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Aliases for ERBB4 Gene

Aliases for ERBB4 Gene

  • Erb-B2 Receptor Tyrosine Kinase 4 2 3
  • HER4 3 4 6
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 4 2 3
  • Tyrosine Kinase-Type Cell Surface Receptor HER4 3 4
  • Human Epidermal Growth Factor Receptor 4 2 3
  • Proto-Oncogene-Like Protein C-ErbB-4 3 4
  • EC 2.7.10.1 4 63
  • P180erbB4 3 4
  • ALS19 3 6
  • V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4 2
  • Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4 3
  • V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 3
  • Receptor Tyrosine-Protein Kinase ErbB-4 3
  • EC 2.7.10 63

External Ids for ERBB4 Gene

Previous GeneCards Identifiers for ERBB4 Gene

  • GC02M210522
  • GC02M210971
  • GC02M212210
  • GC02M212449
  • GC02M212072
  • GC02M211955
  • GC02M204087

Summaries for ERBB4 Gene

Entrez Gene Summary for ERBB4 Gene

  • This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERBB4 Gene

ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with ERBB4 include amyotrophic lateral sclerosis 19 and amyotrophic lateral sclerosis 1. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include protein homodimerization activity and protein tyrosine kinase activity. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for ERBB4 Gene

  • Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Tocris Summary for ERBB4 Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB4 Gene

Genomics for ERBB4 Gene

Regulatory Elements for ERBB4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERBB4 Gene

Start:
211,375,717 bp from pter
End:
212,539,155 bp from pter
Size:
1,163,439 bases
Orientation:
Minus strand

Genomic View for ERBB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERBB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB4 Gene

Proteins for ERBB4 Gene

  • Protein details for ERBB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15303-ERBB4_HUMAN
    Recommended name:
    Receptor tyrosine-protein kinase erbB-4
    Protein Accession:
    Q15303
    Secondary Accessions:
    • B7ZLD7
    • B7ZLE2
    • B7ZLE3
    • Q2M1W1
    • Q59EW4

    Protein attributes for ERBB4 Gene

    Size:
    1308 amino acids
    Molecular mass:
    146808 Da
    Quaternary structure:
    • Monomer in the absence of bound ligand. Homodimer or heterodimer with another ERBB family member upon ligand binding, thus forming heterotetramers. Interacts with EGFR and ERBB2. Interacts with CBFA2T3 (By similarity). Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and SNTB2 (via its PDZ domain). Interacts with MUC1. Interacts (via its PPxy motifs) with WWOX. Interacts (via the PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1). Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1. Interacts (via its intracellular domain) with TRIM28. Interacts (via the intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1 but represses ERBB4-mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1, U5S1, U2SURP, ITCH, HNRPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 AND ARS2. Interacts (phosphorylated isoform JM-A CYT-1 and isoform JM-B CYT-1) with PIK3R1. Interacts with SHC1. Interacts with GRB2. Interacts (soluble intracellular domain) with STAT5A. Interacts (soluble intracellular domain) with BCL2. Interacts (phosphorylated) with STAT1.

    Three dimensional structures from OCA and Proteopedia for ERBB4 Gene

    Alternative splice isoforms for ERBB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERBB4 Gene

Proteomics data for ERBB4 Gene at MOPED

Post-translational modifications for ERBB4 Gene

  • Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligands trigger phosphorylation at specific tyrosine residues, thereby creating binding sites for scaffold proteins and effectors. Constitutively phosphorylated at a basal level when overexpressed in heterologous systems; ligand binding leads to increased phosphorylation. Phosphorylation at Tyr-1035 is important for interaction with STAT1. Phosphorylation at Tyr-1056 is important for interaction with PIK3R1. Phosphorylation at Tyr-1242 is important for interaction with SHC1. Phosphorylation at Tyr-1188 may also contribute to the interaction with SHC1. Isoform JM-A CYT-2 is constitutively phosphorylated on tyrosine residues in a ligand-independent manner. E4ICD2 but not E4ICD1 is phosphorylated on tyrosine residues.
  • Isoform JM-A CYT-1 and isoform JM-A CYT-2 are processed by ADAM17. Proteolytic processing in response to ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation results in the production of 120 kDa soluble receptor forms and intermediate membrane-anchored 80 kDa fragments (m80HER4), which are further processed by a presenilin-dependent gamma-secretase to release a cytoplasmic intracellular domain (E4ICD; E4ICD1/s80Cyt1 or E4ICD2/s80Cyt2, depending on the isoform). Membrane-anchored 80 kDa fragments of the processed isoform JM-A CYT-1 are more readily degraded by the proteasome than fragments of isoform JM-A CYT-2, suggesting a prevalence of E4ICD2 over E4ICD1. Isoform JM-B CYT-1 and isoform JM-B CYT-2 lack the ADAM17 cleavage site and are not processed by ADAM17, precluding further processing by gamma-secretase.
  • Ubiquitinated. During mitosis, the ERBB4 intracellular domain is ubiquitinated by the APC/C complex and targeted to proteasomal degradation. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are ubiquitinated by WWP1. The ERBB4 intracellular domain (E4ICD1) is ubiquitinated, and this involves NEDD4.
  • Ubiquitination at Lys722, Lys745, Lys858, and Lys1265
  • Glycosylation at Asn138, Asn174, Asn181, Asn253, Asn358, Asn410, Asn473, Asn495, Asn548, Asn576, and Asn620
  • Modification sites at PhosphoSitePlus

Other Protein References for ERBB4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERBB4 (HER4)

Domains for ERBB4 Gene

Suggested Antigen Peptide Sequences for ERBB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15303

UniProtKB/Swiss-Prot:

ERBB4_HUMAN :
  • Q15303
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with ERBB4: view

Function for ERBB4 Gene

Molecular function for ERBB4 Gene

GENATLAS Biochemistry: avian erythroblastic leukemia v(erb-b) viral oncogene homolog 4,heregulin beta 1 receptor (180kDa)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Binding of a cognate ligand leads to dimerization and activation by autophosphorylation on tyrosine residues. In vitro kinase activity is increased by Mg(2+). Inhibited by PD153035, lapatinib, gefitinib (iressa, ZD1839), AG1478 and BIBX1382BS.
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Enzyme Numbers (IUBMB) for ERBB4 Gene

Gene Ontology (GO) - Molecular Function for ERBB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 18334220
GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA 18334220
GO:0004716 receptor signaling protein tyrosine kinase activity IEA --
GO:0005154 epidermal growth factor receptor binding IPI 8617750
genes like me logo Genes that share ontologies with ERBB4: view
genes like me logo Genes that share phenotypes with ERBB4: view

Animal Models for ERBB4 Gene

MGI Knock Outs for ERBB4:

Animal Model Products

CRISPR Products

miRNA for ERBB4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERBB4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ERBB4 Gene

Localization for ERBB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB4 Gene

Cell membrane; Single-pass type I membrane protein. Note=In response to NRG1 treatment, the activated receptor is internalized.
ERBB4 intracellular domain: Nucleus. Mitochondrion. Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERBB4 Gene COMPARTMENTS Subcellular localization image for ERBB4 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 4
extracellular 4
cytoskeleton 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ERBB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 15534001
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA 16778220
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ERBB4: view

Pathways for ERBB4 Gene

genes like me logo Genes that share pathways with ERBB4: view

Pathways by source for ERBB4 Gene

1 Sino Biological pathway for ERBB4 Gene
1 Cell Signaling Technology pathway for ERBB4 Gene
1 BioSystems pathway for ERBB4 Gene
1 PharmGKB pathway for ERBB4 Gene
2 GeneGo (Thomson Reuters) pathways for ERBB4 Gene
1 R&D Systems pathway for ERBB4 Gene
4 Tocris pathways for ERBB4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for ERBB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration ISS --
GO:0001934 positive regulation of protein phosphorylation TAS 15534001
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation --
GO:0007165 signal transduction IDA 10572067
genes like me logo Genes that share ontologies with ERBB4: view

Compounds for ERBB4 Gene

(5) Tocris Compounds for ERBB4 Gene

Compound Action Cas Number
AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor [170449-18-0]
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
AG 825 Selective ErbB2 inhibitor [149092-50-2]
Iressa Orally active, selective EGFR inhibitor [184475-35-2]
PD 153035 hydrochloride EGFR-kinase inhibitor [183322-45-4]

(2) HMDB Compounds for ERBB4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(7) IUPHAR Ligand for ERBB4 Gene

Ligand Type Action Affinity Pubmed IDs
neuregulin-1 None None
neuregulin-3 None None
betacellulin None None
neuregulin-4 None None
epiregulin None None
HB-EGF None None
neuregulin-2 None None

(32) Novoseek inferred chemical compound relationships for ERBB4 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 80.8 116
pd158780 79.1 1
hrgbeta1 77.2 2
trastuzumab 71.9 4
pertuzumab 67.9 1
genes like me logo Genes that share compounds with ERBB4: view

Transcripts for ERBB4 Gene

mRNA/cDNA for ERBB4 Gene

(10) Additional mRNA sequences :
(6) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERBB4 Gene

V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERBB4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ERBB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERBB4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: -

ExUns: 27 ^ 28a · 28b
SP1:
SP2:

Relevant External Links for ERBB4 Gene

GeneLoc Exon Structure for
ERBB4
ECgene alternative splicing isoforms for
ERBB4

Expression for ERBB4 Gene

mRNA expression in normal human tissues for ERBB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERBB4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (4.5) and Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERBB4 Gene

SOURCE GeneReport for Unigene cluster for ERBB4 Gene Hs.390729

mRNA Expression by UniProt/SwissProt for ERBB4 Gene

Q15303-ERBB4_HUMAN
Tissue specificity: Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
genes like me logo Genes that share expressions with ERBB4: view

In Situ Assay Products

Orthologs for ERBB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERBB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERBB4 35
  • 99.64 (n)
  • 99.92 (a)
ERBB4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERBB4 35
  • 91.55 (n)
  • 96.84 (a)
ERBB4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERBB4 35
  • 93.3 (n)
  • 97.84 (a)
ERBB4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Erbb4 35
  • 89.94 (n)
  • 97.29 (a)
Erbb4 16
Erbb4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERBB4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERBB4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Erbb4 35
  • 89.93 (n)
  • 96.56 (a)
chicken
(Gallus gallus)
Aves ERBB4 35
  • 82.22 (n)
  • 93.29 (a)
ERBB4 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERBB4 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia erbb4 35
  • 75.84 (n)
  • 84.31 (a)
zebrafish
(Danio rerio)
Actinopterygii ERBB4 (3 of 4) 36
  • 87 (a)
OneToMany
ERBB4 (4 of 4) 36
  • 78 (a)
OneToMany
erbb4a 35
  • 69.76 (n)
  • 75.3 (a)
erbb4a 36
  • 68 (a)
OneToMany
erbb4b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Egfr 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea let-23 37
  • 28 (a)
F09G2.1 37
  • 31 (a)
Species with no ortholog for ERBB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERBB4 Gene

ENSEMBL:
Gene Tree for ERBB4 (if available)
TreeFam:
Gene Tree for ERBB4 (if available)

Paralogs for ERBB4 Gene

Paralogs for ERBB4 Gene

genes like me logo Genes that share paralogs with ERBB4: view

Variants for ERBB4 Gene

Sequence variations from dbSNP and Humsavar for ERBB4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3452 -- 211,946,681(-) ATACC(C/T)GTAAT intron-variant
rs16775 -- 212,324,573(-) TTCAC(C/T)GATCC intron-variant
rs707283 -- 211,969,445(-) AAAGT(A/G)TGTAT intron-variant
rs707284 -- 211,974,321(-) TTACC(A/G)TTACT intron-variant
rs714393 -- 211,833,993(+) GAAAA(C/T)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERBB4 Gene

Variant ID Type Subtype PubMed ID
nsv834523 CNV Gain 17160897
nsv875776 CNV Gain 21882294
nsv821892 CNV Gain 20364138
nsv460065 CNV Loss 19166990
nsv875777 CNV Gain 21882294
nsv818108 CNV Gain 17921354
nsv520702 CNV Loss 19592680
nsv875778 CNV Loss 21882294
nsv460066 CNV Loss 19166990
esv274655 CNV Insertion 20981092
nsv460067 CNV Gain 19166990
dgv4422n71 CNV Loss 21882294
esv2664538 CNV Deletion 23128226
nsv528570 CNV Loss 19592680
nsv470512 CNV Loss 18288195
nsv460068 CNV Loss 19166990
nsv875782 CNV Loss 21882294
nsv460069 CNV Loss 19166990
nsv460070 CNV Loss 19166990
nsv875783 CNV Loss 21882294
esv2519305 CNV Deletion 19546169
esv2098674 CNV Deletion 18987734
esv2721423 CNV Deletion 23290073
esv4037 CNV Deletion 18987735
esv2567329 CNV Deletion 19546169
nsv213952 CNV Loss 16902084
esv1034805 CNV Deletion 17803354
esv7939 CNV Loss 19470904
esv34128 CNV Loss 18971310
esv2670570 CNV Deletion 23128226
nsv875784 CNV Loss 21882294
esv270191 CNV Insertion 20981092
nsv875785 CNV Loss 21882294
nsv834525 CNV Gain 17160897
esv2721424 CNV Deletion 23290073
esv2112410 CNV Deletion 18987734
esv2721425 CNV Deletion 23290073
esv2721426 CNV Deletion 23290073
esv997888 CNV Deletion 20482838
esv273002 CNV Insertion 20981092
esv270993 CNV Insertion 20981092
esv267983 CNV Insertion 20981092
esv272994 CNV Insertion 20981092
dgv4423n71 CNV Loss 21882294
nsv875787 CNV Gain+Loss 21882294
nsv875790 CNV Loss 21882294
nsv213755 CNV Loss 16902084
esv2721427 CNV Deletion 23290073
esv2673624 CNV Deletion 23128226
nsv821893 CNV Loss 20364138
esv25751 CNV Loss 19812545
esv2675399 CNV Deletion 23128226
esv23750 CNV Loss 19812545
nsv875791 CNV Loss 21882294
nsv875792 CNV Loss 21882294
nsv525127 CNV Loss 19592680
dgv4424n71 CNV Loss 21882294
dgv4425n71 CNV Loss 21882294
esv270926 CNV Insertion 20981092
esv268536 CNV Insertion 20981092
nsv470513 CNV Loss 18288195
dgv4426n71 CNV Loss 21882294
nsv875799 CNV Loss 21882294
nsv875800 CNV Loss 21882294
nsv875801 CNV Loss 21882294
dgv487n27 CNV Loss 19166990
dgv4427n71 CNV Loss 21882294
nsv875805 CNV Gain 21882294
nsv507066 CNV Insertion 20534489
nsv875806 CNV Loss 21882294
nsv875807 CNV Loss 21882294
nsv460074 CNV Loss 19166990
nsv834526 CNV Gain 17160897
nsv834527 CNV Loss 17160897
dgv488n27 CNV Loss 19166990
dgv4428n71 CNV Loss 21882294
nsv875809 CNV Loss 21882294
nsv460079 CNV Loss 19166990
dgv489n27 CNV Loss 19166990
nsv527162 CNV Loss 19592680
nsv818109 CNV Gain 17921354
dgv490n27 CNV Loss 19166990
dgv491n27 CNV Loss 19166990
nsv519556 CNV Gain 19592680
esv273888 CNV Insertion 20981092
esv269110 CNV Insertion 20981092
esv988519 CNV Insertion 20482838
esv1345178 CNV Insertion 17803354
esv271063 CNV Insertion 20981092
nsv10218 CNV Loss 18304495
dgv29n50 CNV Loss 21212237
nsv818110 CNV Loss 17921354
nsv516174 CNV Loss 19592680
esv29362 CNV Loss 19812545
esv2657326 CNV Deletion 23128226
esv33432 CNV Loss 17666407
esv2422123 CNV Deletion 20811451
nsv514117 CNV Loss 21397061
nsv442848 CNV CNV 18776908
nsv818113 CNV Loss 17921354
dgv1286e1 CNV Complex 17122850
dgv1287e1 CNV Complex 17122850
nsv214237 CNV Insertion 16902084
nsv875811 CNV Loss 21882294
nsv3149 CNV Loss 18451855
esv34076 CNV Loss 18971310
esv2663972 CNV Deletion 23128226
esv2656561 CNV Deletion 23128226
esv29110 CNV Loss 19812545
nsv875812 CNV Gain 21882294

Relevant External Links for ERBB4 Gene

HapMap Linkage Disequilibrium report
ERBB4
Human Gene Mutation Database (HGMD)
ERBB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB4 Gene

Disorders for ERBB4 Gene

(1) OMIM Diseases for ERBB4 Gene (600543)

UniProtKB/Swiss-Prot

ERBB4_HUMAN
  • Amyotrophic lateral sclerosis 19 (ALS19) [MIM:615515]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:24119685}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ERBB4 Gene

(41) Novoseek inferred disease relationships for ERBB4 Gene

Disease -log(P) Hits PubMed IDs
viral leukemia 69.6 3
breast cancer 65.7 63
breast carcinoma 54.8 12
tumors 54 71
cancer 46.6 31

Relevant External Links for ERBB4

Genetic Association Database (GAD)
ERBB4
Human Genome Epidemiology (HuGE) Navigator
ERBB4
Tumor Gene Database (TGDB):
ERBB4
genes like me logo Genes that share disorders with ERBB4: view

Publications for ERBB4 Gene

  1. HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. (PMID: 8617750) Cohen B.D. … Fell H.P. (J. Biol. Chem. 1996) 3 4 23
  2. Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. (PMID: 9419975) Komurasaki T. … Morimoto S. (Oncogene 1997) 3 4 23
  3. Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor. (PMID: 7689552) Culouscou J.-M. … Shoyab M. (J. Biol. Chem. 1993) 3 4 23
  4. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. (PMID: 8383326) Plowman G.D. … Shoyab M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  5. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. (PMID: 10353604) Elenius K. … Klagsbrun M. (Oncogene 1999) 3 4 23

Products for ERBB4 Gene

  • Addgene plasmids for ERBB4

Sources for ERBB4 Gene

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