External Ids for ERF Gene
Previous GeneCards Identifiers for ERF Gene
ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
GeneCards Summary for ERF Gene
ERF (Ets2 Repressor Factor) is a Protein Coding gene. Diseases associated with ERF include craniosynostosis 4 and kleeblattschaedel syndrome. Among its related pathways are Cellular Senescence and Oncogene Induced Senescence. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ETV2.
UniProtKB/Swiss-Prot for ERF Gene
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).