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ERBB4 Gene

protein-coding GIFtS: 75

GC02M211955

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
(Previous name: v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
HER4 ^², ³, ⁵
MGC138404 ^²
p180erbB4 ^², ³

Descriptions
Tyrosine kinase-type cell surface receptor HER4 ^², ³
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 ^²
receptor tyrosine-protein kinase erbB-4 ^²
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 ^¹
v-erb-a erythroblastic leukemia viral oncogene homolog 4 ^²
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ^²

External Ids
HGNC: 3432¹
Entrez Gene: 2066²
UniProtKB: Q15303³
Ensembl: ENSG00000178568⁷

Search outside databases for aliases for ERBB4 gene

Previous GC identifers: GC02M210522 GC02M210971 GC02M212210 GC02M212449 GC02M212072

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ERBB4:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor

subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a

transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a

PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors

and induces a variety of cellular responses including mitogenesis and differentiation. Multiple

proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment.

Mutations in this gene have been associated with cancer. Alternatively spliced variants which

encode different protein isoforms have been described; however, not all variants have been fully

characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303

Function: Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding

EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell

differentiation. Not activated by EGF, TGF-A, and amphiregulin

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ERBB4 gene

Entrez Gene cytogenetic band: 2q33.3-q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q33.3-q34

ERBB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M211955: (about GC identifiers)

Start:	211,948,687 bp from pter
End:	213,111,810 bp from pter
Size:	1,163,124 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303 (See protein sequence)

Recommended Name: Receptor tyrosine-protein kinase erbB-4 precursor

Size: 1308 amino acids; 146808 Da

Subunit: Homodimer or heterodimer with each of the other ERBB receptors (Potential). Interacts with

PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with CBFA2T3, MUC1 and WWOX

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

2AHX (3D)

2R4B (3D)

3BBT (3D)

3BBW (3D)

3BCE (3D)

Secondary accessions: Q2M1W1 Q59EW4

Alternative splicing: 3 isoforms: Q15303-1 Q15303-2 Q15303-3

Post-translational modifications:

Isoform JM-A is processed but not isoform JM-B. So, they respectively represent cleavable and

non-cleavable forms of the receptor¹

Ligand-binding increases phosphorylation on tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001036064.1 NP_005226.1

ENSEMBL proteins:

ENSP00000385565 ENSP00000260943 ENSP00000342235

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ERBB4
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ERBB4
	R&D Systems Recombinant & Natural Proteins for ERBB4 (ErbB4/HER4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ErbB 4)
	Human Recombinant Proteins from Abnova (ERBB4)

OriGene Purified Recombinant Human Protein: ERBB4

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8383326
GO:0016020	membrane	IEA	--
GO:0016323	basolateral plasma membrane	IDA	12646923

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Antibodies for ERBB4:

	Invitrogen Antibodies for ERBB4
	Millipore Mono- and Polyclonal Antibodies for the study of ERBB4
	Sigma-Aldrich Antibody Arrays and Antibodies for ERBB4
	R&D Systems Antibodies for ERBB4 (ErbB4/HER4)
	Cell Signaling Technology (CST) Antibodies for ERBB4 (HER4)
	Antibodies from Abcam (ErbB 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ERBB4)
	Novus Biologicals Antibodies for ERBB4

Assays for ERBB4:

	Invitrogen Assays for ERBB4
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ERBB4 (ErbB4/HER4) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15303

ProtoNet protein and cluster: Q15303

5/6 Blocks protein families (see all 6 ):

IPB000494 Epidermal growth-factor receptor (EGFR)

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

IPB004019 YLP motif

IPB006211 Furin-like cysteine rich region

IPB006212 Furin-like repeat

UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303

Domain: The WW-binding motifs mediate interaction with WWOX

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ERBB4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ERBB4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042599

Applied Biosystems Silencer® siRNAs for ERBB4

Sigma-Aldrich siRNA and siRNA Panels for ERBB4

Sigma-Aldrich shRNA Panels and shRNA for ERBB4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042599
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042599
untagged cDNA clones in CMV expression vector (see all 3): NM_001042599

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005235

UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303

Function: Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding

EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell

differentiation. Not activated by EGF, TGF-A, and amphiregulin

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for ERBB4:

avian erythroblastic leukemia v(erb-b) viral oncogene homolog 4,heregulin beta 1 receptor (180kDa)

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Erbb4):

	behavior/neurological	craniofacial	embryogenesis	endocrine/exocrine gland
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system
reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS	8383326
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	IPI	9419975 10572067 11867753
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ERBB4 (Your Favorite Gene powered by Ingenuity)

Neuregulin Signaling
Agrin Interactions at Neuromuscular Junction

GeneDecks ERBB4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ERBB4

5/74 Interacting proteins for ERBB4 (Q15303^{1, 2} ENSP00000342235³) via UniProtKB, MINT, and/or STRING (see all 74 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353², ENSP00000357432³	MINT-61533 MINT-61522 MINT-61529 MINT-61536 MINT-74739 MINT-74740 STRING (score=.996)
GRB2	P62993², ENSP00000339007³	MINT-61531 MINT-61528 MINT-61534 MINT-61527 MINT-61530 MINT-61532 STRING (score=.984)
DLG4	P78352¹, ENSP00000293813³	EBI-80371, EBI-80389 STRING (score=.996)
ERBB2	P04626¹, ENSP00000269571³	EBI-80371, EBI-641062 STRING (score=.974)
EGFR	P00533¹, ENSP00000275493³	EBI-80371, EBI-297353 STRING (score=.962)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	IDA	10572067
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--
GO:0007275	multicellular organismal development	TAS	8383326
GO:0007399	nervous system development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ERBB4

Sigma-Aldrich Small Molecules for ERBB4:

Inhibitor

Compounds for ERBB4 available from Tocris Bioscience

Compound	Action	CAS number
HDS 029	Potent inhibitor of the ErbB receptor family
JNJ 28871063 hydrochloride	Potent ErbB receptor family inhibitor	[944341-54-2]
PD 158780	Potent ErbB receptor family inhibitor	[171179-06-9]

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10/15 Novoseek chemical compound relationships for ERBB4 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	80.20	138	9016763 (3), 15219672 (3), 9419975 (2), 11679632 (2) (see all 99)
pd158780	79.56	1	15555917 (1)
hrgbeta1	77.75	2	12209601 (1), 15714117 (1)
pertuzumab	71.61	1	16857824 (1)
phosphotyrosine	56.45	3	9685416 (2), 8579117 (1)
phosphatidylinositol	42.77	8	8617750 (2), 10353604 (2), 11389077 (1), 9710588 (1) (see all 6)
phosphoinositide	29.96	5	10722704 (1), 18819924 (1), 11343971 (1)
12-o-tetradecanoylphorbol 13-acetate	21.81	7	11679632 (1), 10944525 (1), 12807903 (1), 16061658 (1)
progesterone	10.31	3	8579117 (1), 15534105 (1), 11036938 (1)
oxygen	2.26	1	9685416 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ERBB4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ERBB4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042599

Sigma-Aldrich siRNA and siRNA Panels for ERBB4

Sigma-Aldrich shRNA Panels and shRNA for ERBB4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001042599 NM_005235

REFSEQ mRNAs for ERBB4 gene (2 alternative transcripts):

NM_001042599.1 NM_005235.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001042599 NM_005235

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042599
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042599
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001042599

Additional cDNA sequence:

AB209697.1 AF007153.1 AK126298.1 AK308606.1 BC112199.1 BC143741.1 BC143747.1 BC143749.1

CR627023.1 L07868.1

3 DOTS entries:

DT.207790 DT.414957 DT.86845746

4 AceView cDNA sequences:

AI793060 AI793236 AI253036 AW438696

highest scoring ESTs for ERBB4:

L07868 AI793060 AF007153 AI375572 AJ712278 AL118790 AL699877 AL699888 AL700733 AL701131

Unigene Cluster for ERBB4:

V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Hs.390729 [show with all ESTs]

Unigene Representative Sequence: NM_005235

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB4

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:
SP2:																																																			-

ExUns:	27	^	28a	·	28b
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for ERBB4

3 Ensembl transcripts including schematic representations:

ENST00000402597 ENST00000260943 ENST00000342788

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ERBB4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ERBB4

¹ / ² / ³

12 probe-sets matching ERBB4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37273_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.16	AF007153	0.60	1.00	0.82	1
82181_at²^{, 3}	U95-D	1	1.00	1.00	0.85	1.02	N52194	0.20	1.00	0.72	1
1727_at²^{, 3}	U95-A	1	1.00	1.00	-0.33	0.23	L07868	1.00	0.82	0.92	1
92081_at²^{, 3}	U95-D	1	1.00	1.00	0.92	0.86	AI375572	0.60	1.00	0.82	1
206794_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005235	0.60	1.00	0.82	1
214053_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW772192	0.40	1.00	0.76	1
233498_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
233494_at*²	U133-B	NULL	0.00	0.00	--	--	--	--	--	--	--
206794_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214053_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233498_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233494_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks ERBB4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATCTGTCAG

SOURCE GeneReport for Unigene cluster: Hs.390729
Expression variation in blood from EXPOLDB for ERBB4
UniProtKB/Swiss-Prot: ERBB4_HUMAN, Q15303
Tissue specificity: Expressed at highest levels in brain, heart, kidney, in addition to skeletal
muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus,
lung, salivary gland, and pancreas. Isoform JM-A and isoform JM-B are expressed in cerebellum, but
only the isoform JM-B is expressed in the heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ERBB4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ERBB4¹	--	v-erb-a erythroblastic leukemia viral oncogene homolog more	93.91(n) 98.78(a)	488508 XM_545629.2 XP_545629.2
chimpanzee (Pan troglodytes)	ERBB4¹	--	v-erb-a erythroblastic leukemia viral oncogene homolog more	99.64(n) 99.92(a)	459919 XM_516067.2 XP_516067.2
rat (Rattus norvegicus)	Erbb4¹	--	v-erb-a erythroblastic leukemia viral oncogene homolog more	89.93(n) 96.56(a)	59323 NM_021687.1 NP_067719.1
mouse (Mus musculus)	Erbb4^{1, 5}	1 (35.10 cM)⁵	v-erb-a erythroblastic leukemia viral oncogene homolog more^{1, 5}	90.04(n)¹ 97.32(a)¹	13869¹ XM_136682.7¹ XP_136682.7¹ AC099604⁵ AC107673⁵ (see all 10)
chicken (Gallus gallus)	ERBB4¹	--	v-erb-a erythroblastic leukemia viral oncogene homolog more	82.22(n) 93.29(a)	395671 NM_001030365.1 NP_001025536.1

About this table Species with no ortholog for ERBB4

ENSEMBL Gene Tree for ERBB4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ERBB4 gene

ERBB3² ERBB2² EGFR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/7475 NCBI SNPs in ERBB4 are shown (see all 7475 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 2428)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1595065^1,2	A,C,F,H,O	211950886(-)	`ACTACT/CGCATA`	2	--	ut3¹		7	NA EU EA WA	536
	rs1972820^1,2	A,C,F,H,O	211951667(-)	`TCAGGT/CATAAT`	2	--	ut3¹		6	EU EA NA	414
	rs1836724^1,2	A,C,F,H,O	211953197(-)	`AGCTCT/CTGGTT`	2	--	ut3¹		11	NA EU EA WA	956
	rs2128321^1,2	A,C,F,H	213113521(-)	`CGCACG/TCTCAG`	2	--	ng3¹		4	EU EA WA	410
	rs7355673^1,2	A,C,F,H	213112634(+)	`CGCAGT/CACTCT`	2	--	ng3¹		4	EU EA WA	410
	rs11895168^1,2	A,C,F,H	211950437(+)	`CCATAC/AAGAGC`	2	--	ut3¹		11	NA EU EA WA	978
	rs1595066^1,2	C,F,H,O	211949970(-)	`GTAAGG/ATACTT`	2	--	ut3¹		5	MN EU EA WA	602
	rs11887436^1,2	A,C,F,H	211952424(+)	`TTTCCC/GAAGTG`	2	--	ut3¹		8	EU EA WA	832
	rs1971801^1,2	A,C,F,H	211948582(-)	`TGCCCA/GTATTT`	2	--	ng5¹		4	EU EA WA	416
	rs10932374^1,2	A,C,F,H	211952648(+)	`TTATCG/ATGGTT`	2	--	ut3¹		15	NA EU EA WA	1340

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HapMap Linkage Disequilibrium images for ERBB4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600543

10/39 Novoseek disease relationships for ERBB4 gene (see all 39 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
viral leukemia	72.97	6	18854870 (1), 17376983 (1), 15878319 (1)
breast cancer	65.65	83	15735025 (6), 18567793 (4), 17909041 (3), 10537315 (3) (see all 30)
breast carcinoma	54.57	13	18426733 (2), 16187281 (1), 8062828 (1), 9699674 (1) (see all 11)
tumors	53.74	99	12678544 (3), 12637154 (3), 18426733 (3), 18575766 (2) (see all 49)
cancer	45.48	41	16962163 (2), 15735025 (2), 19098003 (2), 10535875 (1) (see all 26)
medulloblastoma childhood	44.53	3	9242460 (2), 9731505 (1)
medulloblastoma	34.07	2	9242460 (1), 16878160 (1)
nsclc	33.26	9	16253759 (1), 16187281 (1), 16463386 (1), 19098003 (1) (see all 6)
schizophrenia	32.18	35	17164265 (5), 16402353 (3), 19336245 (3), 18243664 (3) (see all 15)
mammary tumor	31.57	6	17120616 (3), 8383326 (1)

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Human Gene Mutation Database: ERBB4
Genetic Association Database: ERBB4
Human Genome Epidemiology Navigator: ERBB4 (12 documents)
Tumor Gene Database: ERBB4

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/415 PubMed articles for ERBB4 gene (see all 415 ):

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. (PubMed id 16061658)^{1, 3, 4} Aqeilan R.I.... Croce C.M. (2005)
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. (PubMed id 16203964)^{1, 3, 4} Bouyain S....Leahy D.J. (2005)
A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. (PubMed id 9334263)^{1, 3, 4} Elenius K....Klagsbrun M. (1997)
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. (PubMed id 8383326)^{1, 3, 4} Plowman G.D.... Shoyab M. (1993)
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. (PubMed id 16249994)^{3, 6} Norton N....O'Donovan M.C. (2006)
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. (PubMed id 17018285)^{2, 3} Sardi S.P....Corfas G. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. (PubMed id 10725395)^{3, 4} Garcia R.A.... Buonanno A. (2000)
Localization of the human HER4/erbB-4 gene to chromosome 2. (PubMed id 7700649)^{2, 3} Zimonjic D.B....Kraus M.H. (1995)
Inter-conversion of neuregulin2 full and partial agonists for ErbB4. (PubMed id 17945187)^{1, 3} Wilson K.J....Riese D.J. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2066	HGNC: 3432	AceView: ERBB4.1	Ensembl:ENSG00000178568	euGenes: HUgn2066
ECgene: ERBB4	H-InvDB: ERBB4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ERBB4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ERBB4
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for ERBB4 gene:

Weizmann Institute:

"Neuregulin-4 (NRG4), a Novel Growth Factor Which Acts Through the Erbb4 Receptor Tyrosine Kinase; Sequences, Antibodies To and Uses Thereof."

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ERBB4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ERBB4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ERBB4		Antibodies for ERBB4
	Explore super-pooled esiRNAs		Proteins for ERBB4
	Lentivirus-delivered shRNAs for ERBB4		Small molecules for ERBB4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ERBB4)
	Antibodies (ERBB4)
	Chimera RNAi (ERBB4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ERBB4 (HER4)

	Recombinant Proteins (ErbB 4)
	Antibodies (ErbB 4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for ERBB4

	Drugs for ERBB4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ERBB4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ERBB4 Gene at Home site.
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ERBB4 Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for ERBB4

Summaries
for ERBB4

Genomic Location
for ERBB4

Proteins
for ERBB4

Protein Domains/
Families
for ERBB4

Gene Function
for ERBB4

Pathways & Interactions
for ERBB4

Drugs & Compounds
for ERBB4

Transcripts
for ERBB4

Expression
for ERBB4

Orthologs
for ERBB4

Paralogs
for ERBB4

SNPs/Variants
for ERBB4

Disorders & Mutations
for ERBB4

Medical News
for ERBB4

Publications
for ERBB4

Search for ERBB4

Genome Databases showing ERBB4

Other Databases showing ERBB4

Specialized Databases showing ERBB4

Licensable Technologies
for ERBB4

Services
for ERBB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ERBB4 Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor ERBB4

Summariesfor ERBB4

Genomic Locationfor ERBB4

Proteinsfor ERBB4

Protein Domains/Familiesfor ERBB4

Gene Functionfor ERBB4

Pathways & Interactionsfor ERBB4

Drugs & Compoundsfor ERBB4

Transcriptsfor ERBB4

Expression for ERBB4

Orthologsfor ERBB4

Paralogsfor ERBB4

SNPs/Variantsfor ERBB4

Disorders & Mutationsfor ERBB4

Medical Newsfor ERBB4

Publicationsfor ERBB4

Search for ERBB4

Genome Databases showing ERBB4

Other Databases showing ERBB4

Specialized Databases showing ERBB4

Licensable Technologiesfor ERBB4

Servicesfor ERBB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ERBB4

Summaries
for ERBB4

Genomic Location
for ERBB4

Proteins
for ERBB4

Protein Domains/
Families
for ERBB4

Gene Function
for ERBB4

Pathways & Interactions
for ERBB4

Drugs & Compounds
for ERBB4

Transcripts
for ERBB4

Expression
for ERBB4

Orthologs
for ERBB4

Paralogs
for ERBB4

SNPs/Variants
for ERBB4

Disorders & Mutations
for ERBB4

Medical News
for ERBB4

Publications
for ERBB4

Licensable Technologies
for ERBB4

Services
for ERBB4