Aliases for ERCC4 Gene
- Excision Repair Cross-Complementation Group 4 2 3
- XPF 3 4 6
- Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4 2 3
- Xeroderma Pigmentosum Group F-Complementing Protein 3 4
- DNA Repair Protein Complementing XP-F Cells 3 4
- DNA Excision Repair Protein ERCC-4 3 4
- ERCC11 3 4
- FANCQ 3 6
External Ids for ERCC4 Gene
Previous Symbols for ERCC4 Gene
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
GeneCards Summary for ERCC4 Gene
ERCC4 (Excision Repair Cross-Complementation Group 4) is a Protein Coding gene. Diseases associated with ERCC4 include fanconi anemia, complementation group q and xfe progeroid syndrome. Among its related pathways are Cell Cycle, Mitotic and Chks in Checkpoint Regulation. GO annotations related to this gene include protein C-terminus binding and single-stranded DNA binding.
UniProtKB/Swiss-Prot for ERCC4 Gene
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.