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ERBB4 Gene

protein-coding   GIFtS: 76
GCID: GC02M212210

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog...

(Previous name: v-erb-a avian erythroblastic leukemia viral oncogene homolog-like...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 41 2     ALS192 5
HER42 3 5     V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 41
Proto-Oncogene-Like Protein C-ErbB-42 3     Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 42
Tyrosine Kinase-Type Cell Surface Receptor HER42 3     Receptor Tyrosine-Protein Kinase ErbB-42
p180erbB42 3     V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 42
EC 2.7.10.13 8     EC 2.7.108

External Ids:    HGNC: 34321   Entrez Gene: 20662   Ensembl: ENSG000001785687   OMIM: 6005435   UniProtKB: Q153033   

Export aliases for ERBB4 gene to outside databases

Previous GC identifers: GC02M210522 GC02M210971 GC02M212449 GC02M212072 GC02M211955 GC02M204087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERBB4 Gene:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It
encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a
tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein
binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including
mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and
an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced
variants which encode different protein isoforms have been described; however, not all variants have been fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ERBB4 Gene:
ERBB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is a protein-coding gene. Diseases associated with ERBB4 include amyotrophic lateral sclerosis 19, and left ventricular outflow tract obstruction. GO annotations related to this gene include protein tyrosine kinase activity and protein homodimerization activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF
family members and regulates development of the heart, the central nervous system and the mammary gland, gene
transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle
differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal
development of the embryonic central nervous system, especially for normal neural crest cell migration and normal
axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as
cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and
HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that
then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by
alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family
members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and
context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases
MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the
activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and
isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to
NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1,
and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization
of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2
gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote
nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and
activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2
promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can
also translocate to mitochondria and promote apoptosis

summary for ERBB4 Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERBB4 gene promoter:
         STAT1   p53   AP-1   ATF-2   c-Jun   STAT5A   NF-kappaB   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERBB4 promoter sequence
   Search Chromatin IP Primers for ERBB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERBB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3-q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33.3-q34

ERBB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M212210:  view genomic region     (about GC identifiers)

Start:
212,240,442 bp from pter      End:
213,403,565 bp from pter
Size:
1,163,124 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-4 precursor  
Size: 1308 amino acids; 146808 Da
Subunit: Monomer in the absence of bound ligand. Homodimer or heterodimer with another ERBB family member upon
ligand binding, thus forming heterotetramers. Interacts with EGFR and ERBB2. Interacts with CBFA2T3 (By
similarity). Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and
SNTB2 (via its PDZ domain). Interacts with MUC1. Interacts (via its PPxy motifs) with WWOX. Interacts (via the
PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1). Interacts (isoform JM-A CYT-1
and isoform JM-B CYT-1) with WWP1. Interacts (via its intracellular domain) with TRIM28. Interacts (via the
intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1
but represses ERBB4-mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1,
U5S1, U2SURP, ITCH, HNRPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 AND ARS2. Interacts (phosphorylated isoform
JM-A CYT-1 and isoform JM-B CYT-1) with PIK3R1. Interacts with SHC1. Interacts with GRB2. Interacts (soluble
intracellular domain) with STAT5A. Interacts (soluble intracellular domain) with BCL2. Interacts (phosphorylated)
with STAT1
Caution: Conflicting reports about the role of ERBB4 in mediating apoptosis, differentiation, or tumor cell
proliferation may be explained by the opposite functions of the different isoforms and their intracellular
fragments, and by the formation of heterodimers with other EGF receptor family members (PubMed:18454307 and
PubMed:21811097). Thus, heterodimer formation of a kinase-dead ERBB4 mutant with ERBB2 is sufficient for the
activation of AKT1, MAPK1/ERK2 and MAPK3/ERK1 (PubMed:19098003)
Selected PDB 3D structures from and Proteopedia for ERBB4 (see all 10):
2AHX (3D)        2L2T (3D)        2LCX (3D)        2R4B (3D)        3BBT (3D)        3BBW (3D)    
Secondary accessions: B7ZLD7 B7ZLE2 B7ZLE3 Q2M1W1 Q59EW4
Alternative splicing: 4 isoforms:  Q15303-1   Q15303-2   Q15303-3   Q15303-4   (Proteolytical processing generates E4ICD2 (s80Cyt2))

Explore the universe of human proteins at neXtProt for ERBB4: NX_Q15303

Explore proteomics data for ERBB4 at MOPED

Post-translational modifications: 

  • Isoform JM-A CYT-1 and isoform JM-A CYT-2 are processed by ADAM17. Proteolytic processing in response to ligand or
    12-O-tetradecanoylphorbol-13-acetate stimulation results in the production of 120 kDa soluble receptor forms and
    intermediate membrane-anchored 80 kDa fragments (m80HER4), which are further processed by a presenilin-dependent
    gamma-secretase to release a cytoplasmic intracellular domain (E4ICD; E4ICD1/s80Cyt1 or E4ICD2/s80Cyt2, depending
    on the isoform). Membrane-anchored 80 kDa fragments of the processed isoform JM-A CYT-1 are more readily degraded
    by the proteasome than fragments of isoform JM-A CYT-2, suggesting a prevalence of E4ICD2 over E4ICD1. Isoform
    JM-B CYT-1 and isoform JM-B CYT-2 lack the ADAM17 cleavage site and are not processed by ADAM17, precluding
    further processing by gamma-secretase1
  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e.
    one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligands trigger
    phosphorylation at specific tyrosine residues, thereby creating binding sites for scaffold proteins and
    effectors. Constitutively phosphorylated at a basal level when overexpressed in heterologous systems; ligand
    binding leads to increased phosphorylation. Phosphorylation at Tyr-1035 is important for interaction with STAT1.
    Phosphorylation at Tyr-1056 is important for interaction with PIK3R1. Phosphorylation at Tyr-1242 is important
    for interaction with SHC1. Phosphorylation at Tyr-1188 may also contribute to the interaction with SHC1. Isoform
    JM-A CYT-2 is constitutively phosphorylated on tyrosine residues in a ligand-independent manner. E4ICD2 but not
    E4ICD1 is phosphorylated on tyrosine residues1
  • Ubiquitinated. During mitosis, the ERBB4 intracellular domain is ubiquitinated by the APC/C complex and targeted
    to proteasomal degradation. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are ubiquitinated by WWP1. The ERBB4
    intracellular domain (E4ICD1) is ubiquitinated, and this involves NEDD41
  • Ubiquitination2 at Lys722, Lys745, Lys858, Lys1265
  • Glycosylation2 at Asn138, Asn174, Asn181, Asn253, Asn358, Asn410, Asn473, Asn495, Asn548, Asn576,
                                 Asn620
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ERBB4 (Q15303) (see all 25)
     KPYDGIP  DTDCFAC  RDLAARN  RYLVIQG 


    See ERBB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036064.1  NP_005226.1  

    ENSEMBL proteins: 
     ENSP00000342235   ENSP00000403204   ENSP00000260943   ENSP00000405564   ENSP00000385565  
    Reactome Protein details: Q15303

    ERBB4 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ERBB4 Protein
    R&D Systems Recombinant & Natural Proteins for ERBB4 (ErbB4/Her4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ERBB4
    OriGene Protein Over-expression Lysate for ERBB4
    OriGene MassSpec for ERBB4
    OriGene Custom Protein Services for ERBB4
    GenScript Custom Purified and Recombinant Proteins Services for ERBB4
    Novus Biologicals ERBB4 Protein
    Novus Biologicals ERBB4 Lysates
    Sino Biological Recombinant Protein for ERBB4
    Sino Biological Cell Lysate for ERBB4
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ERBB4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB4
    R&D Systems Antibodies for ERBB4 (ErbB4/Her4)
    Cell Signaling Technology (CST) Antibodies for ERBB4  (HER4)
    OriGene Antibodies for ERBB4
    OriGene Custom Antibody Services for ERBB4
    Novus Biologicals ERBB4 Antibodies
    Abcam antibodies for ERBB4
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ERBB4
    LSBio Antibodies in human, mouse, rat for ERBB4

    ERBB4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ERBB4
    R&D Systems ELISAs for ERBB4 (ErbB4/Her4)         (see all)
    GenScript ERBB4-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB4 (HER4)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
    ErbB (epidermal growth factor) receptor family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000494 EGF_rcpt_L

    Graphical View of Domain Structure for InterPro Entry Q15303

    ProtoNet protein and cluster: Q15303

    Selected Blocks protein domains (see all 6):
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB004019 YLP motif
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    ERBB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERBB4_HUMAN, Q15303
    Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF
    family members and regulates development of the heart, the central nervous system and the mammary gland, gene
    transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle
    differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal
    development of the embryonic central nervous system, especially for normal neural crest cell migration and normal
    axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as
    cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and
    HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that
    then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by
    alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family
    members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and
    context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases
    MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the
    activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and
    isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to
    NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1,
    and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization
    of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2
    gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote
    nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and
    activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2
    promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can
    also translocate to mitochondria and promote apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Binding of a cognate ligand leads to dimerization and activation by autophosphorylation on
    tyrosine residues. In vitro kinase activity is increased by Mg(2+). Inhibited by PD153035, lapatinib, gefitinib
    (iressa, ZD1839), AG1478 and BIBX1382BS

         Genatlas biochemistry entry for ERBB4:
    avian erythroblastic leukemia v(erb-b) viral oncogene homolog 4,heregulin beta 1 receptor (180kDa)

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA18334220
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA18334220
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
    GO:0005154epidermal growth factor receptor binding IPI8617750
         
    ERBB4 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ERBB4:
     Decreased focal adhesion (FA)   Decreased viability with cispl  Increased G1 DNA content  Increased HPV18 LCR reporter a 
     Increased cell death HMECs cel  Synthetic lethal/sick with VHL 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Erbb4):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  hematopoietic system  immune system  integument  mortality/aging 
     muscle  nervous system  normal  reproductive system  respiratory system 

    ERBB4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Erbb4tm1Grl for ERBB4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERBB4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERBB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERBB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERBB4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERBB4:
    hsa-mir-19a-3p (MIRT003533), hsa-mir-372-3p (MIRT003532), hsa-mir-146a-5p (MIRT005806), hsa-mir-302d-3p (MIRT003534)

    Block miRNA regulation of human, mouse, rat ERBB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB4 (see all 189):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-193a-3p hsa-miR-146a hsa-miR-199a-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERBB4
    Predesigned siRNA for gene silencing in human, mouse, rat ERBB4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERBB4

    Clone
    Products:
         
    OriGene clones in human, mouse for ERBB4 (see all 14)
    OriGene ORF clones in mouse, rat for ERBB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB4 (NM_005235)
    Sino Biological Human cDNA Clone for ERBB4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERBB4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERBB4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERBB4_HUMAN, Q15303: Cell membrane; Single-pass type I membrane protein. Note=In response to NRG1 treatment, the
    activated receptor is internalized
    ERBB4_HUMAN, Q15303: ERBB4 intracellular domain: Nucleus. Mitochondrion. Note=Following proteolytical processing
    E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly
    more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    plasma membrane5
    cytosol4
    extracellular4
    cytoskeleton2
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA15534001
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA16778220

    ERBB4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERBB4 About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66
    3Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ERBB4
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ERBB4 (see all 35)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB4
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB4
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ERBB4
        Development ERBB-family signaling
    Cell adhesion ECM remodeling

    1 BioSystems Pathway for ERBB4
        ErbB signaling pathway

    1 Sino Biological Pathway for ERBB4
        EGFR Signaling Pathway

    Selected Reactome Pathways for ERBB4 (see all 11)
        Downregulation of ERBB4 signaling
    GRB2 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling
    Signaling by ERBB2

    1 PharmGKB Pathway for ERBB4
        EGFR Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for ERBB4):
        ErbB signaling pathway
    Calcium signaling pathway
    Endocytosis
    Proteoglycans in cancer


    ERBB4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB4: 
              Cancer Drug Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ERBB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERBB4 (Q153031, 2, 3 ENSP000003422354) via UniProtKB, MINT, STRING, and/or I2D (see all 210)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL2P426841, 2, 3, ENSP000003565954EBI-80371,EBI-1102694 MINT-74457 MINT-74456 MINT-74458 MINT-74455 I2D: score=2 STRING: ENSP00000356595
    GRB2P629932, 3, ENSP000003390074MINT-61531 MINT-61528 MINT-61534 MINT-61527 MINT-61530 MINT-61532 I2D: score=4 STRING: ENSP00000339007
    ERBB2P046261, 3, ENSP000002695714EBI-80371,EBI-641062 I2D: score=4 STRING: ENSP00000269571
    PIK3R2O004592, 3, ENSP000002222544MINT-61526 I2D: score=4 STRING: ENSP00000222254
    ABL1P005192, 3, ENSP000003614234MINT-74431 I2D: score=2 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration ISS--
    GO:0001934positive regulation of protein phosphorylation TAS15534001
    GO:0006351transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction IDA10572067

    ERBB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ERBB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for ERBB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 IUPHAR Ligands for ERBB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian))    About this table
    LigandTypeActionAffinityPubmed IDs
    neuregulin-1
    NoneNone--
    neuregulin-3
    NoneNone--
    betacellulin
    NoneNone--
    neuregulin-4
    NoneNone--
    epiregulin
    NoneNone--
    HB-EGF
    NoneNone--
    neuregulin-2
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for ERBB4 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.8 144 9016763 (3), 15219672 (3), 9419975 (2), 11679632 (2) (see all 99)
    pd158780 79.1 1 15555917 (1)
    hrgbeta1 77.2 2 12209601 (1), 15714117 (1)
    trastuzumab 71.9 10 19624808 (3), 15634652 (1)
    pertuzumab 67.9 1 16857824 (1)
    gefitinib 62.8 1 16253759 (1)
    lapatinib 59.9 2 16020981 (1)
    cetuximab 59 1 18316572 (1)
    pd153035 56 1 17608728 (1)
    phosphotyrosine 55.3 3 9685416 (2), 8579117 (1)



    ERBB4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ERBB4 gene (2 alternative transcripts): 
    NM_001042599.1  NM_005235.2  

    Unigene Cluster for ERBB4:

    V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
    Hs.390729  [show with all ESTs]
    Unigene Representative Sequence: NM_005235
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342788(uc002veg.1 uc010zji.1) ENST00000436443(uc002veh.1 uc010zjj.1)
    ENST00000484594(uc010fut.1) ENST00000260943 ENST00000463121 ENST00000484474
    ENST00000435846 ENST00000459774 ENST00000402597
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat ERBB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB4 (see all 189):
    hsa-miR-411* hsa-miR-579 hsa-miR-140-5p hsa-miR-520f hsa-miR-193a-3p hsa-miR-146a hsa-miR-199a-3p hsa-miR-519a
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    OriGene ORF clones in mouse, rat for ERBB4
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    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB4 (NM_005235)
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    Additional mRNA sequence: 

    AB209697.1 AF007153.1 AK126298.1 AK308606.1 BC112199.1 BC143741.1 BC143747.1 BC143749.1 
    CR627023.1 L07868.1 

    3 DOTS entries:

    DT.207790  DT.414957  DT.86845746 

    4 AceView cDNA sequences:

    AI793236 AI253036 AI793060 AW438696 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                        -   

    ExUns: 27 ^ 28a · 28b
    SP1:                  
    SP2:                  


    ECgene alternative splicing isoforms for ERBB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERBB4 expression in normal human tissues (normalized intensities)      ERBB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTGTCAG
    ERBB4 Expression
    About this image


    ERBB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             Oligodendrocyte-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
    ERBB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERBB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390729

    UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303
    Tissue specificity: Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle,
    parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and
    pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is
    expressed in the heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB4: 
              Cancer Drug Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ERBB4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erbb41 , 5 v-erb-a erythroblastic leukemia viral oncogene homolog more1, 5 89.94(n)1
    97.29(a)1
      1 (33.80 cM)5
    138691  NM_010154.11  NP_034284.11 
     680321865 
    chicken
    (Gallus gallus)
    Aves ERBB41 v-erb-a erythroblastic leukemia viral oncogene homolog more 82.22(n)
    93.29(a)
      395671  NM_001030365.1  NP_001025536.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERBB46
    v-erb-b2 avian erythroblastic leukemia viral oncog...
    87(a)
    1 ↔ 1
    1(114201462-114930727)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia erbb41 v-erb-a erythroblastic leukemia viral oncogene homolog more 75.84(n)
    84.31(a)
      100493234  XM_004917849.1  XP_004917906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii erbb4a1 v-erb-a erythroblastic leukemia viral oncogene homolog more 69.76(n)
    75.3(a)
      100007677  NM_001143751.1  NP_001137223.1 


    ENSEMBL Gene Tree for ERBB4 (if available)
    TreeFam Gene Tree for ERBB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ERBB4 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    Selected SIMAP similar genes for ERBB4 using alignment to 10 protein entries:     ERBB4_HUMAN (see all proteins) (see all similar genes):
    c-erbB-3    EGFR    ERBB3    ERBB2    ABL1    tec
    TXK    EPHA2    HER-2    TNK2    BCR/ABL fusion    BTK
    BTK kinase deficient isoform 2    BTK kinase deficient isoform 4    DKFZp686M05208    EPHB1    MST1R    BTK kinase deficient isoform 3

    ERBB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERBB4 (see all 25398)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708114
    Amyotrophic lateral sclerosis 19 (ALS19)4--see VAR_0708112 R W mis40--------
    VAR_0421134
    A colorectal adenocarcinoma sample4--see VAR_0421132 T I mis40--------
    VAR_0708104
    Amyotrophic lateral sclerosis 19 (ALS19)4--see VAR_0708102 R Q mis40--------
    VAR_0421144
    A lung squamous cell carcinoma sample4--see VAR_0421142 S Y mis40--------
    rs779825121,2
    C,Funtested1211978105(-) TGATCA/GTCATA 2 -- int10--------
    rs664822681,2
    C--204092135(+) CTTAA-/GACACT 2 -- ut310--------
    rs1136037521,2
    C--204125063(+) AAAAA-/AGAAAG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1445080221,2
    C--204138228(+) ATATA-/ATAAACAAA
    CAGCAACATAT
    AAATA
    2 -- int10--------
    rs2021605631,2
    C--204140045(+) CCAGG-/AAAAAAA 2 -- int10--------
    rs1412678441,2
    C--204142968(+) ATTGG-/TTTTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ERBB4 (212240442 - 212490442 bp, first 250kb of ERBB4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ERBB4 (see all 110):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721424CNV Deletion23290073
    esv4037CNV Deletion18987735
    esv2721427CNV Deletion23290073
    esv2670570CNV Deletion23128226
    esv2112410CNV Deletion18987734
    esv997888CNV Deletion20482838
    esv2663972CNV Deletion23128226
    esv2664538CNV Deletion23128226
    esv2673624CNV Deletion23128226
    esv2721425CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ERBB4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERBB4
    DNA2.0 Custom Variant and Variant Library Synthesis for ERBB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600543   
    OMIM disorders: 615515  
    Selected diseases for ERBB4 (see all 61):    About MalaCards
    amyotrophic lateral sclerosis 19    left ventricular outflow tract obstruction    warthin tumor    early myoclonic encephalopathy
    medulloblastoma    atypical teratoid rhabdoid tumor    amyotrophic lateral sclerosis    rhabdoid tumor
    childhood medulloblastoma    endometrial stromal sarcoma    estrogen-receptor positive breast cancer    pilocytic astrocytoma
    insulinoma    cblc    leukemia    ductal carcinoma in situ
    malignant pleural mesothelioma    laryngeal squamous cell carcinoma    squamous cell carcinoma    major depressive disorder

    3 diseases from the University of Copenhagen DISEASES database for ERBB4:
    Schizophrenia     Breast cancer     Carcinoma

    ERBB4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ERBB4 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    viral leukemia 69.6 6 18854870 (1), 17376983 (1), 15878319 (1)
    breast cancer 65.7 98 15735025 (6), 19561640 (5), 18567793 (4), 17909041 (3) (see all 35)
    breast carcinoma 54.8 13 18426733 (2), 16187281 (1), 8062828 (1), 9699674 (1) (see all 11)
    tumors 54 103 12678544 (3), 12637154 (3), 18426733 (3), 18575766 (2) (see all 52)
    cancer 46.6 43 16962163 (2), 15735025 (2), 19098003 (2), 10535875 (1) (see all 28)
    medulloblastoma childhood 42.8 3 9242460 (2), 9731505 (1)
    medulloblastoma 40.3 2 9242460 (1), 16878160 (1)
    schizophrenia 37.7 45 17164265 (5), 20467458 (4), 16402353 (3), 19336245 (3) (see all 18)
    nsclc 32.8 9 16253759 (1), 16187281 (1), 16463386 (1), 19098003 (1) (see all 6)
    mammary tumor 29.8 6 17120616 (3), 8383326 (1)

    Genetic Association Database (GAD): ERBB4
    Human Genome Epidemiology (HuGE) Navigator: ERBB4 (28 documents)
    Tumor Gene Database (TGDB): ERBB4

    Export disorders for ERBB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERBB4 gene, integrated from 10 sources (see all 537):
    (articles sorted by number of sources associating them with ERBB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. (PubMed id 9135143)1, 2, 9 Elenius K.... Klagsbrun M. (EMBO J. 1997)
    2. Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines. (PubMed id 17120616)1, 2, 9 Pitfield S.E.... Riese D.J. II (Oncol. Res. 2006)
    3. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. (PubMed id 16061658)1, 2, 9 Aqeilan R.I.... Croce C.M. (Cancer Res. 2005)
    4. WW domain containing E3 ubiquitin protein ligase 1 targets the full- length ErbB4 for ubiquitin-mediated degradation in breast cancer. (PubMed id 19561640)1, 2, 9 Li Y.... Chen C. (Oncogene 2009)
    5. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. (PubMed id 12807903)1, 2, 9 Komuro A.... Sudol M. (J. Biol. Chem. 2003)
    6. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. (PubMed id 10353604)1, 2, 9 Elenius K....Klagsbrun M. (Oncogene 1999)
    7. Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer. (PubMed id 19098003)1, 2, 9 Tvorogov D.... Elenius K. (J. Biol. Chem. 2009)
    8. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. (PubMed id 18721752)1, 2, 9 Kaushansky A....MacBeath G. (Chem. Biol. 2008)
    9. HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. (PubMed id 8617750)1, 2, 9 Cohen B.D.... Fell H.P. (J. Biol. Chem. 1996)
    10. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. (PubMed id 16203964)1, 2, 9 Bouyain S.... Leahy D.J. (Proc. Natl. Acad. Sci. U.S.A. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2066 HGNC: 3432 AceView: ERBB4.1 Ensembl:ENSG00000178568 euGenes: HUgn2066
    ECgene: ERBB4 Kegg: 2066 H-InvDB: ERBB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERBB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERBB4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERBB4 gene:
    Search GeneIP for patents involving ERBB4

    Licensable Technologies for ERBB4 gene:
    Weizmann Institute:"Neuregulin-4 (NRG4), a Novel Growth Factor Which Acts Through the Erbb4 Receptor Tyrosine Kinase; Sequences, Antibodies To and Uses Thereof."
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB4
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERBB4
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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