequencing:
cDNA sequence: M17254
genomic clones: pS166 to P178O22


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ERG_HUMAN, P11308 (See protein sequence)
Recommended Name: Transcriptional regulator ERG  
Size: 486 amino acids; 54608 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with
SETDB1
4 PDB 3D structures from and Proteopedia for ERG:
1SXE (3D)        4IRG (3D)        4IRH (3D)        4IRI (3D)    
Secondary accessions: B4DTW5 B4E0T4 Q16113 Q6XXX4 Q6XXX5 Q8IXK9
Alternative splicing: 6 isoforms:  P11308-3   P11308-1   P11308-2   P11308-4   P11308-5   P11308-6   

Explore the universe of human proteins at neXtProt for ERG: NX_P11308

Explore proteomics data for ERG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ERG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001129626.1  NP_001129627.1  NP_001230357.1  NP_001230358.1  NP_001230361.1  NP_004440.1  NP_891548.1  

    ENSEMBL proteins: 
     ENSP00000381877   ENSP00000381879   ENSP00000288319   ENSP00000381871   ENSP00000381882  
     ENSP00000414150   ENSP00000381881   ENSP00000396268   ENSP00000381891   ENSP00000394694  
     ENSP00000415659  

    ERG Human Recombinant Protein Products:

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    OriGene MassSpec for ERG
    OriGene Custom Protein Services for ERG
    GenScript Custom Purified and Recombinant Proteins Services for ERG
    Novus Biologicals ERG Proteins
    Novus Biologicals ERG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERG

    ERG Antibody Products:

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    Abcam antibodies for ERG
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    ThermoFisher Antibody for ERG
    LSBio Antibodies in human, mouse, rat for ERG

    ERG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ERG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ERG
    Cloud-Clone Corp. CLIAs for ERG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry P11308

    ProtoNet protein and cluster: P11308

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ERG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERG_HUMAN, P11308
    Function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of
    SETDB1 histone methyltransferase and subsequent modification of local chromatin structure

         Genatlas biochemistry entry for ERG:
    avian erythroblastosis virus E26 (v-ets) oncogene related protein,rearranged in myeloid leukemia with
    translocation t(16;21)(p11;q11) (see FUS) and in Ewing sarcoma with t(21;22) translocation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding TAS8502479
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0004871signal transducer activity TAS8502479
    GO:0005515protein binding IPI--
         
    ERG for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Erg):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  normal 

    ERG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERG

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ACAGGAAGTG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERG:
    hsa-mir-133b (MIRT016692), hsa-mir-145-5p (MIRT007094)

    Block miRNA regulation of human, mouse, rat ERG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERG (see all 75):
    hsa-miR-361-5p hsa-miR-3146 hsa-miR-200a hsa-miR-128 hsa-miR-1258 hsa-miR-30d hsa-miR-219-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidERG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERG
    Predesigned siRNA for gene silencing in human, mouse, rat ERG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERG

    Clone
    Products:
         
    OriGene clones in human, mouse for ERG (see all 21)
    OriGene ORF clones in mouse, rat for ERG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ERG (NM_001136154)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERG

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ERG
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERG_HUMAN, P11308: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661

    ERG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERG About    
    See pathways by source

    SuperPathContained pathways About
    1Prostate Cancer
    Prostate Cancer0.32
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ERG
        Prostate Cancer


    1 Kegg Pathway  (Kegg details for ERG):
        Transcriptional misregulation in cancer


    ERG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ERG: 
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ERG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERG (P113081, 2, 3 ENSP000003818914) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 2, 3, ENSP000003638224EBI-79704,EBI-608057 MINT-8388488 I2D: score=3 STRING: ENSP00000363822
    EZH2Q159102, 3, ENSP000003201474MINT-8388497 I2D: score=1 STRING: ENSP00000320147
    ETS2P150363, ENSP000003533444I2D: score=3 STRING: ENSP00000353344
    SETDB1Q150473, ENSP000003579654I2D: score=3 STRING: ENSP00000357965
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0006468protein phosphorylation TAS8502479

    ERG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ERG gene (8 alternative transcripts): 
    NM_001136154.1  NM_001136155.1  NM_001243428.1  NM_001243429.1  NM_001243432.1  NM_004449.4  NM_182918.3  NM_001243433.1  

    Unigene Cluster for ERG:

    V-ets erythroblastosis virus E26 oncogene homolog (avian)
    Hs.473819  [show with all ESTs]
    Unigene Representative Sequence: NM_001243428
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398905 ENST00000398907 ENST00000288319(uc002yxa.3 uc011aek.2)
    ENST00000398897 ENST00000398911(uc010gnv.3 uc010gnx.3) ENST00000417133(uc010gnw.3)
    ENST00000398910 ENST00000453032 ENST00000398919 ENST00000481609(uc010gny.1)
    ENST00000492833 ENST00000468474(uc002yxc.4) ENST00000473107 ENST00000485493(uc010gnz.3)
    ENST00000442448(uc021wjd.1 uc011ael.2 uc002yxb.3) ENST00000429727(uc011aem.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERG (see all 75):
    hsa-miR-361-5p hsa-miR-3146 hsa-miR-200a hsa-miR-128 hsa-miR-1258 hsa-miR-30d hsa-miR-219-5p hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidERG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERG
    Predesigned siRNA for gene silencing in human, mouse, rat ERG
    Clone
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    OriGene clones in human, mouse for ERG (see all 21)
    OriGene ORF clones in mouse, rat for ERG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ERG (NM_001136154)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ERG
    OriGene qSTAR qPCR primer pairs in human, mouse for ERG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERG
      QuantiTect SYBR Green Assays in human, mouse, rat ERG
      QuantiFast Probe-based Assays in human, mouse, rat ERG

    Additional mRNA sequence: 

    AK297807.1 AK300395.1 AK301277.1 AK303518.1 AK304662.1 AK309469.1 AY204740.1 AY204741.1 
    AY204742.1 AY204743.1 BC040168.1 DQ204772.1 DQ204773.2 DQ831522.1 EU090248.1 FJ423744.1 
    M21535.1 S77574.1 U17630.1 

    10 DOTS entries:

    DT.91659622  DT.100740571  DT.109790  DT.86849626  DT.102830579  DT.426858  DT.95310949  DT.95310911 
    DT.91657433  DT.92412828 

    Selected AceView cDNA sequences (see all 47):

    AY204742 NM_004449 AY204741 AF015313 BQ926242 AU136709 BC040168 R82162 
    BX952555 AU185916 AI168805 R82102 AY204740 AW772271 NM_182918 BX100094 
    AU280022 CB269538 R82103 BI713036 CA405791 AI767442 BG259459 BQ233264 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ERG (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                          -     -     -     -     -                                         -                                             
    SP2:                                      -     -     -                                         -                       -                     
    SP3:                          -     -     -     -     -     -                             -     -                       -                     
    SP4:                          -     -     -     -     -                                                                                       
    SP5:                                            -     -                                                                                       


    ECgene alternative splicing isoforms for ERG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ERG Expression
    About this image


    ERG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Interzone Cells Autopod Synovial Joint
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Thymus (Hematopoietic System)
             Thymus
    ERG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473819
        Pathway & Disease-focused RT2 Profiler PCR Array including ERG: 
              Prostate Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ERG
    OriGene qSTAR qPCR primer pairs in human, mouse for ERG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERG
    QuantiTect SYBR Green Assays in human, mouse, rat ERG
    QuantiFast Probe-based Assays in human, mouse, rat ERG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ERG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erg1 , 5 avian erythroblastosis virus E-26 (v-ets) oncogene more1, 5 89.85(n)1
    97.12(a)1
      16 (56.04 cM)5
    138761  NM_133659.21  NP_598420.11 
     953591695 
    chicken
    (Gallus gallus)
    Aves ERG1 v-ets erythroblastosis virus E26 oncogene homolog 84.84(n)
    95.18(a)
      374146  NM_204280.1  NP_989611.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERG6
    v-ets avian erythroblastosis virus E26 oncogene ho...
    93(a)
    1 ↔ 1
    3(140169440-140264337)
    African clawed frog
    (Xenopus laevis)
    Amphibia erg-A2 v-ets erythroblastosis virus E26 oncogene like 81.47(n)    AJ224125.1 
    zebrafish
    (Danio rerio)
    Actinopterygii erg1 v-ets erythroblastosis virus E26 oncogene like (avian) 71.11(n)
    71.6(a)
      494073  NM_001008616.1  NP_001008616.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets65A3 DNA binding 62(a)
    (best of 2)
      65A6   --


    ENSEMBL Gene Tree for ERG (if available)
    TreeFam Gene Tree for ERG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERG gene
    ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  ETS22  
    FEV2  ETV42  ETV22  FLI12  
    9 SIMAP similar genes for ERG using alignment to 6 protein entries:     ERG_HUMAN (see all proteins):
    NDRG1-ERG fusion    TLS-ERG    erg    EWSR1/FLI1 fusion    ETV2    EWS-Fli1
    FLI1    ELK3    FEV

    ERG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERG (see all 6452)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010466101,2
    Cuntested130320104(+) ACAGGA/C/GGTGTT 7 -- int11EU 1309
    rs285796081,2
    C,F--25228495(+) TCTATT/GTTTTT 7 -- int1 trp32Minor allele frequency- G:0.25NA WA 4
    rs676901721,2
    C--25265735(+) ACAAA-/AAAAG 
            
    AAAGA
    7 -- int10--------
    rs560006651,2
    C--25271214(+) TGTGTA/GTATAT 7 -- int10--------
    rs1425999651,2
    --25271266(+) TATATA/GTGTGT 7 -- int10--------
    rs2013703561,2
    C--25271291(+) TGTGT-/GCATATA 7 -- int10--------
    rs123296411,2
    C,A--25271292(+) gtgtgT/Catata 7 -- int13Minor allele frequency- C:0.20WA CSA 5
    rs130468731,2
    F--25271315(+) gtgtgC/Tatata 7 -- int12Minor allele frequency- T:0.33NA 6
    rs1419310581,2
    C--25271315(+) GTGTG-/TATATAT 7 -- int10--------
    rs1387357511,2
    C--25308892(+) TGTTG-/CCTC  
     AAACAAA
    CCTCC
    7 -- int10--------

    HapMap Linkage Disequilibrium report for ERG (39751949 - 40001949 bp, first 250kb of ERG)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ERG (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2852CNV Deletion18987735
    esv2264168CNV Deletion18987734
    esv2723416CNV Deletion23290073
    esv2723418CNV Deletion23290073
    esv2672087CNV Deletion23128226
    esv2723419CNV Deletion23290073
    esv2658330CNV Deletion23128226
    esv2667140CNV Deletion23128226
    nsv3515CNV Insertion18451855
    esv2629526CNV Insertion19546169

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing ERG:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing ERG
    DNA2.0 Custom Variant and Variant Library Synthesis for ERG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165080    OMIM disorders: --

    UniProtKB/Swiss-Prot: ERG_HUMAN, P11308
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone
    and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group
    of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural
    tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the
    tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration
    involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1
  • Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation
    t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4

  • Selected diseases for ERG (see all 33):    
    About MalaCards
    extraskeletal ewing sarcoma    peripheral primitive neuroectodermal tumor    branch retinal artery occlusion    prostate small cell carcinoma
    myeloid leukemia    mn1    cytogenetically normal acute myeloid leukemia    retinal artery occlusion
    small cell carcinoma    liposarcoma    prostate cancer    myxoid liposarcoma
    acute myeloid leukemia    prostatitis    primitive neuroectodermal tumor    sarcoma
    angiosarcoma    down syndrome    leukemia    prostate adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ERG:
    Cerebrovascular accident

    ERG for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ERG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 76.5 2 2149958 (1), 20014889 (1), 17646667 (1)
    ewings sarcoma 74.6 6 8187069 (1), 8076344 (1), 12907633 (1), 7533529 (1) (see all 6)
    liposarcoma myxoid 70.7 1 7566973 (1)
    myeloid leukemia 60.9 4 8234289 (1), 8187069 (1), 10779324 (1), 8545449 (1)
    leukemia 41 6 17646667 (2), 16275934 (2), 2149958 (1), 19666492 (1) (see all 5)
    down syndrome 30.2 1 9315229 (1)
    cancer 4.97 4 16275934 (2), 8076344 (1), 19666492 (1)
    tumors 0.826 1 9071576 (1)

    Genetic Association Database (GAD): ERG
    Human Genome Epidemiology (HuGE) Navigator: ERG (33 documents)
    Tumor Gene Database (TGDB): ERG

    Export disorders for ERG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERG gene, integrated from 10 sources (see all 255):
    (articles sorted by number of sources associating them with ERG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). (PubMed id 16303180)1, 2, 9 Moore S.D....Dal Cin P. (Leuk. Res. 2006)
    2. ERG gene is translocated in an Ewing's sarcoma cell line. (PubMed id 8076344)1, 2, 9 Dunn T.... Viola M.V. (Cancer Genet. Cytogenet. 1994)
    3. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. (PubMed id 8187069)1, 2, 9 Ichikawa H.... Ohki M. (Cancer Res. 1994)
    4. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    5. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. (PubMed id 20662065)1, 4 Clancy R.M....Buyon J.P. (Arthritis Rheum. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genetic variation in the upstream region of ERG and prostate cancer. (PubMed id 19205910)1, 4 LindstrAPm S....Wiklund F. (amp 2009)
    8. Utility of incorporating genetic variants for the early detection of prostate cancer. (PubMed id 19223501)1, 4 Nam R.K....Narod S.A. (Clin. Cancer Res. 2009)
    9. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    10. Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer. (PubMed id 18694509)1, 4 FitzGerald L.M....Huntsman D.G. (BMC Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2078 HGNC: 3446 AceView: ERG Ensembl:ENSG00000157554 euGenes: HUgn2078
    ECgene: ERG Kegg: 2078 H-InvDB: ERG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERG gene:
    Search GeneIP for patents involving ERG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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