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ERF Gene

protein-coding   GIFtS: 60
GCID: GC19M042751

Ets2 Repressor Factor

  See ERF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ets2 Repressor Factor1 2 3
PE-22 3
CRS42 5
PE22 5
ETS Domain-Containing Transcription Factor ERF2

External Ids:    HGNC: 34441   Entrez Gene: 20772   Ensembl: ENSG000001057227   OMIM: 6118885   UniProtKB: P505483   

Export aliases for ERF gene to outside databases

Previous GC identifers: GC19M043398 GC19M043143 GC19M047427 GC19M047443 GC19M039182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERF Gene:
Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation.
They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro
et al., 1997 (PubMed 9192842)). For further information on ETS transcription factors, see ETS1 (MIM
164720).(supplied by OMIM, Mar 2008)

GeneCards Summary for ERF Gene:
ERF (Ets2 repressor factor) is a protein-coding gene. Diseases associated with ERF include craniosynostosis 4, and crouzon syndrome. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other
genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental
cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast
stem cell differentiation (By similarity)

Gene Wiki entry for ERF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERF gene promoter:
         CREB   p53   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ERF promoter sequence
   Search Chromatin IP Primers for ERF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

ERF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERF gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042751:  view genomic region     (about GC identifiers)

Start:
42,751,717 bp from pter      End:
42,759,309 bp from pter
Size:
7,593 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ERF_HUMAN, P50548 (See protein sequence)
Recommended Name: ETS domain-containing transcription factor ERF  
Size: 548 amino acids; 58703 Da
Sequence caution: Sequence=BAD92508.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown
because it seems to be derived from a pre-mRNA;
Secondary accessions: B2RAP1 Q59G38 Q9UPI7

Explore the universe of human proteins at neXtProt for ERF: NX_P50548

Explore proteomics data for ERF at MOPED

Post-translational modifications: 

  • Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF1
  • Ubiquitination2 at Lys105
  • Modification sites at PhosphoSitePlus

  • See ERF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006485.2  
    ENSEMBL proteins: 
     ENSP00000222329   ENSP00000388173   ENSP00000469274   ENSP00000468962  
    Reactome Protein details: P50548

    ERF Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ERF
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    Novus Biologicals ERF Proteins
    Novus Biologicals ERF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERF

     
    Search eBioscience for Proteins for ERF 

    ERF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ERF
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    ThermoFisher Antibody for ERF
    LSBio Antibodies in human, mouse, rat for ERF

    ERF Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ERF
    Cloud-Clone Corp. CLIAs for ERF
    Search eBioscience for ELISAs for ERF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P50548

    ProtoNet protein and cluster: P50548

    1 Blocks protein domain: IPB011071 Polysaccharide lyase family 8-like

    UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Find genes that share domains with ERF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERF_HUMAN, P50548
    Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other
    genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental
    cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast
    stem cell differentiation (By similarity)

         Genatlas biochemistry entry for ERF:
    Ets 2 repressor factor,ubiquitously expressed with highest levels in the testis,ovary,pancreas,heart,regulated by
    MAPK phosphorylation during cell cycle and mitogenic stimulation,putatively involved in carcinogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003714transcription corepressor activity IDA7588608
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ERF           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Erf):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  mortality/aging  nervous system  normal 
     skeleton 

    Find genes that share phenotypes with ERF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ERF: Erftm2.1Gmav Erftm1Gmav

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERF

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERF:
    hsa-mir-1914-5p (MIRT035783), hsa-mir-124-3p (MIRT022909), hsa-mir-877-5p (MIRT037283)

    Block miRNA regulation of human, mouse, rat ERF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERF (see all 54):
    hsa-miR-2052 hsa-miR-4254 hsa-miR-1321 hsa-miR-607 hsa-miR-19b-2* hsa-miR-300 hsa-miR-218-1* hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidERF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERF
    Predesigned siRNA for gene silencing in human, mouse, rat ERF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERF

    Clone
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    OriGene clones in human, mouse for ERF (see all 6)
    OriGene ORF clones in mouse, rat for ERF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERF (NM_006494)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERF

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ERF
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERF_HUMAN, P50548: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    endoplasmic reticulum2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ERF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERF About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    2Oncogene Induced Senescence
    Oncogene Induced Senescence


    Find genes that share SuperPaths with ERF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ERF
        Oncogene Induced Senescence


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERF
    Interactions:

        GeneGlobe Interaction Network for ERF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ERF (P505482, 3 ENSP000002223294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1A1P487292, 3, ENSP000002617984MINT-17504 I2D: score=4 STRING: ENSP00000261798
    EPHB2P293233, ENSP000003637634I2D: score=2 STRING: ENSP00000363763
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    XPO1O149803I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA7588608
    GO:0001701in utero embryonic development ----
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ERF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ERF gene: 
    NM_006494.2  

    Unigene Cluster for ERF:

    Ets2 repressor factor
    Hs.655969  [show with all ESTs]
    Unigene Representative Sequence: AB209271
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222329(uc002otd.4 uc002ote.4) ENST00000440177 ENST00000595448
    ENST00000593944 ENST00000598965 ENST00000596818 ENST00000595941
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERF (see all 54):
    hsa-miR-2052 hsa-miR-4254 hsa-miR-1321 hsa-miR-607 hsa-miR-19b-2* hsa-miR-300 hsa-miR-218-1* hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidERF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERF
    Predesigned siRNA for gene silencing in human, mouse, rat ERF
    Clone
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    OriGene clones in human, mouse for ERF (see all 6)
    OriGene ORF clones in mouse, rat for ERF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERF (NM_006494)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ERF
    OriGene qSTAR qPCR primer pairs in human, mouse for ERF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERF
      QuantiTect SYBR Green Assays in human, mouse, rat ERF
      QuantiFast Probe-based Assays in human, mouse, rat ERF

    Additional mRNA sequence: 

    AB209271.1 AK297666.1 AK300627.1 AK314278.1 BC022231.1 U15655.1 

    11 DOTS entries:

    DT.447339  DT.91970023  DT.405428  DT.97797263  DT.100814282  DT.97783835  DT.91956960  DT.95117815 
    DT.95373284  DT.97805074  DT.121059737 

    Selected AceView cDNA sequences (see all 530):

    BM771527 F04129 BQ774755 AI767552 BM722957 AI270547 AA749280 BU625841 
    AI992027 AI393051 AI274122 BF477727 BU730675 CB852788 NM_019884 BM770276 
    AI937545 T05176 BQ026791 AI682929 AI635545 AI760234 CK820293 AI347109 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ERF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -           -                           
    SP2:                    -           -                           
    SP3:              -     -                                       
    SP4:                                                            


    ECgene alternative splicing isoforms for ERF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGGCGGG
    ERF Expression
    About this image

    ERF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655969

    UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
    Tissue specificity: Highest levels in testis, ovary, pancreas, and heart

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    QuantiFast Probe-based Assays in human, mouse, rat ERF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ERF gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erf1 , 5 Ets2 repressor factor1, 5 88.44(n)1
    95.07(a)1
      7 (13.73 cM)5
    138751  NM_010155.31  NP_034285.31 
     252425615 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167542 Xenopus laevis transcribed sequence with weak similarity more 79.76(n)    CA981084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133422 Transcribed sequence with weak similarity to protein more 75.92(n)    BG799140.1 


    ENSEMBL Gene Tree for ERF (if available)
    TreeFam Gene Tree for ERF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERF gene
    ETV12  ETV32  ETV52  ETV3L2  ETS12  GABPA2  ETS22  ERG2  
    FEV2  ETV42  ETV22  FLI12  
    7 SIMAP similar genes for ERF using alignment to 4 protein entries:     ERF_HUMAN (see all proteins):
    ETV1    ETV2    EWSR1/FLI1 fusion    ELK1    FEV    ETV3L
    ETV3

    Find genes that share paralogs with ERF           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ERF
    PGOHUM00000259336


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERF (see all 184)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0700984
    Craniosynostosis 4 (CRS4)4--see VAR_0700982 R Q mis40--------
    VAR_0700994
    Craniosynostosis 4 (CRS4)4--see VAR_0700992 R C mis40--------
    rs1851478991,2
    --42751275(+) TCAGAA/GCAACA 1 -- ds50010--------
    rs1895590681,2
    C--42751354(+) GGGTGA/TGGGAA 1 -- ds50010--------
    rs1824072831,2
    --42751422(+) GGTTGC/TGGTGA 1 -- ds50010--------
    rs1871761941,2
    --42751529(+) CTGGGA/GCTCAT 1 -- ds50010--------
    rs1920531441,2
    --42751696(+) CACCGA/GGCACC 1 -- ds50010--------
    rs10536501,2
    C--42751771(-) GAGTAG/AAGGGG 1 -- ut312Minor allele frequency- A:0.00MN NA 186
    rs788548911,2
    C--42752078(+) GTTCAA/C/TTATAA 2 -- ut312CSA NA 121
    rs115571151,2
    C,H--42752125(+) TATGAG/AAAACC 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 104

    HapMap Linkage Disequilibrium report for ERF (42751717 - 42759309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ERF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv833834CNV Loss17160897
    dgv3884n71CNV Loss21882294
    nsv833833CNV Loss17160897
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    Human Gene Mutation Database (HGMD): ERF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERF
    DNA2.0 Custom Variant and Variant Library Synthesis for ERF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611888   
    OMIM disorders: 600775  
    UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
  • Craniosynostosis 4 (CRS4) [MIM:600775]: A primary abnormality of skull growth involving premature fusion
    of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain
    resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated
    promptly to avoid permanent neurodevelopmental disability. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 7 diseases for ERF:    
    About MalaCards
    craniosynostosis 4    crouzon syndrome    venezuelan equine encephalitis    pericardial mesothelioma
    craniosynostosis, type 1    werdnig-hoffmann disease    craniosynostosis

    2 diseases from the University of Copenhagen DISEASES database for ERF:
    Venezuelan equine encephalitis     Pericardial mesothelioma

    Find genes that share disorders with ERF           About GenesLikeMe

    1 Novoseek inferred disease relationship for ERF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 16.5 2 9192842 (1), 17525531 (1)


    Export disorders for ERF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERF gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ERF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. (PubMed id 7588608)1, 2, 3, 9 Sgouras D.N....Mavrothalassitis G.J. (EMBO J. 1995)
    2. Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). (PubMed id 9192842)1, 2, 3, 9 de Castro C.M.... Kaufman R.E. (Genomics 1997)
    3. Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. (PubMed id 23354439)1, 2 Twigg S.R....Wilkie A.O. (Nat. Genet. 2013)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. (PubMed id 9136988)1, 9 Liu D....Mavrothalassitis G. (Oncogene 1997)
    8. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. (PubMed id 17525531)1, 9 Hester K.D....Glass C.K. (Cell Cycle 2007)
    9. Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells. (PubMed id 12533699)1, 9 Bain M....Sinclair J. (J. Gen. Virol. 2003)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2077 HGNC: 3444 AceView: ERFandGSK3A Ensembl:ENSG00000105722 euGenes: HUgn2077
    ECgene: ERF H-InvDB: ERF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ERF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ERF gene:
    Search GeneIP for patents involving ERF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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