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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERF Gene

protein-coding   GIFtS: 55
GCID: GC19M042751

Ets2 Repressor Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ets2 Repressor Factor1 2 3
PE-22 3
PE22 5
CRS42
ETS Domain-Containing Transcription Factor ERF2

External Ids:    HGNC: 34441   Entrez Gene: 20772   Ensembl: ENSG000001057227   OMIM: 6118885   UniProtKB: P505483   

Export aliases for ERF gene to outside databases

Previous GC identifers: GC19M043398 GC19M043143 GC19M047427 GC19M047443 GC19M039182


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERF Gene:
Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation.
They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro
et al., 1997 (PubMed 9192842)). For further information on ETS transcription factors, see ETS1 (MIM
164720).(supplied by OMIM, Mar 2008)

GeneCards Summary for ERF Gene: 
ERF (Ets2 repressor factor) is a protein-coding gene. Diseases associated with ERF include western equine encephalitis, and venezuelan equine encephalitis. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other
genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental
cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast
stem cell differentiation (By similarity)

Gene Wiki entry for ERF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERF gene promoter:
         CREB   p53   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ERF promoter sequence
   Search SABiosciences Chromatin IP Primers for ERF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

ERF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERF gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042751:  view genomic region     (about GC identifiers)

Start:
42,751,717 bp from pter      End:
42,759,309 bp from pter
Size:
7,593 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ERF_HUMAN, P50548 (See protein sequence)
Recommended Name: ETS domain-containing transcription factor ERF  
Size: 548 amino acids; 58703 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92508.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown
because it seems to be derived from a pre-mRNA;
Secondary accessions: B2RAP1 Q59G38 Q9UPI7

Explore the universe of human proteins at neXtProt for ERF: NX_P50548

Explore proteomics data for ERF at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50548

  • ERF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ERF Protein Expression
    REFSEQ proteins: NP_006485.2  
    ENSEMBL proteins: 
     ENSP00000222329   ENSP00000388173   ENSP00000469274   ENSP00000468962  

    Human Recombinant Protein Products for ERF: 
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    OriGene Protein Over-expression Lysate for ERF
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ERF
    GenScript Custom Purified and Recombinant Proteins Services for ERF
    Novus Biologicals ERF Proteins
    Novus Biologicals ERF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERF 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ERF for ontologies           About GeneDecksing



    ERF Antibody Products: 
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    ThermoFisher Antibody for ERF
    LSBio Antibodies in human, mouse, rat for ERF 

    Assay Products for ERF: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ERF 
    Cloud-Clone Corp. CLIAs for ERF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P50548

    ProtoNet protein and cluster: P50548

    1 Blocks protein domain: IPB011071 Polysaccharide lyase family 8-like

    UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ERF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERF_HUMAN, P50548
    Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other
    genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental
    cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast
    stem cell differentiation (By similarity)

         Genatlas biochemistry entry for ERF:
    Ets 2 repressor factor,ubiquitously expressed with highest levels in the testis,ovary,pancreas,heart,regulated by
    MAPK phosphorylation during cell cycle and mitogenic stimulation,putatively involved in carcinogenesis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IDA7588608
    GO:0043565sequence-specific DNA binding IEA--
         
    ERF for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Erf):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  mortality/aging  nervous system  normal 
     skeleton 

    ERF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ERF: Erftm2.1Gmav Erftm1Gmav

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ERF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ERF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERF
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ERF (see all 54):
    hsa-miR-2052 hsa-miR-4254 hsa-miR-1321 hsa-miR-607 hsa-miR-19b-2* hsa-miR-300 hsa-miR-218-1* hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidERF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ERF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERF

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ERF

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ERF (see all 6)
    OriGene ORF clones in mouse, rat for ERF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERF (NM_006494)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERF
    Sirion Biotech Customized lentivirus for stable overexpression of ERF 
                         Customized lentivirus expression plasmids for stable overexpression of ERF 

    Cell Line
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    Search LifeMap BioReagents cell lines for ERF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ERF (P505482, 3 ENSP000002223294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1A1P487292, 3, ENSP000002617984MINT-17504 I2D: score=4 STRING: ENSP00000261798
    EPHB2P293233, ENSP000003637634I2D: score=2 STRING: ENSP00000363763
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    XPO1O149803I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA7588608
    GO:0001701in utero embryonic development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007049cell cycle NAS7588608

    ERF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ERF

    Search CenterWatch for drugs/clinical trials and news about ERF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ERF gene: 
    NM_006494.2  

    Unigene Cluster for ERF:

    Ets2 repressor factor
    Hs.655969  [show with all ESTs]
    Unigene Representative Sequence: AB209271
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222329(uc002otd.4 uc002ote.4) ENST00000440177 ENST00000595448
    ENST00000593944 ENST00000598965 ENST00000596818 ENST00000595941
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERF
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ERF (see all 54):
    hsa-miR-2052 hsa-miR-4254 hsa-miR-1321 hsa-miR-607 hsa-miR-19b-2* hsa-miR-300 hsa-miR-218-1* hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidERF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ERF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERF
    Clone
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    OriGene clones in human, mouse for ERF (see all 6)
    OriGene ORF clones in mouse, rat for ERF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ERF (NM_006494)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERF
    Sirion Biotech Customized lentivirus for stable overexpression of ERF 
                         Customized lentivirus expression plasmids for stable overexpression of ERF 
    Primer
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    OriGene qPCR primer pairs and template standards for ERF
    OriGene qSTAR qPCR primer pairs in human, mouse for ERF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ERF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERF

    Additional mRNA sequence: 

    AB209271.1 AK297666.1 AK300627.1 AK314278.1 BC022231.1 U15655.1 

    11 DOTS entries:

    DT.447339  DT.91970023  DT.405428  DT.97797263  DT.100814282  DT.97783835  DT.91956960  DT.95117815 
    DT.95373284  DT.97805074  DT.121059737 

    24/530 AceView cDNA sequences (see all 530):

    AA164445 BM766575 BQ884265 BQ961902 AI393051 AA749280 BM677955 BU625841 
    BQ674633 CB852788 BF365463 BQ673346 BM707789 BQ187945 AI767552 BU617983 
    AI985110 AI274122 BM975480 AI992027 AI347109 BM722957 BQ026791 F05463 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ERF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -           -                           
    SP2:                    -           -                           
    SP3:              -     -                                       
    SP4:                                                            


    ECgene alternative splicing isoforms for ERF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGGCGGG
    ERF Expression
    About this image


    See ERF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERF

    SOURCE GeneReport for Unigene cluster: Hs.655969

    UniProtKB/Swiss-Prot: ERF_HUMAN, P50548
    Tissue specificity: Highest levels in testis, ovary, pancreas, and heart

        SABiosciences Custom PCR Arrays for ERF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ERF gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erf1 , 5 Ets2 repressor factor1, 5 89.48(n)1
    96.9(a)1
      7 (13.73 cM)5
    138751  NM_010155.31  NP_034285.31 
     252425615 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167542 Xenopus laevis transcribed sequence with weak similarity more 79.76(n)    CA981084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133422 Transcribed sequence with weak similarity to protein more 75.92(n)    BG799140.1 


    ENSEMBL Gene Tree for ERF (if available)
    TreeFam Gene Tree for ERF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERF gene
    ELK42  ETV12  ETV32  ETV52  ETV3L2  ETS12  GABPA2  ETS22  
    ELK12  ERG2  FEV2  ETV42  ETV22  FLI12  ELK32  
    7 SIMAP similar genes for ERF using alignment to 4 protein entries:     ERF_HUMAN (see all proteins):
    ETV1    ETV2    EWSR1/FLI1 fusion    ELK1    FEV    ETV3L
    ETV3

    ERF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ERF
    PGOHUM00000259336


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in ERF are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851478991,2
    --42751275(+) TCAGAA/GCAACA 1 -- ds50010--------
    rs1895590681,2
    C--42751354(+) GGGTGA/TGGGAA 1 -- ds50010--------
    rs1824072831,2
    --42751422(+) GGTTGC/TGGTGA 1 -- ds50010--------
    rs1871761941,2
    --42751529(+) CTGGGA/GCTCAT 1 -- ds50010--------
    rs1920531441,2
    --42751696(+) CACCGA/GGCACC 1 -- ds50010--------
    rs10536501,2
    C--42751771(-) GAGTAG/AAGGGG 1 -- ut312Minor allele frequency- A:0.00MN NA 186
    rs788548911,2
    C--42752078(+) GTTCAA/C/TTATAA 2 -- ut312CSA NA 121
    rs115571151,2
    C,H--42752125(+) TATGAG/AAAACC 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 104
    rs1473762791,2
    --42752528(+) AAGAGA/CGCTGC 1 -- ut310--------
    rs1833340821,2
    C--42752650(+) TGGGCC/TGTGGC 2 T syn10--------

    HapMap Linkage Disequilibrium report for ERF (42751717 - 42759309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ERF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv833834CNV Loss17160897
    dgv3884n71CNV Loss21882294
    nsv833833CNV Loss17160897
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ERF
    DNA2.0 Custom Variant and Variant Library Synthesis for ERF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611888    OMIM disorders: --

    6 diseases for ERF:    About MalaCards
    western equine encephalitis    venezuelan equine encephalitis    pericardial mesothelioma    encephalitis
    pulmonary embolism    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for ERF:
    Venezuelan equine encephalitis     Pericardial mesothelioma

    ERF for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ERF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 16.5 2 9192842 (1), 17525531 (1)


    Export disorders for ERF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERF gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ERF)
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    world of online information

    1. ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. (PubMed id 7588608)1, 2, 3, 9 Sgouras D.N....Mavrothalassitis G.J. (1995)
    2. Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). (PubMed id 9192842)1, 2, 3, 9 de Castro C.M.... Kaufman R.E. (1997)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. (PubMed id 9136988)1, 9 Liu D....Mavrothalassitis G. (1997)
    7. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. (PubMed id 17525531)1, 9 Hester K.D....Glass C.K. (2007)
    8. Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells. (PubMed id 12533699)1, 9 Bain M....Sinclair J. (2003)
    9. Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. (PubMed id 23354439)1 Twigg S.R....Wilkie A.O. (2013)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2077 HGNC: 3444 AceView: ERFandGSK3A Ensembl:ENSG00000105722 euGenes: HUgn2077
    ECgene: ERF H-InvDB: ERF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ERF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ERF gene:
    Search GeneIP for patents involving ERF

    GeneCards and IP:
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